A0A087WPM3_MOUSE Loading...

Integrin-linked kinase-associated serine/threonine phosphatase 2C

AlphaFold DB , UniProt , Accession A0A087WPM3, Species MOUSE (Mus musculus, Mouse), Gene Ilkap, Length 78 aa.

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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1M61.6Low68.8Low220 Ų220150.7 Ų150.7100%1.08481%0.806SS**  0120.207.272.190.700105.3L3M1-L3 VanDerWaalsContact O-N 3.13Å; M1-L3 PolarHBondContact O-N 3.13Å
2D73.9Confident68.1Low154 Ų154153.5 Ų153.582%0.82480%0.797SS**  trans-65.6114.3-170.1-62.5-46.3000110.1F4D2-F4 PolarHBondContact O-N 3.26Å
3L74.8Confident67.7Low159 Ų159147.5 Ų147.583%0.83278%0.784SS**THydrogen-bonded Turntrans-73.8-4.6-179.1-173.457.3000112.7M1M1-L3 VanDerWaalsContact O-N 3.13Å; M1-L3 PolarHBondContact O-N 3.13Å
4F71.4Confident66.9Low188 Ų188145.7 Ų145.783%0.82579%0.785SS**THydrogen-bonded Turntrans-95.47.8-177.7-63.3-82.5000113.4D2D2-F4 PolarHBondContact O-N 3.26Å
5G65.4Low66.6Low62 Ų62147.7 Ų147.764%0.63978%0.776SS**SBendtrans-80-15-174.100000116.5
6D69.1Low65.8Low161 Ų161146.3 Ų146.386%0.86178%0.779SS**SBendtrans-121.110.9-172.5-64.9-39.8000114.1P8D6-P8 WeakPolarHBondContact O-CD 3.27Å
7L70.6Confident64.9Low143 Ų143143.4 Ų143.475%0.74977%0.773SS**SBendtrans-72.2121.3169.9-16871.4000106.8E9L7-E9 VanDerWaalsContact O-N 3.17Å; L7-E9 PolarHBondContact O-N 3.17Å
8P72.1Confident64.5Low101 Ų101141.7 Ų141.766%0.65678%0.782SS**PPolyproline II helixtrans-52.3131.2174.323.2-33000107.4D6D6-P8 WeakPolarHBondContact O-CD 3.27Å
9E69.4Low64.1Low172 Ų172137.6 Ų137.680%0.80478%0.775SS**PPolyproline II helixtrans-50.4125.2168.5-84.2-148.2145.800106.2L7 E11L7-E9 VanDerWaalsContact O-N 3.17Å; L7-E9 PolarHBondContact O-N 3.17Å; E9-E11 PolarHBondContact O-N 2.78Å
10P67.6Low63.8Low112 Ų112139.5 Ų139.573%0.72777%0.774SS**  trans-55.1111.8177.822.1-31.4000105.6R12P10-R12 WeakPolarHBondContact O-CA 3.44Å; P10-R12 PolarHBondContact O-N 3.06Å
11E60.5Low63.5Low186 Ų186140.2 Ų140.287%0.86977%0.772SS**THydrogen-bonded Turntrans-40.3105.5-169.8-69-173.1139.300108.4E9 A13E9-E11 PolarHBondContact O-N 2.78Å; E11-A13 VanDerWaalsContact C-N 3.34Å; E11-A13 WeakPolarHBondContact O-CA 3.47Å; E11-A13 PolarHBondContact O-N 2.82Å
12R60.8Low63.3Low184 Ų184135.1 Ų135.169%0.69477%0.765SS**THydrogen-bonded Turntrans-15.992.2-171.1-164.9-176-128.3152.91110.3P10P10-R12 WeakPolarHBondContact O-CA 3.44Å; P10-R12 PolarHBondContact O-N 3.06Å
13A62.1Low62.5Low76 Ų76136.5 Ų136.563%0.62877%0.766SS**  trans-41.3135.2-174.100000108.3E11 R15E11-A13 VanDerWaalsContact C-N 3.34Å; E11-A13 WeakPolarHBondContact O-CA 3.47Å; E11-A13 PolarHBondContact O-N 2.82Å; A13-R15 PolarHBondContact O-N 2.78Å
14P57.6Low61.5Low122 Ų122131.9 Ų131.979%0.79276%0.757SS**  trans-42.7108.7-167.2-26.629.4000108.6P16P14-P16 VanDerWaalsContact O-CD 3.27Å; P14-P16 WeakPolarHBondContact O-CD 3.43Å
