A0A087WV45_HUMAN Loading...

Transthyretin

AlphaFold DB , UniProt , Accession A0A087WV45, Species HUMAN (Homo sapiens, Human), Gene TTR, Length 23 aa.

						>A0A087WV45_HUMAN|A0A087WV45|TTR
MASHRLLLLCLAGLVFVSEAGPT
					

Structure Viewer

Loading PAE data...

(Predicted Aligned Error values between residue pairs)

Download Structure PDB PAE Table

Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	56.3	Low	82.7	Confident	243 Å²	243	123.5 Å²	123.5	100%	1.197	65%	0.65	S	S	*	*				0	64.3	0	-65.5	179.4	-175.9	0	0	110.8
2	A	63.3	Low	83.4	Confident	71 Å²	71	118.5 Å²	118.5	59%	0.587	64%	0.639	S	S	*	*			trans	-113.7	-13.8	-176.6	0	0	0	0	0	113.8
3	S	74.8	Confident	83.8	Confident	80 Å²	80	112.4 Å²	112.4	56%	0.559	62%	0.621	S	S	*	*	H	α-helix	trans	-73.5	-38.7	-173.1	173.4	0	0	0	0	113.2	R5 L6 L7	S3-R5 PolarHBondContact O-N 3.48Å; S3-R5 VanDerWaalsContact C-N 3.34Å; S3-L6 PolarHBondContact O-N 3.27Å; S3-L7 WeakPolarHBondContact O-CG 3.41Å; S3-L7 PolarHBondContact O-N 3.08Å
4	H	82.8	Confident	84.2	Confident	139 Å²	139	113.1 Å²	113.1	64%	0.644	62%	0.622	S	S	*	*	H	α-helix	trans	-64.2	-37.7	-176.9	-157.5	-102.4	0	0	0	112.9	L7 L8	H4-L7 PolarHBondContact O-N 3.43Å; H4-L8 VanDerWaalsContact O-CG 3.31Å; H4-L8 WeakPolarHBondContact O-CG 3.48Å; H4-L8 PolarHBondContact O-N 3.45Å
5	R	85.8	Confident	84.4	Confident	202 Å²	202	111.7 Å²	111.7	76%	0.762	62%	0.618	S	S	*	*	H	α-helix	trans	-65.1	-41.9	175.7	-81.1	179	151.8	-140.1	-3.6	112.2	S3 L8 L9	S3-R5 PolarHBondContact O-N 3.48Å; S3-R5 VanDerWaalsContact C-N 3.34Å; R5-L8 PolarHBondContact O-N 3.05Å; R5-L9 VanDerWaalsContact O-CG 3.31Å; R5-L9 WeakPolarHBondContact O-CG 3.33Å; R5-L9 PolarHBondContact O-N 2.96Å; R5-L9 VanDerWaalsContact O-N 3.08Å
6	L	89.8	Confident	84.5	Confident	112 Å²	112	114.5 Å²	114.5	59%	0.586	62%	0.622	S	S	*	*	H	α-helix	trans	-64.6	-41.3	175.9	-85.7	160.1	0	0	0	111.7	S3 L8 L9 C10	S3-L6 PolarHBondContact O-N 3.27Å; L6-L8 PolarHBondContact O-N 2.89Å; L6-L9 PolarHBondContact O-N 3.2Å; L6-C10 PolarHBondContact O-N 3.33Å
7	L	89.5	Confident	84.4	Confident	97 Å²	97	113.7 Å²	113.7	51%	0.508	62%	0.622	S	S	.	*	H	α-helix	trans	-62.4	-43.2	176.8	-71	171.5	0	0	0	112	S3 H4 L9 C10 L11	S3-L7 WeakPolarHBondContact O-CG 3.41Å; S3-L7 PolarHBondContact O-N 3.08Å; H4-L7 PolarHBondContact O-N 3.43Å; L7-L9 VanDerWaalsContact C-N 3.34Å; L7-L9 PolarHBondContact O-N 3.34Å; L7-C10 PolarHBondContact O-N 2.95Å; L7-L11 WeakPolarHBondContact O-CB 3.31Å; L7-L11 WeakPolarHBondContact O-CG 3.31Å; L7-L11 PolarHBondContact O-N 3.5Å
8	L	92.9	Very high	84.2	Confident	96 Å²	96	112.2 Å²	112.2	50%	0.503	62%	0.621	S	S	.	*	H	α-helix	trans	-63.3	-39.9	175.7	-69.6	172.3	0	0	0	112.1	H4 R5 L6 L11 A12	H4-L8 VanDerWaalsContact O-CG 3.31Å; H4-L8 WeakPolarHBondContact O-CG 3.48Å; H4-L8 PolarHBondContact O-N 3.45Å; R5-L8 PolarHBondContact O-N 3.05Å; L6-L8 PolarHBondContact O-N 2.89Å; L8-L11 PolarHBondContact O-N 3.31Å; L8-A12 WeakPolarHBondContact O-CB 3.36Å; L8-A12 PolarHBondContact O-N 3.41Å
