A0A087WYF3_HUMAN Loading...

APC regulator of WNT signaling pathway

AlphaFold DB , UniProt , Accession A0A087WYF3, Species HUMAN (Homo sapiens, Human), Gene APC, Length 58 aa.

						>A0A087WYF3_HUMAN|A0A087WYF3|APC
MYASLGSGPVAPLPASVPPSVLGSWSTGGSRSCVRQETKSPGGARTSGHWASVWQVQG
					

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(Predicted Aligned Error values between residue pairs)

Download Structure PDB PAE Table

Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	51.7	Low	65.9	Low	239 Å²	239	130.1 Å²	130.1	100%	1.177	81%	0.81	S	S	*	*				0	102.2	0	-72.9	-83.1	176	0	0	106.8
2	Y	58.9	Low	66.5	Low	233 Å²	233	129.8 Å²	129.8	91%	0.914	81%	0.812	S	S	*	*			trans	-89.3	113.5	177.6	-67	-83	0	0	0	107.8	S4	Y2-S4 VanDerWaalsContact O-N 3.11Å; Y2-S4 PolarHBondContact O-N 3.44Å
3	A	58.4	Low	66.6	Low	92 Å²	92	127.3 Å²	127.3	76%	0.76	79%	0.788	S	S	*	*			trans	-67.1	110	173.4	0	0	0	0	0	107.9	L5	A3-L5 PolarHBondContact O-N 3.41Å
4	S	66.6	Low	66.7	Low	119 Å²	119	124.1 Å²	124.1	83%	0.832	77%	0.77	S	S	*	*			trans	-67.9	104.2	166.7	-66.9	0	0	0	0	106.6	Y2 G6	Y2-S4 VanDerWaalsContact O-N 3.11Å; Y2-S4 PolarHBondContact O-N 3.44Å; S4-G6 VanDerWaalsContact C-N 3.26Å; S4-G6 PolarHBondContact O-N 3.21Å
5	L	68.3	Low	66.7	Low	171 Å²	171	123.7 Å²	123.7	90%	0.895	78%	0.784	S	S	*	*			trans	-62.9	96	168.5	-73.7	157.8	0	0	0	106.1	A3 S7	A3-L5 PolarHBondContact O-N 3.41Å; L5-S7 PolarHBondContact O-N 3.19Å
6	G	66.4	Low	66.6	Low	70 Å²	70	122.8 Å²	122.8	72%	0.722	78%	0.782	S	S	*	*			trans	-54.5	134.5	179	0	0	0	0	0	109.7	S4 G8	S4-G6 VanDerWaalsContact C-N 3.26Å; S4-G6 PolarHBondContact O-N 3.21Å; G6-G8 PolarHBondContact O-N 3.25Å
7	S	70.4	Confident	66.3	Low	119 Å²	119	118.5 Å²	118.5	83%	0.832	76%	0.755	S	S	*	*			trans	-65.9	101.3	168.9	-172.7	0	0	0	0	107.5	L5	L5-S7 PolarHBondContact O-N 3.19Å
8	G	71.5	Confident	66.3	Low	47 Å²	47	115.5 Å²	115.5	49%	0.485	74%	0.736	S	S	.	*	P	Polyproline II helix	trans	-65.1	167.2	174.3	0	0	0	0	0	111.7	G6 V10	G6-G8 PolarHBondContact O-N 3.25Å; G8-V10 PolarHBondContact O-N 2.91Å
9	P	66.4	Low	66.2	Low	142 Å²	142	115.4 Å²	115.4	92%	0.922	74%	0.736	S	S	*	*	P	Polyproline II helix	trans	-57.4	116.1	177.2	23.5	-32.1	0	0	0	109.8	A11	P9-A11 PolarHBondContact O-N 2.87Å
