A0A023IP90_HUMAN Loading...

Integrin a4 subunit

AlphaFold DB , UniProt , Accession A0A023IP90, Species HUMAN (Homo sapiens, Human), Gene ITGA4, Length 31 aa.

						>A0A023IP90_HUMAN|A0A023IP90|ITGA4
WTGSLFVYNITTNKYKAFLDKQNQVKFGSYL
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	W	58.6	Low	68.1	Low	282 Å²	282	120.7 Å²	120.7	100%	1.068	62%	0.619	S	S	*	*				0	74.9	0	169.1	41.2	0	0	108.6
2	T	65.6	Low	68.8	Low	103 Å²	103	114.9 Å²	114.9	63%	0.632	59%	0.594	S	S	*	*			trans	-151.2	-24.3	-175.7	22.3	0	0	0	110.5	S4 L5	T2-S4 PolarHBondContact O-N 3.42Å; T2-S4 VanDerWaalsContact C-N 3.29Å; T2-L5 PolarHBondContact O-N 2.79Å
3	G	60	Low	69.1	Low	48 Å²	48	114.5 Å²	114.5	50%	0.495	59%	0.593	S	S	.	*	H	α-helix	trans	-61.9	-28.6	175.8	0	0	0	0	114.9	L5 V7	G3-L5 PolarHBondContact O-N 3.31Å; G3-V7 WeakPolarHBondContact O-CG2 3.14Å; G3-V7 PolarHBondContact O-N 3.29Å; G3-V7 VanDerWaalsContact O-N 3.1Å; G3-V7 VanDerWaalsContact O-CG2 3.24Å
4	S	69.1	Low	69.5	Low	73 Å²	73	117.2 Å²	117.2	51%	0.51	60%	0.598	S	S	.	*	H	α-helix	trans	-67.7	-36.1	-179.7	54.1	0	0	0	113	T2 Y8	T2-S4 PolarHBondContact O-N 3.42Å; T2-S4 VanDerWaalsContact C-N 3.29Å; S4-Y8 VanDerWaalsContact O-CB 3.27Å; S4-Y8 WeakPolarHBondContact O-CB 3.24Å; S4-Y8 PolarHBondContact O-N 3.05Å
5	L	75.3	Confident	69.7	Low	132 Å²	132	119.4 Å²	119.4	69%	0.691	60%	0.597	S	S	*	*	H	α-helix	trans	-73.3	-38.9	-178.4	-160.2	73.9	0	0	111.6	T2 G3 Y8 N9	T2-L5 PolarHBondContact O-N 2.79Å; G3-L5 PolarHBondContact O-N 3.31Å; L5-Y8 PolarHBondContact O-N 3.48Å; L5-N9 WeakPolarHBondContact O-CB 2.89Å; L5-N9 PolarHBondContact O-N 2.72Å
6	F	66.3	Low	70	Confident	146 Å²	146	120.7 Å²	120.7	64%	0.64	60%	0.598	S	S	*	*	H	α-helix	trans	-64.1	-44.7	173.4	-82.4	-87.7	0	0	111.5	N9 I10	F6-N9 PolarHBondContact O-N 3.48Å; F6-I10 WeakPolarHBondContact O-CB 3.2Å; F6-I10 PolarHBondContact O-N 3.35Å; F6-I10 WeakPolarHBondContact O-CG1 3.18Å; F6-I10 WeakPolarHBondContact O-CD1 3.06Å
7	V	67.6	Low	70.2	Confident	90 Å²	90	116.6 Å²	116.6	55%	0.545	59%	0.588	S	S	.	*	H	α-helix	trans	-65.8	-41.4	176.9	174.6	0	0	0	111.3	G3 N9 I10 T11	G3-V7 WeakPolarHBondContact O-CG2 3.14Å; G3-V7 PolarHBondContact O-N 3.29Å; G3-V7 VanDerWaalsContact O-N 3.1Å; G3-V7 VanDerWaalsContact O-CG2 3.24Å; V7-N9 PolarHBondContact O-N 2.82Å; V7-I10 PolarHBondContact O-N 2.91Å; V7-T11 WeakPolarHBondContact O-CB 3.27Å; V7-T11 PolarHBondContact O-N 3.23Å; V7-T11 PolarHBondContact O-OG1 3.33Å
