A0A068BDS6_HUMAN Loading...

Truncated breast and ovarian cancer susceptibility protein 2

AlphaFold DB , UniProt , Accession A0A068BDS6, Species HUMAN (Homo sapiens, Human), Gene BRCA2, Length 62 aa.

						>A0A068BDS6_HUMAN|A0A068BDS6|BRCA2
EPNDTDPLDSNVAHQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	E	44.3	Very low	60	Low	232 Å²	232	136.3 Å²	136.3	100%	1.084	76%	0.759	S	S	*	*				0	113.6	0	-158.5	161.7	-173.9	0	107
2	P	56.1	Low	60	Low	118 Å²	118	131.7 Å²	131.7	77%	0.766	74%	0.736	S	S	*	*			trans	-80.8	128.5	179.6	31.8	-27.4	0	0	108.4	D4	P2-D4 PolarHBondContact O-N 3.46Å
3	N	61.9	Low	59.9	Low	152 Å²	152	127.9 Å²	127.9	81%	0.813	73%	0.732	S	S	*	*			trans	-63.6	109.8	176.2	-68.3	-71.7	0	0	109	T5	N3-T5 PolarHBondContact O-N 3.26Å
4	D	61.2	Low	60.1	Low	170 Å²	170	131.3 Å²	131.3	91%	0.909	74%	0.738	S	S	*	*			trans	-68.5	80.9	164.1	-99.6	-24.6	0	0	107.9	P2 D6	P2-D4 PolarHBondContact O-N 3.46Å; D4-D6 PolarHBondContact O-N 2.95Å
5	T	69.5	Low	60.3	Low	117 Å²	117	133.4 Å²	133.4	72%	0.718	74%	0.74	S	S	*	*			trans	-87.3	104.6	165.4	-49.9	0	0	0	107.7	N3	N3-T5 PolarHBondContact O-N 3.26Å
6	D	63.4	Low	60.8	Low	104 Å²	104	135.5 Å²	135.5	56%	0.556	74%	0.739	S	S	*	*			trans	-59.8	122.4	-179.7	-161.5	-15	0	0	109.9	D4 L8 D9	D4-D6 PolarHBondContact O-N 2.95Å; D6-L8 PolarHBondContact O-N 3.05Å; D6-D9 PolarHBondContact O-N 3.12Å; D6-D9 VanDerWaalsContact O-N 3.08Å
7	P	60.9	Low	60.7	Low	121 Å²	121	134.2 Å²	134.2	79%	0.786	74%	0.738	S	S	*	*	T	Hydrogen-bonded Turn	trans	-64.7	-9.5	-178.9	25.7	-35.5	0	0	113.4
8	L	62.8	Low	60.7	Low	147 Å²	147	138.8 Å²	138.8	77%	0.77	75%	0.75	S	S	*	*	T	Hydrogen-bonded Turn	trans	-89	-1.8	176.4	-63.1	178.8	0	0	113.9	D6 S10	D6-L8 PolarHBondContact O-N 3.05Å; L8-S10 PolarHBondContact O-N 2.94Å
9	D	56.5	Low	60.1	Low	127 Å²	127	140.1 Å²	140.1	68%	0.679	75%	0.751	S	S	*	*			trans	-76.5	51.6	169.1	-153.4	12.9	0	0	110.7	D6 N11	D6-D9 PolarHBondContact O-N 3.12Å; D6-D9 VanDerWaalsContact O-N 3.08Å; D9-N11 PolarHBondContact O-N 2.97Å; D9-N11 VanDerWaalsContact O-N 3.1Å
10	S	61.6	Low	59.9	Low	83 Å²	83	139.3 Å²	139.3	58%	0.58	76%	0.757	S	S	*	*			trans	-80.8	77.5	168.7	-179.7	0	0	0	107.4	L8 V12	L8-S10 PolarHBondContact O-N 2.94Å; S10-V12 PolarHBondContact O-N 2.75Å; S10-V12 WeakPolarHBondContact OG-CB 3.3Å; S10-V12 WeakPolarHBondContact OG-CG2 3.44Å
