A0A087WQL9_MOUSE Loading...

Lysine (K)-specific demethylase 2A

AlphaFold DB , UniProt , Accession A0A087WQL9, Species MOUSE (Mus musculus, Mouse), Gene Kdm2a, Length 35 aa.

						>A0A087WQL9_MOUSE|A0A087WQL9|Kdm2a
MEPEEERIRYSQRLVDLCRGQPNIQSHFQDSQGTR
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	60.8	Low	87.7	Confident	155 Å²	155	115 Å²	115	76%	0.764	54%	0.542	S	S	*	.				0	117.3	0	-167.9	-165.4	-77.3	0	0	105	E6 R9	M1-E6 HydrophobicContact SD-CB 4.25Å; M1-R9 PolarHBondContact SD-NH2 3.09Å
2	E	82.1	Confident	88.1	Confident	127 Å²	127	114.5 Å²	114.5	59%	0.593	54%	0.539	S	S	*	.			trans	-70.8	136.2	-175.2	-69.1	-57.8	123.9	0	0	109.9	E4 E5 E6	E2-E4 PolarHBondContact O-N 2.85Å; E2-E5 HydrophobicContact CB-CG 4.09Å; E2-E5 PolarHBondContact N-OE2 3.4Å; E2-E5 WeakPolarHBondContact O-CB 3.45Å; E2-E5 PolarHBondContact O-N 2.8Å; E2-E6 PolarHBondContact O-N 2.9Å
3	P	83.5	Confident	88.4	Confident	101 Å²	101	120.3 Å²	120.3	66%	0.656	55%	0.553	S	S	*	*	H	α-helix	trans	-54	-27.9	-179.2	-27.7	34.5	0	0	0	114.1	R7	P3-R7 PolarHBondContact O-N 3.36Å
4	E	90.8	Very high	88.6	Confident	115 Å²	115	116.9 Å²	116.9	54%	0.537	54%	0.54	S	S	.	.	H	α-helix	trans	-71.1	-39.8	177.3	178.7	155.1	-138.2	0	0	113.1	E2 E6 R7 I8	E2-E4 PolarHBondContact O-N 2.85Å; E4-E6 PolarHBondContact O-N 3.32Å; E4-E6 VanDerWaalsContact C-N 3.27Å; E4-R7 PolarHBondContact O-N 3.05Å; E4-R7 IonicContact OE1-NH2 3.09Å; E4-R7 PolarHBondContact OE1-NH2 3.49Å; E4-R7 VanDerWaalsContact OE1-NH2 3.09Å; E4-I8 HydrophobicContact CG-CD1 3.95Å; E4-I8 VanDerWaalsContact O-CG1 3.29Å; E4-I8 WeakPolarHBondContact O-CG1 3.49Å; E4-I8 PolarHBondContact O-N 3.12Å
5	E	90.6	Very high	88.6	Confident	99 Å²	99	113.8 Å²	113.8	46%	0.463	53%	0.533	S	S	.	.	H	α-helix	trans	-67.2	-31.3	177.6	-64.6	177.6	150.5	0	0	111.8	E2 R9	E2-E5 HydrophobicContact CB-CG 4.09Å; E2-E5 PolarHBondContact N-OE2 3.4Å; E2-E5 WeakPolarHBondContact O-CB 3.45Å; E2-E5 PolarHBondContact O-N 2.8Å; E5-R9 IonicContact OE2-NH2 3.91Å; E5-R9 PolarHBondContact O-NE 3.33Å; E5-R9 WeakPolarHBondContact O-CG 3.32Å; E5-R9 WeakPolarHBondContact O-CB 3.29Å; E5-R9 PolarHBondContact O-N 3.36Å
6	E	91.2	Very high	88.5	Confident	120 Å²	120	112.9 Å²	112.9	56%	0.561	53%	0.533	S	S	*	.	H	α-helix	trans	-70.4	-44.2	174.4	-173.1	171.7	-160.9	0	0	111	M1 E2 E4 I8 R9 Y10	M1-E6 HydrophobicContact SD-CB 4.25Å; E2-E6 PolarHBondContact O-N 2.9Å; E4-E6 PolarHBondContact O-N 3.32Å; E4-E6 VanDerWaalsContact C-N 3.27Å; E6-I8 VanDerWaalsContact C-N 3.34Å; E6-I8 PolarHBondContact O-N 2.78Å; E6-R9 PolarHBondContact O-N 2.71Å; E6-Y10 WeakPolarHBondContact O-CB 3.5Å; E6-Y10 PolarHBondContact O-N 3Å
