A0A068BFX3_HUMAN Loading...

Truncated breast and ovarian cancer susceptibility protein 2

AlphaFold DB , UniProt , Accession A0A068BFX3, Species HUMAN (Homo sapiens, Human), Gene BRCA2, Length 60 aa.

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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1G46.4Very low56.4Low131 Ų131140.9 Ų140.9100%1.35180%0.803SS**  098.5000000108.3K3G1-K3 PolarHBondContact O-N 2.86Å
2T52.2Low56.7Low132 Ų132138.9 Ų138.981%0.8180%0.795SS**  trans-84.1110.6179.9-49.80000107V4T2-V4 VanDerWaalsContact C-N 3.27Å; T2-V4 PolarHBondContact O-N 3.43Å
3K60.5Low57.1Low207 Ų207141.4 Ų141.490%0.980%0.803SS**  trans-61.695.3167.1-99.2-168.5167.8-174.40107G1 S5G1-K3 PolarHBondContact O-N 2.86Å; K3-S5 PolarHBondContact O-N 3.14Å; K3-S5 VanDerWaalsContact O-N 3.12Å
4V57.5Low57Low128 Ų128136.5 Ų136.578%0.77680%0.8SS**  trans-62.4112.1165.4171.90000105.6T2 L6T2-V4 VanDerWaalsContact C-N 3.27Å; T2-V4 PolarHBondContact O-N 3.43Å; V4-L6 PolarHBondContact O-N 3.12Å; V4-L6 VanDerWaalsContact O-N 3.14Å
5S62.8Low57.5Low78 Ų78139.7 Ų139.755%0.54580%0.8SS.*  trans-60.4113.8177.4-173.40000108.2K3 V7K3-S5 PolarHBondContact O-N 3.14Å; K3-S5 VanDerWaalsContact O-N 3.12Å; S5-V7 PolarHBondContact O-N 2.79Å; S5-V7 WeakPolarHBondContact OG-CB 3.38Å; S5-V7 WeakPolarHBondContact OG-CG2 3.19Å
6L58.6Low57.7Low168 Ų168142.3 Ų142.388%0.8880%0.802SS**THydrogen-bonded Turntrans-7048.3171.8-174.568.1000110.4V4V4-L6 PolarHBondContact O-N 3.12Å; V4-L6 VanDerWaalsContact O-N 3.14Å
7V56.4Low58.2Low93 Ų93144.6 Ų144.656%0.56481%0.806SS**THydrogen-bonded Turntrans-124.2-1.8-173.9-178.40000111.4S5S5-V7 PolarHBondContact O-N 2.79Å; S5-V7 WeakPolarHBondContact OG-CB 3.38Å; S5-V7 WeakPolarHBondContact OG-CG2 3.19Å
8E54.3Low58.7Low175 Ų175141.2 Ų141.282%0.81880%0.799SS**THydrogen-bonded Turntrans-85.2-8.3176.9-78.9-176.5155.500114.5
9N55Low59Low139 Ų139138.1 Ų138.174%0.74379%0.787SS**THydrogen-bonded Turntrans-105.322.1-175.9-131.54.2000114.9
10I57.8Low59.2Low133 Ų133137.1 Ų137.168%0.68279%0.786SS**  trans-102.720.5174.1-33.1179.5000111.7V12I10-V12 VanDerWaalsContact C-N 3.26Å; I10-V12 PolarHBondContact O-N 3.5Å
11H58.5Low59.4Low166 Ų166139.2 Ų139.277%0.76979%0.786SS**  trans-89.514.4170.4-87.8-80.6000113.6
12V60.8Low60.2Low117 Ų117139.7 Ų139.771%0.70976%0.758SS**SBendtrans-87.7-8.2-175.2171.30000114.8I10I10-V12 VanDerWaalsContact C-N 3.26Å; I10-V12 PolarHBondContact O-N 3.5Å
13L61.8Low60.7Low171 Ų171139.3 Ų139.390%0.89576%0.755SS**SBendtrans-132.637.4-168.1-156.165.6000116
14G55.3Low60.9Low73 Ų73138.5 Ų138.575%0.75375%0.751SS**  trans-133.44.4-179.200000115.9
15K64.5Low61.2Low185 Ų185139.2 Ų139.280%0.80475%0.748SS**SBendtrans-98.6106.2165.4-27.9-80.8-179.8167.30103.7Q17K15-Q17 PolarHBondContact O-N 2.82Å