11	N	61.8	Low	59.5	Low	128 Å²	128	136.1 Å²	136.1	68%	0.684	76%	0.756	S	S	*	*			trans	-74.2	39.9	156.1	71.3	-0.5	0	0	110.8	D9 A13	D9-N11 PolarHBondContact O-N 2.97Å; D9-N11 VanDerWaalsContact O-N 3.1Å; N11-A13 PolarHBondContact O-N 2.88Å
12	V	60	Low	60.2	Low	81 Å²	81	128.7 Å²	128.7	49%	0.491	73%	0.73	S	S	.	*			trans	-79.7	50.4	171.9	-175.5	0	0	0	108.8	S10 H14 Q15	S10-V12 PolarHBondContact O-N 2.75Å; S10-V12 WeakPolarHBondContact OG-CB 3.3Å; S10-V12 WeakPolarHBondContact OG-CG2 3.44Å; V12-H14 PolarHBondContact O-N 2.82Å; V12-Q15 HydrophobicContact CG1-CG 3.55Å
13	A	58.3	Low	60.2	Low	83 Å²	83	130.2 Å²	130.2	69%	0.686	73%	0.732	S	S	*	*			trans	-86.2	11.1	174.8	0	0	0	0	112.5	N11	N11-A13 PolarHBondContact O-N 2.88Å
14	H	62.6	Low	60.1	Low	175 Å²	175	131.2 Å²	131.2	81%	0.81	73%	0.729	S	S	*	*			trans	-133.2	45.8	-177.6	-56.2	-54.9	0	0	112.6	V12	V12-H14 PolarHBondContact O-N 2.82Å
15	Q	63.9	Low	60	Low	163 Å²	163	130.1 Å²	130.1	76%	0.762	72%	0.722	S	S	*	*			trans	-85.6	111.8	161.5	-73.8	-169.1	-32.8	0	109.1	V12	V12-Q15 HydrophobicContact CG1-CG 3.55Å
16	K	68.3	Low	59.7	Low	167 Å²	167	129.7 Å²	129.7	73%	0.726	72%	0.723	S	S	*	*	P	Polyproline II helix	trans	-55.2	130.4	170.2	-169.6	-178.3	-179.1	-163.2	107.6	F18	K16-F18 PolarHBondContact O-N 2.8Å; K16-F18 VanDerWaalsContact O-N 3.12Å
17	P	59.5	Low	59.7	Low	113 Å²	113	134 Å²	134	73%	0.734	74%	0.737	S	S	*	*	P	Polyproline II helix	trans	-56.6	124.2	171.4	-19.3	29.8	0	0	107.8	E19	P17-E19 PolarHBondContact O-N 2.94Å
18	F	59.4	Low	59.5	Low	217 Å²	217	136 Å²	136	95%	0.952	74%	0.736	S	S	*	*	P	Polyproline II helix	trans	-57.3	116.7	170.4	-99.6	-92.4	0	0	107.4	K16 S20	K16-F18 PolarHBondContact O-N 2.8Å; K16-F18 VanDerWaalsContact O-N 3.12Å; F18-S20 PolarHBondContact O-N 2.87Å
19	E	49.1	Very low	59.5	Low	164 Å²	164	134.9 Å²	134.9	77%	0.766	74%	0.735	S	S	*	*	P	Polyproline II helix	trans	-62.1	127	-175.9	-158.2	164.2	-169.5	0	108.8	P17 G21	P17-E19 PolarHBondContact O-N 2.94Å; E19-G21 PolarHBondContact O-N 2.76Å
20	S	58	Low	59.8	Low	124 Å²	124	133.8 Å²	133.8	87%	0.867	73%	0.733	S	S	*	*			trans	-55.7	101.4	-178.8	-179	0	0	0	110.8	F18	F18-S20 PolarHBondContact O-N 2.87Å
21	G	50.6	Low	59.5	Low	72 Å²	72	135.1 Å²	135.1	74%	0.742	74%	0.739	S	S	*	*			trans	-107.3	77.4	174.2	0	0	0	0	110.6	E19 D23	E19-G21 PolarHBondContact O-N 2.76Å; G21-D23 PolarHBondContact O-N 2.99Å
