A0A023IPA8_HUMAN Loading...

Integrin a4 subunit

AlphaFold DB , UniProt , Accession A0A023IPA8, Species HUMAN (Homo sapiens, Human), Gene ITGA4, Length 27 aa.

						>A0A023IPA8_HUMAN|A0A023IPA8|ITGA4
LFVYNITTNKYKAFLDKQNQVKFGSYL
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	L	61.2	Low	68.7	Low	180 Å²	180	133.2 Å²	133.2	94%	0.942	65%	0.653	S	S	*	*				0	-41.7	0	-151.6	62.2	0	0	113.1	N5	L1-N5 PolarHBondContact O-N 3.15Å
2	F	58.3	Low	69.5	Low	180 Å²	180	133 Å²	133	79%	0.789	65%	0.646	S	S	*	*	H	α-helix	trans	-63.9	-40.9	178.5	-64.5	-81.5	0	0	114.6	N5 I6	F2-N5 PolarHBondContact O-N 3.4Å; F2-I6 VanDerWaalsContact O-CG1 3.27Å; F2-I6 WeakPolarHBondContact O-CG1 3.09Å; F2-I6 PolarHBondContact O-N 3.46Å; F2-I6 WeakPolarHBondContact O-CD1 3.49Å
3	V	62.8	Low	70.3	Confident	108 Å²	108	126.9 Å²	126.9	66%	0.655	63%	0.631	S	S	*	*	H	α-helix	trans	-66.6	-39.8	-179.2	-178.1	0	0	0	112.4	I6 T7	V3-I6 PolarHBondContact O-N 3.4Å; V3-T7 WeakPolarHBondContact O-CB 3.26Å; V3-T7 PolarHBondContact O-N 2.94Å; V3-T7 PolarHBondContact O-OG1 3.04Å
4	Y	63.5	Low	71	Confident	187 Å²	187	126.1 Å²	126.1	73%	0.733	62%	0.622	S	S	*	*	H	α-helix	trans	-62.3	-43.6	174.9	-103	-85.6	0	0	111.3	I6 T7 T8	Y4-I6 PolarHBondContact O-N 3.1Å; Y4-T7 PolarHBondContact O-N 2.92Å; Y4-T8 PolarHBondContact O-N 3.37Å; Y4-T8 VanDerWaalsContact O-OG1 3.12Å; Y4-T8 PolarHBondContact O-OG1 3.36Å; Y4-T8 WeakPolarHBondContact O-CB 3.48Å
5	N	62.1	Low	71.7	Confident	114 Å²	114	122.3 Å²	122.3	61%	0.61	61%	0.605	S	S	*	*	H	α-helix	trans	-64.7	-40.2	177.2	-98.6	58.4	0	0	113.1	L1 F2 N9	L1-N5 PolarHBondContact O-N 3.15Å; F2-N5 PolarHBondContact O-N 3.4Å; N5-N9 WeakPolarHBondContact O-CB 3.45Å; N5-N9 PolarHBondContact O-N 2.84Å
6	I	72.6	Confident	72	Confident	113 Å²	113	120.6 Å²	120.6	58%	0.579	60%	0.598	S	S	*	*	H	α-helix	trans	-67.4	-46.7	178.1	-65.6	163.5	0	0	110.3	F2 V3 Y4 N9 K10	F2-I6 VanDerWaalsContact O-CG1 3.27Å; F2-I6 WeakPolarHBondContact O-CG1 3.09Å; F2-I6 PolarHBondContact O-N 3.46Å; F2-I6 WeakPolarHBondContact O-CD1 3.49Å; V3-I6 PolarHBondContact O-N 3.4Å; Y4-I6 PolarHBondContact O-N 3.1Å; I6-N9 PolarHBondContact O-N 3.44Å; I6-K10 VanDerWaalsContact O-CB 3.3Å; I6-K10 WeakPolarHBondContact O-CB 3.43Å; I6-K10 PolarHBondContact O-N 2.77Å
