A0A060KPS6_HUMAN Loading...

Cystic fibrosis transmembrane conductance regulator

AlphaFold DB , UniProt , Accession A0A060KPS6, Species HUMAN (Homo sapiens, Human), Gene CFTR, Length 28 aa.

						>A0A060KPS6_HUMAN|A0A060KPS6|CFTR
AVYKDADLYLLDSPFGYLDVLTEKEILE
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	A	46.1	Very low	55.2	Low	145 Å²	145	142.2 Å²	142.2	100%	1.198	76%	0.758	S	S	*	*				0	117.1	0	0	0	0	0	107.2	Y3	A1-Y3 VanDerWaalsContact O-N 3.16Å; A1-Y3 PolarHBondContact O-N 3.16Å
2	V	50.7	Low	55.3	Low	133 Å²	133	144 Å²	144	81%	0.806	77%	0.768	S	S	*	*			trans	-77	95.8	-178.9	178.9	0	0	0	107.2	K4	V2-K4 PolarHBondContact O-N 3.34Å
3	Y	53	Low	55.1	Low	207 Å²	207	140.1 Å²	140.1	81%	0.812	76%	0.759	S	S	*	*			trans	-89.4	58.9	168.5	-121.2	-95.8	0	0	106.8	A1	A1-Y3 VanDerWaalsContact O-N 3.16Å; A1-Y3 PolarHBondContact O-N 3.16Å
4	K	56.1	Low	55.2	Low	156 Å²	156	133.6 Å²	133.6	68%	0.678	73%	0.728	S	S	*	*				72.3	76.7	100	-154.6	-171.9	-167.8	-173.3	110.1	V2 A6 Y9	V2-K4 PolarHBondContact O-N 3.34Å; K4-A6 PolarHBondContact O-N 2.78Å; K4-Y9 PolarHBondContact O-OH 2.92Å
5	D	56.7	Low	55.2	Low	165 Å²	165	133.9 Å²	133.9	88%	0.882	72%	0.72	S	S	*	*			trans	-35.7	98.5	169.8	-51.7	-72.7	0	0	111.9
6	A	60.2	Low	55.2	Low	43 Å²	43	129.6 Å²	129.6	36%	0.355	72%	0.717	S	S	.	*			trans	-133.5	128.5	172.8	0	0	0	0	107.9	K4 L8 Y9	K4-A6 PolarHBondContact O-N 2.78Å; A6-L8 PolarHBondContact O-N 3.3Å; A6-Y9 HydrophobicContact CB-CD1 4.44Å; A6-Y9 HydrophobicContact CB-CE1 3.97Å; A6-Y9 HydrophobicContact CB-CE2 4.17Å; A6-Y9 WeakPolarHBondContact O-CE2 3.16Å
7	D	58.5	Low	55.1	Low	181 Å²	181	135.8 Å²	135.8	97%	0.968	73%	0.729	S	S	*	*	S	Bend	trans	-69.8	-16.9	-179.2	-59.5	-60.4	0	0	112.7
8	L	49.7	Very low	54.9	Low	134 Å²	134	133.9 Å²	133.9	70%	0.702	72%	0.718	S	S	*	*			trans	-147.5	121	178.1	-176.8	65.6	0	0	110.9	A6	A6-L8 PolarHBondContact O-N 3.3Å
9	Y	59.3	Low	54.8	Low	117 Å²	117	134.3 Å²	134.3	46%	0.459	72%	0.72	S	S	.	*			trans	-100.3	108.2	172.2	-63.7	-91.7	0	0	109.2	K4 A6 L11	K4-Y9 PolarHBondContact O-OH 2.92Å; A6-Y9 HydrophobicContact CB-CD1 4.44Å; A6-Y9 HydrophobicContact CB-CE1 3.97Å; A6-Y9 HydrophobicContact CB-CE2 4.17Å; A6-Y9 WeakPolarHBondContact O-CE2 3.16Å; Y9-L11 PolarHBondContact O-N 3.31Å
10	L	56.9	Low	54.8	Low	160 Å²	160	133.6 Å²	133.6	84%	0.838	72%	0.72	S	S	*	*			trans	-81.1	102.2	167.5	-71.1	169.4	0	0	108
11	L	60	Low	54.7	Low	123 Å²	123	134.5 Å²	134.5	64%	0.644	72%	0.724	S	S	*	*			trans	-93.5	98.7	177	-61.8	168.3	0	0	108.2	Y9 S13 P14	Y9-L11 PolarHBondContact O-N 3.31Å; L11-S13 PolarHBondContact O-N 3.19Å; L11-P14 HydrophobicContact CB-CB 4.15Å; L11-P14 HydrophobicContact CG-CG 4.38Å; L11-P14 HydrophobicContact CD2-CB 4.37Å; L11-P14 HydrophobicContact CD1-CG 4.05Å; L11-P14 HydrophobicContact CD1-CB 4.37Å; L11-P14 HydrophobicContact CB-CG 3.72Å
12	D	56.6	Low	55.1	Low	164 Å²	164	130.9 Å²	130.9	88%	0.877	69%	0.687	S	S	*	*	S	Bend	trans	-80.3	100.1	170.1	-157.7	6.7	0	0	108.2