22	S	59.2	Low	59.5	Low	76 Å²	76	133.8 Å²	133.8	53%	0.531	74%	0.74	S	S	.	*			trans	6.1	97.5	159.2	177.6	0	0	0	116.6	K24	S22-K24 VanDerWaalsContact O-CE 3.29Å; S22-K24 WeakPolarHBondContact O-CE 3.36Å; S22-K24 PolarHBondContact O-N 3.46Å
23	D	55.7	Low	59.7	Low	150 Å²	150	138 Å²	138	80%	0.802	76%	0.759	S	S	*	*			trans	25.8	65.5	132.3	-54.5	-40.8	0	0	117.9	G21	G21-D23 PolarHBondContact O-N 2.99Å
24	K	59.3	Low	59.9	Low	174 Å²	174	137.8 Å²	137.8	76%	0.757	76%	0.757	S	S	*	*			trans	-138.5	56.9	159.6	64.1	-158.8	76.2	168.5	111.1	S22 S26	S22-K24 VanDerWaalsContact O-CE 3.29Å; S22-K24 WeakPolarHBondContact O-CE 3.36Å; S22-K24 PolarHBondContact O-N 3.46Å; K24-S26 PolarHBondContact O-N 2.7Å
25	I	59.1	Low	60.1	Low	147 Å²	147	134.2 Å²	134.2	75%	0.754	75%	0.75	S	S	*	*			trans	-67.5	93.5	159.5	-56.7	96.7	0	0	106.1	K27	I25-K27 PolarHBondContact O-N 2.75Å
26	S	63.9	Low	60.4	Low	107 Å²	107	134.8 Å²	134.8	75%	0.748	75%	0.753	S	S	*	*			trans	-55.1	121	166.5	-173.9	0	0	0	107	K24 E28	K24-S26 PolarHBondContact O-N 2.7Å; S26-E28 PolarHBondContact O-N 3.06Å
27	K	62.5	Low	60.4	Low	194 Å²	194	137.4 Å²	137.4	84%	0.843	76%	0.759	S	S	*	*			trans	-70.8	68.8	-179.6	-66	-179.1	-179.9	-167.8	109.8	I25 V29	I25-K27 PolarHBondContact O-N 2.75Å; K27-V29 VanDerWaalsContact C-N 3.3Å; K27-V29 PolarHBondContact O-N 2.98Å
28	E	57.9	Low	61.1	Low	164 Å²	164	137.4 Å²	137.4	77%	0.766	76%	0.761	S	S	*	*			trans	-82.1	91.1	156.7	-167.3	173.1	-168.9	0	106.1	S26 V30	S26-E28 PolarHBondContact O-N 3.06Å; E28-V30 PolarHBondContact O-N 2.88Å
29	V	62.9	Low	61.8	Low	124 Å²	124	135.4 Å²	135.4	75%	0.752	76%	0.755	S	S	*	*			trans	-68.5	87.7	167.6	-179.1	0	0	0	105.5	K27 P31	K27-V29 VanDerWaalsContact C-N 3.3Å; K27-V29 PolarHBondContact O-N 2.98Å; V29-P31 WeakPolarHBondContact O-CD 3.44Å
30	V	62.7	Low	63	Low	104 Å²	104	135.4 Å²	135.4	63%	0.63	76%	0.759	S	S	*	*			trans	-52.6	123.9	159.1	174.1	0	0	0	105	E28 S32	E28-V30 PolarHBondContact O-N 2.88Å; V30-S32 PolarHBondContact O-N 2.66Å
31	P	54.9	Low	63.7	Low	110 Å²	110	134.7 Å²	134.7	71%	0.714	75%	0.75	S	S	*	*			trans	-62.3	100	172.3	23.6	-28.2	0	0	105.6	V29 L33	V29-P31 WeakPolarHBondContact O-CD 3.44Å; P31-L33 PolarHBondContact O-N 3.01Å
32	S	62.8	Low	64.6	Low	100 Å²	100	137.8 Å²	137.8	70%	0.699	75%	0.748	S	S	*	*			trans	-50	117.7	163.6	178.6	0	0	0	104.2	V30 A34	V30-S32 PolarHBondContact O-N 2.66Å; S32-A34 PolarHBondContact O-N 2.73Å