7	T	71.9	Confident	72.2	Confident	87 Å²	87	122.3 Å²	122.3	53%	0.534	60%	0.602	S	S	.	*	H	α-helix	trans	-67.6	-41.4	179.8	-56.8	0	0	0	111.5	V3 Y4 K10 Y11	V3-T7 WeakPolarHBondContact O-CB 3.26Å; V3-T7 PolarHBondContact O-N 2.94Å; V3-T7 PolarHBondContact O-OG1 3.04Å; Y4-T7 PolarHBondContact O-N 2.92Å; T7-K10 PolarHBondContact O-N 2.77Å; T7-Y11 WeakPolarHBondContact O-CB 3.26Å; T7-Y11 PolarHBondContact O-N 3.22Å
8	T	74.2	Confident	72.3	Confident	75 Å²	75	121.1 Å²	121.1	46%	0.46	59%	0.594	S	S	.	*	H	α-helix	trans	-64.7	-43.2	175.2	-75.1	0	0	0	111.9	Y4 Y11 K12	Y4-T8 PolarHBondContact O-N 3.37Å; Y4-T8 VanDerWaalsContact O-OG1 3.12Å; Y4-T8 PolarHBondContact O-OG1 3.36Å; Y4-T8 WeakPolarHBondContact O-CB 3.48Å; T8-Y11 PolarHBondContact O-N 3.46Å; T8-K12 HydrophobicContact CG2-CG 4.22Å; T8-K12 VanDerWaalsContact O-CB 3.3Å; T8-K12 WeakPolarHBondContact O-CB 3.11Å; T8-K12 WeakPolarHBondContact O-CG 3.07Å; T8-K12 PolarHBondContact O-N 2.92Å
9	N	73.1	Confident	72	Confident	116 Å²	116	118.2 Å²	118.2	62%	0.62	58%	0.581	S	S	*	*	H	α-helix	trans	-64.7	-43.7	177.6	-171.1	-59.3	0	0	111	N5 I6 Y11 K12 A13	N5-N9 WeakPolarHBondContact O-CB 3.45Å; N5-N9 PolarHBondContact O-N 2.84Å; I6-N9 PolarHBondContact O-N 3.44Å; N9-Y11 PolarHBondContact O-N 3.42Å; N9-K12 PolarHBondContact O-N 3.48Å; N9-A13 WeakPolarHBondContact O-CB 3.4Å; N9-A13 PolarHBondContact O-N 3.42Å
10	K	76.9	Confident	71.6	Confident	160 Å²	160	118.7 Å²	118.7	70%	0.696	58%	0.583	S	S	*	*	H	α-helix	trans	-63.7	-40.6	176.1	-161.3	179	-164.3	-179	112.4	I6 T7 A13 F14	I6-K10 VanDerWaalsContact O-CB 3.3Å; I6-K10 WeakPolarHBondContact O-CB 3.43Å; I6-K10 PolarHBondContact O-N 2.77Å; T7-K10 PolarHBondContact O-N 2.77Å; K10-A13 PolarHBondContact O-N 3.24Å; K10-F14 WeakPolarHBondContact O-CB 2.96Å; K10-F14 PolarHBondContact O-N 2.87Å
11	Y	78.6	Confident	71.1	Confident	145 Å²	145	118.4 Å²	118.4	57%	0.569	59%	0.587	S	S	*	*	H	α-helix	trans	-67.8	-43.1	177.1	-177	-98.8	0	0	111.9	T7 T8 N9 F14 L15	T7-Y11 WeakPolarHBondContact O-CB 3.26Å; T7-Y11 PolarHBondContact O-N 3.22Å; T8-Y11 PolarHBondContact O-N 3.46Å; N9-Y11 PolarHBondContact O-N 3.42Å; Y11-F14 PolarHBondContact O-N 2.95Å; Y11-L15 HydrophobicContact CE1-CD2 4.5Å; Y11-L15 VanDerWaalsContact O-CB 3.28Å; Y11-L15 WeakPolarHBondContact O-CB 3.1Å; Y11-L15 PolarHBondContact O-N 3.03Å
