A0A068JCC9_HUMAN Loading...

Epidermal growth factor receptor

AlphaFold DB , UniProt , Accession A0A068JCC9, Species HUMAN (Homo sapiens, Human), Gene EGFR, Length 33 aa.

						>A0A068JCC9_HUMAN|A0A068JCC9|EGFR
GVWIPEGEKVKIPVAIKELREATSPKANKEILD
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	G	46.1	Very low	54.2	Low	134 Å²	134	135.5 Å²	135.5	100%	1.381	75%	0.75	S	S	*	*				0	137.7	0	0	0	0	0	0	108.5
2	V	49.1	Very low	54.6	Low	114 Å²	114	133.3 Å²	133.3	69%	0.691	73%	0.734	S	S	*	*			trans	-89.1	118.7	177.1	173.5	0	0	0	0	107.4	I4	V2-I4 HydrophobicContact CG1-CG1 3.98Å; V2-I4 HydrophobicContact CG1-CD1 4.5Å
3	W	52.9	Low	54.7	Low	216 Å²	216	129.6 Å²	129.6	82%	0.818	72%	0.72	S	S	*	*			trans	-83.5	131.7	172.2	-172.8	83.1	0	0	0	109.1	P5	W3-P5 HydrophobicContact CE3-CG 4.32Å; W3-P5 HydrophobicContact CE3-CB 4.39Å; W3-P5 HydrophobicContact CZ3-CG 3.71Å; W3-P5 HydrophobicContact CZ3-CB 3.56Å; W3-P5 HydrophobicContact CZ2-CB 4.42Å; W3-P5 HydrophobicContact CH2-CG 4.27Å; W3-P5 HydrophobicContact CH2-CB 3.58Å
4	I	55.7	Low	54.9	Low	133 Å²	133	125.9 Å²	125.9	68%	0.682	70%	0.702	S	S	*	*			trans	-124.4	110.8	-176.9	-56.3	175.2	0	0	0	106.7	V2	V2-I4 HydrophobicContact CG1-CG1 3.98Å; V2-I4 HydrophobicContact CG1-CD1 4.5Å
5	P	60.7	Low	55.4	Low	39 Å²	39	120.1 Å²	120.1	25%	0.253	68%	0.677	S	S	.	*			trans	-67.8	135.1	174.5	22.8	-26.8	0	0	0	110	W3 G7 V10	W3-P5 HydrophobicContact CE3-CG 4.32Å; W3-P5 HydrophobicContact CE3-CB 4.39Å; W3-P5 HydrophobicContact CZ3-CG 3.71Å; W3-P5 HydrophobicContact CZ3-CB 3.56Å; W3-P5 HydrophobicContact CZ2-CB 4.42Å; W3-P5 HydrophobicContact CH2-CG 4.27Å; W3-P5 HydrophobicContact CH2-CB 3.58Å; P5-G7 PolarHBondContact O-N 3.34Å; P5-V10 HydrophobicContact CG-CB 3.89Å; P5-V10 HydrophobicContact CG-CG2 4.01Å
6	E	59	Low	55.9	Low	206 Å²	206	118.9 Å²	118.9	96%	0.963	67%	0.667	S	S	*	*	S	Bend	trans	-70.9	117.6	173.2	-77.2	-171.9	78.3	0	0	110
7	G	58.5	Low	56.2	Low	77 Å²	77	119.7 Å²	119.7	79%	0.794	66%	0.662	S	S	*	*	S	Bend	trans	135.2	-29.6	159	0	0	0	0	0	116.6	P5	P5-G7 PolarHBondContact O-N 3.34Å
8	E	53.1	Low	56.5	Low	169 Å²	169	120.3 Å²	120.3	79%	0.79	66%	0.659	S	S	*	*	S	Bend	trans	-150.2	150.3	-179.8	-153	140.1	86.6	0	0	110.6	V10	E8-V10 PolarHBondContact O-N 2.64Å
9	K	52.8	Low	56.8	Low	188 Å²	188	120.2 Å²	120.2	82%	0.817	66%	0.657	S	S	*	*			trans	-63.1	69.7	176.9	-69.3	170	-178.5	167.3	0	109.8	K11	K9-K11 PolarHBondContact O-N 3.18Å
10	V	53.9	Low	56.9	Low	75 Å²	75	124.2 Å²	124.2	46%	0.455	66%	0.662	S	S	.	*			trans	-74.7	79.7	168.9	-174.8	0	0	0	0	104.8	P5 E8 I12	P5-V10 HydrophobicContact CG-CB 3.89Å; P5-V10 HydrophobicContact CG-CG2 4.01Å; E8-V10 PolarHBondContact O-N 2.64Å; V10-I12 PolarHBondContact O-N 2.79Å