33	L	63	Low	65.3	Low	171 Å²	171	139.7 Å²	139.7	90%	0.895	76%	0.762	S	S	*	*			trans	-59.4	88.2	164.9	-77.8	161.1	0	0	104	P31 C35	P31-L33 PolarHBondContact O-N 3.01Å; L33-C35 PolarHBondContact O-N 3.3Å
34	A	62.9	Low	65.6	Low	77 Å²	77	135.6 Å²	135.6	64%	0.636	76%	0.755	S	S	*	*			trans	-61.3	91.4	169.3	0	0	0	0	102.9	S32 E36	S32-A34 PolarHBondContact O-N 2.73Å; A34-E36 PolarHBondContact O-N 3.48Å
35	C	66.6	Low	66.1	Low	100 Å²	100	133 Å²	133	68%	0.676	75%	0.749	S	S	*	*			trans	-57.1	94.2	157.2	-166.7	0	0	0	102.2	L33 W37	L33-C35 PolarHBondContact O-N 3.3Å; C35-W37 PolarHBondContact O-N 2.95Å
36	E	69.4	Low	66.6	Low	176 Å²	176	133.2 Å²	133.2	82%	0.822	75%	0.752	S	S	*	*			trans	-61.1	94.9	176	-83.5	-172.5	148.4	0	104.5	A34 S38	A34-E36 PolarHBondContact O-N 3.48Å; E36-S38 PolarHBondContact O-N 2.99Å; E36-S38 VanDerWaalsContact O-N 3.12Å
37	W	68.5	Low	66.7	Low	222 Å²	222	130.9 Å²	130.9	84%	0.841	74%	0.744	S	S	*	*			trans	-53	124.3	167.7	-69.6	83.4	0	0	105.6	C35 Q39	C35-W37 PolarHBondContact O-N 2.95Å; W37-Q39 PolarHBondContact O-N 2.9Å
38	S	75.1	Confident	66.9	Low	113 Å²	113	125.5 Å²	125.5	79%	0.79	74%	0.736	S	S	*	*			trans	-54.1	112	176.5	-57.4	0	0	0	107.4	E36 L40	E36-S38 PolarHBondContact O-N 2.99Å; E36-S38 VanDerWaalsContact O-N 3.12Å; S38-L40 PolarHBondContact O-N 2.94Å
39	Q	73.7	Confident	67.4	Low	175 Å²	175	126.6 Å²	126.6	82%	0.818	74%	0.741	S	S	*	*			trans	-63.5	111.3	179.5	-67.5	-168.7	11	0	107.1	W37 T41	W37-Q39 PolarHBondContact O-N 2.9Å; Q39-T41 PolarHBondContact O-N 3.38Å
40	L	75.4	Confident	67.4	Low	163 Å²	163	129.5 Å²	129.5	85%	0.853	75%	0.749	S	S	*	*			trans	-67	101	174.3	-75.6	172	0	0	107.8	S38 L42	S38-L40 PolarHBondContact O-N 2.94Å; L40-L42 PolarHBondContact O-N 2.85Å
41	T	71.1	Confident	67.6	Low	110 Å²	110	133.1 Å²	133.1	68%	0.675	76%	0.759	S	S	*	*			trans	-81.1	113.4	172.6	50	0	0	0	108.2	Q39 S43	Q39-T41 PolarHBondContact O-N 3.38Å; T41-S43 PolarHBondContact O-N 3.08Å
42	L	70.8	Confident	68.4	Low	136 Å²	136	136.7 Å²	136.7	71%	0.712	76%	0.763	S	S	*	*			trans	-79.1	40	177.8	-64.5	176.4	0	0	112.1	L40 G44 L45	L40-L42 PolarHBondContact O-N 2.85Å; L42-G44 PolarHBondContact O-N 3.02Å; L42-L45 HydrophobicContact CB-CB 4.41Å; L42-L45 HydrophobicContact CD1-CD2 4.47Å; L42-L45 PolarHBondContact O-N 3.23Å