15R61.5Low60.8Low175 Ų175131.7 Ų131.766%0.6675%0.751SS**  trans-53.2117172.4-79-173.3-97.5-175-6.8102.8A13 S17A13-R15 PolarHBondContact O-N 2.78Å; R15-S17 VanDerWaalsContact C-N 3.3Å; R15-S17 PolarHBondContact O-N 2.79Å
16P54.3Low60.5Low126 Ų126132.8 Ų132.882%0.81875%0.747SS**  trans-54.8107.6-174.318.7-29.7000105.5P14 A18P14-P16 VanDerWaalsContact O-CD 3.27Å; P14-P16 WeakPolarHBondContact O-CD 3.43Å; P16-A18 PolarHBondContact O-N 2.7Å
17S50.7Low60.1Low96 Ų96130.3 Ų130.367%0.67174%0.737SS**  trans-58119.8174.849.80000103.6R15 G19R15-S17 VanDerWaalsContact C-N 3.3Å; R15-S17 PolarHBondContact O-N 2.79Å; S17-G19 PolarHBondContact O-N 2.87Å
18A58.2Low59.7Low113 Ų113129.7 Ų129.793%0.93473%0.734SS**SBendtrans-44.7112173.700000108.3P16P16-A18 PolarHBondContact O-N 2.7Å
19G56Low59.1Low64 Ų64132.1 Ų132.166%0.6674%0.735SS**  trans104.476.6-179.700000115.2S17S17-G19 PolarHBondContact O-N 2.87Å
20K58.4Low58.7Low175 Ų175129.7 Ų129.776%0.76172%0.723SS**SBend-179.7110.4116.3-120.2135.8160.7168.50110.6A22K20-A22 PolarHBondContact O-N 3.03Å
21E57.1Low58.5Low156 Ų156131.4 Ų131.473%0.72973%0.726SS**  trans54.662.8133.4-57.2169.4-142.300116.5Q23E21-Q23 PolarHBondContact O-N 3.38Å
22A57Low58.6Low112 Ų112128 Ų12893%0.92671%0.714SS**  trans-76.859.114800000109.1K20K20-A22 PolarHBondContact O-N 3.03Å
23Q56.9Low58.8Low184 Ų184124.4 Ų124.486%0.8671%0.714SS**  trans-106.995.7169.3-75.2-111.1-2.400106.3E21E21-Q23 PolarHBondContact O-N 3.38Å
24G53.8Low58.7Low62 Ų62126.3 Ų126.364%0.63972%0.72SS**  trans14594.2172.600000112.3
25R58Low58.6Low183 Ų183125 Ų12569%0.69172%0.719SS**SBendtrans-48.1138.3141.7-74.8168.167.5176.7-0.4106.4V27 E30R25-V27 PolarHBondContact O-N 2.68Å; R25-V27 WeakPolarHBondContact O-CG2 3.32Å; R25-E30 IonicContact CZ-OE1 3.6Å; R25-E30 IonicContact NH2-OE1 2.68Å; R25-E30 PolarHBondContact NH2-OE1 2.84Å; R25-E30 IonicContact NH2-OE2 3.83Å
26P59.6Low58.1Low86 Ų86121.9 Ų121.956%0.55872%0.724SS**  trans-58.1106.9172.924-31.5000107.6L28P26-L28 PolarHBondContact O-N 2.81Å
27V60Low57.9Low108 Ų108120.9 Ų120.966%0.65572%0.72SS**THydrogen-bonded Turntrans-70.618.7-174.5-145.20000111.9R25R25-V27 PolarHBondContact O-N 2.68Å; R25-V27 WeakPolarHBondContact O-CG2 3.32Å
28L61.3Low58.3Low130 Ų130122 Ų12268%0.68172%0.723SS**THydrogen-bonded Turntrans-90.8-13.9-174.4-58.7179.3000112.7P26 L32P26-L28 PolarHBondContact O-N 2.81Å; L28-L32 WeakPolarHBondContact O-CG 3.45Å; L28-L32 WeakPolarHBondContact O-CD1 3.47Å
29F60.5Low57.9Low153 Ų153123.1 Ų123.167%0.67171%0.713SS**SBendtrans-109.6-2.8-179.8-59.6-72.3000113.9
30E60.4Low58.1Low121 Ų121125.1 Ų125.157%0.56572%0.717SS**SBendtrans-101.8-12.7-179.3-51.6-63.3155.200112.5R25R25-E30 IonicContact CZ-OE1 3.6Å; R25-E30 IonicContact NH2-OE1 2.68Å; R25-E30 PolarHBondContact NH2-OE1 2.84Å; R25-E30 IonicContact NH2-OE2 3.83Å
