A0A075BRI2_HUMAN Loading...

Methyl CpG binding protein 2

AlphaFold DB , UniProt , Accession A0A075BRI2, Species HUMAN (Homo sapiens, Human), Gene MECP2, Length 54 aa.

>A0A075BRI2_HUMAN|A0A075BRI2|MECP2
PAKTQPAVATAATAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1P44.5Very low54.9Low177 Ų177110.5 Ų110.5100%1.14969%0.687SS**  0106029.2-13.3000111.7K3P1-K3 PolarHBondContact O-N 3.23Å
2A44.8Very low55.4Low95 Ų95105.6 Ų105.679%0.78567%0.666SS**  trans-64.8125178.300000110.5T4A2-T4 PolarHBondContact O-N 2.95Å; A2-T4 VanDerWaalsContact O-N 3.1Å
3K56.4Low55.8Low209 Ų209102.8 Ų102.891%0.90965%0.647SS**  trans-77.288.8171.9-74.7178.6175.1176.50108.5P1 Q5P1-K3 PolarHBondContact O-N 3.23Å; K3-Q5 PolarHBondContact O-N 3.31Å
4T53.7Low56.3Low117 Ų11799.4 Ų99.472%0.71863%0.634SS**  trans-73.694.7173.6-57.50000110A2A2-T4 PolarHBondContact O-N 2.95Å; A2-T4 VanDerWaalsContact O-N 3.1Å
5Q53.5Low56.6Low134 Ų13496.3 Ų96.363%0.62662%0.621SS**  trans42.1125.7142.5-67.1-177.5-2800121.3K3 A7K3-Q5 PolarHBondContact O-N 3.31Å; Q5-A7 PolarHBondContact O-N 3.07Å; Q5-A7 HydrophobicContact CB-CB 4.1Å
6P58.8Low57Low110 Ų11097.6 Ų97.671%0.71462%0.616SS**THydrogen-bonded Turntrans-71.7-2.8163.231.3-33.5000113.8V8 A9 T10P6-V8 VanDerWaalsContact C-N 3.29Å; P6-V8 PolarHBondContact O-N 3.23Å; P6-A9 PolarHBondContact O-N 3.18Å; P6-T10 PolarHBondContact O-N 3.04Å; P6-T10 PolarHBondContact O-OG1 2.8Å
7A55.7Low57.4Low50 Ų50101.6 Ų101.641%0.41362%0.622SS.*Hα-helixtrans-63.2-29.6-173.100000113.9Q5 T10 A11Q5-A7 PolarHBondContact O-N 3.07Å; Q5-A7 HydrophobicContact CB-CB 4.1Å; A7-T10 PolarHBondContact O-N 3.13Å; A7-A11 WeakPolarHBondContact O-CB 3.49Å; A7-A11 PolarHBondContact O-N 2.78Å
8V58.7Low57.6Low106 Ų106106.1 Ų106.164%0.64263%0.627SS**Hα-helixtrans-68.8-37.1179.5-170.50000111.2P6 A11 A12P6-V8 VanDerWaalsContact C-N 3.29Å; P6-V8 PolarHBondContact O-N 3.23Å; V8-A11 PolarHBondContact O-N 2.87Å; V8-A12 WeakPolarHBondContact O-CB 3.13Å; V8-A12 PolarHBondContact O-N 3.26Å
9A58.9Low58Low66 Ų66108.4 Ų108.455%0.54563%0.629SS.*Hα-helixtrans-70.7-35.2176.600000112P6 T13P6-A9 PolarHBondContact O-N 3.18Å; A9-T13 WeakPolarHBondContact O-CG2 3.25Å; A9-T13 PolarHBondContact O-N 2.64Å; A9-T13 VanDerWaalsContact O-N 3.13Å; A9-T13 PolarHBondContact O-OG1 2.75Å
10T58.4Low58.1Low91 Ų91110 Ų11056%0.55863%0.629SS**Hα-helixtrans-70.6-37.2174.8-500000112P6 A7 T13 A14P6-T10 PolarHBondContact O-N 3.04Å; P6-T10 PolarHBondContact O-OG1 2.8Å; A7-T10 PolarHBondContact O-N 3.13Å; T10-T13 WeakPolarHBondContact CA-OG1 3.18Å; T10-T13 PolarHBondContact O-OG1 2.82Å; T10-T13 VanDerWaalsContact O-OG1 3.08Å; T10-A14 WeakPolarHBondContact O-CB 3.34Å; T10-A14 PolarHBondContact O-N 3.28Å