10	V	71.3	Confident	65.8	Low	122 Å²	122	114.1 Å²	114.1	74%	0.739	73%	0.73	S	S	*	*	P	Polyproline II helix	trans	-76.4	119.6	174.6	176.2	0	0	0	0	107.3	G8	G8-V10 PolarHBondContact O-N 2.91Å
11	A	75.4	Confident	65.3	Low	77 Å²	77	112.9 Å²	112.9	64%	0.636	72%	0.721	S	S	*	*	P	Polyproline II helix	trans	-59.3	133.2	175.4	0	0	0	0	0	109.4	P9 L13	P9-A11 PolarHBondContact O-N 2.87Å; A11-L13 PolarHBondContact O-N 3.26Å
12	P	72.1	Confident	65.7	Low	127 Å²	127	106.7 Å²	106.7	83%	0.825	69%	0.692	S	S	*	*	P	Polyproline II helix	trans	-62.8	127.8	178.9	25.5	-32.4	0	0	0	108.8
13	L	67.9	Low	65.7	Low	97 Å²	97	98.9 Å²	98.9	51%	0.508	68%	0.682	S	S	.	*	P	Polyproline II helix	trans	-64.6	139.9	172	-112.8	81	0	0	0	109.2	A11 A15 V17 L22	A11-L13 PolarHBondContact O-N 3.26Å; L13-A15 PolarHBondContact O-N 3.26Å; L13-V17 HydrophobicContact CD2-CB 4.31Å; L13-V17 HydrophobicContact CD2-CG1 4.23Å; L13-L22 HydrophobicContact CD1-CD2 4.29Å; L13-L22 HydrophobicContact CD2-CD1 3.33Å; L13-L22 HydrophobicContact CD2-CD2 3.64Å; L13-L22 HydrophobicContact CD2-CG 3.83Å
14	P	67.9	Low	65.5	Low	82 Å²	82	98.7 Å²	98.7	53%	0.532	68%	0.676	S	S	.	*	P	Polyproline II helix	trans	-58.4	131.3	173	-8.7	19.4	0	0	0	108.4	S16 V17	P14-S16 PolarHBondContact O-N 3.43Å; P14-V17 HydrophobicContact CB-CG2 4.03Å; P14-V17 PolarHBondContact O-N 2.89Å; P14-V17 HydrophobicContact CG-CG2 3.73Å
15	A	66.8	Low	64.9	Low	118 Å²	118	104 Å²	104	98%	0.975	68%	0.677	S	S	*	*	T	Hydrogen-bonded Turn	trans	-57.9	-11.4	179.8	0	0	0	0	0	113.8	L13	L13-A15 PolarHBondContact O-N 3.26Å
16	S	65.1	Low	64.3	Low	109 Å²	109	100.6 Å²	100.6	76%	0.762	67%	0.668	S	S	*	*	T	Hydrogen-bonded Turn	trans	-90.8	-4.6	177.2	-174.2	0	0	0	0	114.2	P14 P18	P14-S16 PolarHBondContact O-N 3.43Å; S16-P18 VanDerWaalsContact O-CD 3.24Å; S16-P18 WeakPolarHBondContact O-CD 3.24Å
17	V	62.3	Low	63.9	Low	51 Å²	51	103.9 Å²	103.9	31%	0.309	67%	0.674	S	S	.	*	S	Bend	trans	-89	108.6	178.3	-178.7	0	0	0	0	108.3	L13 P14 V21 L22	L13-V17 HydrophobicContact CD2-CB 4.31Å; L13-V17 HydrophobicContact CD2-CG1 4.23Å; P14-V17 HydrophobicContact CB-CG2 4.03Å; P14-V17 PolarHBondContact O-N 2.89Å; P14-V17 HydrophobicContact CG-CG2 3.73Å; V17-V21 HydrophobicContact CG1-CB 3.88Å; V17-V21 HydrophobicContact CG1-CG1 4.09Å; V17-L22 HydrophobicContact CG1-CD1 4.2Å