31D64Low58.1Low148 Ų148119.7 Ų119.779%0.79171%0.711SS**SBendtrans-114.715.1177.4-150.428.8000112.6
32L63.4Low58.3Low115 Ų115118.5 Ų118.560%0.60272%0.72SS**SBendtrans-93.4127.2164.7-64.2178.2000107.6L28L28-L32 WeakPolarHBondContact O-CG 3.45Å; L28-L32 WeakPolarHBondContact O-CD1 3.47Å
33P63.2Low58.5Low107 Ų107116.4 Ų116.470%0.69571%0.709SS**PPolyproline II helixtrans-55.4138.3165.425.9-32.4000107.1A35P33-A35 PolarHBondContact O-N 2.85Å
34P61.7Low59Low116 Ų116110.1 Ų110.175%0.75369%0.694SS**PPolyproline II helixtrans-49.9122.7176.320.3-31000107.2S36P34-S36 VanDerWaalsContact C-N 3.34Å; P34-S36 PolarHBondContact O-N 3.26Å
35A53.7Low59.5Low94 Ų94111.1 Ų111.178%0.77769%0.689SS**SBendtrans-51.7103.3-177.600000108.3P33 S37P33-A35 PolarHBondContact O-N 2.85Å; A35-S37 PolarHBondContact O-N 2.93Å
36S53Low59.9Low110 Ų110108.9 Ų108.977%0.76969%0.69SS**  trans27.164.1162.5-165.20000114.8P34 T38P34-S36 VanDerWaalsContact C-N 3.34Å; P34-S36 PolarHBondContact O-N 3.26Å; S36-T38 PolarHBondContact O-N 2.91Å; S36-T38 VanDerWaalsContact O-N 3.13Å
37S50.2Low60Low106 Ų106112.6 Ų112.674%0.74171%0.705SS**  trans-8090.2155.4-72.90000106.8A35 D39A35-S37 PolarHBondContact O-N 2.93Å; S37-D39 PolarHBondContact O-N 2.73Å
38T57.3Low59.9Low118 Ų118114.3 Ų114.372%0.72470%0.703SS**  trans-62.467.6154.1-179.80000109.3S36 S40S36-T38 PolarHBondContact O-N 2.91Å; S36-T38 VanDerWaalsContact O-N 3.13Å; T38-S40 PolarHBondContact O-N 2.99Å; T38-S40 PolarHBondContact O-OG 3.15Å
39D49.5Very low59.9Low137 Ų137114.4 Ų114.473%0.73371%0.705SS**  trans-92.385163.1-168.654.3000106.1S37 G41S37-D39 PolarHBondContact O-N 2.73Å; D39-G41 VanDerWaalsContact C-N 3.27Å; D39-G41 PolarHBondContact O-N 3.49Å
40S61.2Low60Low106 Ų106114.5 Ų114.574%0.74171%0.712SS**  47.150.885.8-61.90000112.9T38T38-S40 PolarHBondContact O-N 2.99Å; T38-S40 PolarHBondContact O-OG 3.15Å
41G57.4Low60.3Low61 Ų61113.9 Ų113.963%0.62971%0.712SS**  trans-142.882.2173.400000112.5D39 G43D39-G41 VanDerWaalsContact C-N 3.27Å; D39-G41 PolarHBondContact O-N 3.49Å; G41-G43 PolarHBondContact O-N 3.13Å
42S63.1Low60.3Low131 Ų131112.1 Ų112.192%0.91671%0.709SS**  trans-13.888.4156.4163.50000115.2
43G61.1Low60.5Low68 Ų68112.5 Ų112.570%0.70172%0.718SS**  trans-114.647.7-176.300000114G41G41-G43 PolarHBondContact O-N 3.13Å
44G66.7Low60.3Low53 Ų53111.7 Ų111.755%0.54672%0.721SS.*  trans75.9146167.400000115.3L46G44-L46 PolarHBondContact O-N 3.1Å
45P63.9Low60.1Low82 Ų82111.4 Ų111.453%0.53273%0.728SS.*  trans-65107.3174.428.5-31.4000108.6L47 F48P45-L47 PolarHBondContact O-N 2.94Å; P45-L47 VanDerWaalsContact O-N 3.1Å; P45-F48 HydrophobicContact CB-CD2 4.2Å