7	R	92.9	Very high	88.3	Confident	150 Å²	150	113 Å²	113	57%	0.566	54%	0.537	S	S	*	.	H	α-helix	trans	-59.5	-44.2	175.2	-173.8	-176.5	67.1	-170.6	-3.1	111.9	P3 E4 Y10 S11	P3-R7 PolarHBondContact O-N 3.36Å; E4-R7 PolarHBondContact O-N 3.05Å; E4-R7 IonicContact OE1-NH2 3.09Å; E4-R7 PolarHBondContact OE1-NH2 3.49Å; E4-R7 VanDerWaalsContact OE1-NH2 3.09Å; R7-Y10 PolarHBondContact O-N 2.91Å; R7-S11 WeakPolarHBondContact O-CB 3.3Å; R7-S11 PolarHBondContact O-N 3.08Å; R7-S11 PolarHBondContact O-OG 2.99Å; R7-S11 VanDerWaalsContact O-OG 3.09Å
8	I	93.4	Very high	88.1	Confident	77 Å²	77	111.8 Å²	111.8	40%	0.395	54%	0.541	S	S	.	.	H	α-helix	trans	-62.4	-46.6	178.7	-69.8	165.1	0	0	0	110.5	E4 E6 Y10 S11 Q12	E4-I8 HydrophobicContact CG-CD1 3.95Å; E4-I8 VanDerWaalsContact O-CG1 3.29Å; E4-I8 WeakPolarHBondContact O-CG1 3.49Å; E4-I8 PolarHBondContact O-N 3.12Å; E6-I8 VanDerWaalsContact C-N 3.34Å; E6-I8 PolarHBondContact O-N 2.78Å; I8-Y10 PolarHBondContact O-N 3.41Å; I8-S11 PolarHBondContact O-N 3.38Å; I8-Q12 VanDerWaalsContact CG2-NE2 3.33Å; I8-Q12 VanDerWaalsContact O-CG 3.3Å; I8-Q12 WeakPolarHBondContact O-CG 3.45Å; I8-Q12 PolarHBondContact O-N 3.25Å
9	R	92.8	Very high	87.8	Confident	115 Å²	115	116.2 Å²	116.2	43%	0.434	55%	0.551	S	S	.	*	H	α-helix	trans	-63.1	-40.3	177.7	-81	-179.1	-83.4	-177	-16	112.9	M1 E5 E6 Q12 R13	M1-R9 PolarHBondContact SD-NH2 3.09Å; E5-R9 IonicContact OE2-NH2 3.91Å; E5-R9 PolarHBondContact O-NE 3.33Å; E5-R9 WeakPolarHBondContact O-CG 3.32Å; E5-R9 WeakPolarHBondContact O-CB 3.29Å; E5-R9 PolarHBondContact O-N 3.36Å; E6-R9 PolarHBondContact O-N 2.71Å; R9-Q12 PolarHBondContact O-N 3.48Å; R9-R13 PolarHBondContact O-N 3.21Å
10	Y	93.1	Very high	87.2	Confident	147 Å²	147	113.6 Å²	113.6	58%	0.576	56%	0.557	S	S	*	*	H	α-helix	trans	-62.5	-47.9	175.8	179.8	-101.9	0	0	0	111.4	E6 R7 I8 Q12 R13 L14	E6-Y10 WeakPolarHBondContact O-CB 3.5Å; E6-Y10 PolarHBondContact O-N 3Å; R7-Y10 PolarHBondContact O-N 2.91Å; I8-Y10 PolarHBondContact O-N 3.41Å; Y10-Q12 PolarHBondContact O-N 2.89Å; Y10-R13 PolarHBondContact O-N 3.48Å; Y10-L14 VanDerWaalsContact O-N 3.08Å; Y10-L14 PolarHBondContact O-N 3.35Å; Y10-L14 HydrophobicContact CE1-CG 4.11Å; Y10-L14 HydrophobicContact CE1-CD1 3.44Å; Y10-L14 VanDerWaalsContact CE1-CD1 3.44Å; Y10-L14 HydrophobicContact CD1-CD1 4.04Å
11	S	93.8	Very high	86.2	Confident	59 Å²	59	113.9 Å²	113.9	41%	0.413	56%	0.557	S	S	.	*	H	α-helix	trans	-61	-42	177.2	-64.5	0	0	0	0	112.5	R7 I8 R13 L14 V15	R7-S11 WeakPolarHBondContact O-CB 3.3Å; R7-S11 PolarHBondContact O-N 3.08Å; R7-S11 PolarHBondContact O-OG 2.99Å; R7-S11 VanDerWaalsContact O-OG 3.09Å; I8-S11 PolarHBondContact O-N 3.38Å; S11-R13 PolarHBondContact O-N 3.31Å; S11-L14 PolarHBondContact O-N 3.23Å; S11-V15 WeakPolarHBondContact O-CG2 3.42Å; S11-V15 PolarHBondContact O-N 3.25Å; S11-V15 VanDerWaalsContact O-N 3.1Å