18	P	66.5	Low	63.1	Low	64 Å²	64	101.4 Å²	101.4	42%	0.416	67%	0.667	S	S	.	*			trans	-66	144	177.4	28.8	-33.1	0	0	0	109.1	S16 S20 V21	S16-P18 VanDerWaalsContact O-CD 3.24Å; S16-P18 WeakPolarHBondContact O-CD 3.24Å; P18-S20 WeakPolarHBondContact CB-OG 3.48Å; P18-S20 PolarHBondContact O-N 2.97Å; P18-V21 HydrophobicContact CG-CG2 3.82Å; P18-V21 PolarHBondContact O-N 3.25Å
19	P	63.1	Low	62.2	Low	113 Å²	113	102.7 Å²	102.7	73%	0.734	68%	0.681	S	S	*	*	H	α-helix	trans	-58.3	-20.5	-176.8	20.8	-31.5	0	0	0	113.2	V21 L22	P19-V21 PolarHBondContact O-N 3.45Å; P19-L22 PolarHBondContact O-N 3.31Å
20	S	58.6	Low	61.9	Low	90 Å²	90	101.5 Å²	101.5	63%	0.629	68%	0.676	S	S	*	*	H	α-helix	trans	-63.1	-20.2	172.4	38.3	0	0	0	0	114.5	P18	P18-S20 WeakPolarHBondContact CB-OG 3.48Å; P18-S20 PolarHBondContact O-N 2.97Å
21	V	56.6	Low	61	Low	89 Å²	89	107.3 Å²	107.3	54%	0.539	68%	0.684	S	S	.	*	H	α-helix	trans	-81.9	-26.4	176.2	175.1	0	0	0	0	111.9	V17 P18 P19 G23	V17-V21 HydrophobicContact CG1-CB 3.88Å; V17-V21 HydrophobicContact CG1-CG1 4.09Å; P18-V21 HydrophobicContact CG-CG2 3.82Å; P18-V21 PolarHBondContact O-N 3.25Å; P19-V21 PolarHBondContact O-N 3.45Å; V21-G23 VanDerWaalsContact C-N 3.32Å; V21-G23 PolarHBondContact O-N 3.4Å
22	L	59.5	Low	60	Low	109 Å²	109	108.3 Å²	108.3	57%	0.571	69%	0.687	S	S	*	*	H	α-helix	trans	-74.3	-22.5	178.7	-73.3	100.2	0	0	0	113.5	L13 V17 P19	L13-L22 HydrophobicContact CD1-CD2 4.29Å; L13-L22 HydrophobicContact CD2-CD1 3.33Å; L13-L22 HydrophobicContact CD2-CD2 3.64Å; L13-L22 HydrophobicContact CD2-CG 3.83Å; V17-L22 HydrophobicContact CG1-CD1 4.2Å; P19-L22 PolarHBondContact O-N 3.31Å
23	G	57.9	Low	59.1	Low	68 Å²	68	107.6 Å²	107.6	70%	0.701	68%	0.684	S	S	*	*	T	Hydrogen-bonded Turn	trans	-88.2	-7.4	178.9	0	0	0	0	0	114.5	V21 W25	V21-G23 VanDerWaalsContact C-N 3.32Å; V21-G23 PolarHBondContact O-N 3.4Å; G23-W25 VanDerWaalsContact C-N 3.28Å; G23-W25 VanDerWaalsContact O-N 3.09Å; G23-W25 PolarHBondContact O-N 3.48Å
24	S	55.7	Low	58	Low	89 Å²	89	109.8 Å²	109.8	62%	0.622	70%	0.701	S	S	*	*			trans	-90.6	64.4	-176.9	-167.3	0	0	0	0	110.7	S26	S24-S26 PolarHBondContact O-N 2.96Å
