A0A075BRJ5_HUMAN Loading...

Methyl CpG binding protein 2

AlphaFold DB , UniProt , Accession A0A075BRJ5, Species HUMAN (Homo sapiens, Human), Gene MECP2, Length 67 aa.

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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1R52.4Low57.6Low307 Ų307136.3 Ų136.3100%1.15883%0.832SS**  0124.90-90.8-175.1176.1-125.81.1107.3
2G51.8Low58.4Low90 Ų90141.2 Ų141.293%0.92883%0.833SS**  trans79.5131.4173.200000113.2
3G47.3Very low59.2Low74 Ų74141.5 Ų141.576%0.76382%0.822SS**  cis-146138.36.600000110.5
4S58.9Low59.7Low122 Ų122140.1 Ų140.185%0.85382%0.819SS**  trans-68128.91551730000107.3
5L61Low60.3Low162 Ų162136.6 Ų136.685%0.84881%0.813SS**  trans14789.7173.5-83.2156.2000102.7
6E60.8Low60.5Low197 Ų197139.9 Ų139.992%0.92181%0.813SS**SBend-168.7111.595.6-77.5162.2113.700104.4
7S59.6Low60.6Low115 Ų115139.4 Ų139.480%0.80481%0.813SS**  -160.4130.775.9-175.30000106.3G9S7-G9 PolarHBondContact O-N 3.05Å
8D60.8Low60.5Low160 Ų160141 Ų14186%0.85681%0.812SS**  trans-67.658.4168.5-144.1-62.4000108.5C10D8-C10 PolarHBondContact O-N 3.33Å
9G60.1Low60Low60 Ų60138.9 Ų138.962%0.61980%0.804SS**  trans-75.347.4-178.600000110.1S7 P11S7-G9 PolarHBondContact O-N 3.05Å; G9-P11 VanDerWaalsContact O-N 3.16Å; G9-P11 WeakPolarHBondContact O-CD 3.12Å
10C59.3Low59.8Low94 Ų94136.8 Ų136.864%0.63580%0.803SS**  trans-48.5119.8159.6-163.10000105.9D8 K12D8-C10 PolarHBondContact O-N 3.33Å; C10-K12 VanDerWaalsContact C-N 3.32Å; C10-K12 PolarHBondContact O-N 3.26Å
11P62.2Low59.6Low118 Ų118136.4 Ų136.477%0.76680%0.802SS**  trans-59.9104.4174.422.3-29.6000107G9 E13G9-P11 VanDerWaalsContact O-N 3.16Å; G9-P11 WeakPolarHBondContact O-CD 3.12Å; P11-E13 PolarHBondContact O-N 3Å
12K67.3Low59.8Low195 Ų195125.7 Ų125.785%0.84878%0.779SS**  trans-70.1114.5177-174.9162.7178.9163.70106.7C10C10-K12 VanDerWaalsContact C-N 3.32Å; C10-K12 PolarHBondContact O-N 3.26Å
13E68.6Low59.9Low146 Ų146127.6 Ų127.668%0.68277%0.773SS**SBendtrans81.5133.6178.2-47.3-151.7114.500115.5P11 A15P11-E13 PolarHBondContact O-N 3Å; E13-A15 PolarHBondContact O-N 3.02Å
14P66.4Low60Low121 Ų121127.9 Ų127.979%0.78677%0.768SS**  trans-59.7128.4164.127.2-31.5000107.5K16P14-K16 PolarHBondContact O-N 2.99Å
15A67.5Low59.6Low88 Ų88126.1 Ų126.173%0.72776%0.761SS**  trans-47.6120.4174.700000108.7E13 T17E13-A15 PolarHBondContact O-N 3.02Å; A15-T17 VanDerWaalsContact C-N 3.28Å; A15-T17 PolarHBondContact O-N 3.01Å
16K63.6Low59.2Low189 Ų189124.3 Ų124.382%0.82276%0.756SS**  trans-61.2101167.5-74.5179177.1169.20106P14 Q18P14-K16 PolarHBondContact O-N 2.99Å; K16-Q18 PolarHBondContact O-N 2.99Å
17T61.9Low58.8Low131 Ų131118.2 Ų118.280%0.80474%0.74SS**  trans-61.790.2172.8-48.60000107.5A15A15-T17 VanDerWaalsContact C-N 3.28Å; A15-T17 PolarHBondContact O-N 3.01Å
18Q59.7Low58.4Low169 Ų169116 Ų11679%0.7973%0.729SS**  trans-68.1129.6152.3-81.1-161.6-24.300105.8K16 A20K16-Q18 PolarHBondContact O-N 2.99Å; Q18-A20 PolarHBondContact O-N 2.76Å
