A0A087WTW8_HUMAN Loading...

Phosphodiesterase 1B

AlphaFold DB , UniProt , Accession A0A087WTW8, Species HUMAN (Homo sapiens, Human), Gene PDE1B, Length 50 aa.

						>A0A087WTW8_HUMAN|A0A087WTW8|PDE1B
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLPHGVIFYGSYQF
					

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(Predicted Aligned Error values between residue pairs)

Download Structure PDB PAE Table

Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	40.8	Very low	58.2	Low	237 Å²	237	156 Å²	156	100%	1.167	83%	0.83	S	S	*	*				0	97.3	0	41.1	169.8	-178.9	0	0	107.1
2	E	62.1	Low	58.4	Low	190 Å²	190	153.8 Å²	153.8	89%	0.888	82%	0.818	S	S	*	*			trans	-86	117.8	169.4	-77.2	-82.3	108.2	0	0	107
3	L	54.9	Low	58.3	Low	161 Å²	161	153.8 Å²	153.8	84%	0.843	81%	0.81	S	S	*	*			trans	-146.8	87.2	170.6	-75.8	179.6	0	0	0	109.8
4	S	60.8	Low	58.3	Low	112 Å²	112	152 Å²	152	78%	0.783	80%	0.795	S	S	*	*				140.1	136.3	119.1	-78	0	0	0	0	113.9
5	P	63.5	Low	58.2	Low	124 Å²	124	149.4 Å²	149.4	81%	0.805	80%	0.795	S	S	*	*			trans	-89.7	158	-171.5	37.5	-34.2	0	0	0	112.1
6	R	59.3	Low	58.5	Low	245 Å²	245	149.4 Å²	149.4	93%	0.925	80%	0.795	S	S	*	*			trans	129.9	111.1	148.2	-157.7	160.6	-176.2	91.9	-1.9	113
7	S	61.8	Low	58.4	Low	114 Å²	114	145.2 Å²	145.2	80%	0.797	78%	0.779	S	S	*	*			trans	-52.6	164.2	171.9	-124.3	0	0	0	0	114.3
8	P	66.5	Low	58.5	Low	98 Å²	98	143.2 Å²	143.2	64%	0.636	78%	0.775	S	S	*	*			trans	-94.1	-177.3	-148.5	41.8	-40.6	0	0	0	113.5
9	P	52.8	Low	58.5	Low	118 Å²	118	140.2 Å²	140.2	77%	0.766	77%	0.766	S	S	*	*			trans	-99.2	125.2	135	15.8	2.2	0	0	0	108.8	M11	P9-M11 PolarHBondContact O-N 3.04Å
10	E	59.8	Low	58.5	Low	155 Å²	155	139.1 Å²	139.1	72%	0.724	77%	0.766	S	S	*	*			trans	-21.7	127	157.3	-68.8	147.8	99.2	0	0	112.1	L12	E10-L12 HydrophobicContact CB-CG 4.37Å; E10-L12 PolarHBondContact O-N 3.1Å
11	M	57.6	Low	58.4	Low	162 Å²	162	139.1 Å²	139.1	80%	0.798	77%	0.765	S	S	*	*			trans	-63.1	80.3	157.3	-72.8	-170.3	-36.7	0	0	107.6	P9 E13	P9-M11 PolarHBondContact O-N 3.04Å; M11-E13 PolarHBondContact O-N 3.43Å
12	L	60.4	Low	59.3	Low	130 Å²	130	133.6 Å²	133.6	68%	0.681	74%	0.736	S	S	*	*			trans	-71.1	63.9	142.7	-59	176.8	0	0	0	106.1	E10 E14	E10-L12 HydrophobicContact CB-CG 4.37Å; E10-L12 PolarHBondContact O-N 3.1Å; L12-E14 PolarHBondContact O-N 2.67Å
13	E	57	Low	59.2	Low	154 Å²	154	132.2 Å²	132.2	72%	0.72	73%	0.734	S	S	*	*			trans	-71.8	86.5	146.3	-81.2	-163.1	98.4	0	0	104.3	M11 S15	M11-E13 PolarHBondContact O-N 3.43Å; E13-S15 PolarHBondContact O-N 2.92Å; E13-S15 PolarHBondContact O-OG 2.71Å; E13-S15 VanDerWaalsContact O-OG 3.1Å
