A0A075TKX8_HUMAN Loading...

MLL/FLNA fusion protein

AlphaFold DB , UniProt , Accession A0A075TKX8, Species HUMAN (Homo sapiens, Human), Gene FLNA fusion, Length 70 aa.

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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1P49.2Very low71.2Confident175 Ų175157 Ų157100%1.13683%0.826SS**  085.6020.71.7000110.4Q3P1-Q3 PolarHBondContact O-N 3.37Å
2E53Low71.9Confident181 Ų181163.1 Ų163.185%0.84683%0.829SS**  trans-75.8107176.3-168.3-149.8110.700108.5S4E2-S4 PolarHBondContact O-N 3.03Å
3Q59Low72.2Confident177 Ų177159.8 Ų159.883%0.82783%0.825SS**  trans-78.7101.7175-66.3-1533.200109.2P1 K5P1-Q3 PolarHBondContact O-N 3.37Å; Q3-K5 PolarHBondContact O-N 2.98Å
4S67.1Low72.9Confident92 Ų92156.8 Ų156.864%0.64383%0.825SS**  trans-56.9105.2169.7-179.40000109.3E2 Q6E2-S4 PolarHBondContact O-N 3.03Å; S4-Q6 VanDerWaalsContact C-N 3.34Å; S4-Q6 PolarHBondContact O-N 3.21Å
5K77.1Confident73.3Confident200 Ų200155.9 Ų155.987%0.8782%0.819SS**  trans-70.793176-67.5178.2-176.8177.70107.9Q3 K7Q3-K5 PolarHBondContact O-N 2.98Å; K5-K7 PolarHBondContact O-N 2.97Å
6Q75.1Confident73.5Confident180 Ų180153.5 Ų153.584%0.84182%0.816SS**  trans-61.1108.7169.9-66.5-176.6-0.400108.4S4 K8S4-Q6 VanDerWaalsContact C-N 3.34Å; S4-Q6 PolarHBondContact O-N 3.21Å; Q6-K8 PolarHBondContact O-N 3.18Å; Q6-K8 VanDerWaalsContact O-N 3.08Å
7K78.9Confident73.6Confident190 Ų190151.7 Ų151.783%0.82681%0.812SS**  trans-67.6108.7176.2-176.8160179.3172.90107.9K5 V9K5-K7 PolarHBondContact O-N 2.97Å; K7-V9 PolarHBondContact O-N 3.16Å
8K80.1Confident73.8Confident208 Ų208154.4 Ų154.490%0.90482%0.815SS**  trans-62.298.5175.1-172.3178.7-179.3-174.50108.8Q6Q6-K8 PolarHBondContact O-N 3.18Å; Q6-K8 VanDerWaalsContact O-N 3.08Å
9V79.3Confident73.5Confident123 Ų123155.9 Ų155.975%0.74582%0.817SS**PPolyproline II helixtrans-71.1128.9175.5173.10000108.1K7K7-V9 PolarHBondContact O-N 3.16Å
10A81.9Confident73.1Confident78 Ų78155.8 Ų155.865%0.64581%0.81SS**PPolyproline II helixtrans-61.3139.8176.200000110R12A10-R12 PolarHBondContact O-N 3.41Å
11P82.2Confident72.4Confident123 Ų123152.6 Ų152.680%0.79980%0.799SS**PPolyproline II helixtrans-55.4136.7174.6-2231.8000110.5
12R80.3Confident72.9Confident230 Ų230152.9 Ų152.987%0.86878%0.782SS**PPolyproline II helixtrans-63133.3173.2-68.5-178.8-180-115.31.5108.5A10 S14A10-R12 PolarHBondContact O-N 3.41Å; R12-S14 PolarHBondContact O-N 2.85Å; R12-S14 VanDerWaalsContact O-N 3.16Å
13P75.6Confident73.2Confident120 Ų120152.3 Ų152.378%0.77978%0.779SS**PPolyproline II helixtrans-62.9120.3175.923.7-30.7000109.4I15P13-I15 PolarHBondContact O-N 3.38Å
14S81.7Confident73.1Confident118 Ų118151.1 Ų151.183%0.82577%0.771SS**  trans-70.4107.2174.1-59.50000108.9R12 P16R12-S14 PolarHBondContact O-N 2.85Å; R12-S14 VanDerWaalsContact O-N 3.16Å; S14-P16 WeakPolarHBondContact O-CD 3.44Å