9	L	91.1	Very high	83.9	Confident	125 Å²	125	114.8 Å²	114.8	65%	0.654	63%	0.628	S	S	*	*	H	α-helix	trans	-66	-41.3	175.4	-70.5	170.5	0	0	0	111.9	R5 L6 L7 A12 G13	R5-L9 VanDerWaalsContact O-CG 3.31Å; R5-L9 WeakPolarHBondContact O-CG 3.33Å; R5-L9 PolarHBondContact O-N 2.96Å; R5-L9 VanDerWaalsContact O-N 3.08Å; L6-L9 PolarHBondContact O-N 3.2Å; L7-L9 VanDerWaalsContact C-N 3.34Å; L7-L9 PolarHBondContact O-N 3.34Å; L9-A12 PolarHBondContact O-N 3.17Å; L9-G13 PolarHBondContact O-N 3.16Å
10	C	90.6	Very high	83.4	Confident	89 Å²	89	112.7 Å²	112.7	60%	0.601	63%	0.626	S	S	*	*	H	α-helix	trans	-62.1	-44.9	173.9	-84.4	0	0	0	0	111.9	L6 L7 G13 L14	L6-C10 PolarHBondContact O-N 3.33Å; L7-C10 PolarHBondContact O-N 2.95Å; C10-G13 PolarHBondContact O-N 3.38Å; C10-L14 WeakPolarHBondContact O-CB 3.39Å; C10-L14 PolarHBondContact O-N 2.99Å
11	L	92.7	Very high	82.6	Confident	105 Å²	105	109 Å²	109	55%	0.55	61%	0.614	S	S	.	*	H	α-helix	trans	-63.5	-41.8	177.7	-73.4	169.9	0	0	0	111.7	L7 L8 G13 L14 V15	L7-L11 WeakPolarHBondContact O-CB 3.31Å; L7-L11 WeakPolarHBondContact O-CG 3.31Å; L7-L11 PolarHBondContact O-N 3.5Å; L8-L11 PolarHBondContact O-N 3.31Å; L11-G13 PolarHBondContact O-N 2.96Å; L11-L14 PolarHBondContact O-N 3.43Å; L11-V15 WeakPolarHBondContact O-CG2 3.43Å; L11-V15 PolarHBondContact O-N 2.96Å
12	A	90.9	Very high	82.9	Confident	63 Å²	63	103.9 Å²	103.9	52%	0.521	60%	0.599	S	S	.	*	H	α-helix	trans	-61.9	-42.9	176.6	0	0	0	0	0	112.4	L8 L9 F16	L8-A12 WeakPolarHBondContact O-CB 3.36Å; L8-A12 PolarHBondContact O-N 3.41Å; L9-A12 PolarHBondContact O-N 3.17Å; A12-F16 PolarHBondContact O-N 3.43Å
13	G	89	Confident	82.7	Confident	39 Å²	39	110.3 Å²	110.3	40%	0.402	63%	0.631	S	S	.	*	H	α-helix	trans	-66.2	-37.7	175.5	0	0	0	0	0	112.9	L9 C10 L11 F16 V17	L9-G13 PolarHBondContact O-N 3.16Å; C10-G13 PolarHBondContact O-N 3.38Å; L11-G13 PolarHBondContact O-N 2.96Å; G13-F16 PolarHBondContact O-N 2.87Å; G13-V17 WeakPolarHBondContact O-CG2 3.4Å; G13-V17 PolarHBondContact O-N 2.99Å; G13-V17 VanDerWaalsContact O-N 3.07Å
14	L	89.5	Confident	83.1	Confident	122 Å²	122	111.9 Å²	111.9	64%	0.639	64%	0.635	S	S	*	*	H	α-helix	trans	-64.9	-41.7	178.9	-162.6	72	0	0	0	111.8	C10 L11 V17 S18	C10-L14 WeakPolarHBondContact O-CB 3.39Å; C10-L14 PolarHBondContact O-N 2.99Å; L11-L14 PolarHBondContact O-N 3.43Å; L14-V17 PolarHBondContact O-N 3.06Å; L14-S18 WeakPolarHBondContact O-CB 3.37Å; L14-S18 PolarHBondContact O-N 3.28Å
15	V	87.8	Confident	83.1	Confident	92 Å²	92	110.4 Å²	110.4	56%	0.558	64%	0.635	S	S	*	*	H	α-helix	trans	-63.5	-44.1	175.2	172.6	0	0	0	0	110.8	L11 V17 S18 E19	L11-V15 WeakPolarHBondContact O-CG2 3.43Å; L11-V15 PolarHBondContact O-N 2.96Å; V15-V17 PolarHBondContact O-N 3.49Å; V15-V17 VanDerWaalsContact C-N 3.33Å; V15-S18 PolarHBondContact O-N 3.38Å; V15-S18 VanDerWaalsContact O-N 3.16Å; V15-E19 HydrophobicContact CG1-CG 4.33Å; V15-E19 WeakPolarHBondContact O-CG 3.32Å; V15-E19 PolarHBondContact O-N 3.06Å