14	E	58.7	Low	59.5	Low	128 Å²	128	131.9 Å²	131.9	60%	0.598	73%	0.725	S	S	*	*			trans	-56.6	69.4	-173.1	-154.1	166.4	132.8	0	0	110.6	L12 D16 C17	L12-E14 PolarHBondContact O-N 2.67Å; E14-D16 PolarHBondContact O-N 3.14Å; E14-D16 VanDerWaalsContact O-N 3.14Å; E14-C17 HydrophobicContact CG-CB 4Å; E14-C17 PolarHBondContact O-N 3.48Å; E14-C17 PolarHBondContact OE1-SG 3.23Å
15	S	57.7	Low	59.5	Low	113 Å²	113	131 Å²	131	79%	0.79	72%	0.719	S	S	*	*	T	Hydrogen-bonded Turn	trans	-82.6	28.1	174.2	-54.8	0	0	0	0	110.6	E13	E13-S15 PolarHBondContact O-N 2.92Å; E13-S15 PolarHBondContact O-OG 2.71Å; E13-S15 VanDerWaalsContact O-OG 3.1Å
16	D	62.3	Low	59.6	Low	150 Å²	150	128.9 Å²	128.9	80%	0.802	71%	0.713	S	S	*	*	T	Hydrogen-bonded Turn	trans	-148.4	26.4	172	-135.8	-82.3	0	0	0	110.8	E14 P18	E14-D16 PolarHBondContact O-N 3.14Å; E14-D16 VanDerWaalsContact O-N 3.14Å; D16-P18 WeakPolarHBondContact O-CD 3.06Å
17	C	56.2	Low	59.7	Low	78 Å²	78	122.9 Å²	122.9	53%	0.527	71%	0.705	S	S	.	*			trans	-78.1	106.4	159.5	-143.3	0	0	0	0	106.3	E14 S19	E14-C17 HydrophobicContact CG-CB 4Å; E14-C17 PolarHBondContact O-N 3.48Å; E14-C17 PolarHBondContact OE1-SG 3.23Å; C17-S19 PolarHBondContact O-N 2.78Å
18	P	60.5	Low	59.7	Low	109 Å²	109	122.5 Å²	122.5	71%	0.708	70%	0.702	S	S	*	*			trans	-59.8	121.3	169.5	26	-32.7	0	0	0	106.6	D16	D16-P18 WeakPolarHBondContact O-CD 3.06Å
19	S	59	Low	59.6	Low	85 Å²	85	127.5 Å²	127.5	59%	0.594	71%	0.714	S	S	*	*			trans	-43.5	128.3	177	-176.5	0	0	0	0	109.6	C17 L21	C17-S19 PolarHBondContact O-N 2.78Å; S19-L21 PolarHBondContact O-N 3.06Å
20	P	58.3	Low	60.1	Low	118 Å²	118	128.9 Å²	128.9	77%	0.766	71%	0.708	S	S	*	*	S	Bend	trans	-73.2	35.2	176.1	31.7	-34.3	0	0	0	111.5	E22	P20-E22 PolarHBondContact O-N 3.17Å; P20-E22 VanDerWaalsContact O-N 3.12Å
21	L	56.4	Low	60.3	Low	141 Å²	141	128 Å²	128	74%	0.738	71%	0.706	S	S	*	*			trans	-84.4	67.5	153.8	-109.4	146.1	0	0	0	107	S19 L23	S19-L21 PolarHBondContact O-N 3.06Å; L21-L23 PolarHBondContact O-N 2.86Å
22	E	60.3	Low	60.5	Low	120 Å²	120	130.3 Å²	130.3	56%	0.561	71%	0.706	S	S	*	*			trans	-37.4	106.4	159	-53.3	-169	105.2	0	0	107.6	P20 K24	P20-E22 PolarHBondContact O-N 3.17Å; P20-E22 VanDerWaalsContact O-N 3.12Å; E22-K24 HydrophobicContact CB-CB 4.47Å; E22-K24 HydrophobicContact CB-CD 4.04Å; E22-K24 HydrophobicContact CB-CG 3.97Å; E22-K24 PolarHBondContact O-N 3.35Å; E22-K24 WeakPolarHBondContact OE1-CE 3.33Å; E22-K24 IonicContact OE1-NZ 2.67Å; E22-K24 PolarHBondContact OE1-NZ 2.67Å; E22-K24 WeakPolarHBondContact OE2-CE 3.03Å; E22-K24 IonicContact OE2-NZ 2.74Å; E22-K24 PolarHBondContact OE2-NZ 2.96Å
