A0A096MVY1_PAPAN Loading...

Gamma-aminobutyric acid receptor-associated protein-like 2

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

AlphaFold DB (P60520), UniProt , Accession A0A096MVY1, Species PAPAN (Papio anubis, Olive baboon), Gene GABARAPL2, Length 117 aa.