46L66.4Low60.6Low137 Ų137112.5 Ų112.572%0.71773%0.73SS**SBendtrans-51.1116.3172.9-61.2172.8000109.6G44 F48G44-L46 PolarHBondContact O-N 3.1Å; L46-F48 WeakPolarHBondContact O-CD2 3.41Å; L46-F48 WeakPolarHBondContact O-CE2 2.99Å; L46-F48 PolarHBondContact O-N 3.2Å
47L61.8Low60.9Low164 Ų164110.7 Ų110.786%0.85973%0.728SS**SBendtrans57.17.9160.5-54.3174.4000117.2P45P45-L47 PolarHBondContact O-N 2.94Å; P45-L47 VanDerWaalsContact O-N 3.1Å
48F57.2Low60.7Low143 Ų143112.8 Ų112.863%0.62773%0.732SS**G310 helixtrans-83.2-3.7167.8-60.8-74.6000112P45 L46 D50 L51P45-F48 HydrophobicContact CB-CD2 4.2Å; L46-F48 WeakPolarHBondContact O-CD2 3.41Å; L46-F48 WeakPolarHBondContact O-CE2 2.99Å; L46-F48 PolarHBondContact O-N 3.2Å; F48-D50 PolarHBondContact O-N 3.35Å; F48-L51 HydrophobicContact CD1-CD1 4.18Å; F48-L51 PolarHBondContact O-N 2.78Å
49D62.8Low60.8Low132 Ų132113.1 Ų113.171%0.70674%0.739SS**G310 helixtrans-69.6-10.2-178.4-66.4-38.7000113.5
50D61.8Low60.7Low155 Ų155108.9 Ų108.983%0.82973%0.727SS**G310 helixtrans-132.333.1173.4-144.110.2000113.1F48F48-D50 PolarHBondContact O-N 3.35Å
51L66.3Low60.6Low108 Ų108108.4 Ų108.457%0.56572%0.724SS**SBendtrans-108.5133.5160.5-65.5178.6000107.7F48 P53F48-L51 HydrophobicContact CD1-CD1 4.18Å; F48-L51 PolarHBondContact O-N 2.78Å; L51-P53 VanDerWaalsContact O-N 3.17Å
52P65.5Low60.4Low111 Ų111114.5 Ų114.572%0.72173%0.733SS**  trans-53.6131.7169.825.4-32.8000106.5A54P52-A54 PolarHBondContact O-N 2.6Å
53P67.4Low59.8Low124 Ų124112.6 Ų112.681%0.80572%0.719SS**  trans-49.4117.1-176.315.8-28.6000107.4L51 A55L51-P53 VanDerWaalsContact O-N 3.17Å; P53-A55 PolarHBondContact O-N 2.95Å
54A57.9Low59.1Low90 Ų90121.8 Ų121.874%0.74473%0.733SS**  trans-49115.3175.800000104.9P52 S56P52-A54 PolarHBondContact O-N 2.6Å; A54-S56 PolarHBondContact O-N 2.88Å; A54-S56 WeakPolarHBondContact O-CB 3.47Å
55A58.6Low58.6Low109 Ų109127 Ų12790%0.90175%0.748SS**  trans-6381.1-166.800000109.6P53 G57P53-A55 PolarHBondContact O-N 2.95Å; A55-G57 PolarHBondContact O-N 3.4Å
56S62.6Low58.2Low117 Ų117126.7 Ų126.782%0.81875%0.751SS**  trans-95.392.2-179.1179.40000105.8A54A54-S56 PolarHBondContact O-N 2.88Å; A54-S56 WeakPolarHBondContact O-CB 3.47Å
57G60.3Low57.8Low72 Ų72127 Ų12774%0.74276%0.759SS**  trans61.994.8150.700000116.5A55A55-G57 PolarHBondContact O-N 3.4Å
58N46.1Very low57.4Low151 Ų151122 Ų12281%0.80775%0.748SS**  -133.3113124.3-164.839.8000109.8G60N58-G60 PolarHBondContact O-N 3.1Å
59S58.6Low57.1Low125 Ų125124.1 Ų124.187%0.87476%0.757SS**  trans-6393.5158.7-178.60000106.9
60G47.9Very low57Low47 Ų47123.1 Ų123.149%0.48576%0.76SS.*  trans-140.989.9177.500000107.7N58N58-G60 PolarHBondContact O-N 3.1Å
61S59.4Low56.9Low97 Ų97126.2 Ų126.268%0.67876%0.76SS**  trans-29.6140.8147.4176.40000111.4
62F52.8Low56.9Low188 Ų188126 Ų12683%0.82577%0.768SS**  trans77.5104.8-176.1-55-86.4000113.9