11	K	54.5	Low	56.9	Low	139 Å²	139	124.3 Å²	124.3	60%	0.604	66%	0.659	S	S	*	*			trans	-52.2	125.1	-178.9	-66.7	173	-179.4	173.5	0	106.2	K9 P13 V14	K9-K11 PolarHBondContact O-N 3.18Å; K11-P13 HydrophobicContact CB-CG 3.56Å; K11-P13 CarbonylContact O-C 3.53Å; K11-P13 WeakPolarHBondContact O-CD 3.33Å; K11-V14 PolarHBondContact O-N 2.7Å; K11-V14 WeakPolarHBondContact O-CB 3.26Å
12	I	59.1	Low	57.1	Low	110 Å²	110	119.7 Å²	119.7	56%	0.564	61%	0.607	S	S	*	*	H	α-helix	trans	-29.1	-40.9	167.9	-61.3	167.9	0	0	0	113.9	V10 V14 A15 I16	V10-I12 PolarHBondContact O-N 2.79Å; I12-V14 PolarHBondContact O-N 2.81Å; I12-A15 PolarHBondContact O-N 2.79Å; I12-I16 PolarHBondContact O-N 2.88Å; I12-I16 WeakPolarHBondContact O-CG1 3.48Å; I12-I16 VanDerWaalsContact O-CG1 3.3Å; I12-I16 WeakPolarHBondContact O-CB 3.36Å; I12-I16 HydrophobicContact CG2-CG1 4.16Å; I12-I16 HydrophobicContact CG2-CD1 3.52Å
13	P	55.7	Low	57.1	Low	85 Å²	85	119.2 Å²	119.2	55%	0.552	61%	0.605	S	S	*	*	H	α-helix	trans	-59.8	-36.7	171.7	20.2	-35.7	0	0	0	116.4	K11 K17	K11-P13 HydrophobicContact CB-CG 3.56Å; K11-P13 CarbonylContact O-C 3.53Å; K11-P13 WeakPolarHBondContact O-CD 3.33Å; P13-K17 WeakPolarHBondContact O-CA 3.49Å; P13-K17 WeakPolarHBondContact O-CB 3.15Å; P13-K17 PolarHBondContact O-N 3.4Å
14	V	58	Low	56.9	Low	77 Å²	77	112.4 Å²	112.4	47%	0.467	59%	0.59	S	S	.	*	H	α-helix	trans	-66.9	-44.1	175.5	173.9	0	0	0	0	110.2	K11 I12 K17 E18	K11-V14 PolarHBondContact O-N 2.7Å; K11-V14 WeakPolarHBondContact O-CB 3.26Å; I12-V14 PolarHBondContact O-N 2.81Å; V14-K17 PolarHBondContact O-N 3.37Å; V14-E18 WeakPolarHBondContact O-CB 3.45Å; V14-E18 PolarHBondContact O-N 3.39Å
15	A	61.8	Low	56.6	Low	40 Å²	40	112.3 Å²	112.3	33%	0.331	60%	0.598	S	S	.	*	H	α-helix	trans	-68	-40.2	177.2	0	0	0	0	0	112.4	I12 L19	I12-A15 PolarHBondContact O-N 2.79Å; A15-L19 PolarHBondContact O-N 3.47Å; A15-L19 WeakPolarHBondContact O-CG 3.46Å; A15-L19 WeakPolarHBondContact O-CB 2.95Å; A15-L19 VanDerWaalsContact O-CB 3.26Å; A15-L19 WeakPolarHBondContact O-CD1 3.09Å
16	I	63.3	Low	56.2	Low	101 Å²	101	119.7 Å²	119.7	52%	0.518	63%	0.626	S	S	.	*	H	α-helix	trans	-69.8	-37.6	174.8	-67.2	173.2	0	0	0	111	I12 R20	I12-I16 PolarHBondContact O-N 2.88Å; I12-I16 WeakPolarHBondContact O-CG1 3.48Å; I12-I16 VanDerWaalsContact O-CG1 3.3Å; I12-I16 WeakPolarHBondContact O-CB 3.36Å; I12-I16 HydrophobicContact CG2-CG1 4.16Å; I12-I16 HydrophobicContact CG2-CD1 3.52Å; I16-R20 WeakPolarHBondContact O-CB 3.48Å; I16-R20 PolarHBondContact O-N 2.8Å
17	K	61.4	Low	55.8	Low	132 Å²	132	112.5 Å²	112.5	57%	0.574	60%	0.602	S	S	*	*	H	α-helix	trans	-63.3	-49.2	174.7	176.3	174.3	176.2	-176.9	0	110.2	P13 V14 R20 E21	P13-K17 WeakPolarHBondContact O-CA 3.49Å; P13-K17 WeakPolarHBondContact O-CB 3.15Å; P13-K17 PolarHBondContact O-N 3.4Å; V14-K17 PolarHBondContact O-N 3.37Å; K17-R20 PolarHBondContact O-N 3.1Å; K17-E21 WeakPolarHBondContact O-CG 3.3Å; K17-E21 PolarHBondContact O-N 3.28Å; K17-E21 VanDerWaalsContact O-CG 3.28Å; K17-E21 WeakPolarHBondContact O-CB 3.24Å; K17-E21 WeakPolarHBondContact CG-OE2 3.21Å; K17-E21 WeakPolarHBondContact CE-OE2 3.37Å
