Download updated protein structures

UniProt 2026_01

All species

  • alphasync_cif_2026_01.tar (9.5 GB)

    70,617 updated structures covering 41,281 reviewed and canonical reference proteome proteins from UniProt (large proteins as multiple fragments).

  • alphasync_pae_2026_01.tar (22.0 GB)

    Predicted Aligned Error (PAE) values for the above structures, excluding fragmented proteins (>2700 aa).

  • alphasync_params_2026_01.tar (72 MB)

    AlphaFold parameters and versions used for the above structures.

The archives above contain newly predicted structures from AlphaSync, as well as PAE scores and the AlphaFold 2.3.2 parameters used. They include proteins whose sequences have been updated or added to UniProt since the latest AlphaFold DB release.

AlphaSync now covers a total of 925 species, 43 of which now have complete coverage, and 43 including isoforms. This includes all reviewed and canonical reference proteome proteins from UniProt, and excludes small peptides below 16 aa or proteins containing ambiguous sequence characters such as B, Z or X.

The completed species include model organisms such as human, mouse, Drosophila, C. elegans, A. thaliana, rice, yeast, E. coli and many of the Global Health Proteomes from the AlphaFold Protein Structure Database. Please see the Browse section for a full list of completed species.

Many of these are fragment structures for proteins longer than 2700 aa, as predicted by DeepMind in Tunyasuvunakool et al. in Nature (2021) for the human proteome only. AlphaSync also provides these for other species. It then combines information across fragments.

Each file is a TAR archive containing gzip-compressed mmCIF or JSON files, as in the AlphaFold Protein Structure Database. The parameter files are in a simple JSON format.

AlphaSync data by St. Jude Children's Research Hospital is licensed under CC BY 4.0.

U.S. Privacy Notice - Disclaimer / Registrations / Copyright Statement - Linking Policy - Notice of Privacy Practices (HIPAA) - Notice of Non‑Discrimination
© Copyright 2026 St. Jude Children's Research Hospital, a not-for-profit, section 501(c)(3).