A0A023J7R6_HUMAN Loading...

21-hydroxylase

AlphaFold DB , UniProt , Accession A0A023J7R6, Species HUMAN (Homo sapiens, Human), Gene CYP21A2, Length 29 aa.

						>A0A023J7R6_HUMAN|A0A023J7R6|CYP21A2
FFPNPGLRRLKQAIEKRDHIVEMQLRQHK
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	F	65.2	Low	82.8	Confident	247 Å²	247	117.8 Å²	117.8	100%	1.083	58%	0.579	S	S	*	*				0	119.4	0	-145.5	-103	0	0	0	106.8	P3	F1-P3 VanDerWaalsContact O-CD 3.24Å; F1-P3 WeakPolarHBondContact O-CD 3.34Å
2	F	63.1	Low	83.6	Confident	112 Å²	112	116.4 Å²	116.4	49%	0.491	57%	0.57	S	S	.	*			trans	-81.5	105.4	168.3	-85.5	-85.3	0	0	0	105.8	N4 R8 K11	F2-N4 PolarHBondContact O-N 3.04Å; F2-R8 HydrophobicContact CB-CB 4.26Å; F2-K11 HydrophobicContact CE1-CD 4.01Å; F2-K11 HydrophobicContact CE2-CD 4.13Å; F2-K11 HydrophobicContact CZ-CD 3.46Å; F2-K11 VanDerWaalsContact CZ-CD 3.46Å
3	P	78.3	Confident	84.4	Confident	114 Å²	114	111.8 Å²	111.8	74%	0.74	56%	0.562	S	S	*	*	S	Bend	trans	-65.3	-16.9	-167.7	27.4	-34.5	0	0	0	112.2	F1	F1-P3 VanDerWaalsContact O-CD 3.24Å; F1-P3 WeakPolarHBondContact O-CD 3.34Å
4	N	82	Confident	85.1	Confident	78 Å²	78	108.6 Å²	108.6	42%	0.417	55%	0.546	S	S	.	.			trans	-123.6	120	-179.2	-175.7	-15.9	0	0	0	110.7	F2 G6 L7 R8	F2-N4 PolarHBondContact O-N 3.04Å; N4-G6 PolarHBondContact O-N 3.36Å; N4-G6 PolarHBondContact OD1-N 2.92Å; N4-L7 HydrophobicContact CB-CB 4.39Å; N4-L7 HydrophobicContact CB-CD1 4.08Å; N4-L7 HydrophobicContact CB-CG 4.09Å; N4-L7 PolarHBondContact O-N 3.08Å; N4-L7 VanDerWaalsContact O-N 3.15Å; N4-R8 PolarHBondContact O-N 3.26Å
5	P	83.9	Confident	85.7	Confident	93 Å²	93	107.9 Å²	107.9	60%	0.604	54%	0.541	S	S	*	.	H	α-helix	trans	-60.2	-26.6	176.7	24.2	-33.4	0	0	0	113.3	R8 R9	P5-R8 PolarHBondContact O-N 3.02Å; P5-R9 WeakPolarHBondContact O-CG 3.41Å; P5-R9 PolarHBondContact O-N 2.94Å; P5-R9 VanDerWaalsContact O-N 3.11Å
6	G	89.1	Confident	86.3	Confident	38 Å²	38	110.4 Å²	110.4	39%	0.392	55%	0.547	S	S	.	.	H	α-helix	trans	-65.8	-40.8	174.8	0	0	0	0	0	113.2	N4 R8 R9 L10	N4-G6 PolarHBondContact O-N 3.36Å; N4-G6 PolarHBondContact OD1-N 2.92Å; G6-R8 VanDerWaalsContact C-N 3.33Å; G6-R8 PolarHBondContact O-N 3.35Å; G6-R9 PolarHBondContact O-N 2.98Å; G6-L10 PolarHBondContact O-N 3.18Å
7	L	88.8	Confident	86.7	Confident	88 Å²	88	112.7 Å²	112.7	46%	0.461	55%	0.548	S	S	.	.	H	α-helix	trans	-68	-34.8	176.2	-67.6	178.2	0	0	0	111.9	N4 L10 K11	N4-L7 HydrophobicContact CB-CB 4.39Å; N4-L7 HydrophobicContact CB-CD1 4.08Å; N4-L7 HydrophobicContact CB-CG 4.09Å; N4-L7 PolarHBondContact O-N 3.08Å; N4-L7 VanDerWaalsContact O-N 3.15Å; L7-L10 PolarHBondContact O-N 3.45Å; L7-K11 PolarHBondContact O-N 3.42Å
