A0A087WNR6_MOUSE Loading...

Cysteine protease

Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.

AlphaFold DB , UniProt , Accession A0A087WNR6, Species MOUSE (Mus musculus, Mouse), Gene Atg4b, Length 63 aa.

						>A0A087WNR6_MOUSE|A0A087WNR6|Atg4b
VELTDSCFIPDESFHCQHPPSRMGIGELDPSIAVGFFCKTEEDFNDWCQQVKKVCSCPCPEPR
					

Structure Viewer

Loading PAE data...

(Predicted Aligned Error values between residue pairs)

Download Structure PDB PAE Table

Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	V	42	Very low	67.4	Low	189 Å²	189	132.4 Å²	132.4	100%	1.145	74%	0.738	S	S	*	*				0	97.7	0	-179.2	0	0	0	0	105.1	L3	V1-L3 PolarHBondContact O-N 3.14Å
2	E	42.1	Very low	69.7	Low	171 Å²	171	129.4 Å²	129.4	80%	0.799	71%	0.714	S	S	*	*			trans	-69.2	123	179.3	-71	-75.4	99.3	0	0	108.3	T4	E2-T4 VanDerWaalsContact C-N 3.3Å; E2-T4 PolarHBondContact O-N 3.13Å; E2-T4 VanDerWaalsContact O-N 3.09Å
3	L	55.3	Low	71.7	Confident	177 Å²	177	127.8 Å²	127.8	93%	0.927	72%	0.717	S	S	*	*			trans	-78.9	77.7	174.9	-96.7	146.8	0	0	0	108.8	V1	V1-L3 PolarHBondContact O-N 3.14Å
4	T	59.7	Low	73.4	Confident	110 Å²	110	130.4 Å²	130.4	68%	0.675	72%	0.718	S	S	*	*			trans	-137.4	74.7	171.2	62.4	0	0	0	0	109.9	E2	E2-T4 VanDerWaalsContact C-N 3.3Å; E2-T4 PolarHBondContact O-N 3.13Å; E2-T4 VanDerWaalsContact O-N 3.09Å
5	D	54.8	Low	74.8	Confident	159 Å²	159	128.1 Å²	128.1	85%	0.85	70%	0.699	S	S	*	*			trans	-139.7	67.9	158.2	-125.1	-45.2	0	0	0	107.5	C7	D5-C7 PolarHBondContact O-N 3.18Å
6	S	64.6	Low	76.1	Confident	108 Å²	108	126.8 Å²	126.8	76%	0.755	70%	0.701	S	S	*	*			trans	-57.8	99.2	156.4	49.1	0	0	0	0	105.8	F8	S6-F8 VanDerWaalsContact C-N 3.34Å; S6-F8 PolarHBondContact O-N 3.26Å
7	C	66.2	Low	77.3	Confident	106 Å²	106	128.2 Å²	128.2	72%	0.716	70%	0.701	S	S	*	*			trans	-49.1	101.3	171.8	-176	0	0	0	0	107.8	D5 I9	D5-C7 PolarHBondContact O-N 3.18Å; C7-I9 PolarHBondContact O-N 3.2Å; C7-I9 VanDerWaalsContact O-N 3.12Å
8	F	79.9	Confident	78.3	Confident	159 Å²	159	129.3 Å²	129.3	70%	0.697	70%	0.7	S	S	*	*			trans	-78.3	100.4	-177.7	-175.5	-94	0	0	0	107	S6 P10	S6-F8 VanDerWaalsContact C-N 3.34Å; S6-F8 PolarHBondContact O-N 3.26Å; F8-P10 HydrophobicContact CE1-CB 4.43Å; F8-P10 WeakPolarHBondContact O-CD 3.35Å
9	I	89.8	Confident	79.3	Confident	121 Å²	121	128.3 Å²	128.3	62%	0.621	70%	0.701	S	S	*	*			trans	-86.4	114.2	173.1	-61.2	175	0	0	0	106.3	C7 D11	C7-I9 PolarHBondContact O-N 3.2Å; C7-I9 VanDerWaalsContact O-N 3.12Å; I9-D11 PolarHBondContact O-N 3.36Å
10	P	92.4	Very high	80.2	Confident	82 Å²	82	127.7 Å²	127.7	53%	0.532	70%	0.703	S	S	.	*			trans	-66.7	103.5	175.5	27.5	-32.6	0	0	0	108.9	F8 E12	F8-P10 HydrophobicContact CE1-CB 4.43Å; F8-P10 WeakPolarHBondContact O-CD 3.35Å; P10-E12 VanDerWaalsContact C-OE2 3.23Å; P10-E12 VanDerWaalsContact CA-OE2 3.26Å; P10-E12 WeakPolarHBondContact CA-OE2 3.41Å; P10-E12 WeakPolarHBondContact CB-OE2 3.45Å