11A60.6Low58.3Low60 Ų60114.8 Ų114.850%0.49664%0.637SS.*Hα-helixtrans-69-40176.200000112.4A7 V8 A14 A15A7-A11 WeakPolarHBondContact O-CB 3.49Å; A7-A11 PolarHBondContact O-N 2.78Å; V8-A11 PolarHBondContact O-N 2.87Å; A11-A14 PolarHBondContact O-N 3.46Å; A11-A15 WeakPolarHBondContact O-CB 3.4Å; A11-A15 PolarHBondContact O-N 2.79Å; A11-A15 VanDerWaalsContact O-CB 3.31Å
12A60.7Low59.2Low52 Ų52108.4 Ų108.443%0.4360%0.604SS.*Hα-helixtrans-64.2-46.4176.300000111.9V8 A15 E16V8-A12 WeakPolarHBondContact O-CB 3.13Å; V8-A12 PolarHBondContact O-N 3.26Å; A12-A15 PolarHBondContact O-N 3.31Å; A12-E16 PolarHBondContact O-N 2.72Å
13T60.8Low60.3Low70 Ų70112.9 Ų112.943%0.42961%0.608SS.*Hα-helixtrans-67.8-35.5176.748.50000112.9A9 T10 K17A9-T13 WeakPolarHBondContact O-CG2 3.25Å; A9-T13 PolarHBondContact O-N 2.64Å; A9-T13 VanDerWaalsContact O-N 3.13Å; A9-T13 PolarHBondContact O-OG1 2.75Å; T10-T13 WeakPolarHBondContact CA-OG1 3.18Å; T10-T13 PolarHBondContact O-OG1 2.82Å; T10-T13 VanDerWaalsContact O-OG1 3.08Å; T13-K17 VanDerWaalsContact O-CG 3.29Å; T13-K17 WeakPolarHBondContact O-CG 3.19Å; T13-K17 PolarHBondContact O-N 2.81Å
14A62.1Low60.7Low55 Ų55106.2 Ų106.246%0.45560%0.599SS.*Hα-helixtrans-67.3-38.2173.700000112.2T10 A11 K17 Y18T10-A14 WeakPolarHBondContact O-CB 3.34Å; T10-A14 PolarHBondContact O-N 3.28Å; A11-A14 PolarHBondContact O-N 3.46Å; A14-K17 PolarHBondContact O-N 2.9Å; A14-Y18 PolarHBondContact O-N 2.89Å; A14-Y18 VanDerWaalsContact O-N 3.16Å
15A62.1Low61.3Low53 Ų53108.9 Ų108.944%0.43860%0.604SS.*Hα-helixtrans-65.3-43.5175.100000111.6A11 A12 Y18 K19A11-A15 WeakPolarHBondContact O-CB 3.4Å; A11-A15 PolarHBondContact O-N 2.79Å; A11-A15 VanDerWaalsContact O-CB 3.31Å; A12-A15 PolarHBondContact O-N 3.31Å; A15-Y18 PolarHBondContact O-N 2.81Å; A15-K19 WeakPolarHBondContact O-CG 3.42Å; A15-K19 PolarHBondContact O-N 2.76Å
16E63Low61.9Low116 Ų116109.9 Ų109.954%0.54260%0.602SS.*Hα-helixtrans-59.1-47173-90.8176.5108.400112.1A12 Y18 K19 H20A12-E16 PolarHBondContact O-N 2.72Å; E16-Y18 PolarHBondContact O-N 3.41Å; E16-K19 PolarHBondContact O-N 3.08Å; E16-K19 VanDerWaalsContact O-N 3.11Å; E16-H20 PolarHBondContact O-CD2 2.86Å; E16-H20 PolarHBondContact O-N 3.36Å
17K63.1Low62.3Low167 Ų167114 Ų11473%0.72661%0.608SS**Hα-helixtrans-60-30.3178.1-72.8-176.5-172.2-160.10113.4T13 A14T13-K17 VanDerWaalsContact O-CG 3.29Å; T13-K17 WeakPolarHBondContact O-CG 3.19Å; T13-K17 PolarHBondContact O-N 2.81Å; A14-K17 PolarHBondContact O-N 2.9Å
18Y61.3Low63Low182 Ų182117.4 Ų117.471%0.71462%0.62SS**Hα-helixtrans-77.2-33.8177.4-170.8-101.7000112.6A14 A15 E16A14-Y18 PolarHBondContact O-N 2.89Å; A14-Y18 VanDerWaalsContact O-N 3.16Å; A15-Y18 PolarHBondContact O-N 2.81Å; E16-Y18 PolarHBondContact O-N 3.41Å
19K65.8Low63.4Low150 Ų150117.8 Ų117.865%0.65262%0.617SS**Hα-helixtrans-68.7-37.2179.3-65.4-70.6176.9178.30112.6A15 E16 R21A15-K19 WeakPolarHBondContact O-CG 3.42Å; A15-K19 PolarHBondContact O-N 2.76Å; E16-K19 PolarHBondContact O-N 3.08Å; E16-K19 VanDerWaalsContact O-N 3.11Å; K19-R21 VanDerWaalsContact C-N 3.3Å; K19-R21 PolarHBondContact O-N 2.81Å