23	L	59.7	Low	60.7	Low	162 Å²	162	129.8 Å²	129.8	85%	0.848	70%	0.702	S	S	*	*			trans	-68.9	56	163.8	-74.3	170.4	0	0	0	108.6	L21 S25	L21-L23 PolarHBondContact O-N 2.86Å; L23-S25 PolarHBondContact O-N 3.12Å
24	K	60.7	Low	61.1	Low	153 Å²	153	130.2 Å²	130.2	67%	0.665	70%	0.702	S	S	*	*			trans	-78.1	61.1	158	-70.2	173.3	-177.7	166.4	0	107.8	E22	E22-K24 HydrophobicContact CB-CB 4.47Å; E22-K24 HydrophobicContact CB-CD 4.04Å; E22-K24 HydrophobicContact CB-CG 3.97Å; E22-K24 PolarHBondContact O-N 3.35Å; E22-K24 WeakPolarHBondContact OE1-CE 3.33Å; E22-K24 IonicContact OE1-NZ 2.67Å; E22-K24 PolarHBondContact OE1-NZ 2.67Å; E22-K24 WeakPolarHBondContact OE2-CE 3.03Å; E22-K24 IonicContact OE2-NZ 2.74Å; E22-K24 PolarHBondContact OE2-NZ 2.96Å
25	S	60.9	Low	61.3	Low	94 Å²	94	131.5 Å²	131.5	66%	0.657	71%	0.712	S	S	*	*			trans	-139.9	81.5	146	50.7	0	0	0	0	106.7	L23	L23-S25 PolarHBondContact O-N 3.12Å
26	A	66.4	Low	61.5	Low	80 Å²	80	135.2 Å²	135.2	66%	0.661	71%	0.709	S	S	*	*			trans	-36.5	142.1	149.9	0	0	0	0	0	108.5	S28	A26-S28 PolarHBondContact O-N 3.05Å
27	P	60.8	Low	61.5	Low	119 Å²	119	133.5 Å²	133.5	77%	0.773	71%	0.709	S	S	*	*	S	Bend	trans	-41.9	118.3	-170.4	16.5	-31.6	0	0	0	109	K29	P27-K29 PolarHBondContact O-N 3.29Å
28	S	62.5	Low	61.6	Low	105 Å²	105	137.1 Å²	137.1	73%	0.734	72%	0.722	S	S	*	*			trans	-49.1	113.7	-178	-177.6	0	0	0	0	106.4	A26 K30	A26-S28 PolarHBondContact O-N 3.05Å; S28-K30 PolarHBondContact O-N 2.71Å
29	K	63.3	Low	61.5	Low	203 Å²	203	137.3 Å²	137.3	88%	0.883	72%	0.723	S	S	*	*			trans	-71.1	53.6	-175.9	-169.2	-179.1	177.6	168	0	109.7	P27 M31	P27-K29 PolarHBondContact O-N 3.29Å; K29-M31 PolarHBondContact O-N 2.9Å
30	K	63.9	Low	61.6	Low	147 Å²	147	142.7 Å²	142.7	64%	0.639	74%	0.738	S	S	*	*			trans	-100	58.3	168.6	-169.3	151.1	174.4	178.5	0	106.3	S28 W32	S28-K30 PolarHBondContact O-N 2.71Å; K30-W32 VanDerWaalsContact CE-NE1 3.29Å; K30-W32 VanDerWaalsContact CE-CZ2 3.5Å
31	M	64.9	Low	61.5	Low	138 Å²	138	140 Å²	140	68%	0.68	73%	0.733	S	S	*	*			trans	-90.8	101.4	168.9	-155.9	166.8	61.8	0	0	105.7	K29 I33	K29-M31 PolarHBondContact O-N 2.9Å; M31-I33 VanDerWaalsContact C-N 3.28Å; M31-I33 HydrophobicContact CE-CD1 4.38Å; M31-I33 HydrophobicContact CE-CG1 4.43Å; M31-I33 PolarHBondContact O-N 3.12Å