15I79.3Confident72.6Confident143 Ų143151.5 Ų151.573%0.73377%0.766SS**  trans-74.9122.5172-57.3178.6000107.5P13 V17P13-I15 PolarHBondContact O-N 3.38Å; I15-V17 PolarHBondContact O-N 3.23Å
16P75.8Confident71.7Confident118 Ų118147.6 Ų147.677%0.76675%0.754SS**  trans-66.1106.1177.624.5-30.8000109.6S14 K18S14-P16 WeakPolarHBondContact O-CD 3.44Å; P16-K18 PolarHBondContact O-N 2.9Å
17V76.2Confident70.8Confident123 Ų123141.6 Ų141.675%0.74574%0.74SS**  trans-73.7108.4171-67.70000108.1I15 Q19I15-V17 PolarHBondContact O-N 3.23Å; V17-Q19 PolarHBondContact O-N 3.08Å
18K76Confident69.7Low201 Ų201141.3 Ų141.387%0.87473%0.733SS**  trans-61.6108.4167.2-76.5-163.8179.1-172.60107.6P16 K20P16-K18 PolarHBondContact O-N 2.9Å; K18-K20 PolarHBondContact O-N 3.01Å
19Q68.4Low68.6Low182 Ų182137.5 Ų137.585%0.8572%0.722SS**  trans-62.3109.6173.4-62.9-175.538.400107.8V17V17-Q19 PolarHBondContact O-N 3.08Å
20K65.7Low67.5Low154 Ų154141.6 Ų141.667%0.6773%0.725SS**  trans-68.3141.4172.6-82.9-110.9-179176.90108.7K18 K22K18-K20 PolarHBondContact O-N 3.01Å; K20-K22 PolarHBondContact O-N 3.4Å
21P58.6Low66.3Low89 Ų89144.3 Ų144.358%0.57872%0.724SS**  trans-51.7134.8173.7-23.832.8000110.3E23 K24P21-E23 PolarHBondContact O-N 3.2Å; P21-K24 PolarHBondContact O-N 3.4Å
22K59.8Low64.9Low180 Ų180140.1 Ų140.178%0.78370%0.703SS**THydrogen-bonded Turntrans-56.2-10.4-175.9-77.8177176.1172.30114.1K20 L25K20-K22 PolarHBondContact O-N 3.4Å; K22-L25 PolarHBondContact O-N 3.49Å
23E59.6Low63.7Low169 Ų169135 Ų13579%0.7969%0.693SS**Hα-helixtrans-75.1-23.4-177.5-49.7-167.5129.700113.3P21P21-E23 PolarHBondContact O-N 3.2Å
24K57.2Low62.8Low153 Ų153133.4 Ų133.467%0.66568%0.683SS**Hα-helixtrans-88.6-4.3174.9-119.4154-175.31580114P21P21-K24 PolarHBondContact O-N 3.4Å
25L56.1Low61.5Low100 Ų100133.9 Ų133.952%0.52468%0.676SS.*Hα-helixtrans-82-28.2174.4-69.4171000112K22 G27 R28 L29K22-L25 PolarHBondContact O-N 3.49Å; L25-G27 PolarHBondContact O-N 3.26Å; L25-R28 PolarHBondContact O-N 2.92Å; L25-L29 WeakPolarHBondContact O-CB 3.44Å; L25-L29 PolarHBondContact O-N 2.93Å
26L57.3Low60.3Low118 Ų118133.1 Ų133.162%0.61867%0.673SS**Hα-helixtrans-69-32.5177.3-62.7176.5000112.5R28 R30L26-R28 VanDerWaalsContact C-N 3.33Å; L26-R28 PolarHBondContact O-N 3.49Å; L26-R30 PolarHBondContact O-N 3.17Å
27G56.8Low59.5Low53 Ų53134.6 Ų134.655%0.54667%0.674SS.*Hα-helixtrans-68.9-27.8173.500000113.9L25L25-G27 PolarHBondContact O-N 3.26Å
28R56.4Low58.6Low184 Ų184139.7 Ų139.769%0.69468%0.68SS**Hα-helixtrans-89.3-25.9176.1-63.7-17974.3-157.73.7112.7L25 L26 R30 Q31 G32L25-R28 PolarHBondContact O-N 2.92Å; L26-R28 VanDerWaalsContact C-N 3.33Å; L26-R28 PolarHBondContact O-N 3.49Å; R28-R30 VanDerWaalsContact C-N 3.32Å; R28-Q31 PolarHBondContact O-N 3.3Å; R28-G32 PolarHBondContact O-N 2.91Å