20H59.8Low63.7Low139 Ų139120.4 Ų120.464%0.64463%0.626SS**THydrogen-bonded Turntrans-82.1-4.4-176.5-61.9-58.7000114.6E16 G22E16-H20 PolarHBondContact O-CD2 2.86Å; E16-H20 PolarHBondContact O-N 3.36Å; H20-G22 PolarHBondContact O-N 3.46Å
21R62.8Low64.1Low212 Ų212121.3 Ų121.380%0.864%0.636SS**THydrogen-bonded Turntrans-74.3-13.7-179.7-154.3-179.1-150.9176.17.8113.8K19K19-R21 VanDerWaalsContact C-N 3.3Å; K19-R21 PolarHBondContact O-N 2.81Å
22G62.3Low64.5Low43 Ų43122.8 Ų122.844%0.44364%0.642SS.*THydrogen-bonded Turntrans-122.5-19.9-170.500000116.2H20H20-G22 PolarHBondContact O-N 3.46Å
23E68.3Low65Low188 Ų188125.9 Ų125.988%0.87966%0.661SS**SBendtrans-98.6-14.6-163.1-62.9-125.2124.700114.9
24G65.3Low65.8Low70 Ų70129.9 Ų129.972%0.72268%0.676SS**SBendtrans-122-16.7-166.700000118.6
25E64.8Low66.5Low173 Ų173132.8 Ų132.881%0.80869%0.691SS**  trans-132.1-2.1-163.4-151.6-172.8173.200115.2K27E25-K27 PolarHBondContact O-N 2.94Å
26R66.9Low67Low155 Ų155139.1 Ų139.159%0.58570%0.703SS**  trans-80.476.5174.7-60.9-173.4-174.8-163.80.7109.4D28 I29R26-D28 WeakPolarHBondContact CA-OD1 3.33Å; R26-I29 HydrophobicContact CB-CG1 3.78Å; R26-I29 WeakPolarHBondContact O-CG1 3.29Å; R26-I29 HydrophobicContact CB-CD1 3.9Å
27K67.1Low67.6Low196 Ų196139.6 Ų139.685%0.85272%0.717SS**  trans-81.1-5.8167.8-62.6-165.7179.9-175.30112E25E25-K27 PolarHBondContact O-N 2.94Å
28D69.7Low67.8Low122 Ų122138.1 Ų138.165%0.65272%0.716SS**  trans-95.7-8.8-175.737.8-66.6000113.1R26 V30R26-D28 WeakPolarHBondContact CA-OD1 3.33Å; D28-V30 PolarHBondContact O-N 3.29Å
29I66.9Low68.3Low114 Ų114137.4 Ų137.459%0.58571%0.713SS**  trans-77.873.6164.545.8175000109.2R26 S31R26-I29 HydrophobicContact CB-CG1 3.78Å; R26-I29 WeakPolarHBondContact O-CG1 3.29Å; R26-I29 HydrophobicContact CB-CD1 3.9Å; I29-S31 PolarHBondContact O-N 3.16Å
30V65.5Low68.7Low121 Ų121138 Ų13873%0.73372%0.718SS**  trans-62.788.7159.2-175.90000106.2D28 S32D28-V30 PolarHBondContact O-N 3.29Å; V30-S32 PolarHBondContact O-N 2.92Å
31S67.4Low69.4Low110 Ų110137 Ų13777%0.76971%0.713SS**  trans-59.992.8159.4-850000105.3I29 S33I29-S31 PolarHBondContact O-N 3.16Å; S31-S33 VanDerWaalsContact C-N 3.26Å; S31-S33 PolarHBondContact O-N 3.46Å
32S68.4Low70.3Confident90 Ų90132.5 Ų132.563%0.62971%0.712SS**  trans-63.493.6179.263.80000107.2V30 M34V30-S32 PolarHBondContact O-N 2.92Å; S32-M34 PolarHBondContact O-N 3.44Å
33S72.1Confident71Confident117 Ų117136.7 Ų136.782%0.81873%0.728SS**  trans-73.7-7.1174.557.50000111.8S31S31-S33 VanDerWaalsContact C-N 3.26Å; S31-S33 PolarHBondContact O-N 3.46Å