11	D	94.9	Very high	81	Confident	74 Å²	74	127.5 Å²	127.5	40%	0.396	71%	0.711	S	S	.	*			trans	-103.2	1.9	-174.3	80.1	-26.5	0	0	0	113.1	I9 S13 F14 H15	I9-D11 PolarHBondContact O-N 3.36Å; D11-S13 PolarHBondContact O-N 3.41Å; D11-F14 HydrophobicContact CB-CD2 3.99Å; D11-F14 WeakPolarHBondContact O-CB 3.27Å; D11-F14 WeakPolarHBondContact O-CD2 3.32Å; D11-F14 PolarHBondContact O-N 2.94Å; D11-H15 PolarHBondContact O-CD2 2.67Å; D11-H15 IonicContact OD1-NE2 3.96Å; D11-H15 IonicContact OD2-CD2 3.61Å; D11-H15 IonicContact OD2-CE1 3.93Å; D11-H15 IonicContact OD2-NE2 2.83Å; D11-H15 PolarHBondContact OD2-NE2 3.3Å
12	E	95	Very high	83.6	Confident	97 Å²	97	130.2 Å²	130.2	45%	0.453	70%	0.701	S	S	.	*	G	3₁₀ helix	trans	-60.1	-28.3	-171.2	-58.7	82.5	177.5	0	0	112	P10 F14 H15	P10-E12 VanDerWaalsContact C-OE2 3.23Å; P10-E12 VanDerWaalsContact CA-OE2 3.26Å; P10-E12 WeakPolarHBondContact CA-OE2 3.41Å; P10-E12 WeakPolarHBondContact CB-OE2 3.45Å; E12-F14 VanDerWaalsContact C-N 3.26Å; E12-F14 PolarHBondContact O-N 3.25Å; E12-H15 PolarHBondContact O-N 3.5Å
13	S	94.9	Very high	86.2	Confident	108 Å²	108	127.5 Å²	127.5	76%	0.755	69%	0.69	S	S	*	*	G	3₁₀ helix	trans	-69.4	-16.9	176.3	69.9	0	0	0	0	114.7	D11	D11-S13 PolarHBondContact O-N 3.41Å
14	F	95.6	Very high	88.2	Confident	165 Å²	165	120.7 Å²	120.7	72%	0.724	66%	0.663	S	S	*	*	G	3₁₀ helix	trans	-87.5	-8.5	175.7	-58.1	-75.2	0	0	0	113	D11 E12	D11-F14 HydrophobicContact CB-CD2 3.99Å; D11-F14 WeakPolarHBondContact O-CB 3.27Å; D11-F14 WeakPolarHBondContact O-CD2 3.32Å; D11-F14 PolarHBondContact O-N 2.94Å; E12-F14 VanDerWaalsContact C-N 3.26Å; E12-F14 PolarHBondContact O-N 3.25Å
15	H	95.3	Very high	90	Very high	96 Å²	96	123 Å²	123	44%	0.444	67%	0.669	S	S	.	*	S	Bend	trans	-114.3	122	-177.4	-57.6	-82.5	0	0	0	110.4	D11 E12 Q17	D11-H15 PolarHBondContact O-CD2 2.67Å; D11-H15 IonicContact OD1-NE2 3.96Å; D11-H15 IonicContact OD2-CD2 3.61Å; D11-H15 IonicContact OD2-CE1 3.93Å; D11-H15 IonicContact OD2-NE2 2.83Å; D11-H15 PolarHBondContact OD2-NE2 3.3Å; E12-H15 PolarHBondContact O-N 3.5Å; H15-Q17 PolarHBondContact O-N 2.91Å
16	C	95.4	Very high	92	Very high	107 Å²	107	119.5 Å²	119.5	72%	0.723	67%	0.671	S	S	*	*			trans	-72.6	113.1	174.2	-172.5	0	0	0	0	110.4	H18	C16-H18 VanDerWaalsContact C-N 3.32Å
17	Q	95.5	Very high	93.6	Very high	151 Å²	151	121 Å²	121	71%	0.706	67%	0.666	S	S	*	*			trans	-87.6	2.7	178.7	-59.6	-61.9	-29.5	0	0	114	H15	H15-Q17 PolarHBondContact O-N 2.91Å
18	H	95.7	Very high	95.1	Very high	147 Å²	147	120.6 Å²	120.6	68%	0.681	66%	0.656	S	S	*	*	S	Bend	trans	-96.9	161.1	179.6	-59.3	93.4	0	0	0	110.7	C16	C16-H18 VanDerWaalsContact C-N 3.32Å
19	P	96.9	Very high	95.9	Very high	111 Å²	111	117.7 Å²	117.7	72%	0.721	65%	0.648	S	S	*	*	P	Polyproline II helix	trans	-53.9	140.5	171.2	-25.1	34.8	0	0	0	111.5	S21	P19-S21 PolarHBondContact O-N 3.46Å
20	P	97.6	Very high	96.3	Very high	115 Å²	115	117.6 Å²	117.6	75%	0.747	66%	0.655	S	S	*	*	P	Polyproline II helix	trans	-57.4	128.5	178.7	-25.7	34	0	0	0	112.1
21	S	96.6	Very high	96.5	Very high	125 Å²	125	118.5 Å²	118.5	87%	0.874	66%	0.663	S	S	*	*	P	Polyproline II helix	trans	-61.9	149.4	175.4	-58.8	0	0	0	0	111.5	P19	P19-S21 PolarHBondContact O-N 3.46Å