19P51Low58.1Low102 Ų102117.1 Ų117.166%0.66273%0.729SS**  trans-65.2111.8168.931.5-32.2000105V21P19-V21 HydrophobicContact CB-CG2 3.59Å; P19-V21 HydrophobicContact CG-CG2 4.04Å; P19-V21 PolarHBondContact O-N 3.15Å
20A56.6Low58.1Low96 Ų96122.5 Ų122.579%0.79374%0.735SS**  trans-69.364.917200000108.8Q18 A22Q18-A20 PolarHBondContact O-N 2.76Å; A20-A22 PolarHBondContact O-N 2.68Å; A20-A22 VanDerWaalsContact O-N 3.12Å
21V55.6Low58Low129 Ų129127.4 Ų127.478%0.78274%0.742SS**  trans-86.651.8174.4-1490000108.7P19P19-V21 HydrophobicContact CB-CG2 3.59Å; P19-V21 HydrophobicContact CG-CG2 4.04Å; P19-V21 PolarHBondContact O-N 3.15Å
22A55.4Low58.1Low81 Ų81130.2 Ų130.267%0.66974%0.742SS**SBendtrans-160.866.9176.500000110.3A20A20-A22 PolarHBondContact O-N 2.68Å; A20-A22 VanDerWaalsContact O-N 3.12Å
23T53.6Low57.6Low131 Ų131128.8 Ų128.880%0.80474%0.738SS**SBendtrans-176.1-11.2150.619.10000114.4
24A50Low57.6Low79 Ų79133.6 Ų133.665%0.65375%0.75SS**SBendtrans-95.1-0.4178.500000115T26A24-T26 VanDerWaalsContact C-N 3.3Å; A24-T26 PolarHBondContact O-N 2.86Å
25A50.5Low57.6Low85 Ų85130.8 Ų130.870%0.70274%0.743SS**THydrogen-bonded Turntrans-72.5-17.9-175.200000114.2
26T52.1Low57.4Low124 Ų124135.4 Ų135.476%0.76175%0.75SS**THydrogen-bonded Turntrans-91.3-10.8-177.854.50000114.1A24A24-T26 VanDerWaalsContact C-N 3.3Å; A24-T26 PolarHBondContact O-N 2.86Å
27A52.7Low57.5Low69 Ų69130 Ų13057%0.5775%0.747SS**THydrogen-bonded Turntrans-100.4-24.2-178.200000113.9
28A51.9Low57.5Low70 Ų70131.2 Ų131.258%0.57974%0.744SS**SBendtrans-91.3-8.4-170.900000115.2K30 Y31A28-K30 PolarHBondContact O-N 2.96Å; A28-K30 VanDerWaalsContact O-N 3.11Å; A28-Y31 PolarHBondContact O-N 2.7Å
29E54.8Low57.8Low183 Ų183132 Ų13286%0.85574%0.74SS**THydrogen-bonded Turntrans-66-18-175-158.2-175.7128.400113.9
30K60Low58.7Low173 Ų173135.9 Ų135.975%0.75275%0.746SS**THydrogen-bonded Turntrans-98.8-3.3-176.543.5-178.2173.8-81.20115.2A28A28-K30 PolarHBondContact O-N 2.96Å; A28-K30 VanDerWaalsContact O-N 3.11Å
31Y56.8Low59.1Low197 Ų197137.8 Ų137.877%0.77374%0.743SS**SBendtrans-10990.1178-159.1-100.1000111.4A28 H33A28-Y31 PolarHBondContact O-N 2.7Å; Y31-H33 PolarHBondContact O-N 2.89Å
32K64.1Low59.6Low176 Ų176139 Ų13977%0.76574%0.744SS**  trans1.3102.8154.5-58.7-71.2-176.1179.60115
33H57Low60.1Low165 Ų165140.9 Ų140.976%0.76475%0.747SS**  trans-120.463.2152.4-117.5-84.2000109.2Y31 G35Y31-H33 PolarHBondContact O-N 2.89Å; H33-G35 PolarHBondContact O-N 2.64Å; H33-G35 VanDerWaalsContact O-N 3.08Å
34R68.4Low60.7Low247 Ų247139.7 Ų139.793%0.93274%0.743SS**  trans-82.177.7169.1-153.9-161.1-147.5-159.58.8107.8
35G65.4Low61.5Low63 Ų63141.1 Ų141.165%0.64975%0.748SS**SBendtrans88.1107.5169.500000114.6H33H33-G35 PolarHBondContact O-N 2.64Å; H33-G35 VanDerWaalsContact O-N 3.08Å
36E64.3Low62.4Low184 Ų184142.4 Ų142.486%0.8675%0.752SS**  -176.3125.6118.3-98-156.9124.300108.9
37G65.1Low63.5Low75 Ų75144.2 Ų144.277%0.77375%0.754SS**  trans80.9145.4153.600000118
38E63.4Low64.5Low157 Ų157146.5 Ų146.573%0.73476%0.763SS**  trans88.5111.6147.1-143.9179.4157.700117.5
