A0A061I2H1_CRIGR Loading...

Next to BRCA1 gene 1 protein

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion.

AlphaFold DB , UniProt , Accession A0A061I2H1, Species CRIGR (Cricetulus griseus, Chinese hamster), Gene Nbr1, Length 979 aa.