22	R	97.2	Very high	96.7	Very high	246 Å²	246	120.1 Å²	120.1	93%	0.928	67%	0.671	S	S	*	*			trans	-131.5	149.8	177.7	-64.9	-175.7	170.6	-145.5	-2.9	110.1
23	M	97.2	Very high	96.8	Very high	113 Å²	113	120.4 Å²	120.4	56%	0.557	69%	0.69	S	S	*	*			trans	-144.7	159.3	171.3	64.7	-175.6	-65	0	0	109.6	E27	M23-E27 HydrophobicContact CE-CB 3.62Å; M23-E27 WeakPolarHBondContact CE-O 3.2Å
24	G	97.6	Very high	96.9	Very high	35 Å²	35	120.2 Å²	120.2	36%	0.361	68%	0.684	S	S	.	*			trans	-68.2	143.2	172.2	0	0	0	0	0	110.9	G26 E27	G24-G26 PolarHBondContact O-N 3.19Å; G24-E27 PolarHBondContact N-OE2 3.14Å; G24-E27 WeakPolarHBondContact O-CB 3.45Å; G24-E27 PolarHBondContact O-N 3.11Å
25	I	96.6	Very high	97	Very high	158 Å²	158	115.7 Å²	115.7	81%	0.81	68%	0.684	S	S	*	*	G	3₁₀ helix	trans	-61.7	-33.8	-179.5	-63.9	167.9	0	0	0	111.3	E27 L28	I25-E27 PolarHBondContact O-N 3.32Å; I25-L28 WeakPolarHBondContact O-CB 3.44Å; I25-L28 PolarHBondContact O-N 3.06Å
26	G	97.4	Very high	97.2	Very high	86 Å²	86	117.5 Å²	117.5	89%	0.887	69%	0.691	S	S	*	*	G	3₁₀ helix	trans	-70.8	-6.9	176.8	0	0	0	0	0	114.8	G24	G24-G26 PolarHBondContact O-N 3.19Å
27	E	97.8	Very high	97.3	Very high	139 Å²	139	120.9 Å²	120.9	65%	0.65	69%	0.693	S	S	*	*	G	3₁₀ helix	trans	-95.4	-3.1	176.1	-56.2	177.9	122.8	0	0	111.9	M23 G24 I25	M23-E27 HydrophobicContact CE-CB 3.62Å; M23-E27 WeakPolarHBondContact CE-O 3.2Å; G24-E27 PolarHBondContact N-OE2 3.14Å; G24-E27 WeakPolarHBondContact O-CB 3.45Å; G24-E27 PolarHBondContact O-N 3.11Å; I25-E27 PolarHBondContact O-N 3.32Å
28	L	97.5	Very high	97.4	Very high	97 Å²	97	115.5 Å²	115.5	51%	0.508	67%	0.672	S	S	.	*	S	Bend	trans	-72.9	130.1	178.3	-169.7	71.3	0	0	0	110.2	I25 I32	I25-L28 WeakPolarHBondContact O-CB 3.44Å; I25-L28 PolarHBondContact O-N 3.06Å; L28-I32 HydrophobicContact CD2-CG2 4.18Å; L28-I32 HydrophobicContact CG-CG2 4.3Å
29	D	97.7	Very high	97.5	Very high	98 Å²	98	116.7 Å²	116.7	52%	0.524	68%	0.675	S	S	.	*			trans	-64.8	140.1	172.3	-173.8	-92.5	0	0	0	110.6	S31 I32	D29-S31 PolarHBondContact O-N 2.95Å; D29-S31 WeakPolarHBondContact OD1-CA 3.48Å; D29-S31 VanDerWaalsContact OD1-CB 3.23Å; D29-S31 WeakPolarHBondContact OD1-CB 3.41Å; D29-S31 PolarHBondContact OD1-N 3.42Å; D29-S31 PolarHBondContact OD1-OG 3.42Å; D29-I32 WeakPolarHBondContact O-CG2 3.48Å
30	P	97.3	Very high	97.6	Very high	120 Å²	120	114.5 Å²	114.5	78%	0.779	66%	0.66	S	S	*	*	S	Bend	trans	-63.7	-21.2	179.7	-24.3	34.8	0	0	0	115	I32	P30-I32 PolarHBondContact O-N 3.13Å; P30-I32 VanDerWaalsContact O-N 3.14Å
31	S	97.9	Very high	97.7	Very high	101 Å²	101	116.4 Å²	116.4	71%	0.706	66%	0.659	S	S	*	*			trans	-80.1	93.6	179.3	68.7	0	0	0	0	111	D29	D29-S31 PolarHBondContact O-N 2.95Å; D29-S31 WeakPolarHBondContact OD1-CA 3.48Å; D29-S31 VanDerWaalsContact OD1-CB 3.23Å; D29-S31 WeakPolarHBondContact OD1-CB 3.41Å; D29-S31 PolarHBondContact OD1-N 3.42Å; D29-S31 PolarHBondContact OD1-OG 3.42Å