8	R	87.8	Confident	87.1	Confident	151 Å²	151	111.2 Å²	111.2	57%	0.57	54%	0.543	S	S	*	.	H	α-helix	trans	-62.7	-43.4	173.5	-173.1	178.3	174.9	-175.8	0.1	111.3	F2 N4 P5 G6 K11 Q12	F2-R8 HydrophobicContact CB-CB 4.26Å; N4-R8 PolarHBondContact O-N 3.26Å; P5-R8 PolarHBondContact O-N 3.02Å; G6-R8 VanDerWaalsContact C-N 3.33Å; G6-R8 PolarHBondContact O-N 3.35Å; R8-K11 PolarHBondContact O-N 3.49Å; R8-Q12 WeakPolarHBondContact O-CG 3.36Å; R8-Q12 PolarHBondContact O-N 3.36Å; R8-Q12 VanDerWaalsContact O-N 3.09Å
9	R	89.8	Confident	87.5	Confident	185 Å²	185	110.5 Å²	110.5	70%	0.698	54%	0.538	S	S	*	.	H	α-helix	trans	-64.7	-40.7	175.5	-70.7	177.7	-176.6	176.4	1.5	112	P5 G6 Q12 A13	P5-R9 WeakPolarHBondContact O-CG 3.41Å; P5-R9 PolarHBondContact O-N 2.94Å; P5-R9 VanDerWaalsContact O-N 3.11Å; G6-R9 PolarHBondContact O-N 2.98Å; R9-Q12 PolarHBondContact O-N 3.14Å; R9-A13 WeakPolarHBondContact O-CB 3.11Å; R9-A13 PolarHBondContact O-N 3.27Å
10	L	91.4	Very high	87.8	Confident	98 Å²	98	108.8 Å²	108.8	51%	0.513	53%	0.531	S	S	.	.	H	α-helix	trans	-62	-45.7	176.7	-179.5	60.9	0	0	0	111.5	G6 L7 Q12 A13 I14	G6-L10 PolarHBondContact O-N 3.18Å; L7-L10 PolarHBondContact O-N 3.45Å; L10-Q12 PolarHBondContact O-N 2.85Å; L10-A13 PolarHBondContact O-N 2.94Å; L10-I14 HydrophobicContact CD1-CD1 4.12Å; L10-I14 HydrophobicContact CD1-CG1 4.4Å; L10-I14 HydrophobicContact CG-CD1 3.99Å; L10-I14 WeakPolarHBondContact O-CG1 3.4Å; L10-I14 PolarHBondContact O-N 3.45Å
11	K	91.3	Very high	88.1	Confident	92 Å²	92	106.6 Å²	106.6	40%	0.4	52%	0.524	S	S	.	.	H	α-helix	trans	-59.2	-45.6	176.2	-169.7	174.6	-168	-82	0	111.8	F2 L7 R8 A13 I14 E15	F2-K11 HydrophobicContact CE1-CD 4.01Å; F2-K11 HydrophobicContact CE2-CD 4.13Å; F2-K11 HydrophobicContact CZ-CD 3.46Å; F2-K11 VanDerWaalsContact CZ-CD 3.46Å; L7-K11 PolarHBondContact O-N 3.42Å; R8-K11 PolarHBondContact O-N 3.49Å; K11-A13 VanDerWaalsContact C-N 3.33Å; K11-A13 PolarHBondContact O-N 3.33Å; K11-I14 PolarHBondContact O-N 2.86Å; K11-E15 IonicContact NZ-OE1 2.67Å; K11-E15 PolarHBondContact NZ-OE1 3.44Å; K11-E15 WeakPolarHBondContact O-CB 3.23Å; K11-E15 WeakPolarHBondContact O-CG 3.47Å; K11-E15 PolarHBondContact O-N 3.2Å
12	Q	92.6	Very high	89.4	Confident	101 Å²	101	100 Å²	100	47%	0.472	50%	0.497	S	S	.	.	H	α-helix	trans	-62.5	-38.5	176.2	-72	176.2	-37.9	0	0	112.6	R8 R9 L10 K16	R8-Q12 WeakPolarHBondContact O-CG 3.36Å; R8-Q12 PolarHBondContact O-N 3.36Å; R8-Q12 VanDerWaalsContact O-N 3.09Å; R9-Q12 PolarHBondContact O-N 3.14Å; L10-Q12 PolarHBondContact O-N 2.85Å; Q12-K16 VanDerWaalsContact O-CB 3.24Å; Q12-K16 WeakPolarHBondContact O-CB 3.21Å; Q12-K16 PolarHBondContact O-N 2.93Å