12	Q	92.6	Very high	86.2	Confident	109 Å²	109	111.7 Å²	111.7	51%	0.509	55%	0.554	S	S	.	*	H	α-helix	trans	-60.3	-44.9	175.7	-74.7	165.1	-6.6	0	0	111.5	I8 R9 Y10 L14 V15 D16	I8-Q12 VanDerWaalsContact CG2-NE2 3.33Å; I8-Q12 VanDerWaalsContact O-CG 3.3Å; I8-Q12 WeakPolarHBondContact O-CG 3.45Å; I8-Q12 PolarHBondContact O-N 3.25Å; R9-Q12 PolarHBondContact O-N 3.48Å; Y10-Q12 PolarHBondContact O-N 2.89Å; Q12-L14 VanDerWaalsContact C-N 3.33Å; Q12-L14 PolarHBondContact O-N 3.44Å; Q12-V15 PolarHBondContact O-N 3.19Å; Q12-D16 PolarHBondContact O-N 3.14Å
13	R	92	Very high	85.1	Confident	190 Å²	190	112 Å²	112	72%	0.717	56%	0.56	S	S	*	*	H	α-helix	trans	-61.2	-38.8	177.5	-174.1	179.8	-69.5	178.6	-2.1	112.8	R9 Y10 S11 L17	R9-R13 PolarHBondContact O-N 3.21Å; Y10-R13 PolarHBondContact O-N 3.48Å; S11-R13 PolarHBondContact O-N 3.31Å; R13-L17 WeakPolarHBondContact O-CB 3.4Å; R13-L17 PolarHBondContact O-N 2.98Å
14	L	90.3	Very high	84	Confident	72 Å²	72	113.5 Å²	113.5	38%	0.377	56%	0.561	S	S	.	*	H	α-helix	trans	-66	-41.4	176	-70	-178.5	0	0	0	112	Y10 S11 Q12 L17 C18	Y10-L14 VanDerWaalsContact O-N 3.08Å; Y10-L14 PolarHBondContact O-N 3.35Å; Y10-L14 HydrophobicContact CE1-CG 4.11Å; Y10-L14 HydrophobicContact CE1-CD1 3.44Å; Y10-L14 VanDerWaalsContact CE1-CD1 3.44Å; Y10-L14 HydrophobicContact CD1-CD1 4.04Å; S11-L14 PolarHBondContact O-N 3.23Å; Q12-L14 VanDerWaalsContact C-N 3.33Å; Q12-L14 PolarHBondContact O-N 3.44Å; L14-L17 PolarHBondContact O-N 3.48Å; L14-C18 PolarHBondContact O-N 2.95Å; L14-C18 PolarHBondContact O-SG 3.09Å
15	V	88.5	Confident	82.6	Confident	71 Å²	71	115.8 Å²	115.8	43%	0.43	57%	0.572	S	S	.	*	H	α-helix	trans	-62.7	-44	176.8	171.2	0	0	0	0	110.9	S11 Q12 L17 C18 R19	S11-V15 WeakPolarHBondContact O-CG2 3.42Å; S11-V15 PolarHBondContact O-N 3.25Å; S11-V15 VanDerWaalsContact O-N 3.1Å; Q12-V15 PolarHBondContact O-N 3.19Å; V15-L17 VanDerWaalsContact C-N 3.33Å; V15-L17 PolarHBondContact O-N 3.18Å; V15-C18 PolarHBondContact O-N 3.49Å; V15-R19 HydrophobicContact CG1-CG 4.37Å; V15-R19 WeakPolarHBondContact O-CB 3.47Å; V15-R19 VanDerWaalsContact O-CG 3.32Å; V15-R19 WeakPolarHBondContact O-CG 3.3Å; V15-R19 PolarHBondContact O-N 3.1Å
16	D	87	Confident	80.9	Confident	100 Å²	100	114.3 Å²	114.3	54%	0.535	57%	0.573	S	S	.	*	H	α-helix	trans	-63.7	-39.9	178.1	-68.2	-24.5	0	0	0	111.9	Q12 C18 R19 G20	Q12-D16 PolarHBondContact O-N 3.14Å; D16-C18 PolarHBondContact O-N 3.18Å; D16-R19 PolarHBondContact O-N 3.04Å; D16-G20 PolarHBondContact O-N 3.05Å