32	I	97.8	Very high	97.8	Very high	107 Å²	107	118 Å²	118	55%	0.549	65%	0.653	S	S	.	*			trans	-130.8	159	-177.6	62.3	172.5	0	0	0	112.1	L28 D29 P30 V34	L28-I32 HydrophobicContact CD2-CG2 4.18Å; L28-I32 HydrophobicContact CG-CG2 4.3Å; D29-I32 WeakPolarHBondContact O-CG2 3.48Å; P30-I32 PolarHBondContact O-N 3.13Å; P30-I32 VanDerWaalsContact O-N 3.14Å; I32-V34 HydrophobicContact CD1-CG2 4.07Å
33	A	97.8	Very high	97.8	Very high	104 Å²	104	109.6 Å²	109.6	86%	0.86	63%	0.626	S	S	*	*			trans	-122.4	119.6	165.7	0	0	0	0	0	108.6
34	V	97.6	Very high	97.9	Very high	104 Å²	104	108.9 Å²	108.9	63%	0.63	62%	0.62	S	S	*	*			trans	-93.3	129.2	175.7	-176.6	0	0	0	0	108.8	I32 F36	I32-V34 HydrophobicContact CD1-CG2 4.07Å; V34-F36 HydrophobicContact CG1-CD2 4.39Å; V34-F36 HydrophobicContact CG1-CE2 3.65Å; V34-F36 HydrophobicContact CG1-CZ 3.8Å
35	G	97.1	Very high	97.9	Very high	70 Å²	70	110.8 Å²	110.8	72%	0.722	62%	0.622	S	S	*	*			trans	-112.1	139	179	0	0	0	0	0	112.1
36	F	98.1	Very high	98	Very high	133 Å²	133	106.8 Å²	106.8	58%	0.583	60%	0.603	S	S	*	*			trans	-124.6	141.1	169.1	-60.1	-86.2	0	0	0	108.7	V34 W47	V34-F36 HydrophobicContact CG1-CD2 4.39Å; V34-F36 HydrophobicContact CG1-CE2 3.65Å; V34-F36 HydrophobicContact CG1-CZ 3.8Å; F36-W47 AromaticContact CD1-CD1 3.65Å; F36-W47 AromaticContact CD1-NE1 3.28Å; F36-W47 VanDerWaalsContact CD1-NE1 3.28Å; F36-W47 AromaticContact CD2-CE2 3.78Å; F36-W47 AromaticContact CD2-CZ2 3.8Å; F36-W47 HydrophobicContact CD2-CZ2 3.8Å; F36-W47 AromaticContact CD2-NE1 3.36Å; F36-W47 AromaticContact CE1-NE1 3.55Å; F36-W47 HydrophobicContact CE2-CZ2 4.06Å; F36-W47 AromaticContact CE2-NE1 3.62Å; F36-W47 AromaticContact CG-CD1 3.82Å; F36-W47 AromaticContact CG-CE2 3.92Å; F36-W47 HydrophobicContact CG-CZ2 4.39Å; F36-W47 AromaticContact CG-NE1 3.18Å; F36-W47 AromaticContact CZ-NE1 3.71Å
37	F	97.9	Very high	98.1	Very high	178 Å²	178	106.2 Å²	106.2	78%	0.781	57%	0.574	S	S	*	*			trans	-113.8	121.9	176	177	-107.3	0	0	0	109.8	K39	F37-K39 HydrophobicContact CE1-CB 3.73Å; F37-K39 HydrophobicContact CE1-CG 4.35Å; F37-K39 HydrophobicContact CZ-CB 3.97Å; F37-K39 HydrophobicContact CZ-CG 4.3Å
38	C	98.4	Very high	98.1	Very high	39 Å²	39	101 Å²	101	26%	0.264	55%	0.552	S	S	.	*			trans	-117	106.6	175.5	-60.2	0	0	0	0	107.2	T40 D43 F44	C38-T40 VanDerWaalsContact C-N 3.3Å; C38-D43 HydrophobicContact CB-CB 3.89Å; C38-F44 HydrophobicContact CB-CB 3.82Å; C38-F44 VanDerWaalsContact SG-CA 3.56Å
39	K	98.1	Very high	98	Very high	171 Å²	171	101.3 Å²	101.3	74%	0.743	55%	0.551	S	S	*	*	S	Bend	trans	-69.1	-36.6	-176.7	-174.3	179.3	177.9	-178.8	0	110.8	F37 D43	F37-K39 HydrophobicContact CE1-CB 3.73Å; F37-K39 HydrophobicContact CE1-CG 4.35Å; F37-K39 HydrophobicContact CZ-CB 3.97Å; F37-K39 HydrophobicContact CZ-CG 4.3Å; K39-D43 PolarHBondContact N-OD2 3.32Å; K39-D43 VanDerWaalsContact N-OD2 3.14Å
40	T	98.8	Very high	98	Very high	66 Å²	66	101.5 Å²	101.5	41%	0.405	55%	0.549	S	S	.	.	S	Bend	trans	-120.1	165.6	-179.4	68.2	0	0	0	0	110.8	C38 E42 D43 F44	C38-T40 VanDerWaalsContact C-N 3.3Å; T40-E42 PolarHBondContact O-N 3.11Å; T40-E42 PolarHBondContact OG1-N 3.14Å; T40-D43 PolarHBondContact N-OD2 3.21Å; T40-D43 PolarHBondContact O-N 2.97Å; T40-D43 PolarHBondContact OG1-N 2.93Å; T40-D43 PolarHBondContact OG1-OD2 3.41Å; T40-F44 PolarHBondContact O-N 2.9Å