12	K	79.3	Confident	71.1	Confident	131 Å²	131	117 Å²	117	57%	0.57	57%	0.573	S	S	*	*	H	α-helix	trans	-59.5	-45	173.5	-72.5	-96.1	104.5	-176.1	111.3	T8 N9 L15 D16	T8-K12 HydrophobicContact CG2-CG 4.22Å; T8-K12 VanDerWaalsContact O-CB 3.3Å; T8-K12 WeakPolarHBondContact O-CB 3.11Å; T8-K12 WeakPolarHBondContact O-CG 3.07Å; T8-K12 PolarHBondContact O-N 2.92Å; N9-K12 PolarHBondContact O-N 3.48Å; K12-L15 PolarHBondContact O-N 3Å; K12-D16 VanDerWaalsContact O-CB 3.26Å; K12-D16 PolarHBondContact O-N 2.95Å; K12-D16 WeakPolarHBondContact O-CB 3.3Å
13	A	79.1	Confident	71.2	Confident	54 Å²	54	115.2 Å²	115.2	45%	0.446	57%	0.566	S	S	.	*	H	α-helix	trans	-66.6	-38.1	177.9	0	0	0	0	113	N9 K10 K17	N9-A13 WeakPolarHBondContact O-CB 3.4Å; N9-A13 PolarHBondContact O-N 3.42Å; K10-A13 PolarHBondContact O-N 3.24Å; A13-K17 WeakPolarHBondContact O-CB 3.39Å; A13-K17 PolarHBondContact O-N 3.46Å
14	F	81.1	Confident	71.1	Confident	116 Å²	116	113.1 Å²	113.1	51%	0.509	57%	0.566	S	S	.	*	H	α-helix	trans	-65.8	-45.8	174.2	178.9	-100.7	0	0	111.7	K10 Y11 K17 Q18	K10-F14 WeakPolarHBondContact O-CB 2.96Å; K10-F14 PolarHBondContact O-N 2.87Å; Y11-F14 PolarHBondContact O-N 2.95Å; F14-K17 PolarHBondContact O-N 2.85Å; F14-Q18 HydrophobicContact CE1-CG 4.19Å; F14-Q18 HydrophobicContact CE2-CG 4.48Å; F14-Q18 VanDerWaalsContact CZ-CD 3.42Å; F14-Q18 HydrophobicContact CZ-CG 4.19Å; F14-Q18 WeakPolarHBondContact O-CG 3.38Å; F14-Q18 PolarHBondContact O-N 3.48Å
15	L	80.3	Confident	71	Confident	69 Å²	69	109.1 Å²	109.1	36%	0.361	57%	0.566	S	S	.	*	H	α-helix	trans	-62.7	-45.3	177.1	-173.2	69.1	0	0	110.8	Y11 K12 K17 Q18 N19	Y11-L15 HydrophobicContact CE1-CD2 4.5Å; Y11-L15 VanDerWaalsContact O-CB 3.28Å; Y11-L15 WeakPolarHBondContact O-CB 3.1Å; Y11-L15 PolarHBondContact O-N 3.03Å; K12-L15 PolarHBondContact O-N 3Å; L15-K17 PolarHBondContact O-N 3.4Å; L15-Q18 PolarHBondContact O-N 3.5Å; L15-Q18 CarbonylContact O-C 3.59Å; L15-N19 WeakPolarHBondContact O-CB 3.27Å; L15-N19 PolarHBondContact O-N 3.39Å