17	L	86.4	Confident	79.5	Confident	114 Å²	114	115.5 Å²	115.5	60%	0.597	58%	0.578	S	S	*	*	H	α-helix	trans	-61.4	-43.3	174.2	-177.3	64.5	0	0	0	111.8	R13 L14 V15 Q21	R13-L17 WeakPolarHBondContact O-CB 3.4Å; R13-L17 PolarHBondContact O-N 2.98Å; L14-L17 PolarHBondContact O-N 3.48Å; V15-L17 VanDerWaalsContact C-N 3.33Å; V15-L17 PolarHBondContact O-N 3.18Å; L17-Q21 VanDerWaalsContact O-CG 3.29Å; L17-Q21 WeakPolarHBondContact O-CG 3.43Å
18	C	83.3	Confident	77.9	Confident	91 Å²	91	117.4 Å²	117.4	62%	0.615	59%	0.591	S	S	*	*	H	α-helix	trans	-69.7	-32.9	178.3	-68.6	0	0	0	0	112.8	L14 V15 D16 Q21	L14-C18 PolarHBondContact O-N 2.95Å; L14-C18 PolarHBondContact O-SG 3.09Å; V15-C18 PolarHBondContact O-N 3.49Å; D16-C18 PolarHBondContact O-N 3.18Å; C18-Q21 PolarHBondContact O-N 3.29Å
19	R	82.4	Confident	76.3	Confident	195 Å²	195	122.2 Å²	122.2	74%	0.736	61%	0.611	S	S	*	*	H	α-helix	trans	-69.6	-31.6	177.8	-78.2	174.6	175	-175.4	-1.7	113.3	V15 D16 Q21	V15-R19 HydrophobicContact CG1-CG 4.37Å; V15-R19 WeakPolarHBondContact O-CB 3.47Å; V15-R19 VanDerWaalsContact O-CG 3.32Å; V15-R19 WeakPolarHBondContact O-CG 3.3Å; V15-R19 PolarHBondContact O-N 3.1Å; D16-R19 PolarHBondContact O-N 3.04Å; R19-Q21 VanDerWaalsContact C-N 3.31Å
20	G	76.7	Confident	74.8	Confident	64 Å²	64	122.4 Å²	122.4	66%	0.66	62%	0.621	S	S	*	*	T	Hydrogen-bonded Turn	trans	-82	-6.1	176.2	0	0	0	0	0	114.2	D16 P22	D16-G20 PolarHBondContact O-N 3.05Å; G20-P22 WeakPolarHBondContact O-CD 3.49Å
21	Q	65.8	Low	73.1	Confident	120 Å²	120	121.3 Å²	121.3	56%	0.561	64%	0.635	S	S	*	*	S	Bend	trans	-73.8	122.2	175.6	-63.7	-127	-51.9	0	0	108.6	L17 C18 R19 N23	L17-Q21 VanDerWaalsContact O-CG 3.29Å; L17-Q21 WeakPolarHBondContact O-CG 3.43Å; C18-Q21 PolarHBondContact O-N 3.29Å; R19-Q21 VanDerWaalsContact C-N 3.31Å; Q21-N23 PolarHBondContact O-N 3.3Å; Q21-N23 VanDerWaalsContact O-N 3.12Å
22	P	60.8	Low	71.7	Confident	109 Å²	109	127.6 Å²	127.6	71%	0.708	66%	0.658	S	S	*	*			trans	-55.1	126.8	168.5	23.6	-30.4	0	0	0	106.5	G20 I24	G20-P22 WeakPolarHBondContact O-CD 3.49Å; P22-I24 WeakPolarHBondContact O-CG1 3.5Å; P22-I24 PolarHBondContact O-N 3.43Å
23	N	59.9	Low	69.8	Low	134 Å²	134	125.8 Å²	125.8	72%	0.717	67%	0.668	S	S	*	*			trans	-46.7	107	176.5	-168.9	7.5	0	0	0	106.7	Q21 Q25	Q21-N23 PolarHBondContact O-N 3.3Å; Q21-N23 VanDerWaalsContact O-N 3.12Å; N23-Q25 PolarHBondContact O-N 3.46Å
24	I	60.4	Low	68.1	Low	132 Å²	132	123.6 Å²	123.6	68%	0.677	68%	0.676	S	S	*	*			trans	-73.3	72.4	173.7	-56.1	173.9	0	0	0	104	P22 S26	P22-I24 WeakPolarHBondContact O-CG1 3.5Å; P22-I24 PolarHBondContact O-N 3.43Å; I24-S26 PolarHBondContact O-N 3.37Å