41	E	98.5	Very high	97.9	Very high	154 Å²	154	98.3 Å²	98.3	72%	0.72	53%	0.527	S	S	*	.	H	α-helix	trans	-64.2	-32.4	172.4	-171.5	-179.9	168.8	0	0	111.9	F44 N45	E41-F44 PolarHBondContact O-N 3.28Å; E41-N45 PolarHBondContact O-N 2.91Å; E41-N45 PolarHBondContact O-ND2 2.91Å; E41-N45 VanDerWaalsContact O-ND2 3.16Å
42	E	98.6	Very high	97.8	Very high	158 Å²	158	100 Å²	100	74%	0.738	52%	0.522	S	S	*	.	H	α-helix	trans	-62.8	-43.2	175.8	-172.6	171.9	-164.3	0	0	111.5	T40 F44 N45 D46	T40-E42 PolarHBondContact O-N 3.11Å; T40-E42 PolarHBondContact OG1-N 3.14Å; E42-F44 VanDerWaalsContact C-N 3.27Å; E42-F44 PolarHBondContact O-N 2.71Å; E42-N45 PolarHBondContact O-N 3.4Å; E42-D46 PolarHBondContact O-N 3.45Å
43	D	98.7	Very high	97.6	Very high	70 Å²	70	101.1 Å²	101.1	37%	0.374	52%	0.523	S	S	.	.	H	α-helix	trans	-59.5	-39.9	174.4	-56.1	-42.7	0	0	0	111.4	C38 K39 T40 D46 W47	C38-D43 HydrophobicContact CB-CB 3.89Å; K39-D43 PolarHBondContact N-OD2 3.32Å; K39-D43 VanDerWaalsContact N-OD2 3.14Å; T40-D43 PolarHBondContact N-OD2 3.21Å; T40-D43 PolarHBondContact O-N 2.97Å; T40-D43 PolarHBondContact OG1-N 2.93Å; T40-D43 PolarHBondContact OG1-OD2 3.41Å; D43-D46 PolarHBondContact O-N 2.9Å; D43-W47 WeakPolarHBondContact O-CB 3.39Å; D43-W47 PolarHBondContact O-N 3.18Å
44	F	98.8	Very high	97.3	Very high	98 Å²	98	101.4 Å²	101.4	43%	0.43	51%	0.513	S	S	.	.	H	α-helix	trans	-68	-39.5	177.8	180	-107.5	0	0	0	112.1	C38 T40 E41 E42 W47 C48	C38-F44 HydrophobicContact CB-CB 3.82Å; C38-F44 VanDerWaalsContact SG-CA 3.56Å; T40-F44 PolarHBondContact O-N 2.9Å; E41-F44 PolarHBondContact O-N 3.28Å; E42-F44 VanDerWaalsContact C-N 3.27Å; E42-F44 PolarHBondContact O-N 2.71Å; F44-W47 AromaticContact CD2-CE3 3.86Å; F44-W47 HydrophobicContact CD2-CE3 3.86Å; F44-W47 HydrophobicContact CD2-CZ3 4.29Å; F44-W47 AromaticContact CE2-CE3 3.62Å; F44-W47 HydrophobicContact CE2-CE3 3.62Å; F44-W47 AromaticContact CE2-CZ3 3.58Å; F44-W47 HydrophobicContact CE2-CZ3 3.58Å; F44-W47 HydrophobicContact CZ-CE3 4.45Å; F44-W47 HydrophobicContact CZ-CZ3 4.23Å; F44-W47 PolarHBondContact O-N 3.16Å; F44-C48 WeakPolarHBondContact O-CB 3.47Å; F44-C48 PolarHBondContact O-N 3.23Å; F44-C48 PolarHBondContact O-SG 3.26Å
45	N	98.4	Very high	96.8	Very high	76 Å²	76	101.2 Å²	101.2	41%	0.406	52%	0.515	S	S	.	.	H	α-helix	trans	-64.7	-41.6	175.5	-75.5	-40.3	0	0	0	111.6	E41 E42 C48 Q49	E41-N45 PolarHBondContact O-N 2.91Å; E41-N45 PolarHBondContact O-ND2 2.91Å; E41-N45 VanDerWaalsContact O-ND2 3.16Å; E42-N45 PolarHBondContact O-N 3.4Å; N45-C48 WeakPolarHBondContact O-CB 3.42Å; N45-C48 PolarHBondContact O-N 3.23Å; N45-Q49 WeakPolarHBondContact O-CG 3.41Å; N45-Q49 PolarHBondContact O-N 3.21Å; N45-Q49 VanDerWaalsContact O-N 3.14Å