29L56.5Low57.7Low128 Ų128133.8 Ų133.867%0.6768%0.676SS**Hα-helixtrans-68.2-32.3175.3-165.168.4000111.9L25 Q31 G32L25-L29 WeakPolarHBondContact O-CB 3.44Å; L25-L29 PolarHBondContact O-N 2.93Å; L29-Q31 VanDerWaalsContact C-N 3.26Å; L29-Q31 PolarHBondContact O-N 3.4Å; L29-G32 PolarHBondContact O-N 3Å
30R56.7Low57.2Low210 Ų210128.1 Ų128.179%0.79267%0.667SS**Hα-helixtrans-68.5-23172.5-66.9-176.371.8-104.80.1113.6L26 R28L26-R30 PolarHBondContact O-N 3.17Å; R28-R30 VanDerWaalsContact C-N 3.32Å
31Q56.8Low56.5Low135 Ų135124.1 Ų124.163%0.63167%0.669SS**Hα-helixtrans-93.9-24.4176-158.1174-2.400112.3R28 L29 N33 C34 L35R28-Q31 PolarHBondContact O-N 3.3Å; L29-Q31 VanDerWaalsContact C-N 3.26Å; L29-Q31 PolarHBondContact O-N 3.4Å; Q31-N33 VanDerWaalsContact C-N 3.26Å; Q31-N33 PolarHBondContact O-N 3.45Å; Q31-C34 PolarHBondContact O-N 3.45Å; Q31-C34 VanDerWaalsContact O-N 3.1Å; Q31-L35 PolarHBondContact O-N 3.34Å
32G51.5Low56.4Low35 Ų35124.9 Ų124.936%0.36168%0.675SS.*Hα-helixtrans-65.7-22.3177.200000114.6R28 L29R28-G32 PolarHBondContact O-N 2.91Å; L29-G32 PolarHBondContact O-N 3Å
33N55.8Low56.6Low123 Ų123121.6 Ų121.666%0.65868%0.675SS**THydrogen-bonded Turntrans-82.8-18.2172.5-161.637.4000113.3Q31Q31-N33 VanDerWaalsContact C-N 3.26Å; Q31-N33 PolarHBondContact O-N 3.45Å
34C56.3Low56.5Low85 Ų85120.3 Ų120.357%0.57467%0.669SS**G310 helixtrans-84.9-10.9173.7-64.20000112.8Q31 L37Q31-C34 PolarHBondContact O-N 3.45Å; Q31-C34 VanDerWaalsContact O-N 3.1Å; C34-L37 PolarHBondContact O-N 3.1Å
35L54.7Low56.4Low128 Ų128117.7 Ų117.767%0.6767%0.667SS**G310 helixtrans-78.1-9.6171.5-66.1177000113Q31 L37Q31-L35 PolarHBondContact O-N 3.34Å; L35-L37 VanDerWaalsContact C-N 3.27Å
36N54.9Low56.5Low127 Ų127122.4 Ų122.468%0.67968%0.678SS**G310 helixtrans-84.64.7170.5-65.4-45.6000113.6
37L57.2Low56.5Low150 Ų150124.2 Ų124.279%0.78569%0.688SS**SBendtrans-123.80.7174.4-70.8174.7000114.3C34 L35 G39C34-L37 PolarHBondContact O-N 3.1Å; L35-L37 VanDerWaalsContact C-N 3.27Å; L37-G39 PolarHBondContact O-N 2.91Å
38R58.6Low56.5Low230 Ų230128.9 Ų128.987%0.86870%0.695SS**THydrogen-bonded Turntrans-101.556.4176.9-160.2161.5-176.3-130.20.5112
39G56.5Low56.2Low76 Ų76127.7 Ų127.778%0.78470%0.697SS**THydrogen-bonded Turntrans-151-4.7170.800000113.6L37L37-G39 PolarHBondContact O-N 2.91Å
40G57.8Low56Low64 Ų64127.7 Ų127.766%0.6671%0.706SS**SBendtrans-86.2106161.100000106.3C42G40-C42 PolarHBondContact O-N 2.98Å
41G52.1Low55.7Low70 Ų70122.8 Ų122.872%0.72270%0.7SS**  trans-48.7117.5166.300000107.1S43G41-S43 PolarHBondContact O-N 2.73Å
42C56.2Low55.5Low104 Ų104124.5 Ų124.570%0.70371%0.713SS**  trans-62.187.1153.8-106.90000104.6G40 E44G40-C42 PolarHBondContact O-N 2.98Å; C42-E44 HydrophobicContact CB-CG 4.07Å; C42-E44 WeakPolarHBondContact CB-OE2 3.4Å; C42-E44 PolarHBondContact O-N 3.37Å