13	A	94.1	Very high	90.8	Very high	57 Å²	57	99.4 Å²	99.4	47%	0.471	50%	0.496	S	S	.	.	H	α-helix	trans	-67.3	-37.7	177	0	0	0	0	0	112.2	R9 L10 K11 R17	R9-A13 WeakPolarHBondContact O-CB 3.11Å; R9-A13 PolarHBondContact O-N 3.27Å; L10-A13 PolarHBondContact O-N 2.94Å; K11-A13 VanDerWaalsContact C-N 3.33Å; K11-A13 PolarHBondContact O-N 3.33Å; A13-R17 WeakPolarHBondContact O-CB 3.39Å; A13-R17 PolarHBondContact O-N 2.98Å; A13-R17 VanDerWaalsContact O-N 3.16Å
14	I	94.1	Very high	91.4	Very high	66 Å²	66	98.9 Å²	98.9	34%	0.338	48%	0.484	S	S	.	.	H	α-helix	trans	-67.5	-52.3	175	-66.4	166.7	0	0	0	110.1	L10 K11 K16 R17 D18	L10-I14 HydrophobicContact CD1-CD1 4.12Å; L10-I14 HydrophobicContact CD1-CG1 4.4Å; L10-I14 HydrophobicContact CG-CD1 3.99Å; L10-I14 WeakPolarHBondContact O-CG1 3.4Å; L10-I14 PolarHBondContact O-N 3.45Å; K11-I14 PolarHBondContact O-N 2.86Å; I14-K16 VanDerWaalsContact C-N 3.29Å; I14-K16 PolarHBondContact O-N 3.16Å; I14-R17 WeakPolarHBondContact O-CB 3.34Å; I14-R17 PolarHBondContact O-N 2.95Å; I14-R17 VanDerWaalsContact O-N 3.08Å; I14-D18 PolarHBondContact O-N 3.39Å
15	E	94.8	Very high	91.8	Very high	98 Å²	98	100.3 Å²	100.3	46%	0.458	49%	0.491	S	S	.	.	H	α-helix	trans	-58.3	-40.3	179.6	-74.2	172.7	176.5	0	0	112.2	K11 D18 H19	K11-E15 IonicContact NZ-OE1 2.67Å; K11-E15 PolarHBondContact NZ-OE1 3.44Å; K11-E15 WeakPolarHBondContact O-CB 3.23Å; K11-E15 WeakPolarHBondContact O-CG 3.47Å; K11-E15 PolarHBondContact O-N 3.2Å; E15-D18 PolarHBondContact O-N 3.08Å; E15-H19 WeakPolarHBondContact O-CB 3.24Å; E15-H19 PolarHBondContact O-N 3.28Å
16	K	95	Very high	92.1	Very high	148 Å²	148	105.3 Å²	105.3	64%	0.643	50%	0.498	S	S	*	.	H	α-helix	trans	-65.2	-40.7	176.8	-173.5	174.2	-178.7	-180	0	112.1	Q12 I14 I20	Q12-K16 VanDerWaalsContact O-CB 3.24Å; Q12-K16 WeakPolarHBondContact O-CB 3.21Å; Q12-K16 PolarHBondContact O-N 2.93Å; I14-K16 VanDerWaalsContact C-N 3.29Å; I14-K16 PolarHBondContact O-N 3.16Å; K16-I20 HydrophobicContact CG-CD1 4.08Å; K16-I20 WeakPolarHBondContact O-CD1 3.34Å; K16-I20 VanDerWaalsContact O-CG1 3.23Å; K16-I20 WeakPolarHBondContact O-CG1 3.44Å; K16-I20 PolarHBondContact O-N 3.04Å; K16-I20 VanDerWaalsContact O-N 3.14Å
17	R	92.6	Very high	92.1	Very high	150 Å²	150	110.7 Å²	110.7	57%	0.566	51%	0.513	S	S	*	.	H	α-helix	trans	-63.9	-48.4	177.3	-173.7	-143.6	-46.9	-177.2	6.8	110.6	A13 I14 H19 I20 V21	A13-R17 WeakPolarHBondContact O-CB 3.39Å; A13-R17 PolarHBondContact O-N 2.98Å; A13-R17 VanDerWaalsContact O-N 3.16Å; I14-R17 WeakPolarHBondContact O-CB 3.34Å; I14-R17 PolarHBondContact O-N 2.95Å; I14-R17 VanDerWaalsContact O-N 3.08Å; R17-H19 VanDerWaalsContact C-N 3.29Å; R17-H19 PolarHBondContact O-N 3.49Å; R17-I20 PolarHBondContact O-N 3.42Å; R17-V21 WeakPolarHBondContact O-CG2 3.4Å; R17-V21 PolarHBondContact O-N 3.35Å