16E60.8Low61.3Low180 Ų180140.3 Ų140.384%0.84175%0.745SS**  trans-45111.5164.1-174.9171.5158.900106.8A18E16-A18 PolarHBondContact O-N 2.89Å
17Q65.9Low61.4Low183 Ų183141.2 Ų141.286%0.85575%0.748SS**  trans-61.2104.6168-175.1-172.581.600102.3K15 S19K15-Q17 PolarHBondContact O-N 2.82Å; Q17-S19 PolarHBondContact O-N 2.66Å
18A67.2Low61.7Low83 Ų83139.9 Ų139.969%0.68675%0.753SS**  trans-59.694.9177.100000105E16 P20E16-A18 PolarHBondContact O-N 2.89Å; A18-P20 VanDerWaalsContact O-N 3.12Å
19S65.1Low62.3Low82 Ų82138.7 Ų138.757%0.57375%0.745SS**  trans-44.9124.3161.7163.70000103.8Q17 K21Q17-S19 PolarHBondContact O-N 2.66Å; S19-K21 PolarHBondContact O-N 2.66Å
20P62.5Low63Low118 Ų118138 Ų13877%0.76675%0.746SS**  trans-56103.3172.521.6-28.3000104.1A18 N22A18-P20 VanDerWaalsContact O-N 3.12Å; P20-N22 PolarHBondContact O-N 2.66Å
21K63Low63.5Low181 Ų181139.9 Ų139.979%0.78775%0.752SS**  trans-54.6100.4-178.8-87.3179.9177176.20103.2S19 V23S19-K21 PolarHBondContact O-N 2.66Å; K21-V23 PolarHBondContact O-N 2.76Å
22N64Low64.1Low141 Ų141137.5 Ų137.575%0.75475%0.749SS**  trans-5.683.8169.354-28.5000109.5P20 K24P20-N22 PolarHBondContact O-N 2.66Å; N22-K24 PolarHBondContact O-N 2.68Å
23V62.4Low64.5Low124 Ų124140.9 Ų140.975%0.75276%0.755SS**  trans-57.9108.7164.7148.6000099.7K21 M25K21-V23 PolarHBondContact O-N 2.76Å; V23-M25 HydrophobicContact CG1-CB 4.1Å; V23-M25 PolarHBondContact O-N 3.02Å
24K64.1Low65.1Low190 Ų190136.9 Ų136.983%0.82674%0.741SS**  trans-6876.3172.2-165.9-178.2-176.9-172.30102.8N22 E26N22-K24 PolarHBondContact O-N 2.68Å; K24-E26 PolarHBondContact O-N 2.64Å
25M63.6Low65.8Low144 Ų144141 Ų14171%0.70975%0.746SS**  trans-64.494.5166-171.7132.1113.100101.1V23 I27V23-M25 HydrophobicContact CG1-CB 4.1Å; V23-M25 PolarHBondContact O-N 3.02Å; M25-I27 PolarHBondContact O-N 2.76Å
26E66.3Low66.1Low101 Ų101136.8 Ų136.847%0.47274%0.736SS.*  trans-51.6116.7-179.5-166.7178.3-177.500105K24 G28 K29K24-E26 PolarHBondContact O-N 2.64Å; E26-G28 PolarHBondContact O-N 2.67Å; E26-K29 HydrophobicContact CB-CD 3.99Å; E26-K29 HydrophobicContact CB-CG 3.96Å; E26-K29 HydrophobicContact CG-CG 4.44Å; E26-K29 PolarHBondContact O-N 2.69Å; E26-K29 WeakPolarHBondContact OE2-CD 3.04Å; E26-K29 WeakPolarHBondContact OE2-CE 3.23Å; E26-K29 WeakPolarHBondContact OE2-CG 3.31Å; E26-K29 IonicContact OE2-NZ 2.71Å; E26-K29 PolarHBondContact OE2-NZ 2.94Å; E26-K29 HydrophobicContact CB-CB 4.08Å
27I60.9Low66.4Low187 Ų187133.5 Ų133.596%0.95973%0.73SS**THydrogen-bonded Turntrans-62.20.7-170.8-66.5165.6000111.7M25M25-I27 PolarHBondContact O-N 2.76Å
28G62.1Low66.6Low64 Ų64130.6 Ų130.666%0.6673%0.725SS**THydrogen-bonded Turntrans-120.64170.800000116E26 T30E26-G28 PolarHBondContact O-N 2.67Å; G28-T30 PolarHBondContact O-N 2.98Å