43S62.7Low55.4Low112 Ų112128.1 Ų128.178%0.78373%0.727SS**  trans-66.375.8142.6-60.80000103.8G41 P45G41-S43 PolarHBondContact O-N 2.73Å; S43-P45 WeakPolarHBondContact O-CD 3.09Å
44E57.9Low55.6Low142 Ų142129.5 Ų129.566%0.66474%0.74SS**  trans-49.5113.9159.4-79.3143.377.900103.7C42 R46C42-E44 HydrophobicContact CB-CG 4.07Å; C42-E44 WeakPolarHBondContact CB-OE2 3.4Å; C42-E44 PolarHBondContact O-N 3.37Å; E44-R46 PolarHBondContact O-N 2.68Å
45P56.4Low54.8Low97 Ų97128 Ų12863%0.6374%0.738SS**  trans-58.6111.5160.925.1-27.4000102.2S43 L47S43-P45 WeakPolarHBondContact O-CD 3.09Å; P45-L47 HydrophobicContact CB-CG 4.31Å; P45-L47 PolarHBondContact O-N 2.82Å; P45-L47 HydrophobicContact CG-CG 4.17Å; P45-L47 HydrophobicContact CG-CD2 4.22Å; P45-L47 HydrophobicContact CB-CD2 4.13Å
46R56.6Low54.7Low200 Ų200127.9 Ų127.976%0.75575%0.746SS**  trans-59.391165.1-70.2171.367.7-150.6-0.6103.2E44 H48E44-R46 PolarHBondContact O-N 2.68Å; R46-H48 PolarHBondContact O-N 2.78Å
47L57.3Low54.6Low156 Ų156125.8 Ų125.882%0.81775%0.746SS**  trans-7253.2178-69.8174000108.3P45P45-L47 HydrophobicContact CB-CG 4.31Å; P45-L47 PolarHBondContact O-N 2.82Å; P45-L47 HydrophobicContact CG-CG 4.17Å; P45-L47 HydrophobicContact CG-CD2 4.22Å; P45-L47 HydrophobicContact CB-CD2 4.13Å
48H56.7Low54.5Low151 Ų151127.2 Ų127.270%0.69975%0.748SS**  trans-118.317.9-174.5-95.7-65.3000112.3R46R46-H48 PolarHBondContact O-N 2.78Å
49H50.3Low54Low158 Ų158120.1 Ų120.173%0.73174%0.739SS**  trans-130.759.8174.2-71.3-68.6000111.5
50C53.1Low53.8Low128 Ų128123.9 Ų123.987%0.86574%0.741SS**  trans-93.479.9147.5-76.60000108.1
51T50.9Low53.8Low108 Ų108126.7 Ų126.766%0.66374%0.74SS**  trans-117.390.1153.2-47.10000106.3V53T51-V53 HydrophobicContact CG2-CG2 3.65Å; T51-V53 PolarHBondContact O-N 2.94Å
52L52.7Low53.9Low171 Ų171130.3 Ų130.390%0.89574%0.743SS**  trans-69.988.8164.6-70.4171.5000106.8V54L52-V54 PolarHBondContact O-N 3.18Å
53V49Very low53.7Low111 Ų111132.9 Ų132.967%0.67374%0.742SS**  trans-75.5101166.5175.90000106.7T51 G55T51-V53 HydrophobicContact CG2-CG2 3.65Å; T51-V53 PolarHBondContact O-N 2.94Å; V53-G55 PolarHBondContact O-N 3.21Å
54V59.9Low53.1Low151 Ų151134.2 Ų134.292%0.91574%0.741SS**  trans-70.2101.5158.6150.80000106.7L52L52-V54 PolarHBondContact O-N 3.18Å
55G38.3Very low53.1Low53 Ų53134 Ų13455%0.54674%0.743SS.*SBendtrans155.2149.5171.300000113.6V53V53-G55 PolarHBondContact O-N 3.21Å
56P52.7Low53.1Low127 Ų127136.5 Ų136.583%0.82575%0.749SS**  trans-95.3157.9-138.236-34.1000114.8
57A53.8Low53.2Low83 Ų83136.9 Ų136.969%0.68675%0.751SS**SBendtrans66.7134.2169.200000114.8
58E54.2Low52.9Low179 Ų179136.1 Ų136.184%0.83675%0.747SS**  trans7153176.3-37-50.4108.400115.7