18	D	93.6	Very high	91.7	Very high	85 Å²	85	114.1 Å²	114.1	46%	0.455	53%	0.526	S	S	.	.	H	α-helix	trans	-61.9	-41.3	-178	-71.9	-2.6	0	0	0	110.9	I14 E15 I20 V21 E22	I14-D18 PolarHBondContact O-N 3.39Å; E15-D18 PolarHBondContact O-N 3.08Å; D18-I20 PolarHBondContact O-N 3.11Å; D18-V21 PolarHBondContact O-N 3.37Å; D18-E22 WeakPolarHBondContact O-CG 3.49Å; D18-E22 PolarHBondContact O-N 2.96Å
19	H	94.4	Very high	90.7	Very high	99 Å²	99	118.5 Å²	118.5	46%	0.458	55%	0.549	S	S	.	.	H	α-helix	trans	-62.9	-41.3	175.9	-170.4	62.9	0	0	0	113.2	E15 R17 E22 M23	E15-H19 WeakPolarHBondContact O-CB 3.24Å; E15-H19 PolarHBondContact O-N 3.28Å; R17-H19 VanDerWaalsContact C-N 3.29Å; R17-H19 PolarHBondContact O-N 3.49Å; H19-E22 PolarHBondContact O-N 2.96Å; H19-M23 WeakPolarHBondContact NE2-CE 3.44Å; H19-M23 WeakPolarHBondContact O-CG 3.47Å; H19-M23 PolarHBondContact O-N 2.9Å
20	I	94.6	Very high	90.7	Very high	76 Å²	76	115.2 Å²	115.2	39%	0.39	54%	0.542	S	S	.	.	H	α-helix	trans	-63.6	-44.4	176	-69.2	164.7	0	0	0	110.3	K16 R17 D18 M23 Q24	K16-I20 HydrophobicContact CG-CD1 4.08Å; K16-I20 WeakPolarHBondContact O-CD1 3.34Å; K16-I20 VanDerWaalsContact O-CG1 3.23Å; K16-I20 WeakPolarHBondContact O-CG1 3.44Å; K16-I20 PolarHBondContact O-N 3.04Å; K16-I20 VanDerWaalsContact O-N 3.14Å; R17-I20 PolarHBondContact O-N 3.42Å; D18-I20 PolarHBondContact O-N 3.11Å; I20-M23 PolarHBondContact O-N 2.95Å; I20-Q24 HydrophobicContact CG2-CG 4.46Å; I20-Q24 WeakPolarHBondContact O-CB 3.44Å; I20-Q24 WeakPolarHBondContact O-CG 3.33Å; I20-Q24 PolarHBondContact O-N 3.45Å
21	V	92.6	Very high	90.7	Very high	62 Å²	62	116.1 Å²	116.1	38%	0.376	54%	0.543	S	S	.	.	H	α-helix	trans	-63.5	-43.5	178.7	172	0	0	0	0	110.7	R17 D18 M23 Q24 L25	R17-V21 WeakPolarHBondContact O-CG2 3.4Å; R17-V21 PolarHBondContact O-N 3.35Å; D18-V21 PolarHBondContact O-N 3.37Å; V21-M23 PolarHBondContact O-N 3.28Å; V21-Q24 PolarHBondContact O-N 3.45Å; V21-L25 HydrophobicContact CG1-CD1 3.72Å; V21-L25 HydrophobicContact CG1-CG 4.22Å; V21-L25 WeakPolarHBondContact O-CB 3.41Å; V21-L25 WeakPolarHBondContact O-CG 3.34Å; V21-L25 PolarHBondContact O-N 3.15Å
22	E	93.6	Very high	90.7	Very high	110 Å²	110	117.4 Å²	117.4	51%	0.514	55%	0.551	S	S	.	*	H	α-helix	trans	-60.9	-44	174.8	-77.7	-169.4	164.8	0	0	112.7	D18 H19 L25 R26	D18-E22 WeakPolarHBondContact O-CG 3.49Å; D18-E22 PolarHBondContact O-N 2.96Å; H19-E22 PolarHBondContact O-N 2.96Å; E22-L25 PolarHBondContact O-N 3.49Å; E22-R26 WeakPolarHBondContact O-CG 3.4Å; E22-R26 PolarHBondContact O-N 3.33Å