39R65.6Low65.5Low187 Ų187154.3 Ų154.371%0.70678%0.778SS**  cis-148.895.1-9.1-89.7156.4-144.9-92.7-1.7104.8
40K68.9Low66.4Low182 Ų182151.2 Ų151.279%0.79177%0.774SS**SBendtrans-72.2155.4146.718-162.9171.5-170.70104.2
41D66.5Low67.1Low137 Ų137149.7 Ų149.773%0.73377%0.774SS**  trans70.151-173.117.1-63.6000114.4V43D41-V43 HydrophobicContact CB-CG2 3.77Å; D41-V43 PolarHBondContact O-N 3.26Å
42I65.3Low68Low155 Ų155150.8 Ų150.880%0.79578%0.776SS**  trans-65.980.2131.431.6167.7000105.9S44I42-S44 PolarHBondContact O-N 2.98Å
43V64.9Low68.6Low120 Ų120150 Ų15073%0.72778%0.776SS**  trans-53.798.7167.6178.80000104.7D41 S45D41-V43 HydrophobicContact CB-CG2 3.77Å; D41-V43 PolarHBondContact O-N 3.26Å; V43-S45 PolarHBondContact O-N 3.06Å
44S67.2Low69.4Low105 Ų105149.4 Ų149.473%0.73477%0.773SS**  trans-47.6116.8166.8-82.40000105I42 S46I42-S44 PolarHBondContact O-N 2.98Å; S44-S46 PolarHBondContact O-N 2.88Å
45S66.4Low69.8Low109 Ų109143.1 Ų143.176%0.76276%0.764SS**  trans-60.885.6-177.355.80000108.6V43 M47V43-S45 PolarHBondContact O-N 3.06Å; S45-M47 PolarHBondContact O-N 2.77Å
46S68.9Low70.3Confident112 Ų112145.7 Ų145.778%0.78377%0.767SS**  trans-84.442.1178.6-167.60000109.1S44 P48S44-S46 PolarHBondContact O-N 2.88Å; S46-P48 WeakPolarHBondContact O-CD 3.09Å
47M75Confident70.7Confident163 Ų163141.9 Ų141.980%0.80375%0.752SS**PPolyproline II helixtrans-81.6117.6165.2-66-122.1-68.700105.5S45 R49S45-M47 PolarHBondContact O-N 2.77Å; M47-R49 PolarHBondContact O-N 2.95Å
48P74Confident71.2Confident117 Ų117143.5 Ų143.576%0.7675%0.752SS**PPolyproline II helixtrans-51.1133.7171.5-20.130.5000107.6S46 P50S46-P48 WeakPolarHBondContact O-CD 3.09Å; P48-P50 VanDerWaalsContact O-N 3.11Å
49R74.5Confident72Confident234 Ų234145.3 Ų145.388%0.88375%0.752SS**PPolyproline II helixtrans-51.8127.1170.9-68.5-175.4-179.8-177.6-0.1106M47 N51M47-R49 PolarHBondContact O-N 2.95Å; R49-N51 PolarHBondContact O-N 3.08Å
50P73Confident72.3Confident118 Ų118141.9 Ų141.977%0.76675%0.752SS**PPolyproline II helixtrans-50.9123.7173.121.3-30.2000105.3P48 R52P48-P50 VanDerWaalsContact O-N 3.11Å; P50-R52 PolarHBondContact O-N 3.36Å
51N74.3Confident72.5Confident141 Ų141138.8 Ų138.875%0.75475%0.751SS**  trans-44.1118.7-176.5-174.3-33.5000106R49 E53R49-N51 PolarHBondContact O-N 3.08Å; N51-E53 PolarHBondContact O-N 3.27Å
52R76Confident73Confident220 Ų220138.6 Ų138.683%0.8375%0.754SS**  trans-59.998.4173.6171.4-176.9173.5156-1.3103.1P50 E54P50-R52 PolarHBondContact O-N 3.36Å; R52-E54 PolarHBondContact O-N 3.11Å
53E76Confident73.3Confident160 Ų160136.2 Ų136.275%0.74875%0.747SS**  trans-48.8112.8179.441.7-171.683.600106N51N51-E53 PolarHBondContact O-N 3.27Å
54E75.2Confident73.8Confident151 Ų151138.4 Ų138.471%0.70675%0.749SS**  trans-46.6136.6162.9-79.8-71.8114.800105.5R52 V56R52-E54 PolarHBondContact O-N 3.11Å; E54-V56 PolarHBondContact O-N 3.35Å; E54-V56 VanDerWaalsContact C-N 3.33Å