16	F	85.3	Confident	83	Confident	157 Å²	157	105.3 Å²	105.3	69%	0.689	63%	0.628	S	S	*	*	H	α-helix	trans	-59.9	-41.3	177.9	-176.6	-95.9	0	0	0	112.8	A12 G13 A20	A12-F16 PolarHBondContact O-N 3.43Å; G13-F16 PolarHBondContact O-N 2.87Å; F16-A20 WeakPolarHBondContact O-CB 3.44Å; F16-A20 PolarHBondContact O-N 3.32Å; F16-A20 VanDerWaalsContact O-N 3.11Å
17	V	82.6	Confident	82.6	Confident	101 Å²	101	104.9 Å²	104.9	61%	0.612	63%	0.63	S	S	*	*	H	α-helix	trans	-68.9	-36.8	176.1	172.1	0	0	0	0	111.7	G13 L14 V15 A20	G13-V17 WeakPolarHBondContact O-CG2 3.4Å; G13-V17 PolarHBondContact O-N 2.99Å; G13-V17 VanDerWaalsContact O-N 3.07Å; L14-V17 PolarHBondContact O-N 3.06Å; V15-V17 PolarHBondContact O-N 3.49Å; V15-V17 VanDerWaalsContact C-N 3.33Å; V17-A20 PolarHBondContact O-N 3.34Å
18	S	81.6	Confident	82.1	Confident	87 Å²	87	105.4 Å²	105.4	61%	0.608	64%	0.638	S	S	*	*	H	α-helix	trans	-67.3	-39.5	178.3	-165.6	0	0	0	0	112.4	L14 V15 A20 G21	L14-S18 WeakPolarHBondContact O-CB 3.37Å; L14-S18 PolarHBondContact O-N 3.28Å; V15-S18 PolarHBondContact O-N 3.38Å; V15-S18 VanDerWaalsContact O-N 3.16Å; S18-A20 VanDerWaalsContact C-N 3.31Å; S18-G21 PolarHBondContact O-N 3.34Å
19	E	77.8	Confident	81.4	Confident	161 Å²	161	106.1 Å²	106.1	75%	0.752	65%	0.647	S	S	*	*	H	α-helix	trans	-74.5	-22.6	175.7	-64.5	-65.5	111.8	0	0	112.4	V15 G21	V15-E19 HydrophobicContact CG1-CG 4.33Å; V15-E19 WeakPolarHBondContact O-CG 3.32Å; V15-E19 PolarHBondContact O-N 3.06Å; E19-G21 PolarHBondContact O-N 3.11Å
20	A	73.1	Confident	80.7	Confident	72 Å²	72	104.7 Å²	104.7	60%	0.595	65%	0.646	S	S	*	*	T	Hydrogen-bonded Turn	trans	-81.5	13.1	172.3	0	0	0	0	0	113.4	F16 V17 S18	F16-A20 WeakPolarHBondContact O-CB 3.44Å; F16-A20 PolarHBondContact O-N 3.32Å; F16-A20 VanDerWaalsContact O-N 3.11Å; V17-A20 PolarHBondContact O-N 3.34Å; S18-A20 VanDerWaalsContact C-N 3.31Å
21	G	67.4	Low	80	Confident	36 Å²	36	105.9 Å²	105.9	37%	0.371	65%	0.649	S	S	.	*	S	Bend	trans	-56.1	151.1	169.4	0	0	0	0	0	111.7	S18 E19 T23	S18-G21 PolarHBondContact O-N 3.34Å; E19-G21 PolarHBondContact O-N 3.11Å; G21-T23 PolarHBondContact O-N 3.07Å
22	P	62.6	Low	78.9	Confident	136 Å²	136	106 Å²	106	88%	0.883	66%	0.658	S	S	*	*			trans	-71.6	104.2	-165	30.8	-33.2	0	0	0	110
23	T	59.5	Low	77.8	Confident	206 Å²	206	109.9 Å²	109.9	100%	1.264	67%	0.67	S	S	*	*			trans	-67.9	0	147.8	52.6	0	0	0	0	109.8	G21	G21-T23 PolarHBondContact O-N 3.07Å

Retrieved 23 of 23 residues in 26.9 ms (Link to these results)

U.S. Privacy Notice - Disclaimer / Registrations / Copyright Statement - Linking Policy - Notice of Privacy Practices (HIPAA) - Notice of Non‑Discrimination
© Copyright 2026 St. Jude Children's Research Hospital, a not-for-profit, section 501(c)(3).