46	D	98.3	Very high	96	Very high	74 Å²	74	102.3 Å²	102.3	40%	0.396	51%	0.512	S	S	.	.	H	α-helix	trans	-61.9	-49.3	173.1	178.8	65.2	0	0	0	111.2	E42 D43 C48 Q49 Q50	E42-D46 PolarHBondContact O-N 3.45Å; D43-D46 PolarHBondContact O-N 2.9Å; D46-C48 VanDerWaalsContact C-N 3.29Å; D46-C48 PolarHBondContact O-N 3.01Å; D46-Q49 WeakPolarHBondContact O-CA 3.48Å; D46-Q49 WeakPolarHBondContact O-CB 3.46Å; D46-Q49 PolarHBondContact O-N 3.28Å; D46-Q50 WeakPolarHBondContact O-CG 3.34Å; D46-Q50 PolarHBondContact O-N 3.14Å; D46-Q50 PolarHBondContact OD2-NE2 3.21Å
47	W	98.2	Very high	94.5	Very high	73 Å²	73	100.1 Å²	100.1	28%	0.277	51%	0.512	S	S	.	.	H	α-helix	trans	-54.9	-44.7	175.8	174.4	80.6	0	0	0	112	F36 D43 F44 Q49 Q50 V51	F36-W47 AromaticContact CD1-CD1 3.65Å; F36-W47 AromaticContact CD1-NE1 3.28Å; F36-W47 VanDerWaalsContact CD1-NE1 3.28Å; F36-W47 AromaticContact CD2-CE2 3.78Å; F36-W47 AromaticContact CD2-CZ2 3.8Å; F36-W47 HydrophobicContact CD2-CZ2 3.8Å; F36-W47 AromaticContact CD2-NE1 3.36Å; F36-W47 AromaticContact CE1-NE1 3.55Å; F36-W47 HydrophobicContact CE2-CZ2 4.06Å; F36-W47 AromaticContact CE2-NE1 3.62Å; F36-W47 AromaticContact CG-CD1 3.82Å; F36-W47 AromaticContact CG-CE2 3.92Å; F36-W47 HydrophobicContact CG-CZ2 4.39Å; F36-W47 AromaticContact CG-NE1 3.18Å; F36-W47 AromaticContact CZ-NE1 3.71Å; D43-W47 WeakPolarHBondContact O-CB 3.39Å; D43-W47 PolarHBondContact O-N 3.18Å; F44-W47 AromaticContact CD2-CE3 3.86Å; F44-W47 HydrophobicContact CD2-CE3 3.86Å; F44-W47 HydrophobicContact CD2-CZ3 4.29Å; F44-W47 AromaticContact CE2-CE3 3.62Å; F44-W47 HydrophobicContact CE2-CE3 3.62Å; F44-W47 AromaticContact CE2-CZ3 3.58Å; F44-W47 HydrophobicContact CE2-CZ3 3.58Å; F44-W47 HydrophobicContact CZ-CE3 4.45Å; F44-W47 HydrophobicContact CZ-CZ3 4.23Å; F44-W47 PolarHBondContact O-N 3.16Å; W47-Q49 VanDerWaalsContact C-N 3.28Å; W47-Q49 PolarHBondContact O-N 2.83Å; W47-Q50 PolarHBondContact O-N 2.86Å; W47-Q50 VanDerWaalsContact O-N 3.13Å; W47-V51 HydrophobicContact CD2-CG2 4.02Å; W47-V51 HydrophobicContact CG-CG2 4.46Å; W47-V51 HydrophobicContact CH2-CG2 4.31Å; W47-V51 HydrophobicContact CZ2-CG2 3.7Å; W47-V51 WeakPolarHBondContact O-CG2 3.4Å; W47-V51 PolarHBondContact O-N 3.35Å
48	C	97.8	Very high	92.8	Very high	29 Å²	29	97.2 Å²	97.2	20%	0.196	51%	0.511	C	S	.	.	H	α-helix	trans	-58	-39.7	175.6	-75.2	0	0	0	0	112.5	F44 N45 D46 K52	F44-C48 WeakPolarHBondContact O-CB 3.47Å; F44-C48 PolarHBondContact O-N 3.23Å; F44-C48 PolarHBondContact O-SG 3.26Å; N45-C48 WeakPolarHBondContact O-CB 3.42Å; N45-C48 PolarHBondContact O-N 3.23Å; D46-C48 VanDerWaalsContact C-N 3.29Å; D46-C48 PolarHBondContact O-N 3.01Å; C48-K52 WeakPolarHBondContact O-CB 3.22Å; C48-K52 WeakPolarHBondContact O-CD 3.46Å; C48-K52 WeakPolarHBondContact O-CG 3.23Å; C48-K52 PolarHBondContact O-N 3.45Å; C48-K52 VanDerWaalsContact O-N 3.11Å
49	Q	96.9	Very high	90.9	Very high	104 Å²	104	100.9 Å²	100.9	49%	0.486	54%	0.536	S	S	.	.	H	α-helix	trans	-68.2	-40.5	176	-66.9	176.8	27	0	0	111.8	N45 D46 W47 K52 K53	N45-Q49 WeakPolarHBondContact O-CG 3.41Å; N45-Q49 PolarHBondContact O-N 3.21Å; N45-Q49 VanDerWaalsContact O-N 3.14Å; D46-Q49 WeakPolarHBondContact O-CA 3.48Å; D46-Q49 WeakPolarHBondContact O-CB 3.46Å; D46-Q49 PolarHBondContact O-N 3.28Å; W47-Q49 VanDerWaalsContact C-N 3.28Å; W47-Q49 PolarHBondContact O-N 2.83Å; Q49-K52 PolarHBondContact O-N 3.35Å; Q49-K53 VanDerWaalsContact O-CG 3.32Å; Q49-K53 WeakPolarHBondContact O-CG 3.34Å; Q49-K53 PolarHBondContact O-N 2.8Å