59A49.6Very low52.6Low81 Ų81135.1 Ų135.167%0.66975%0.747SS**  trans-95.6101.3147.900000106.8I61A59-I61 WeakPolarHBondContact O-CG1 3.47Å; A59-I61 PolarHBondContact O-N 2.79Å; A59-I61 HydrophobicContact CB-CG1 3.82Å
60D52.5Low52.6Low155 Ų155138.3 Ų138.383%0.82977%0.769SS**  trans-5986.4152.8-106.6-67.7000105.8D62D60-D62 PolarHBondContact O-N 2.84Å
61I56.2Low52.5Low124 Ų124138.8 Ų138.864%0.63677%0.765SS**  trans-76.380.9170.7-48.5-179.1000104.6A59 F63A59-I61 WeakPolarHBondContact O-CG1 3.47Å; A59-I61 PolarHBondContact O-N 2.79Å; A59-I61 HydrophobicContact CB-CG1 3.82Å; I61-F63 HydrophobicContact CG2-CB 3.74Å; I61-F63 HydrophobicContact CG2-CD2 3.59Å; I61-F63 HydrophobicContact CG2-CG 4.05Å; I61-F63 PolarHBondContact O-N 2.65Å
62D54Low52.6Low146 Ų146140.4 Ų140.478%0.78177%0.77SS**  trans-7063.1155-113.8-40.8000107.2D60 D64D60-D62 PolarHBondContact O-N 2.84Å; D62-D64 PolarHBondContact O-N 2.92Å; D62-D64 VanDerWaalsContact C-N 3.33Å
63F52.1Low52.6Low158 Ų158138.7 Ų138.769%0.69376%0.763SS**  trans-74.6103.3151-116.2-108.3000102.6I61 I65I61-F63 HydrophobicContact CG2-CB 3.74Å; I61-F63 HydrophobicContact CG2-CD2 3.59Å; I61-F63 HydrophobicContact CG2-CG 4.05Å; I61-F63 PolarHBondContact O-N 2.65Å; F63-I65 HydrophobicContact CB-CG1 4.46Å; F63-I65 PolarHBondContact O-N 2.8Å
64D50.6Low52.8Low139 Ų139140.4 Ų140.474%0.74377%0.768SS**  trans-51.187.2144.8-91.2-59.1000106.1D62 I66D62-D64 PolarHBondContact O-N 2.92Å; D62-D64 VanDerWaalsContact C-N 3.33Å; D64-I66 PolarHBondContact O-N 2.63Å
65I57.2Low52.4Low139 Ų139139.7 Ų139.771%0.71376%0.759SS**  trans-56.4101.2157.8-65171.8000101.2F63 R67F63-I65 HydrophobicContact CB-CG1 4.46Å; F63-I65 PolarHBondContact O-N 2.8Å; I65-R67 PolarHBondContact O-N 3.33Å
66I57.4Low53.3Low149 Ų149145.5 Ų145.576%0.76477%0.773SS**  trans-60.985.5174-57.6-179.7000105.4D64 N68D64-I66 PolarHBondContact O-N 2.63Å; I66-N68 HydrophobicContact CG2-CB 4.44Å; I66-N68 PolarHBondContact O-N 2.94Å
67R58.8Low53.4Low208 Ų208146.8 Ų146.879%0.78577%0.77SS**  trans-7290166.9-169.1-171.7-83.9128.6-10.8103.7I65 D69I65-R67 PolarHBondContact O-N 3.33Å; R67-D69 WeakPolarHBondContact CD-OD2 3.09Å; R67-D69 WeakPolarHBondContact CG-OD2 3.21Å; R67-D69 PolarHBondContact O-N 3.03Å
68N50.9Low53.3Low139 Ų139151.7 Ų151.774%0.74378%0.776SS**  trans-77.177173-167.7-2.5000107.3I66I66-N68 HydrophobicContact CG2-CB 4.44Å; I66-N68 PolarHBondContact O-N 2.94Å
69D50.5Low53.3Low131 Ų131149.4 Ų149.470%0.70177%0.771SS**  trans-86.9119.7163.7-85.9-63000108R67R67-D69 WeakPolarHBondContact CD-OD2 3.09Å; R67-D69 WeakPolarHBondContact CG-OD2 3.21Å; R67-D69 PolarHBondContact O-N 3.03Å
70N49.2Very low53.6Low224 Ų224155.6 Ų155.6100%1.19878%0.78SS**  trans-70.60176.9-171.7-96.4000111.7

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