32	W	60	Low	61.3	Low	209 Å²	209	138.5 Å²	138.5	79%	0.792	73%	0.729	S	S	*	*			trans	-75.1	89.7	179.7	-64.7	53.9	0	0	0	106.3	K30 K34	K30-W32 VanDerWaalsContact CE-NE1 3.29Å; K30-W32 VanDerWaalsContact CE-CZ2 3.5Å; W32-K34 VanDerWaalsContact C-N 3.31Å; W32-K34 PolarHBondContact O-N 2.74Å
33	I	65.4	Low	61.4	Low	120 Å²	120	138.8 Å²	138.8	62%	0.615	73%	0.733	S	S	*	*			trans	-69.5	100.7	174.4	-59	173.7	0	0	0	106.1	M31 L35	M31-I33 VanDerWaalsContact C-N 3.28Å; M31-I33 HydrophobicContact CE-CD1 4.38Å; M31-I33 HydrophobicContact CE-CG1 4.43Å; M31-I33 PolarHBondContact O-N 3.12Å; I33-L35 VanDerWaalsContact C-N 3.26Å; I33-L35 PolarHBondContact O-N 2.67Å
34	K	66.1	Low	61.2	Low	162 Å²	162	139.9 Å²	139.9	70%	0.704	73%	0.731	S	S	*	*			trans	-75.2	90	171.7	-146	168.9	-172.2	169.9	0	106	W32 R36	W32-K34 VanDerWaalsContact C-N 3.31Å; W32-K34 PolarHBondContact O-N 2.74Å; K34-R36 PolarHBondContact O-N 2.91Å
35	L	63.1	Low	61.1	Low	155 Å²	155	141.6 Å²	141.6	81%	0.812	74%	0.735	S	S	*	*			trans	-70.3	74.3	174.7	-126.2	143	0	0	0	108	I33	I33-L35 VanDerWaalsContact C-N 3.26Å; I33-L35 PolarHBondContact O-N 2.67Å
36	R	60.2	Low	60.8	Low	192 Å²	192	140.2 Å²	140.2	73%	0.725	74%	0.736	S	S	*	*			trans	-88	112.5	160.9	-77.8	-174.6	177.3	170.6	-3.2	105.5	K34 L38	K34-R36 PolarHBondContact O-N 2.91Å; R36-L38 PolarHBondContact O-N 2.78Å
37	S	63.6	Low	60.9	Low	114 Å²	114	141.4 Å²	141.4	80%	0.797	74%	0.739	S	S	*	*			trans	-35.8	98.9	-179.6	-48	0	0	0	0	111.7
38	L	57.8	Low	60.4	Low	153 Å²	153	147.2 Å²	147.2	80%	0.801	75%	0.747	S	S	*	*			trans	-82.9	118.7	167.6	-75.4	168.9	0	0	0	106.6	R36 H40	R36-L38 PolarHBondContact O-N 2.78Å; L38-H40 PolarHBondContact O-N 2.97Å
39	P	57.9	Low	59.4	Low	113 Å²	113	151 Å²	151	73%	0.734	75%	0.753	S	S	*	*			trans	-73.3	120.8	178.5	30.8	-29.6	0	0	0	107.3
40	H	60.9	Low	58.4	Low	198 Å²	198	154 Å²	154	92%	0.917	77%	0.767	S	S	*	*	S	Bend	trans	50.1	99.1	168.4	-81.9	-110.1	0	0	0	116.6	L38	L38-H40 PolarHBondContact O-N 2.97Å
41	G	56.6	Low	58.1	Low	63 Å²	63	154.3 Å²	154.3	65%	0.649	77%	0.773	S	S	*	*	S	Bend	trans	129	115.9	153.9	0	0	0	0	0	114.8
42	V	53.3	Low	57.8	Low	109 Å²	109	155.2 Å²	155.2	66%	0.661	78%	0.778	S	S	*	*			trans	68.6	97	158.9	-157.3	0	0	0	0	115.8	F44	V42-F44 PolarHBondContact O-N 2.94Å; V42-F44 HydrophobicContact CG1-CZ 3.97Å; V42-F44 HydrophobicContact CG1-CG 4.47Å; V42-F44 HydrophobicContact CG1-CE1 4.5Å; V42-F44 HydrophobicContact CG1-CE2 3.66Å; V42-F44 HydrophobicContact CG1-CD2 3.93Å; V42-F44 HydrophobicContact CB-CE2 4.11Å; V42-F44 HydrophobicContact CB-CD2 4.47Å