55P76.6Confident74.1Confident116 Ų116144 Ų14475%0.75375%0.754SS**  trans-51105-178.3-1420.6000107.6D57P55-D57 VanDerWaalsContact C-N 3.32Å; P55-D57 PolarHBondContact O-N 3.24Å
56V75Confident74.2Confident117 Ų117144.8 Ų144.871%0.70976%0.755SS**  trans-65106177.6170.20000103E54 S58E54-V56 PolarHBondContact O-N 3.35Å; E54-V56 VanDerWaalsContact C-N 3.33Å; V56-S58 PolarHBondContact O-N 3.04Å
57D73.7Confident74.2Confident103 Ų103148.1 Ų148.155%0.55178%0.778SS**  trans-65.994.9179.7-162.5-12.3000106.3P55 R59P55-D57 VanDerWaalsContact C-N 3.32Å; P55-D57 PolarHBondContact O-N 3.24Å; D57-R59 WeakPolarHBondContact OD1-CG 3.41Å; D57-R59 IonicContact OD2-NH1 3.63Å; D57-R59 IonicContact OD2-NE 3.15Å; D57-R59 IonicContact OD2-CZ 3.85Å; D57-R59 VanDerWaalsContact OD1-NE 3.15Å; D57-R59 PolarHBondContact OD1-NE 3.18Å; D57-R59 IonicContact OD1-NE 3.64Å; D57-R59 IonicContact OD1-CZ 3.65Å; D57-R59 WeakPolarHBondContact OD1-CD 3.37Å; D57-R59 PolarHBondContact O-N 2.83Å
58S75.8Confident74.2Confident110 Ų110147.4 Ų147.477%0.76978%0.776SS**  trans-75.216-17256.30000112.4V56 T60V56-S58 PolarHBondContact O-N 3.04Å; S58-T60 PolarHBondContact O-N 2.95Å
59R78.9Confident74.2Confident194 Ų194148.9 Ų148.973%0.73278%0.777SS**  trans-64.9106.9175-72.5169.6-166177.71.2108.5D57D57-R59 WeakPolarHBondContact OD1-CG 3.41Å; D57-R59 IonicContact OD2-NH1 3.63Å; D57-R59 IonicContact OD2-NE 3.15Å; D57-R59 IonicContact OD2-CZ 3.85Å; D57-R59 VanDerWaalsContact OD1-NE 3.15Å; D57-R59 PolarHBondContact OD1-NE 3.18Å; D57-R59 IonicContact OD1-NE 3.64Å; D57-R59 IonicContact OD1-CZ 3.65Å; D57-R59 WeakPolarHBondContact OD1-CD 3.37Å; D57-R59 PolarHBondContact O-N 2.83Å
60T72.9Confident74.2Confident116 Ų116144.2 Ų144.271%0.71277%0.771SS**  trans-47.2124.215944.80000108.3S58 V62S58-T60 PolarHBondContact O-N 2.95Å; T60-V62 PolarHBondContact O-N 2.78Å
61P73.3Confident74.3Confident117 Ų117145.8 Ų145.876%0.7677%0.772SS**  trans-60.7116.3179.223.7-31.9000108.1T63P61-T63 PolarHBondContact O-N 2.74Å
62V76.6Confident74.3Confident133 Ų133146.1 Ų146.181%0.80677%0.773SS**  trans-70101.6172.7-1800000105.9T60 E64T60-V62 PolarHBondContact O-N 2.78Å; V62-E64 PolarHBondContact O-N 3.12Å
63T71.3Confident74.1Confident105 Ų105141.1 Ų141.164%0.64477%0.769SS**  trans-70.599.3167.656.80000106.8P61 R65P61-T63 PolarHBondContact O-N 2.74Å; T63-R65 PolarHBondContact O-N 2.78Å
64E76Confident74Confident165 Ų165139.8 Ų139.877%0.77177%0.77SS**  trans-57.4111.8166.3-169.8-175117.200107.3V62 V66V62-E64 PolarHBondContact O-N 3.12Å; E64-V66 PolarHBondContact O-N 2.72Å
65R73.7Confident73.9Confident222 Ų222138.9 Ų138.984%0.83878%0.775SS**  trans-85.798.9168.4-64.6-173.9-133.4178.24.6106T63 S67T63-R65 PolarHBondContact O-N 2.78Å; R65-S67 PolarHBondContact O-N 2.8Å
66V68.1Low73.7Confident127 Ų127140.8 Ų140.877%0.7778%0.777SS**  trans-59.4120.1168-173.50000106.9E64E64-V66 PolarHBondContact O-N 2.72Å
67S68.9Low73.6Confident181 Ų181143 Ų143100%1.26678%0.783SS**  trans-115.20178.8-166.10000111R65R65-S67 PolarHBondContact O-N 2.8Å

Retrieved 67 of 67 residues in 43.2 ms (Link to these results)