8	Y	69.9	Low	70.2	Confident	171 Å²	171	116.6 Å²	116.6	67%	0.671	58%	0.583	S	S	*	*	H	α-helix	trans	-64.1	-41	177.6	-162.6	-94.5	0	0	111.8	S4 L5 T12	S4-Y8 VanDerWaalsContact O-CB 3.27Å; S4-Y8 WeakPolarHBondContact O-CB 3.24Å; S4-Y8 PolarHBondContact O-N 3.05Å; L5-Y8 PolarHBondContact O-N 3.48Å; Y8-T12 PolarHBondContact O-OG1 3.38Å; Y8-T12 PolarHBondContact O-N 3.28Å; Y8-T12 WeakPolarHBondContact O-CB 3.42Å
9	N	65.8	Low	70.3	Confident	108 Å²	108	114.9 Å²	114.9	58%	0.578	58%	0.576	S	S	*	*	H	α-helix	trans	-68.8	-42.1	178.5	-163.9	50.4	0	0	112.1	L5 F6 V7 N13	L5-N9 WeakPolarHBondContact O-CB 2.89Å; L5-N9 PolarHBondContact O-N 2.72Å; F6-N9 PolarHBondContact O-N 3.48Å; V7-N9 PolarHBondContact O-N 2.82Å; N9-N13 VanDerWaalsContact O-CB 3.24Å; N9-N13 WeakPolarHBondContact O-CB 3.22Å; N9-N13 PolarHBondContact O-N 2.81Å
10	I	76.4	Confident	70.2	Confident	93 Å²	93	113.6 Å²	113.6	48%	0.477	57%	0.571	S	S	.	*	H	α-helix	trans	-67.1	-43.3	177	-65.5	163.3	0	0	110.9	F6 V7 N13 K14	F6-I10 WeakPolarHBondContact O-CB 3.2Å; F6-I10 PolarHBondContact O-N 3.35Å; F6-I10 WeakPolarHBondContact O-CG1 3.18Å; F6-I10 WeakPolarHBondContact O-CD1 3.06Å; V7-I10 PolarHBondContact O-N 2.91Å; I10-N13 PolarHBondContact O-N 2.95Å; I10-K14 WeakPolarHBondContact O-CB 3.3Å; I10-K14 PolarHBondContact O-N 3.32Å
11	T	74.6	Confident	70.2	Confident	82 Å²	82	115.3 Å²	115.3	50%	0.503	58%	0.575	S	S	.	*	H	α-helix	trans	-70.1	-42.3	-178.4	-51.5	0	0	0	110.9	V7 Y15	V7-T11 WeakPolarHBondContact O-CB 3.27Å; V7-T11 PolarHBondContact O-N 3.23Å; V7-T11 PolarHBondContact O-OG1 3.33Å; T11-Y15 WeakPolarHBondContact O-CB 3.07Å; T11-Y15 PolarHBondContact O-N 2.98Å
12	T	76.1	Confident	70.6	Confident	51 Å²	51	107.1 Å²	107.1	31%	0.313	55%	0.549	S	S	.	.	H	α-helix	trans	-61.3	-45	173.7	-75.9	0	0	0	111.8	Y8 Y15 K16	Y8-T12 PolarHBondContact O-OG1 3.38Å; Y8-T12 PolarHBondContact O-N 3.28Å; Y8-T12 WeakPolarHBondContact O-CB 3.42Å; T12-Y15 PolarHBondContact O-N 3.4Å; T12-K16 HydrophobicContact CG2-CG 4.47Å; T12-K16 PolarHBondContact O-N 2.85Å; T12-K16 WeakPolarHBondContact O-CG 3.19Å; T12-K16 VanDerWaalsContact O-CG 3.29Å; T12-K16 WeakPolarHBondContact O-CB 3.29Å; T12-K16 HydrophobicContact CG2-CD 3.93Å
13	N	72.4	Confident	70.4	Confident	109 Å²	109	104.9 Å²	104.9	58%	0.583	53%	0.533	S	S	*	.	H	α-helix	trans	-68.5	-42.5	-179.1	-158.2	-61.8	0	0	111.3	N9 I10 Y15 K16 A17	N9-N13 VanDerWaalsContact O-CB 3.24Å; N9-N13 WeakPolarHBondContact O-CB 3.22Å; N9-N13 PolarHBondContact O-N 2.81Å; I10-N13 PolarHBondContact O-N 2.95Å; N13-Y15 PolarHBondContact O-N 2.82Å; N13-K16 PolarHBondContact O-N 3.48Å; N13-A17 VanDerWaalsContact O-CB 3.24Å; N13-A17 WeakPolarHBondContact O-CB 3.19Å; N13-A17 PolarHBondContact O-N 2.85Å