43	I	60.9	Low	57.6	Low	125 Å²	125	152.2 Å²	152.2	64%	0.641	78%	0.777	S	S	*	*			trans	-77.8	107.8	159.9	-53.9	-179.2	0	0	0	107.3	Y45	I43-Y45 HydrophobicContact CB-CD2 4.14Å; I43-Y45 HydrophobicContact CB-CE2 3.85Å; I43-Y45 HydrophobicContact CD1-CE2 4.29Å; I43-Y45 HydrophobicContact CG2-CD2 3.57Å; I43-Y45 HydrophobicContact CG2-CE1 4.37Å; I43-Y45 HydrophobicContact CG2-CE2 3.3Å; I43-Y45 HydrophobicContact CG2-CG 4.22Å; I43-Y45 PolarHBondContact O-N 2.89Å; I43-Y45 VanDerWaalsContact O-N 3.12Å
44	F	55.9	Low	57.2	Low	186 Å²	186	154.1 Å²	154.1	82%	0.816	79%	0.787	S	S	*	*			trans	-73.7	96.3	165.1	-72.8	-91.5	0	0	0	108.3	V42 G46	V42-F44 PolarHBondContact O-N 2.94Å; V42-F44 HydrophobicContact CG1-CZ 3.97Å; V42-F44 HydrophobicContact CG1-CG 4.47Å; V42-F44 HydrophobicContact CG1-CE1 4.5Å; V42-F44 HydrophobicContact CG1-CE2 3.66Å; V42-F44 HydrophobicContact CG1-CD2 3.93Å; V42-F44 HydrophobicContact CB-CE2 4.11Å; V42-F44 HydrophobicContact CB-CD2 4.47Å; F44-G46 PolarHBondContact O-N 3.33Å
45	Y	58	Low	56.6	Low	188 Å²	188	153.6 Å²	153.6	74%	0.737	79%	0.792	S	S	*	*			trans	-74	111.1	163.7	-78.1	-81.8	0	0	0	107.7	I43 S47	I43-Y45 HydrophobicContact CB-CD2 4.14Å; I43-Y45 HydrophobicContact CB-CE2 3.85Å; I43-Y45 HydrophobicContact CD1-CE2 4.29Å; I43-Y45 HydrophobicContact CG2-CD2 3.57Å; I43-Y45 HydrophobicContact CG2-CE1 4.37Å; I43-Y45 HydrophobicContact CG2-CE2 3.3Å; I43-Y45 HydrophobicContact CG2-CG 4.22Å; I43-Y45 PolarHBondContact O-N 2.89Å; I43-Y45 VanDerWaalsContact O-N 3.12Å; Y45-S47 PolarHBondContact O-N 3.44Å
46	G	56.3	Low	56.2	Low	66 Å²	66	153.5 Å²	153.5	68%	0.68	79%	0.791	S	S	*	*			trans	-52	122.7	178.2	0	0	0	0	0	111.7	F44	F44-G46 PolarHBondContact O-N 3.33Å
47	S	67.7	Low	55.9	Low	105 Å²	105	150.7 Å²	150.7	73%	0.734	80%	0.795	S	S	*	*	S	Bend	trans	38.8	97.2	146.3	-46.3	0	0	0	0	116.3	Y45	Y45-S47 PolarHBondContact O-N 3.44Å
48	Y	50.4	Low	55.3	Low	240 Å²	240	153.5 Å²	153.5	94%	0.941	80%	0.795	S	S	*	*			trans	178	106.7	137.3	-88.2	-68.4	0	0	0	106.7
49	Q	41.1	Very low	55.1	Low	185 Å²	185	153.6 Å²	153.6	86%	0.864	80%	0.795	S	S	*	*			trans	-114.8	127.3	162.8	-167.3	-128.3	74.4	0	0	106.4
50	F	42.6	Very low	54.9	Low	265 Å²	265	157.3 Å²	157.3	100%	1.162	80%	0.8	S	S	*	*			trans	-96.2	0	171.6	-145	-81.7	0	0	0	108.4

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