16	D	76.7	Confident	70.9	Confident	94 Å²	94	113.3 Å²	113.3	50%	0.503	57%	0.574	S	S	.	*	H	α-helix	trans	-60.2	-44.5	177.6	-171.8	-105.3	0	0	112.1	K12 Q18 N19 Q20	K12-D16 VanDerWaalsContact O-CB 3.26Å; K12-D16 PolarHBondContact O-N 2.95Å; K12-D16 WeakPolarHBondContact O-CB 3.3Å; D16-Q18 PolarHBondContact O-N 3.46Å; D16-N19 CarbonylContact O-C 3.52Å; D16-N19 WeakPolarHBondContact O-CA 3.28Å; D16-N19 WeakPolarHBondContact O-CB 3.3Å; D16-N19 PolarHBondContact O-N 2.93Å; D16-N19 VanDerWaalsContact O-N 3.1Å; D16-Q20 PolarHBondContact O-N 3.12Å
17	K	76.7	Confident	70	Confident	150 Å²	150	119.3 Å²	119.3	65%	0.652	61%	0.606	S	S	*	*	H	α-helix	trans	-62.9	-39.9	175.2	-175.8	176.2	179.7	179.4	112.8	A13 F14 L15 N19	A13-K17 WeakPolarHBondContact O-CB 3.39Å; A13-K17 PolarHBondContact O-N 3.46Å; F14-K17 PolarHBondContact O-N 2.85Å; L15-K17 PolarHBondContact O-N 3.4Å; K17-N19 VanDerWaalsContact C-N 3.3Å
18	Q	73.4	Confident	69.9	Low	101 Å²	101	120.9 Å²	120.9	47%	0.472	61%	0.61	S	S	.	*	H	α-helix	trans	-70.6	-30.1	174.1	-72.7	-169.1	-39.4	0	112.3	F14 L15 D16	F14-Q18 HydrophobicContact CE1-CG 4.19Å; F14-Q18 HydrophobicContact CE2-CG 4.48Å; F14-Q18 VanDerWaalsContact CZ-CD 3.42Å; F14-Q18 HydrophobicContact CZ-CG 4.19Å; F14-Q18 WeakPolarHBondContact O-CG 3.38Å; F14-Q18 PolarHBondContact O-N 3.48Å; L15-Q18 PolarHBondContact O-N 3.5Å; L15-Q18 CarbonylContact O-C 3.59Å; D16-Q18 PolarHBondContact O-N 3.46Å
19	N	66	Low	69.6	Low	65 Å²	65	123.3 Å²	123.3	35%	0.348	62%	0.618	S	S	.	*	H	α-helix	trans	-76.5	-39.5	179.3	-160.1	68.6	0	0	111.3	L15 D16 K17 V21 K22 F23	L15-N19 WeakPolarHBondContact O-CB 3.27Å; L15-N19 PolarHBondContact O-N 3.39Å; D16-N19 CarbonylContact O-C 3.52Å; D16-N19 WeakPolarHBondContact O-CA 3.28Å; D16-N19 WeakPolarHBondContact O-CB 3.3Å; D16-N19 PolarHBondContact O-N 2.93Å; D16-N19 VanDerWaalsContact O-N 3.1Å; K17-N19 VanDerWaalsContact C-N 3.3Å; N19-V21 VanDerWaalsContact C-N 3.25Å; N19-V21 PolarHBondContact O-N 3.32Å; N19-K22 WeakPolarHBondContact O-CA 3.39Å; N19-K22 PolarHBondContact O-N 3.34Å; N19-F23 PolarHBondContact O-N 2.98Å; N19-F23 WeakPolarHBondContact OD1-CE2 3.37Å; N19-F23 WeakPolarHBondContact O-CD2 3.17Å; N19-F23 VanDerWaalsContact O-CD2 3.26Å; N19-F23 WeakPolarHBondContact ND2-CE2 3.21Å; N19-F23 WeakPolarHBondContact ND2-CD2 3.14Å; N19-F23 VanDerWaalsContact CG-CD2 3.47Å