29K66.9Low66.5Low151 Ų151135.4 Ų135.466%0.65773%0.73SS**  trans-83.990.3170.1-87.6-179.3173.3136.30109E26 E31E26-K29 HydrophobicContact CB-CD 3.99Å; E26-K29 HydrophobicContact CB-CG 3.96Å; E26-K29 HydrophobicContact CG-CG 4.44Å; E26-K29 PolarHBondContact O-N 2.69Å; E26-K29 WeakPolarHBondContact OE2-CD 3.04Å; E26-K29 WeakPolarHBondContact OE2-CE 3.23Å; E26-K29 WeakPolarHBondContact OE2-CG 3.31Å; E26-K29 IonicContact OE2-NZ 2.71Å; E26-K29 PolarHBondContact OE2-NZ 2.94Å; E26-K29 HydrophobicContact CB-CB 4.08Å; K29-E31 PolarHBondContact O-N 2.87Å
30T69.1Low66.6Low123 Ų123136.4 Ų136.476%0.75573%0.733SS**  trans-64.9115.7159.230.90000108.1G28 T32G28-T30 PolarHBondContact O-N 2.98Å; T30-T32 PolarHBondContact O-N 3.12Å
31E69.7Low66.9Low173 Ų173137.6 Ų137.681%0.80873%0.732SS**  trans-54.6110.8160.4-96.4177.1133.700106.8K29 F33K29-E31 PolarHBondContact O-N 2.87Å; E31-F33 PolarHBondContact O-N 3.04Å; E31-F33 VanDerWaalsContact O-N 3.15Å
32T70.6Confident66.9Low117 Ų117135.2 Ų135.272%0.71873%0.727SS**  trans-75.9107.6177.3-52.20000105.7T30 S34T30-T32 PolarHBondContact O-N 3.12Å; T32-S34 PolarHBondContact O-N 2.53Å; T32-S34 VanDerWaalsContact O-N 3.15Å
33F69.9Low67Low187 Ų187136.6 Ų136.682%0.8273%0.729SS**  trans-55.7122.3165.3-65.4-79.1000106.6E31 D35E31-F33 PolarHBondContact O-N 3.04Å; E31-F33 VanDerWaalsContact O-N 3.15Å; F33-D35 PolarHBondContact O-N 2.89Å
34S73.4Confident67Low87 Ų87135.4 Ų135.461%0.60872%0.722SS**  trans-55.4133.6-178.8-173.10000109.5T32 V36T32-S34 PolarHBondContact O-N 2.53Å; T32-S34 VanDerWaalsContact O-N 3.15Å; S34-V36 PolarHBondContact O-N 2.97Å; S34-V36 VanDerWaalsContact OG-CG2 3.23Å; S34-V36 WeakPolarHBondContact OG-CG2 3.28Å; S34-V36 PolarHBondContact OG-N 2.87Å
35D69.1Low67.1Low159 Ų159131.6 Ų131.685%0.8572%0.718SS**SBendtrans-63.61.7172.3-68-57.9000113.1F33 P37F33-D35 PolarHBondContact O-N 2.89Å; D35-P37 VanDerWaalsContact O-CD 3.28Å; D35-P37 VanDerWaalsContact O-N 3.14Å; D35-P37 WeakPolarHBondContact O-CD 3.23Å
36V70.9Confident67.4Low98 Ų98129.4 Ų129.459%0.59472%0.717SS**SBendtrans-60.6119.5171.9175.80000107S34 V38S34-V36 PolarHBondContact O-N 2.97Å; S34-V36 VanDerWaalsContact OG-CG2 3.23Å; S34-V36 WeakPolarHBondContact OG-CG2 3.28Å; S34-V36 PolarHBondContact OG-N 2.87Å; V36-V38 PolarHBondContact O-N 2.92Å
37P68.2Low67.4Low111 Ų111130.5 Ų130.572%0.72173%0.73SS**  trans-58.8110175.821.8-29.5000107D35 K39D35-P37 VanDerWaalsContact O-CD 3.28Å; D35-P37 VanDerWaalsContact O-N 3.14Å; D35-P37 WeakPolarHBondContact O-CD 3.23Å; P37-K39 PolarHBondContact O-N 3.31Å
38V68.9Low67.6Low122 Ų122129.6 Ų129.674%0.73972%0.716SS**  trans-57.4110.1168.2178.50000103.9V36 T40V36-V38 PolarHBondContact O-N 2.92Å; V38-T40 PolarHBondContact O-N 2.84Å; V38-T40 PolarHBondContact O-OG1 2.89Å