18	E	61.4	Low	55	Low	131 Å²	131	115.1 Å²	115.1	61%	0.612	60%	0.598	S	S	*	*	H	α-helix	trans	-60.5	-47.4	173.9	-97.1	-146.7	81	0	0	112.1	V14 R20 E21 A22	V14-E18 WeakPolarHBondContact O-CB 3.45Å; V14-E18 PolarHBondContact O-N 3.39Å; E18-R20 VanDerWaalsContact C-N 3.3Å; E18-R20 PolarHBondContact O-N 3.26Å; E18-E21 CarbonylContact O-C 3.59Å; E18-E21 PolarHBondContact O-N 2.98Å; E18-A22 WeakPolarHBondContact O-CA 3.34Å; E18-A22 WeakPolarHBondContact O-CB 3.28Å; E18-A22 PolarHBondContact O-N 2.78Å
19	L	61.7	Low	54.6	Low	118 Å²	118	116 Å²	116	62%	0.618	60%	0.599	S	S	*	*	H	α-helix	trans	-61.4	-40	177.4	-74.7	168.8	0	0	0	111.6	A15 T23	A15-L19 PolarHBondContact O-N 3.47Å; A15-L19 WeakPolarHBondContact O-CG 3.46Å; A15-L19 WeakPolarHBondContact O-CB 2.95Å; A15-L19 VanDerWaalsContact O-CB 3.26Å; A15-L19 WeakPolarHBondContact O-CD1 3.09Å; L19-T23 WeakPolarHBondContact O-CB 2.94Å; L19-T23 PolarHBondContact O-OG1 3.23Å; L19-T23 WeakPolarHBondContact O-CG2 3.09Å; L19-T23 PolarHBondContact O-N 2.7Å
20	R	58.9	Low	54.4	Low	199 Å²	199	115.4 Å²	115.4	75%	0.751	60%	0.599	S	S	*	*	H	α-helix	trans	-69.4	-36.8	177.6	-169.8	172.1	-179.2	-83.9	-0.1	112	I16 K17 E18 T23	I16-R20 WeakPolarHBondContact O-CB 3.48Å; I16-R20 PolarHBondContact O-N 2.8Å; K17-R20 PolarHBondContact O-N 3.1Å; E18-R20 VanDerWaalsContact C-N 3.3Å; E18-R20 PolarHBondContact O-N 3.26Å; R20-T23 VanDerWaalsContact C-OG1 3.28Å; R20-T23 VanDerWaalsContact CA-OG1 3.24Å; R20-T23 WeakPolarHBondContact CA-OG1 3.15Å; R20-T23 PolarHBondContact O-OG1 2.84Å
21	E	57.2	Low	54.4	Low	128 Å²	128	118.9 Å²	118.9	60%	0.598	61%	0.614	S	S	*	*	H	α-helix	trans	-73.3	-38.3	175	-71.3	-171.4	92.6	0	0	111.8	K17 E18 T23 S24	K17-E21 WeakPolarHBondContact O-CG 3.3Å; K17-E21 PolarHBondContact O-N 3.28Å; K17-E21 VanDerWaalsContact O-CG 3.28Å; K17-E21 WeakPolarHBondContact O-CB 3.24Å; K17-E21 WeakPolarHBondContact CG-OE2 3.21Å; K17-E21 WeakPolarHBondContact CE-OE2 3.37Å; E18-E21 CarbonylContact O-C 3.59Å; E18-E21 PolarHBondContact O-N 2.98Å; E21-T23 VanDerWaalsContact C-N 3.34Å; E21-S24 PolarHBondContact O-N 3.37Å; E21-S24 VanDerWaalsContact O-N 3.16Å; E21-S24 WeakPolarHBondContact O-CB 3.41Å
22	A	51.3	Low	54	Low	36 Å²	36	119.9 Å²	119.9	30%	0.298	63%	0.625	S	S	.	*	H	α-helix	trans	-74.8	-19.6	174.9	0	0	0	0	0	113.2	E18 S24	E18-A22 WeakPolarHBondContact O-CA 3.34Å; E18-A22 WeakPolarHBondContact O-CB 3.28Å; E18-A22 PolarHBondContact O-N 2.78Å; A22-S24 PolarHBondContact O-N 2.8Å