13	S	53.2	Low	55.2	Low	93 Å²	93	130.3 Å²	130.3	65%	0.65	68%	0.676	S	S	*	*			trans	52.4	66.8	-179.2	-62.9	0	0	0	116.4	L11 F15	L11-S13 PolarHBondContact O-N 3.19Å; S13-F15 PolarHBondContact O-N 3.19Å
14	P	56.3	Low	55.2	Low	49 Å²	49	128.8 Å²	128.8	32%	0.318	67%	0.673	S	S	.	*	G	3₁₀ helix	trans	-69.7	-12.7	174.7	32.6	-35.5	0	0	113.1	L11	L11-P14 HydrophobicContact CB-CB 4.15Å; L11-P14 HydrophobicContact CG-CG 4.38Å; L11-P14 HydrophobicContact CD2-CB 4.37Å; L11-P14 HydrophobicContact CD1-CG 4.05Å; L11-P14 HydrophobicContact CD1-CB 4.37Å; L11-P14 HydrophobicContact CB-CG 3.72Å
15	F	55	Low	55.2	Low	139 Å²	139	129.3 Å²	129.3	61%	0.61	68%	0.678	S	S	*	*	G	3₁₀ helix	trans	-91.3	2.6	-174.3	-52.7	-67.5	0	0	114.2	S13 Y17	S13-F15 PolarHBondContact O-N 3.19Å; F15-Y17 PolarHBondContact O-N 3.48Å
16	G	55.3	Low	55.2	Low	65 Å²	65	128.3 Å²	128.3	67%	0.67	67%	0.671	S	S	*	*	G	3₁₀ helix	trans	-67	-15.7	-179	0	0	0	0	114.9
17	Y	53.9	Low	54.9	Low	234 Å²	234	133.7 Å²	133.7	92%	0.918	69%	0.693	S	S	*	*	S	Bend	trans	-133.5	4.3	-175.4	-98	-86.5	0	0	114.3	F15	F15-Y17 PolarHBondContact O-N 3.48Å
18	L	50.3	Low	54.2	Low	103 Å²	103	136.8 Å²	136.8	54%	0.539	70%	0.702	S	S	.	*	S	Bend	trans	-99	110.8	178.5	-84	156.3	0	0	108.9	V20	L18-V20 PolarHBondContact O-N 3.24Å
19	D	53.3	Low	54.4	Low	141 Å²	141	136.9 Å²	136.9	75%	0.754	70%	0.702	S	S	*	*			trans	-46.9	136.2	170	-101	-44.2	0	0	110.6	L21 T22	D19-L21 PolarHBondContact O-N 2.74Å; D19-T22 PolarHBondContact O-N 3.33Å
20	V	55.3	Low	54.1	Low	120 Å²	120	137.9 Å²	137.9	73%	0.727	72%	0.715	S	S	*	*	T	Hydrogen-bonded Turn	trans	-51.6	-8.2	-173.5	178.2	0	0	0	114.6	L18	L18-V20 PolarHBondContact O-N 3.24Å
21	L	51.9	Low	54	Low	153 Å²	153	136.7 Å²	136.7	80%	0.801	71%	0.708	S	S	*	*	T	Hydrogen-bonded Turn	trans	-74	-34.5	178.9	-117.2	89.6	0	0	113.9	D19	D19-L21 PolarHBondContact O-N 2.74Å
22	T	54.3	Low	53.6	Low	69 Å²	69	137.5 Å²	137.5	42%	0.423	71%	0.711	S	S	.	*	T	Hydrogen-bonded Turn	trans	-84.5	-13.2	-172	-45.7	0	0	0	113.3	D19 K24	D19-T22 PolarHBondContact O-N 3.33Å; T22-K24 PolarHBondContact O-N 3.21Å
23	E	53.5	Low	53.4	Low	121 Å²	121	135.9 Å²	135.9	57%	0.565	70%	0.701	S	S	*	*	T	Hydrogen-bonded Turn	trans	-69.3	-22.7	179.6	-158.3	173.1	-158.9	0	112.5
24	K	54.1	Low	53.5	Low	175 Å²	175	138.7 Å²	138.7	76%	0.761	70%	0.704	S	S	*	*	T	Hydrogen-bonded Turn	trans	-87.2	-25.7	-173.7	-114.1	-174	175.4	-170	115.6	T22	T22-K24 PolarHBondContact O-N 3.21Å
25	E	55.7	Low	53.3	Low	167 Å²	167	145.1 Å²	145.1	78%	0.78	73%	0.732	S	S	*	*	T	Hydrogen-bonded Turn	trans	-85.1	-13.2	-176.9	-75.3	-178.1	157	0	113.6
26	I	56.1	Low	53.1	Low	143 Å²	143	145.6 Å²	145.6	73%	0.733	74%	0.741	S	S	*	*	S	Bend	trans	-92.2	-13.9	178.9	-63.1	176.4	0	0	111.7
27	L	54.6	Low	53	Low	156 Å²	156	152.3 Å²	152.3	82%	0.817	75%	0.747	S	S	*	*			trans	-95.3	-7.4	-177.1	-128.1	84.8	0	0	114.5
28	E	42.6	Very low	52.9	Low	246 Å²	246	144.9 Å²	144.9	100%	1.15	73%	0.732	S	S	*	*			trans	-102.6	0	172.4	-76.8	-170.9	166.9	0	112.5

Retrieved 28 of 28 residues in 18.9 ms (Link to these results)

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