39K66.4Low67.8Low183 Ų183131.2 Ų131.280%0.79672%0.717SS**  trans-6981.9178.2-164.2178.3-179.1-1760106.1P37 N41P37-K39 PolarHBondContact O-N 3.31Å; K39-N41 PolarHBondContact O-N 3.49Å
40T67.4Low67.8Low104 Ų104130.5 Ų130.564%0.63871%0.714SS**  trans-60.2111.8171-440000104.1V38 I42V38-T40 PolarHBondContact O-N 2.84Å; V38-T40 PolarHBondContact O-OG1 2.89Å; T40-I42 HydrophobicContact CG2-CG1 4.27Å; T40-I42 PolarHBondContact O-N 2.95Å
41N68.2Low67.5Low142 Ų142131 Ų13176%0.75971%0.712SS**  trans-64.979.6170.2-68.6-51.7000106.4K39 E43K39-N41 PolarHBondContact O-N 3.49Å; N41-E43 PolarHBondContact O-N 3.15Å
42I63.9Low67.3Low131 Ų131127.3 Ų127.367%0.67271%0.705SS**  trans-69.583.3161.1-68.9178.3000103.4T40 V44T40-I42 HydrophobicContact CG2-CG1 4.27Å; T40-I42 PolarHBondContact O-N 2.95Å; I42-V44 HydrophobicContact CG2-CG2 3.6Å; I42-V44 PolarHBondContact O-N 2.7Å
43E64.9Low67.1Low170 Ų170130.7 Ų130.779%0.79471%0.713SS**  trans-64.492.1154.4-164.1167.5-150.800104.5N41 C45N41-E43 PolarHBondContact O-N 3.15Å; E43-C45 PolarHBondContact O-N 2.71Å; E43-C45 VanDerWaalsContact C-N 3.34Å
44V63.2Low66.9Low99 Ų99127.7 Ų127.760%0.671%0.706SS**  trans-60.7107.9165.1-175.70000103.7I42 S46I42-V44 HydrophobicContact CG2-CG2 3.6Å; I42-V44 PolarHBondContact O-N 2.7Å; V44-S46 VanDerWaalsContact CG1-OG 3.31Å; V44-S46 WeakPolarHBondContact CG1-OG 2.93Å; V44-S46 PolarHBondContact O-N 3.34Å
45C66.1Low66.7Low110 Ų110132 Ų13274%0.74371%0.71SS**  trans-64.373.5170.3-74.70000109E43 T47E43-C45 PolarHBondContact O-N 2.71Å; E43-C45 VanDerWaalsContact C-N 3.34Å; C45-T47 PolarHBondContact O-N 2.82Å
46S68.6Low66.8Low98 Ų98132.1 Ų132.169%0.68570%0.703SS**  trans-82.766.6172.3-63.20000108.8V44V44-S46 VanDerWaalsContact CG1-OG 3.31Å; V44-S46 WeakPolarHBondContact CG1-OG 2.93Å; V44-S46 PolarHBondContact O-N 3.34Å
47T67.3Low66.8Low124 Ų124133.8 Ų133.876%0.76171%0.705SS**  trans-146.597.8164.9560000105.4C45C45-T47 PolarHBondContact O-N 2.82Å
48Y64.6Low67Low169 Ų169134 Ų13466%0.66370%0.704SS**  -165.3112.870.3-157.6-64.1000107K50Y48-K50 PolarHBondContact OH-NZ 2.77Å; Y48-K50 PolarHBondContact O-N 2.69Å; Y48-K50 HydrophobicContact CG-CG 4.04Å; Y48-K50 HydrophobicContact CG-CD 4.27Å; Y48-K50 HydrophobicContact CE1-CG 3.64Å; Y48-K50 HydrophobicContact CE1-CB 4.48Å; Y48-K50 HydrophobicContact CD1-CG 3.27Å; Y48-K50 HydrophobicContact CD1-CD 3.35Å; Y48-K50 HydrophobicContact CD1-CB 4.09Å; Y48-K50 HydrophobicContact CE1-CD 3.09Å
49S66.6Low66.8Low98 Ų98137 Ų13769%0.68571%0.71SS**  trans-69.594.3162.1-1480000106.1D51S49-D51 PolarHBondContact O-N 2.97Å; S49-D51 VanDerWaalsContact O-N 3.12Å; S49-D51 PolarHBondContact OG-OD2 3.46Å