34M77.7Confident71.4Confident154 Ų154132.2 Ų132.276%0.75971%0.71SS**SBendtrans-74.4124.2173.2-64.9-146-79.700109.3S32 R36S32-M34 PolarHBondContact O-N 3.44Å; M34-R36 PolarHBondContact O-N 3.18Å
35P75.7Confident72.2Confident116 Ų116134.3 Ų134.375%0.75371%0.714SS**PPolyproline II helixtrans-55134.6171.622.7-30.5000108P37P35-P37 WeakPolarHBondContact O-CD 3.42Å
36R74.1Confident73.1Confident186 Ų186135.2 Ų135.270%0.70271%0.71SS**PPolyproline II helixtrans-54117.9177-67.3-172.7-178.4-164.51.3106.8M34 N38M34-R36 PolarHBondContact O-N 3.18Å; R36-N38 PolarHBondContact O-N 3.26Å
37P74.2Confident73.7Confident127 Ų127133.6 Ų133.683%0.82572%0.717SS**THydrogen-bonded Turntrans-59.8113.5-178.922.5-30.3000106.6P35 R39P35-P37 WeakPolarHBondContact O-CD 3.42Å; P37-R39 PolarHBondContact O-N 3.04Å
38N67.6Low74.3Confident135 Ų135129.8 Ų129.872%0.72271%0.713SS**THydrogen-bonded Turntrans30.484.2179.5-142.6-15.4000113.3R36 E40R36-N38 PolarHBondContact O-N 3.26Å; N38-E40 PolarHBondContact O-N 3.19Å
39R71.1Confident74.8Confident168 Ų168130.5 Ų130.563%0.63472%0.721SS**  trans-6586.8159.3179.5179.3172138.14.9105.7P37 E41P37-R39 PolarHBondContact O-N 3.04Å; R39-E41 PolarHBondContact NE-OE1 3.11Å; R39-E41 PolarHBondContact O-N 3.04Å; R39-E41 IonicContact NH2-OE1 3.74Å; R39-E41 IonicContact NE-OE1 2.82Å; R39-E41 IonicContact CZ-OE1 3.69Å
40E74.3Confident75.2Confident163 Ų163130.3 Ų130.376%0.76273%0.726SS**  trans-58.793.8166.732.8-17073.100105.6N38N38-E40 PolarHBondContact O-N 3.19Å
41E75.8Confident75.9Confident117 Ų117132.7 Ų132.755%0.54773%0.729SS.*  trans-50.2136.8162.6-71.4-68.710700105.8R39 V43R39-E41 PolarHBondContact NE-OE1 3.11Å; R39-E41 PolarHBondContact O-N 3.04Å; R39-E41 IonicContact NH2-OE1 3.74Å; R39-E41 IonicContact NE-OE1 2.82Å; R39-E41 IonicContact CZ-OE1 3.69Å; E41-V43 PolarHBondContact O-N 3.29Å
42P80.4Confident76.3Confident118 Ų118138 Ų13877%0.76673%0.732SS**  trans-52.2106.5-179.7-21.730.6000107.6D44P42-D44 VanDerWaalsContact C-N 3.31Å; P42-D44 PolarHBondContact O-N 3.35Å
43V76.8Confident76.5Confident130 Ų130139.7 Ų139.779%0.78874%0.738SS**  trans-65.2106.5175.9171.30000103.5E41 S45E41-V43 PolarHBondContact O-N 3.29Å; V43-S45 VanDerWaalsContact C-N 3.28Å; V43-S45 PolarHBondContact O-N 3.02Å
44D77.6Confident76.5Confident94 Ų94142.9 Ų142.950%0.50376%0.761SS.*  trans-63.796.3-180-170.2-5.8000107.6P42 R46P42-D44 VanDerWaalsContact C-N 3.31Å; P42-D44 PolarHBondContact O-N 3.35Å; D44-R46 VanDerWaalsContact CG-NE 3.35Å; D44-R46 PolarHBondContact OD2-NH2 2.95Å; D44-R46 IonicContact OD2-NH2 2.64Å; D44-R46 VanDerWaalsContact OD2-NE 3.13Å; D44-R46 PolarHBondContact OD2-NE 3.39Å; D44-R46 IonicContact OD2-NE 3.13Å; D44-R46 VanDerWaalsContact OD2-CZ 3.25Å; D44-R46 IonicContact OD2-CZ 3.25Å; D44-R46 IonicContact OD1-NH2 3.81Å; D44-R46 PolarHBondContact OD1-NE 3.27Å; D44-R46 IonicContact OD1-NE 2.78Å; D44-R46 PolarHBondContact OD1-N 3.39Å; D44-R46 IonicContact OD1-CZ 3.7Å; D44-R46 WeakPolarHBondContact OD1-CG 3.45Å; D44-R46 WeakPolarHBondContact OD1-CD 3.31Å; D44-R46 WeakPolarHBondContact OD1-CB 3.44Å; D44-R46 VanDerWaalsContact OD1-CB 3.25Å; D44-R46 PolarHBondContact O-N 3.23Å