14	K	74.6	Confident	70.4	Confident	153 Å²	153	108.5 Å²	108.5	67%	0.665	54%	0.537	S	S	*	.	H	α-helix	trans	-61.9	-42.4	172.1	-85.6	-170.1	179.9	-178.3	112.8	I10 A17 F18	I10-K14 WeakPolarHBondContact O-CB 3.3Å; I10-K14 PolarHBondContact O-N 3.32Å; K14-A17 PolarHBondContact O-N 2.86Å; K14-F18 PolarHBondContact O-N 3.43Å; K14-F18 VanDerWaalsContact O-CB 3.27Å; K14-F18 WeakPolarHBondContact O-CB 3.34Å
15	Y	73.7	Confident	69.9	Low	150 Å²	150	111 Å²	111	59%	0.588	55%	0.549	S	S	*	.	H	α-helix	trans	-66.5	-44.9	179.8	-176.6	-99.5	0	0	111.2	T11 T12 N13 F18 L19	T11-Y15 WeakPolarHBondContact O-CB 3.07Å; T11-Y15 PolarHBondContact O-N 2.98Å; T12-Y15 PolarHBondContact O-N 3.4Å; N13-Y15 PolarHBondContact O-N 2.82Å; Y15-F18 PolarHBondContact O-N 3.5Å; Y15-L19 VanDerWaalsContact O-CB 3.24Å; Y15-L19 WeakPolarHBondContact O-CB 3.39Å; Y15-L19 PolarHBondContact O-N 2.87Å
16	K	74.1	Confident	69.1	Low	140 Å²	140	112 Å²	112	61%	0.609	55%	0.547	S	S	*	.	H	α-helix	trans	-63.5	-40.8	174.5	-71.4	178.1	71.9	79	112.1	T12 N13 L19 D20	T12-K16 HydrophobicContact CG2-CG 4.47Å; T12-K16 PolarHBondContact O-N 2.85Å; T12-K16 WeakPolarHBondContact O-CG 3.19Å; T12-K16 VanDerWaalsContact O-CG 3.29Å; T12-K16 WeakPolarHBondContact O-CB 3.29Å; T12-K16 HydrophobicContact CG2-CD 3.93Å; N13-K16 PolarHBondContact O-N 3.48Å; K16-L19 PolarHBondContact O-N 3.48Å; K16-D20 VanDerWaalsContact O-CB 3.22Å; K16-D20 WeakPolarHBondContact O-CB 3.37Å; K16-D20 PolarHBondContact O-N 2.88Å
17	A	72.5	Confident	68.8	Low	52 Å²	52	110.6 Å²	110.6	43%	0.43	54%	0.541	S	S	.	.	H	α-helix	trans	-67.6	-36.5	176.6	0	0	0	0	112.6	N13 K14 K21	N13-A17 VanDerWaalsContact O-CB 3.24Å; N13-A17 WeakPolarHBondContact O-CB 3.19Å; N13-A17 PolarHBondContact O-N 2.85Å; K14-A17 PolarHBondContact O-N 2.86Å; A17-K21 WeakPolarHBondContact O-CB 3.24Å; A17-K21 PolarHBondContact O-N 3.43Å
18	F	71.2	Confident	68.2	Low	115 Å²	115	110 Å²	110	50%	0.504	55%	0.553	S	S	.	*	H	α-helix	trans	-70.3	-43.7	174.7	-175.7	-105.2	0	0	111.5	K14 Y15 K21 Q22	K14-F18 PolarHBondContact O-N 3.43Å; K14-F18 VanDerWaalsContact O-CB 3.27Å; K14-F18 WeakPolarHBondContact O-CB 3.34Å; Y15-F18 PolarHBondContact O-N 3.5Å; F18-K21 PolarHBondContact O-N 3.49Å; F18-Q22 HydrophobicContact CD1-CG 4.35Å; F18-Q22 PolarHBondContact O-N 2.94Å; F18-Q22 WeakPolarHBondContact O-CG 3.27Å; F18-Q22 VanDerWaalsContact O-CG 3.3Å; F18-Q22 WeakPolarHBondContact O-CB 3.24Å; F18-Q22 HydrophobicContact CZ-CG 4.09Å; F18-Q22 HydrophobicContact CE2-CG 4.34Å; F18-Q22 HydrophobicContact CE1-CG 4.1Å; F18-Q22 VanDerWaalsContact CD1-OE1 3.29Å