43	S	72.3	Confident	69	Low	116 Å²	116	139 Å²	139	81%	0.811	77%	0.766	S	S	*	*	T	Hydrogen-bonded Turn	trans	-69.8	-1.3	-172.9	56.9	0	0	0	114.9	T41	T41-S43 PolarHBondContact O-N 3.08Å
44	G	63.8	Low	69.5	Low	64 Å²	64	135.9 Å²	135.9	66%	0.66	76%	0.756	S	S	*	*	T	Hydrogen-bonded Turn	trans	-121.9	3.3	176.9	0	0	0	0	114.9	L42 N46	L42-G44 PolarHBondContact O-N 3.02Å; G44-N46 PolarHBondContact O-N 2.77Å
45	L	68	Low	70.1	Confident	120 Å²	120	140.1 Å²	140.1	63%	0.628	77%	0.767	S	S	*	*			trans	-81.9	73.1	176.9	-172.3	64.2	0	0	109.3	L42 G47	L42-L45 HydrophobicContact CB-CB 4.41Å; L42-L45 HydrophobicContact CD1-CD2 4.47Å; L42-L45 PolarHBondContact O-N 3.23Å; L45-G47 VanDerWaalsContact C-N 3.25Å; L45-G47 PolarHBondContact O-N 3.1Å
46	N	70.6	Confident	70.7	Confident	152 Å²	152	142.6 Å²	142.6	81%	0.813	77%	0.773	S	S	*	*			trans	-75.6	82.7	172.2	56.8	-1.8	0	0	109.4	G44 A48	G44-N46 PolarHBondContact O-N 2.77Å; N46-A48 PolarHBondContact O-N 2.8Å
47	G	66.1	Low	71.1	Confident	57 Å²	57	142.3 Å²	142.3	59%	0.588	77%	0.771	S	S	*	*			trans	43.4	77.9	163.8	0	0	0	0	113.6	L45 Q49	L45-G47 VanDerWaalsContact C-N 3.25Å; L45-G47 PolarHBondContact O-N 3.1Å; G47-Q49 PolarHBondContact O-N 3.18Å
48	A	67.5	Low	71.6	Confident	82 Å²	82	139.4 Å²	139.4	68%	0.678	77%	0.771	S	S	*	*			trans	-53.4	105.4	150.6	0	0	0	0	105	N46 M50	N46-A48 PolarHBondContact O-N 2.8Å; A48-M50 VanDerWaalsContact C-N 3.3Å; A48-M50 PolarHBondContact O-N 3.01Å
49	Q	66.9	Low	71.8	Confident	186 Å²	186	138.6 Å²	138.6	87%	0.869	77%	0.765	S	S	*	*			trans	-56.7	107.7	171.9	-78.6	-178.4	-5.9	0	103.8	G47 E51	G47-Q49 PolarHBondContact O-N 3.18Å; Q49-E51 PolarHBondContact O-N 2.89Å
50	M	64.4	Low	72	Confident	186 Å²	186	136 Å²	136	92%	0.916	77%	0.766	S	S	*	*			trans	-61.3	93.1	162.3	-83.3	-169.8	-173.3	0	103.6	A48 K52	A48-M50 VanDerWaalsContact C-N 3.3Å; A48-M50 PolarHBondContact O-N 3.01Å; M50-K52 VanDerWaalsContact C-N 3.34Å; M50-K52 PolarHBondContact O-N 3.12Å
51	E	65.4	Low	71.9	Confident	180 Å²	180	133.9 Å²	133.9	84%	0.841	76%	0.763	S	S	*	*			trans	-53.9	110.4	169.2	-159.7	175	-161	0	104.2	Q49 I53	Q49-E51 PolarHBondContact O-N 2.89Å; E51-I53 PolarHBondContact O-N 3.43Å
52	K	72.4	Confident	71.9	Confident	185 Å²	185	139.8 Å²	139.8	80%	0.804	79%	0.791	S	S	*	*			trans	-59.8	110.4	-174.7	-177.9	179.8	176.1	-172.8	105.1	M50 P54	M50-K52 VanDerWaalsContact C-N 3.34Å; M50-K52 PolarHBondContact O-N 3.12Å; K52-P54 VanDerWaalsContact O-CD 3.3Å; K52-P54 WeakPolarHBondContact O-CD 3.45Å