50K66.2Low66.1Low135 Ų135140.5 Ų140.559%0.58773%0.729SS**  trans-82.561.9168.4-77.4-72.4177.1-173.70106.7Y48 S52Y48-K50 PolarHBondContact OH-NZ 2.77Å; Y48-K50 PolarHBondContact O-N 2.69Å; Y48-K50 HydrophobicContact CG-CG 4.04Å; Y48-K50 HydrophobicContact CG-CD 4.27Å; Y48-K50 HydrophobicContact CE1-CG 3.64Å; Y48-K50 HydrophobicContact CE1-CB 4.48Å; Y48-K50 HydrophobicContact CD1-CG 3.27Å; Y48-K50 HydrophobicContact CD1-CD 3.35Å; Y48-K50 HydrophobicContact CD1-CB 4.09Å; Y48-K50 HydrophobicContact CE1-CD 3.09Å; K50-S52 PolarHBondContact O-N 3.34Å
51D64.2Low66.1Low134 Ų134142.4 Ų142.472%0.71773%0.734SS**  trans-74.175.6157-59.8-53.1000105S49 E53S49-D51 PolarHBondContact O-N 2.97Å; S49-D51 VanDerWaalsContact O-N 3.12Å; S49-D51 PolarHBondContact OG-OD2 3.46Å; D51-E53 VanDerWaalsContact C-N 3.29Å; D51-E53 PolarHBondContact O-N 2.94Å
52S65.3Low66Low95 Ų95142.4 Ų142.466%0.66473%0.732SS**  trans-67101.2167.157.30000105.4K50 N54K50-S52 PolarHBondContact O-N 3.34Å; S52-N54 PolarHBondContact O-N 3.3Å
53E65.8Low66.1Low188 Ų188143 Ų14388%0.87974%0.736SS**  trans-54.991.1160.6-70.7176.8162.900107.1D51 Y55D51-E53 VanDerWaalsContact C-N 3.29Å; D51-E53 PolarHBondContact O-N 2.94Å; E53-Y55 PolarHBondContact O-N 3.15Å
54N66.1Low66.1Low125 Ų125141.4 Ų141.467%0.66873%0.732SS**  trans-77.671.1173.3-173.156.4000107.9S52 F56S52-N54 PolarHBondContact O-N 3.3Å; N54-F56 PolarHBondContact O-N 3.2Å; N54-F56 VanDerWaalsContact OD1-CD2 3.23Å; N54-F56 WeakPolarHBondContact OD1-CD2 3.14Å
55Y69.8Low66.3Low177 Ų177144.1 Ų144.169%0.69474%0.741SS**  trans-85.286.1165.6-168.3-106.4000107.9E53 E57E53-Y55 PolarHBondContact O-N 3.15Å; Y55-E57 HydrophobicContact CD1-CG 3.93Å; Y55-E57 HydrophobicContact CE1-CG 3.28Å; Y55-E57 WeakPolarHBondContact CE1-OE1 3.33Å; Y55-E57 VanDerWaalsContact CZ-CD 3.48Å; Y55-E57 PolarHBondContact OH-OE1 2.77Å
56F70.7Confident66.3Low162 Ų162146.3 Ų146.371%0.71174%0.74SS**  trans-89.5106.2160.7-97.4-90.8000108.2N54 T58N54-F56 PolarHBondContact O-N 3.2Å; N54-F56 VanDerWaalsContact OD1-CD2 3.23Å; N54-F56 WeakPolarHBondContact OD1-CD2 3.14Å; F56-T58 HydrophobicContact CD1-CG2 4.42Å; F56-T58 PolarHBondContact O-N 2.81Å
57E71.4Confident66.2Low133 Ų133149.8 Ų149.862%0.62174%0.744SS**  trans-61.3119.5151.9-67.1-78.2-167.200107.7Y55Y55-E57 HydrophobicContact CD1-CG 3.93Å; Y55-E57 HydrophobicContact CE1-CG 3.28Å; Y55-E57 WeakPolarHBondContact CE1-OE1 3.33Å; Y55-E57 VanDerWaalsContact CZ-CD 3.48Å; Y55-E57 PolarHBondContact OH-OE1 2.77Å
58T71.7Confident66.1Low115 Ų115151.8 Ų151.871%0.70674%0.743SS**  trans-138.7105.6160.948.90000111.4F56F56-T58 HydrophobicContact CD1-CG2 4.42Å; F56-T58 PolarHBondContact O-N 2.81Å
59E64.4Low66.2Low184 Ų184150.3 Ų150.386%0.8675%0.75SS**  trans61.1107146.4-56.7-149.5106.400121.1
60Q52.5Low66.2Low258 Ų258155.1 Ų155.1100%1.20676%0.756SS**  trans40.40131.5-63.1-65.1111.900120.1

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