23	T	49.2	Very low	53.1	Low	104 Å²	104	125 Å²	125	64%	0.638	65%	0.653	S	S	*	*	T	Hydrogen-bonded Turn	trans	-76.3	11.3	165.5	51.5	0	0	0	0	113.6	L19 R20 E21 P25	L19-T23 WeakPolarHBondContact O-CB 2.94Å; L19-T23 PolarHBondContact O-OG1 3.23Å; L19-T23 WeakPolarHBondContact O-CG2 3.09Å; L19-T23 PolarHBondContact O-N 2.7Å; R20-T23 VanDerWaalsContact C-OG1 3.28Å; R20-T23 VanDerWaalsContact CA-OG1 3.24Å; R20-T23 WeakPolarHBondContact CA-OG1 3.15Å; R20-T23 PolarHBondContact O-OG1 2.84Å; E21-T23 VanDerWaalsContact C-N 3.34Å; T23-P25 WeakPolarHBondContact O-CD 3.48Å
24	S	47.8	Very low	53	Low	74 Å²	74	127 Å²	127	52%	0.517	66%	0.658	S	S	.	*	S	Bend	trans	-66.4	118	146.3	-168.6	0	0	0	0	107	E21 A22 K26 A27	E21-S24 PolarHBondContact O-N 3.37Å; E21-S24 VanDerWaalsContact O-N 3.16Å; E21-S24 WeakPolarHBondContact O-CB 3.41Å; A22-S24 PolarHBondContact O-N 2.8Å; S24-K26 PolarHBondContact O-N 3.29Å; S24-A27 PolarHBondContact O-N 2.83Å
25	P	49.5	Very low	52.7	Low	131 Å²	131	129.6 Å²	129.6	85%	0.851	67%	0.668	S	S	*	*	T	Hydrogen-bonded Turn	trans	-60.9	8	-165.5	23	-34.4	0	0	0	116.3	T23	T23-P25 WeakPolarHBondContact O-CD 3.48Å
26	K	52.3	Low	52.2	Low	193 Å²	193	134.6 Å²	134.6	84%	0.839	69%	0.687	S	S	*	*	T	Hydrogen-bonded Turn	trans	-100.4	-19.7	-179.6	-90.6	-178.1	170.7	-177.1	0	115.3	S24	S24-K26 PolarHBondContact O-N 3.29Å
27	A	50	Low	51.6	Low	55 Å²	55	136.5 Å²	136.5	46%	0.455	70%	0.697	S	S	.	*	S	Bend	trans	-93.6	-11	-171.6	0	0	0	0	0	114.8	S24 K29	S24-A27 PolarHBondContact O-N 2.83Å; A27-K29 PolarHBondContact O-N 2.66Å; A27-K29 VanDerWaalsContact O-N 3.1Å
28	N	43.1	Very low	50.9	Low	132 Å²	132	136.8 Å²	136.8	71%	0.706	71%	0.705	S	S	*	*	T	Hydrogen-bonded Turn	trans	-78.3	10.9	-176.8	-153.1	64.3	0	0	0	114.6
29	K	44.2	Very low	50.2	Low	188 Å²	188	137.2 Å²	137.2	82%	0.817	71%	0.711	S	S	*	*	T	Hydrogen-bonded Turn	trans	-103.8	-13.1	-177.6	-114.4	-179.2	-177.8	173.8	0	114.5	A27	A27-K29 PolarHBondContact O-N 2.66Å; A27-K29 VanDerWaalsContact O-N 3.1Å
30	E	47.9	Very low	49.4	Very low	176 Å²	176	138.6 Å²	138.6	82%	0.822	72%	0.717	S	S	*	*	S	Bend	trans	-93.3	-14.2	179.5	-116.1	179.4	87.8	0	0	113.3	L32	E30-L32 PolarHBondContact O-N 3.16Å
31	I	53.3	Low	48.7	Very low	148 Å²	148	133.9 Å²	133.9	76%	0.759	72%	0.715	S	S	*	*	T	Hydrogen-bonded Turn	trans	-83.3	3.9	173.2	-46.1	-65	0	0	0	111.3
32	L	47.8	Very low	48	Very low	159 Å²	159	134.4 Å²	134.4	83%	0.832	73%	0.725	S	S	*	*	T	Hydrogen-bonded Turn	trans	-120.5	25.2	178.7	-136	103.9	0	0	0	113	E30	E30-L32 PolarHBondContact O-N 3.16Å
33	D	39.7	Very low	47.7	Very low	217 Å²	217	143.4 Å²	143.4	100%	1.16	76%	0.763	S	S	*	*			trans	-116.2	0	156.6	-163.8	-111.8	0	0	0	109.1

Retrieved 33 of 33 residues in 48.6 ms (Link to these results)

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