25	Q	60.1	Low	66.4	Low	164 Å²	164	135.2 Å²	135.2	77%	0.766	72%	0.715	S	S	*	*			trans	-63.7	74.7	150.4	-83.8	-174.8	-46.3	0	0	105	N23 H27	N23-Q25 PolarHBondContact O-N 3.46Å; Q25-H27 VanDerWaalsContact C-N 3.28Å; Q25-H27 PolarHBondContact O-N 3.41Å
26	S	55.9	Low	65.3	Low	68 Å²	68	138.4 Å²	138.4	48%	0.476	73%	0.729	S	S	.	*			trans	-57.7	97.1	169.5	177.3	0	0	0	0	106.6	I24 F28	I24-S26 PolarHBondContact O-N 3.37Å; S26-F28 VanDerWaalsContact C-N 3.31Å; S26-F28 VanDerWaalsContact O-CD2 3.3Å; S26-F28 WeakPolarHBondContact O-CD2 3.29Å; S26-F28 PolarHBondContact O-N 2.97Å
27	H	61.5	Low	64.1	Low	144 Å²	144	140.4 Å²	140.4	67%	0.667	74%	0.739	S	S	*	*	S	Bend		40.5	54.2	121.1	-160.6	68.6	0	0	0	115.5	Q25 D30	Q25-H27 VanDerWaalsContact C-N 3.28Å; Q25-H27 PolarHBondContact O-N 3.41Å; H27-D30 IonicContact CE1-OD2 3.09Å; H27-D30 PolarHBondContact CE1-OD2 2.99Å; H27-D30 IonicContact ND1-OD2 3.59Å; H27-D30 IonicContact NE2-OD2 3.88Å
28	F	59.5	Low	62.9	Low	191 Å²	191	141.9 Å²	141.9	84%	0.838	75%	0.747	S	S	*	*			trans	-133.1	32	164.2	-71.7	-73	0	0	0	110.9	S26	S26-F28 VanDerWaalsContact C-N 3.31Å; S26-F28 VanDerWaalsContact O-CD2 3.3Å; S26-F28 WeakPolarHBondContact O-CD2 3.29Å; S26-F28 PolarHBondContact O-N 2.97Å
29	Q	59.6	Low	61.7	Low	178 Å²	178	144.9 Å²	144.9	83%	0.832	76%	0.755	S	S	*	*			trans	-101.2	8.4	169.7	-68.4	-151.8	-27.3	0	0	113.8	S31	Q29-S31 PolarHBondContact O-N 3.02Å
30	D	60.9	Low	60.4	Low	118 Å²	118	141.8 Å²	141.8	63%	0.631	76%	0.756	S	S	*	*			trans	-101.6	54.6	178.9	-55	-24.4	0	0	0	111.3	H27	H27-D30 IonicContact CE1-OD2 3.09Å; H27-D30 PolarHBondContact CE1-OD2 2.99Å; H27-D30 IonicContact ND1-OD2 3.59Å; H27-D30 IonicContact NE2-OD2 3.88Å
31	S	58.4	Low	59.3	Low	125 Å²	125	146.9 Å²	146.9	87%	0.874	76%	0.763	S	S	*	*			trans	-127.4	64.8	154.4	-78.7	0	0	0	0	108.2	Q29	Q29-S31 PolarHBondContact O-N 3.02Å
32	Q	63.2	Low	58.8	Low	191 Å²	191	148.9 Å²	148.9	89%	0.893	78%	0.777	S	S	*	*			trans	-61.3	138.5	156.7	-75.3	-125.2	-14.6	0	0	109.6
33	G	53.8	Low	58.7	Low	70 Å²	70	151.9 Å²	151.9	72%	0.722	78%	0.782	S	S	*	*			trans	118.4	90.6	150.2	0	0	0	0	0	115.3	R35	G33-R35 PolarHBondContact O-N 3.09Å
34	T	56.7	Low	58.6	Low	145 Å²	145	153.4 Å²	153.4	89%	0.89	79%	0.788	S	S	*	*			trans	-24.5	116.2	150.9	-28.1	0	0	0	0	113.9
35	R	53.2	Low	58.4	Low	315 Å²	315	155.4 Å²	155.4	100%	1.189	80%	0.798	S	S	*	*				-125.2	0	126.5	-98.6	-171.3	178.7	-172.3	0.8	108.2	G33	G33-R35 PolarHBondContact O-N 3.09Å

Retrieved 35 of 35 residues in 123.4 ms (Link to these results)

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