19	L	71.9	Confident	67.7	Low	85 Å²	85	106.9 Å²	106.9	45%	0.445	56%	0.557	S	S	.	*	H	α-helix	trans	-61.1	-47.1	174.4	-170.3	80.4	0	0	110.7	Y15 K16 Q22 N23	Y15-L19 VanDerWaalsContact O-CB 3.24Å; Y15-L19 WeakPolarHBondContact O-CB 3.39Å; Y15-L19 PolarHBondContact O-N 2.87Å; K16-L19 PolarHBondContact O-N 3.48Å; L19-Q22 CarbonylContact O-C 3.59Å; L19-Q22 PolarHBondContact O-N 3.42Å; L19-N23 PolarHBondContact O-N 3.46Å; L19-N23 WeakPolarHBondContact O-CB 3.45Å
20	D	68.2	Low	67.4	Low	88 Å²	88	110.5 Å²	110.5	47%	0.471	56%	0.563	S	S	.	*	H	α-helix	trans	-59.8	-48.3	176.2	-170.6	-99.4	0	0	111	K16 Q22 N23 Q24	K16-D20 VanDerWaalsContact O-CB 3.22Å; K16-D20 WeakPolarHBondContact O-CB 3.37Å; K16-D20 PolarHBondContact O-N 2.88Å; D20-Q22 VanDerWaalsContact C-N 3.31Å; D20-Q22 PolarHBondContact O-N 3.49Å; D20-N23 CarbonylContact O-C 3.47Å; D20-N23 PolarHBondContact O-N 2.97Å; D20-Q24 WeakPolarHBondContact O-CB 3.27Å; D20-Q24 VanDerWaalsContact O-CG 3.27Å; D20-Q24 WeakPolarHBondContact O-CG 3.33Å; D20-Q24 PolarHBondContact O-N 2.88Å; D20-Q24 PolarHBondContact OD1-NE2 2.94Å
21	K	69.6	Low	66.2	Low	151 Å²	151	117.9 Å²	117.9	66%	0.657	60%	0.603	S	S	*	*	H	α-helix	trans	-62	-35.7	176.9	-174.6	170.4	-178.5	170.6	113.4	A17 F18	A17-K21 WeakPolarHBondContact O-CB 3.24Å; A17-K21 PolarHBondContact O-N 3.43Å; F18-K21 PolarHBondContact O-N 3.49Å
22	Q	66.8	Low	65.8	Low	110 Å²	110	119.7 Å²	119.7	51%	0.514	61%	0.608	S	S	.	*	H	α-helix	trans	-77.7	-24.3	174.6	-73.8	-170.8	-47.7	0	113	F18 L19 D20	F18-Q22 HydrophobicContact CD1-CG 4.35Å; F18-Q22 PolarHBondContact O-N 2.94Å; F18-Q22 WeakPolarHBondContact O-CG 3.27Å; F18-Q22 VanDerWaalsContact O-CG 3.3Å; F18-Q22 WeakPolarHBondContact O-CB 3.24Å; F18-Q22 HydrophobicContact CZ-CG 4.09Å; F18-Q22 HydrophobicContact CE2-CG 4.34Å; F18-Q22 HydrophobicContact CE1-CG 4.1Å; F18-Q22 VanDerWaalsContact CD1-OE1 3.29Å; L19-Q22 CarbonylContact O-C 3.59Å; L19-Q22 PolarHBondContact O-N 3.42Å; D20-Q22 VanDerWaalsContact C-N 3.31Å; D20-Q22 PolarHBondContact O-N 3.49Å
23	N	62.4	Low	65.3	Low	56 Å²	56	123.3 Å²	123.3	30%	0.299	62%	0.623	S	S	.	*	H	α-helix	trans	-94.6	-16.6	-179.2	-153.5	29.3	0	0	112.6	L19 D20 V25 K26 F27	L19-N23 PolarHBondContact O-N 3.46Å; L19-N23 WeakPolarHBondContact O-CB 3.45Å; D20-N23 CarbonylContact O-C 3.47Å; D20-N23 PolarHBondContact O-N 2.97Å; N23-V25 PolarHBondContact O-N 2.65Å; N23-K26 PolarHBondContact O-N 2.86Å; N23-F27 HydrophobicContact CB-CE2 4.03Å; N23-F27 PolarHBondContact O-N 2.97Å; N23-F27 WeakPolarHBondContact O-CD2 3.24Å; N23-F27 WeakPolarHBondContact ND2-CZ 3.17Å; N23-F27 WeakPolarHBondContact ND2-CE2 3.35Å; N23-F27 HydrophobicContact CB-CD2 4.47Å