63C51.6Low57Low91 Ų91127.7 Ų127.762%0.61577%0.77SS**  -166.564.677.5-138.20000112.7L65C63-L65 PolarHBondContact O-N 2.88Å; C63-L65 VanDerWaalsContact O-N 3.1Å
64W46Very low56.8Low261 Ų261127.1 Ų127.199%0.98977%0.766SS**THydrogen-bonded Turntrans-69.25.9164-80.789.8000113.1
65L56.7Low57Low164 Ų164131 Ų13186%0.85977%0.769SS**THydrogen-bonded Turntrans-108.92-174.7-112.194.3000115.3C63C63-L65 PolarHBondContact O-N 2.88Å; C63-L65 VanDerWaalsContact O-N 3.1Å
66A55.4Low57.1Low74 Ų74135.8 Ų135.861%0.61277%0.769SS**SBendtrans-103.25.1-173.100000116
67T57.2Low56.9Low145 Ų145139.3 Ų139.389%0.8977%0.77SS**SBendtrans-135.659.517354.20000111.4
68G53.8Low56.8Low59 Ų59147.5 Ų147.561%0.60880%0.796SS**  trans-170.644.3178.100000113.4S70G68-S70 PolarHBondContact O-N 2.95Å
69F50.5Low57.3Low186 Ų186147.4 Ų147.482%0.81680%0.795SS**  trans-37.9111.4162.7-178.8-99.9000109.3R71F69-R71 HydrophobicContact CD1-CG 3.98Å; F69-R71 HydrophobicContact CE1-CG 4.21Å; F69-R71 PolarHBondContact O-N 3.17Å
70S60.2Low57.3Low112 Ų112148.5 Ų148.578%0.78379%0.791SS**  trans-56.395.4-178.2-55.50000110.2G68 S72G68-S70 PolarHBondContact O-N 2.95Å; S70-S72 VanDerWaalsContact C-N 3.3Å; S70-S72 PolarHBondContact O-N 2.86Å
71R60Low57.8Low220 Ų220154.2 Ų154.283%0.8381%0.808SS**  trans-85.687.9161.6-71.9-165.5-67.7-137.8-1.2107.9F69 L73F69-R71 HydrophobicContact CD1-CG 3.98Å; F69-R71 HydrophobicContact CE1-CG 4.21Å; F69-R71 PolarHBondContact O-N 3.17Å; R71-L73 PolarHBondContact O-N 3.2Å
72S66.3Low57.7Low103 Ų103157.5 Ų157.572%0.7282%0.815SS**  trans-26.7112.6159-179.50000111.7S70 P74S70-S72 VanDerWaalsContact C-N 3.3Å; S70-S72 PolarHBondContact O-N 2.86Å; S72-P74 VanDerWaalsContact O-CD 3.32Å; S72-P74 WeakPolarHBondContact O-CD 3.32Å
73L67.9Low58Low146 Ų146155.6 Ų155.676%0.76482%0.815SS**  trans-75.6116162.4-94.9143.1000107.2R71 Q75R71-L73 PolarHBondContact O-N 3.2Å; L73-Q75 PolarHBondContact O-N 2.95Å
74P62.1Low58.4Low112 Ų112159.9 Ų159.973%0.72783%0.828SS**  trans-68.3101.4164.527.3-30.5000108.2S72 K76S72-P74 VanDerWaalsContact O-CD 3.32Å; S72-P74 WeakPolarHBondContact O-CD 3.32Å; P74-K76 VanDerWaalsContact C-N 3.3Å; P74-K76 PolarHBondContact O-N 2.95Å
75Q63.1Low59.3Low172 Ų172152.7 Ų152.780%0.80482%0.817SS**  trans-61.794.5160.8-72.3-80-2400107.4L73 K77L73-Q75 PolarHBondContact O-N 2.95Å; Q75-K77 PolarHBondContact O-N 3.42Å
76K60.6Low59.5Low209 Ų209151.8 Ų151.891%0.90981%0.814SS**  trans-94.988.9168.5-140171.3-176-169.70108.1P74P74-K76 VanDerWaalsContact C-N 3.3Å; P74-K76 PolarHBondContact O-N 2.95Å
77K58Low59.8Low191 Ų191158.3 Ų158.383%0.8383%0.83SS**  trans-90.2109.1166.4-171.6172.5-171.2176.80107.5Q75Q75-K77 PolarHBondContact O-N 3.42Å
78L58.3Low60.1Low245 Ų245159.5 Ų159.5100%1.28383%0.825SS**  trans-157.20142.7-141.779.7000109.1

Retrieved 78 of 78 residues in 84.6 ms (Link to these results)