45S82.3Confident76.4Confident115 Ų115142.3 Ų142.380%0.80476%0.761SS**  trans-79.25.3-176.459.40000112.3V43 T47V43-S45 VanDerWaalsContact C-N 3.28Å; V43-S45 PolarHBondContact O-N 3.02Å; S45-T47 PolarHBondContact O-N 3.37Å
46R84.5Confident76.4Confident191 Ų191143.7 Ų143.772%0.72176%0.761SS**PPolyproline II helixtrans-64123.4176-67.4-177.9-68.4159.9-4.4108.6D44D44-R46 VanDerWaalsContact CG-NE 3.35Å; D44-R46 PolarHBondContact OD2-NH2 2.95Å; D44-R46 IonicContact OD2-NH2 2.64Å; D44-R46 VanDerWaalsContact OD2-NE 3.13Å; D44-R46 PolarHBondContact OD2-NE 3.39Å; D44-R46 IonicContact OD2-NE 3.13Å; D44-R46 VanDerWaalsContact OD2-CZ 3.25Å; D44-R46 IonicContact OD2-CZ 3.25Å; D44-R46 IonicContact OD1-NH2 3.81Å; D44-R46 PolarHBondContact OD1-NE 3.27Å; D44-R46 IonicContact OD1-NE 2.78Å; D44-R46 PolarHBondContact OD1-N 3.39Å; D44-R46 IonicContact OD1-CZ 3.7Å; D44-R46 WeakPolarHBondContact OD1-CG 3.45Å; D44-R46 WeakPolarHBondContact OD1-CD 3.31Å; D44-R46 WeakPolarHBondContact OD1-CB 3.44Å; D44-R46 VanDerWaalsContact OD1-CB 3.25Å; D44-R46 PolarHBondContact O-N 3.23Å
47T78Confident76.6Confident121 Ų121141.3 Ų141.374%0.74276%0.764SS**PPolyproline II helixtrans-55.4128.2164.540.90000108.1S45 V49S45-T47 PolarHBondContact O-N 3.37Å; T47-V49 PolarHBondContact O-N 3.24Å
48P79.8Confident76.7Confident116 Ų116142.2 Ų142.275%0.75376%0.761SS**PPolyproline II helixtrans-59.9119.1-179.723.3-32000108.2T50P48-T50 PolarHBondContact O-N 3.13Å
49V81.3Confident77.3Confident137 Ų137142.6 Ų142.683%0.8376%0.763SS**  trans-70.9106.5174.3-179.60000106.1T47 E51T47-V49 PolarHBondContact O-N 3.24Å; V49-E51 PolarHBondContact O-N 3.03Å
50T75.4Confident77.7Confident111 Ų111140.9 Ų140.968%0.68177%0.772SS**  trans-72.6108.3167.249.80000107.2P48 R52P48-T50 PolarHBondContact O-N 3.13Å; T50-R52 PolarHBondContact O-N 2.98Å
51E80.6Confident77.9Confident171 Ų171139.4 Ų139.480%0.79977%0.772SS**  trans-61.6104.3171-153.3-173.5122.900107.4V49 V53V49-E51 PolarHBondContact O-N 3.03Å; E51-V53 PolarHBondContact O-N 3.43Å
52R74.9Confident78.1Confident220 Ų220141.1 Ų141.183%0.8379%0.79SS**  trans-87.293.3172.6-73-172.3-76177-3.1107.2T50 S54T50-R52 PolarHBondContact O-N 2.98Å; R52-S54 PolarHBondContact O-N 3.1Å
53V72.9Confident77.9Confident126 Ų126143 Ų14376%0.76479%0.792SS**  trans-59.7117.6167.2-172.40000107.1E51E51-V53 PolarHBondContact O-N 3.43Å
54S71.1Confident78Confident184 Ų184144.2 Ų144.2100%1.28779%0.792SS**  trans-90.90174.1-650000111.2R52R52-S54 PolarHBondContact O-N 3.1Å

Retrieved 54 of 54 residues in 26.7 ms (Link to these results)