24	Q	60.8	Low	64.9	Low	124 Å²	124	124.1 Å²	124.1	58%	0.579	63%	0.625	S	S	*	*	T	Hydrogen-bonded Turn	trans	-57.1	-31.9	174	-90.2	178.4	-19	0	112.5	D20 K26	D20-Q24 WeakPolarHBondContact O-CB 3.27Å; D20-Q24 VanDerWaalsContact O-CG 3.27Å; D20-Q24 WeakPolarHBondContact O-CG 3.33Å; D20-Q24 PolarHBondContact O-N 2.88Å; D20-Q24 PolarHBondContact OD1-NE2 2.94Å; Q24-K26 VanDerWaalsContact C-N 3.29Å; Q24-K26 PolarHBondContact O-N 3.46Å
25	V	58.3	Low	64.3	Low	125 Å²	125	122.4 Å²	122.4	76%	0.758	62%	0.623	S	S	*	*	T	Hydrogen-bonded Turn	trans	-77	-17.2	176.8	-160.8	0	0	0	112	N23	N23-V25 PolarHBondContact O-N 2.65Å
26	K	58.7	Low	63.7	Low	152 Å²	152	120.7 Å²	120.7	66%	0.661	63%	0.625	S	S	*	*	T	Hydrogen-bonded Turn	trans	-97	-18.8	-175.8	-66.6	-166.8	175.6	-165.2	114.3	N23 Q24	N23-K26 PolarHBondContact O-N 2.86Å; Q24-K26 VanDerWaalsContact C-N 3.29Å; Q24-K26 PolarHBondContact O-N 3.46Å
27	F	58.5	Low	63	Low	117 Å²	117	119.4 Å²	119.4	51%	0.513	63%	0.626	S	S	.	*	G	3₁₀ helix	trans	-85	-14	178.3	-71.1	-70.1	0	0	114.7	N23 S29 Y30	N23-F27 HydrophobicContact CB-CE2 4.03Å; N23-F27 PolarHBondContact O-N 2.97Å; N23-F27 WeakPolarHBondContact O-CD2 3.24Å; N23-F27 WeakPolarHBondContact ND2-CZ 3.17Å; N23-F27 WeakPolarHBondContact ND2-CE2 3.35Å; N23-F27 HydrophobicContact CB-CD2 4.47Å; F27-S29 PolarHBondContact O-N 3.32Å; F27-Y30 HydrophobicContact CD1-CD2 4.32Å; F27-Y30 AromaticContact CD1-CE2 3.71Å; F27-Y30 HydrophobicContact CD1-CE2 3.71Å; F27-Y30 HydrophobicContact CE1-CE2 4.29Å
28	G	55.7	Low	62.4	Low	77 Å²	77	124.2 Å²	124.2	79%	0.794	64%	0.64	S	S	*	*	G	3₁₀ helix	trans	-78.9	6.6	176.4	0	0	0	0	115
29	S	58.7	Low	61.7	Low	107 Å²	107	124.9 Å²	124.9	75%	0.748	65%	0.651	S	S	*	*	G	3₁₀ helix	trans	-129	29.5	-177.8	-134.7	0	0	0	112.3	F27 L31	F27-S29 PolarHBondContact O-N 3.32Å; S29-L31 PolarHBondContact O-N 3.1Å
30	Y	59.7	Low	60.8	Low	184 Å²	184	128.3 Å²	128.3	72%	0.722	67%	0.668	S	S	*	*			trans	-78.7	110.9	153.2	-73.6	-87	0	0	106.3	F27	F27-Y30 HydrophobicContact CD1-CD2 4.32Å; F27-Y30 AromaticContact CD1-CE2 3.71Å; F27-Y30 HydrophobicContact CD1-CE2 3.71Å; F27-Y30 HydrophobicContact CE1-CE2 4.29Å
31	L	52.8	Low	60.2	Low	248 Å²	248	131.9 Å²	131.9	100%	1.298	69%	0.686	S	S	*	*			trans	-22.8	0	171.8	-81.1	148.5	0	0	115.1	S29	S29-L31 PolarHBondContact O-N 3.1Å

Retrieved 31 of 31 residues in 10.5 ms (Link to these results)

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