53	I	75.1	Confident	71.9	Confident	147 Å²	147	140 Å²	140	75%	0.754	80%	0.795	S	S	*	*			trans	-47.8	118.5	176.6	-61.4	173.4	0	0	105.8	E51 L55	E51-I53 PolarHBondContact O-N 3.43Å; I53-L55 PolarHBondContact O-N 3.26Å
54	P	74.6	Confident	71.9	Confident	106 Å²	106	141.3 Å²	141.3	69%	0.688	79%	0.794	S	S	*	*			trans	-56.5	117.9	-179.6	-23.1	31.5	0	0	107.3	K52 L56	K52-P54 VanDerWaalsContact O-CD 3.3Å; K52-P54 WeakPolarHBondContact O-CD 3.45Å; P54-L56 PolarHBondContact O-N 2.93Å
55	L	74.4	Confident	72.4	Confident	167 Å²	167	145.6 Å²	145.6	87%	0.874	80%	0.801	S	S	*	*			trans	-65.1	104.3	174.8	-165	82.5	0	0	105.7	I53 H57	I53-L55 PolarHBondContact O-N 3.26Å; L55-H57 PolarHBondContact O-N 3.03Å
56	L	79.2	Confident	72.6	Confident	151 Å²	151	147.1 Å²	147.1	79%	0.791	81%	0.812	S	S	*	*			trans	-59.6	112.5	177.3	-69.1	172.3	0	0	107	P54 I58	P54-L56 PolarHBondContact O-N 2.93Å; L56-I58 WeakPolarHBondContact O-CG1 3.29Å; L56-I58 PolarHBondContact O-N 3.01Å
57	H	78.2	Confident	72.8	Confident	171 Å²	171	146.8 Å²	146.8	79%	0.792	81%	0.812	S	S	*	*			trans	-68.6	99.5	179.9	-178	-86.5	0	0	108.3	L55 S59	L55-H57 PolarHBondContact O-N 3.03Å; H57-S59 PolarHBondContact O-N 3.39Å
58	I	79.1	Confident	73.2	Confident	161 Å²	161	152.7 Å²	152.7	83%	0.826	83%	0.826	S	S	*	*			trans	-78.5	107	174.5	-26.3	176.6	0	0	106.3	L56 S60	L56-I58 WeakPolarHBondContact O-CG1 3.29Å; L56-I58 PolarHBondContact O-N 3.01Å; I58-S60 PolarHBondContact O-N 2.93Å
59	S	78.6	Confident	73.6	Confident	96 Å²	96	157.8 Å²	157.8	67%	0.671	84%	0.837	S	S	*	*	P	Polyproline II helix	trans	-72.3	119.8	172.7	55.8	0	0	0	109.1	H57	H57-S59 PolarHBondContact O-N 3.39Å
60	S	77.6	Confident	74.1	Confident	119 Å²	119	155.6 Å²	155.6	83%	0.832	84%	0.835	S	S	*	*	P	Polyproline II helix	trans	-74.6	132.9	166	-168.7	0	0	0	108.8	I58	I58-S60 PolarHBondContact O-N 2.93Å
61	C	73.9	Confident	75	Confident	119 Å²	119	153.1 Å²	153.1	80%	0.804	83%	0.828	S	S	*	*	P	Polyproline II helix	trans	-88.4	140.1	168.8	-162.2	0	0	0	108.4
62	D	70.9	Confident	75.8	Confident	235 Å²	235	150.6 Å²	150.6	100%	1.257	83%	0.827	S	S	*	*			trans	-70.7	0	166.2	-78	-34.4	0	0	111.1

Retrieved 62 of 62 residues in 12.9 ms (Link to these results)

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