50	Q	96.3	Very high	89.1	Confident	102 Å²	102	98.1 Å²	98.1	48%	0.477	54%	0.535	S	S	.	.	H	α-helix	trans	-62.3	-47.4	177	-64.5	-168.7	36.4	0	0	111.7	D46 W47 K52 K53 V54	D46-Q50 WeakPolarHBondContact O-CG 3.34Å; D46-Q50 PolarHBondContact O-N 3.14Å; D46-Q50 PolarHBondContact OD2-NE2 3.21Å; W47-Q50 PolarHBondContact O-N 2.86Å; W47-Q50 VanDerWaalsContact O-N 3.13Å; Q50-K52 VanDerWaalsContact C-N 3.34Å; Q50-K52 PolarHBondContact O-N 2.85Å; Q50-K53 WeakPolarHBondContact O-CB 3.33Å; Q50-K53 PolarHBondContact O-N 3.22Å; Q50-K53 VanDerWaalsContact O-N 3.14Å; Q50-V54 PolarHBondContact O-N 3.14Å; Q50-V54 VanDerWaalsContact O-N 3.11Å
51	V	96.3	Very high	86.8	Confident	54 Å²	54	103.5 Å²	103.5	33%	0.327	56%	0.556	S	S	.	*	H	α-helix	trans	-59.8	-45.4	177.3	173.8	0	0	0	0	110.8	W47 K53 V54 C55	W47-V51 HydrophobicContact CD2-CG2 4.02Å; W47-V51 HydrophobicContact CG-CG2 4.46Å; W47-V51 HydrophobicContact CH2-CG2 4.31Å; W47-V51 HydrophobicContact CZ2-CG2 3.7Å; W47-V51 WeakPolarHBondContact O-CG2 3.4Å; W47-V51 PolarHBondContact O-N 3.35Å; V51-K53 VanDerWaalsContact C-N 3.29Å; V51-K53 PolarHBondContact O-N 3.48Å; V51-V54 PolarHBondContact O-N 3.3Å; V51-C55 PolarHBondContact O-N 3.22Å; V51-C55 PolarHBondContact O-SG 2.83Å
52	K	95.1	Very high	85	Confident	137 Å²	137	102 Å²	102	60%	0.596	56%	0.56	S	S	*	*	H	α-helix	trans	-57.9	-40.3	176.3	-74.7	169.1	-171.4	174.2	0	112.3	C48 Q49 Q50 C55 S56	C48-K52 WeakPolarHBondContact O-CB 3.22Å; C48-K52 WeakPolarHBondContact O-CD 3.46Å; C48-K52 WeakPolarHBondContact O-CG 3.23Å; C48-K52 PolarHBondContact O-N 3.45Å; C48-K52 VanDerWaalsContact O-N 3.11Å; Q49-K52 PolarHBondContact O-N 3.35Å; Q50-K52 VanDerWaalsContact C-N 3.34Å; Q50-K52 PolarHBondContact O-N 2.85Å; K52-C55 PolarHBondContact O-N 3.27Å; K52-S56 VanDerWaalsContact O-CB 3.27Å; K52-S56 WeakPolarHBondContact O-CB 3.44Å; K52-S56 PolarHBondContact O-N 3.2Å; K52-S56 PolarHBondContact O-OG 2.87Å
53	K	93.3	Very high	82.8	Confident	130 Å²	130	109.4 Å²	109.4	57%	0.565	58%	0.581	S	S	*	*	H	α-helix	trans	-61.8	-47.8	177.2	-70.6	166.9	-170.1	170.2	0	110.8	Q49 Q50 V51 C55 S56 C57	Q49-K53 VanDerWaalsContact O-CG 3.32Å; Q49-K53 WeakPolarHBondContact O-CG 3.34Å; Q49-K53 PolarHBondContact O-N 2.8Å; Q50-K53 WeakPolarHBondContact O-CB 3.33Å; Q50-K53 PolarHBondContact O-N 3.22Å; Q50-K53 VanDerWaalsContact O-N 3.14Å; V51-K53 VanDerWaalsContact C-N 3.29Å; V51-K53 PolarHBondContact O-N 3.48Å; K53-C55 PolarHBondContact O-N 2.53Å; K53-S56 PolarHBondContact O-N 3.03Å; K53-C57 PolarHBondContact O-N 2.99Å; K53-C57 PolarHBondContact O-SG 2.8Å
54	V	91.9	Very high	82	Confident	110 Å²	110	111.4 Å²	111.4	67%	0.667	59%	0.591	S	S	*	*	H	α-helix	trans	-62	-44.5	178.2	177.2	0	0	0	0	111.4	Q50 V51 S56 C57	Q50-V54 PolarHBondContact O-N 3.14Å; Q50-V54 VanDerWaalsContact O-N 3.11Å; V51-V54 PolarHBondContact O-N 3.3Å; V54-S56 VanDerWaalsContact C-N 3.29Å; V54-S56 PolarHBondContact O-N 3.37Å; V54-C57 WeakPolarHBondContact O-CB 3.35Å; V54-C57 PolarHBondContact O-N 3.12Å