20	Q	64.8	Low	69.4	Low	129 Å²	129	123.7 Å²	123.7	60%	0.603	62%	0.617	S	S	*	*	H	α-helix	trans	-53.2	-40.9	175.2	-84.1	-174.9	-66	0	112.8	D16 K22 F23 G24	D16-Q20 PolarHBondContact O-N 3.12Å; Q20-K22 VanDerWaalsContact C-N 3.27Å; Q20-K22 PolarHBondContact O-N 2.81Å; Q20-F23 PolarHBondContact O-N 2.85Å; Q20-G24 PolarHBondContact O-N 2.94Å; Q20-G24 VanDerWaalsContact O-N 3.15Å
21	V	61.3	Low	69	Low	112 Å²	112	121.6 Å²	121.6	68%	0.679	61%	0.613	S	S	*	*	H	α-helix	trans	-66.6	-30.8	177.9	-178.8	0	0	0	111.8	N19	N19-V21 VanDerWaalsContact C-N 3.25Å; N19-V21 PolarHBondContact O-N 3.32Å
22	K	61.3	Low	68.4	Low	151 Å²	151	120.1 Å²	120.1	66%	0.657	62%	0.616	S	S	*	*	H	α-helix	trans	-82.4	-33.1	179	-68.8	-170.9	176	-166.6	113.1	N19 Q20 Y26	N19-K22 WeakPolarHBondContact O-CA 3.39Å; N19-K22 PolarHBondContact O-N 3.34Å; Q20-K22 VanDerWaalsContact C-N 3.27Å; Q20-K22 PolarHBondContact O-N 2.81Å; K22-Y26 WeakPolarHBondContact O-CD2 3.5Å
23	F	60.4	Low	67.7	Low	142 Å²	142	119.4 Å²	119.4	62%	0.623	62%	0.619	S	S	*	*	H	α-helix	trans	-80.5	-23.7	-179.7	-81.7	-101.8	0	0	113.1	N19 Q20 S25	N19-F23 PolarHBondContact O-N 2.98Å; N19-F23 WeakPolarHBondContact OD1-CE2 3.37Å; N19-F23 WeakPolarHBondContact O-CD2 3.17Å; N19-F23 VanDerWaalsContact O-CD2 3.26Å; N19-F23 WeakPolarHBondContact ND2-CE2 3.21Å; N19-F23 WeakPolarHBondContact ND2-CD2 3.14Å; N19-F23 VanDerWaalsContact CG-CD2 3.47Å; Q20-F23 PolarHBondContact O-N 2.85Å; F23-S25 VanDerWaalsContact C-N 3.26Å; F23-S25 PolarHBondContact O-N 3.48Å
24	G	59.3	Low	66.9	Low	65 Å²	65	124.1 Å²	124.1	67%	0.67	63%	0.631	S	S	*	*	T	Hydrogen-bonded Turn	trans	-75.7	-7	174.5	0	0	0	0	115.4	Q20	Q20-G24 PolarHBondContact O-N 2.94Å; Q20-G24 VanDerWaalsContact O-N 3.15Å
25	S	61.4	Low	65.8	Low	103 Å²	103	124.7 Å²	124.7	72%	0.72	64%	0.64	S	S	*	*	T	Hydrogen-bonded Turn	trans	-105.5	6.7	179.7	-110.2	0	0	0	113.7	F23	F23-S25 VanDerWaalsContact C-N 3.26Å; F23-S25 PolarHBondContact O-N 3.48Å
26	Y	60.9	Low	64.6	Low	202 Å²	202	129.3 Å²	129.3	79%	0.792	66%	0.664	S	S	*	*			trans	-100.4	61	167.3	-78.7	-84.8	0	0	109.7	K22	K22-Y26 WeakPolarHBondContact O-CD2 3.5Å
27	L	52.8	Low	63.5	Low	238 Å²	238	132.5 Å²	132.5	100%	1.246	68%	0.678	S	S	*	*			trans	-156.4	0	161.9	-105.8	153.6	0	0	108.6

Retrieved 27 of 27 residues in 13.9 ms (Link to these results)

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