23	M	92.7	Very high	90.5	Very high	99 Å²	99	118.4 Å²	118.4	49%	0.488	56%	0.556	S	S	.	*	H	α-helix	trans	-62.4	-44.5	177.1	-78.8	-172.1	162.1	0	0	111.6	H19 I20 V21 R26 Q27	H19-M23 WeakPolarHBondContact NE2-CE 3.44Å; H19-M23 WeakPolarHBondContact O-CG 3.47Å; H19-M23 PolarHBondContact O-N 2.9Å; I20-M23 PolarHBondContact O-N 2.95Å; V21-M23 PolarHBondContact O-N 3.28Å; M23-R26 PolarHBondContact O-N 3.27Å; M23-Q27 WeakPolarHBondContact O-CG 3.24Å; M23-Q27 PolarHBondContact O-N 2.96Å; M23-Q27 VanDerWaalsContact O-N 3.08Å
24	Q	91.1	Very high	90.3	Very high	102 Å²	102	122.3 Å²	122.3	48%	0.477	56%	0.561	S	S	.	*	H	α-helix	trans	-62.7	-47.9	176.3	-74.7	179.2	-12.9	0	0	111.1	I20 V21 R26 Q27 H28	I20-Q24 HydrophobicContact CG2-CG 4.46Å; I20-Q24 WeakPolarHBondContact O-CB 3.44Å; I20-Q24 WeakPolarHBondContact O-CG 3.33Å; I20-Q24 PolarHBondContact O-N 3.45Å; V21-Q24 PolarHBondContact O-N 3.45Å; Q24-R26 PolarHBondContact O-N 3.09Å; Q24-Q27 PolarHBondContact O-N 2.67Å; Q24-H28 PolarHBondContact O-CD2 3.22Å; Q24-H28 PolarHBondContact O-N 2.83Å
25	L	90.9	Very high	90.1	Very high	109 Å²	109	126 Å²	126	57%	0.571	58%	0.576	S	S	*	*	H	α-helix	trans	-60.7	-32.9	178.7	-73.3	171.7	0	0	0	112.9	V21 E22 K29	V21-L25 HydrophobicContact CG1-CD1 3.72Å; V21-L25 HydrophobicContact CG1-CG 4.22Å; V21-L25 WeakPolarHBondContact O-CB 3.41Å; V21-L25 WeakPolarHBondContact O-CG 3.34Å; V21-L25 PolarHBondContact O-N 3.15Å; E22-L25 PolarHBondContact O-N 3.49Å; L25-K29 PolarHBondContact O-N 3.04Å
26	R	89.8	Confident	89.7	Confident	198 Å²	198	128 Å²	128	75%	0.747	59%	0.585	S	S	*	*	H	α-helix	trans	-71.8	-34	173	-76	-176.3	-174	-157.4	3.3	113.3	E22 M23 Q24	E22-R26 WeakPolarHBondContact O-CG 3.4Å; E22-R26 PolarHBondContact O-N 3.33Å; M23-R26 PolarHBondContact O-N 3.27Å; Q24-R26 PolarHBondContact O-N 3.09Å
27	Q	88.3	Confident	89.3	Confident	151 Å²	151	126.5 Å²	126.5	71%	0.706	58%	0.58	S	S	*	*	H	α-helix	trans	-76.4	-26.6	177.8	-72.5	175.4	4.3	0	0	112.6	M23 Q24	M23-Q27 WeakPolarHBondContact O-CG 3.24Å; M23-Q27 PolarHBondContact O-N 2.96Å; M23-Q27 VanDerWaalsContact O-N 3.08Å; Q24-Q27 PolarHBondContact O-N 2.67Å
28	H	81.3	Confident	89	Confident	159 Å²	159	124.5 Å²	124.5	74%	0.736	58%	0.581	S	S	*	*			trans	-94	1.2	179.8	-68.5	-64.8	0	0	0	114.2	Q24	Q24-H28 PolarHBondContact O-CD2 3.22Å; Q24-H28 PolarHBondContact O-N 2.83Å
29	K	65.8	Low	88.6	Confident	244 Å²	244	128.1 Å²	128.1	100%	1.061	59%	0.593	S	S	*	*			trans	-95.1	0	167.5	-85.3	-167.5	177.3	-169.9	0	110.3	L25	L25-K29 PolarHBondContact O-N 3.04Å

Retrieved 29 of 29 residues in 93.4 ms (Link to these results)

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