55	C	88	Confident	81.1	Confident	99 Å²	99	112.1 Å²	112.1	67%	0.669	60%	0.6	S	S	*	*	H	α-helix	trans	-68.8	-26.2	178.5	-64.7	0	0	0	0	113.7	V51 K52 K53	V51-C55 PolarHBondContact O-N 3.22Å; V51-C55 PolarHBondContact O-SG 2.83Å; K52-C55 PolarHBondContact O-N 3.27Å; K53-C55 PolarHBondContact O-N 2.53Å
56	S	79.8	Confident	80.1	Confident	93 Å²	93	114.1 Å²	114.1	65%	0.65	61%	0.611	S	S	*	*	H	α-helix	trans	-86.1	-10.9	179.4	-54.6	0	0	0	0	113	K52 K53 V54 P58	K52-S56 VanDerWaalsContact O-CB 3.27Å; K52-S56 WeakPolarHBondContact O-CB 3.44Å; K52-S56 PolarHBondContact O-N 3.2Å; K52-S56 PolarHBondContact O-OG 2.87Å; K53-S56 PolarHBondContact O-N 3.03Å; V54-S56 VanDerWaalsContact C-N 3.29Å; V54-S56 PolarHBondContact O-N 3.37Å; S56-P58 WeakPolarHBondContact O-CD 3.26Å
57	C	65.5	Low	79.1	Confident	87 Å²	87	116.5 Å²	116.5	59%	0.588	62%	0.623	S	S	*	*	S	Bend	trans	-65	118.7	170.2	-69.1	0	0	0	0	108.3	K53 V54 C59	K53-C57 PolarHBondContact O-N 2.99Å; K53-C57 PolarHBondContact O-SG 2.8Å; V54-C57 WeakPolarHBondContact O-CB 3.35Å; V54-C57 PolarHBondContact O-N 3.12Å; C57-C59 PolarHBondContact O-N 2.9Å
58	P	62.7	Low	77.9	Confident	118 Å²	118	119.2 Å²	119.2	77%	0.766	65%	0.645	S	S	*	*	P	Polyproline II helix	trans	-58.3	127.5	175.1	22.6	-30.3	0	0	0	108.1	S56 P60	S56-P58 WeakPolarHBondContact O-CD 3.26Å; P58-P60 WeakPolarHBondContact O-CD 3.38Å; P58-P60 VanDerWaalsContact O-N 3.14Å
59	C	58.8	Low	76.6	Confident	115 Å²	115	125.2 Å²	125.2	78%	0.777	68%	0.675	S	S	*	*	P	Polyproline II helix	trans	-54.5	121.6	172.8	-162.2	0	0	0	0	107	C57 E61	C57-C59 PolarHBondContact O-N 2.9Å; C59-E61 PolarHBondContact O-N 3.09Å; C59-E61 VanDerWaalsContact O-N 3.13Å
60	P	61.2	Low	75.1	Confident	113 Å²	113	126.7 Å²	126.7	73%	0.734	69%	0.688	S	S	*	*	P	Polyproline II helix	trans	-59.2	123.4	171.7	23	-29.5	0	0	0	107	P58	P58-P60 WeakPolarHBondContact O-CD 3.38Å; P58-P60 VanDerWaalsContact O-N 3.14Å
61	E	50.1	Low	73.5	Confident	179 Å²	179	128.6 Å²	128.6	84%	0.836	71%	0.705	S	S	*	*	P	Polyproline II helix	trans	-52	134.1	175.8	-85.3	-160.5	117.4	0	0	109.1	C59 R63	C59-E61 PolarHBondContact O-N 3.09Å; C59-E61 VanDerWaalsContact O-N 3.13Å; E61-R63 PolarHBondContact O-N 3.45Å; E61-R63 VanDerWaalsContact O-N 3.14Å
62	P	61.3	Low	71.6	Confident	123 Å²	123	134.8 Å²	134.8	80%	0.799	74%	0.736	S	S	*	*	P	Polyproline II helix	trans	-60.5	120.6	171.6	24.6	-30.1	0	0	0	108.2
63	R	51.2	Low	69.4	Low	314 Å²	314	134.6 Å²	134.6	100%	1.185	75%	0.749	S	S	*	*			trans	-68.5	0	166.9	-81.3	-167.5	-66.6	-139.2	-3.3	110.9	E61	E61-R63 PolarHBondContact O-N 3.45Å; E61-R63 VanDerWaalsContact O-N 3.14Å

Retrieved 63 of 63 residues in 37.6 ms (Link to these results)

U.S. Privacy Notice - Disclaimer / Registrations / Copyright Statement - Linking Policy - Notice of Privacy Practices (HIPAA) - Notice of Non‑Discrimination
© Copyright 2026 St. Jude Children's Research Hospital, a not-for-profit, section 501(c)(3).