25	W	52.6	Low	56.9	Low	230 Å²	230	115.5 Å²	115.5	87%	0.871	71%	0.712	S	S	*	*			trans	-67.2	103.5	163.4	-160.4	-33.7	0	0	0	106.9	G23 T27	G23-W25 VanDerWaalsContact C-N 3.28Å; G23-W25 VanDerWaalsContact O-N 3.09Å; G23-W25 PolarHBondContact O-N 3.48Å; W25-T27 VanDerWaalsContact C-N 3.31Å; W25-T27 PolarHBondContact O-N 3.05Å; W25-T27 PolarHBondContact O-OG1 3.38Å
26	S	57	Low	56.2	Low	100 Å²	100	119.7 Å²	119.7	70%	0.699	71%	0.711	S	S	*	*			trans	-60	97.9	165	-81.4	0	0	0	0	108.3	S24 G28	S24-S26 PolarHBondContact O-N 2.96Å; S26-G28 PolarHBondContact O-N 3.19Å
27	T	56.9	Low	55.6	Low	138 Å²	138	121 Å²	121	85%	0.847	71%	0.705	S	S	*	*			trans	-75.3	52.5	162.2	-13	0	0	0	0	108.9	W25 G29	W25-T27 VanDerWaalsContact C-N 3.31Å; W25-T27 PolarHBondContact O-N 3.05Å; W25-T27 PolarHBondContact O-OG1 3.38Å; T27-G29 PolarHBondContact O-N 3Å
28	G	53.2	Low	54.6	Low	67 Å²	67	124.7 Å²	124.7	69%	0.691	73%	0.728	S	S	*	*			trans	-88.6	94.6	174	0	0	0	0	0	108.4	S26 S30	S26-G28 PolarHBondContact O-N 3.19Å; G28-S30 PolarHBondContact O-N 3.03Å
29	G	53.3	Low	54.3	Low	74 Å²	74	130.8 Å²	130.8	76%	0.763	75%	0.748	S	S	*	*			trans	-45.6	116.3	-167.7	0	0	0	0	0	115.6	T27 R31	T27-G29 PolarHBondContact O-N 3Å; G29-R31 PolarHBondContact O-N 3.09Å; G29-R31 VanDerWaalsContact O-N 3.11Å
30	S	60.8	Low	53.7	Low	118 Å²	118	130.6 Å²	130.6	83%	0.825	75%	0.749	S	S	*	*			trans	-64.6	99.8	148.9	169.9	0	0	0	0	108.3	G28	G28-S30 PolarHBondContact O-N 3.03Å
31	R	51.6	Low	53.6	Low	243 Å²	243	132.2 Å²	132.2	92%	0.917	76%	0.758	S	S	*	*			trans	-125.7	96.9	146.3	-74.8	-169.7	-163.4	-172.1	5.7	107.8	G29	G29-R31 PolarHBondContact O-N 3.09Å; G29-R31 VanDerWaalsContact O-N 3.11Å
32	S	55	Low	53.5	Low	98 Å²	98	132.1 Å²	132.1	69%	0.685	77%	0.774	S	S	*	*			trans	-48.6	153.2	155.4	-172.6	0	0	0	0	110.5
33	C	52.7	Low	52.8	Low	112 Å²	112	130.3 Å²	130.3	76%	0.757	78%	0.783	S	S	*	*			trans	62.7	75.1	156.7	61.9	0	0	0	0	120.4
34	V	45.2	Very low	52.6	Low	144 Å²	144	131.3 Å²	131.3	87%	0.873	78%	0.784	S	S	*	*			trans	-144.2	126.1	136.7	-173	0	0	0	0	110.2	Q36	V34-Q36 PolarHBondContact O-N 2.87Å
35	R	44.4	Very low	52.6	Low	201 Å²	201	139.1 Å²	139.1	76%	0.758	80%	0.8	S	S	*	*			trans	-28.5	119.8	168.9	-174.4	177.2	178.1	161.7	-2.3	113.3	E37	R35-E37 PolarHBondContact O-N 2.87Å; R35-E37 PolarHBondContact NH2-OE2 3.05Å; R35-E37 IonicContact NH2-OE2 3.49Å; R35-E37 IonicContact CZ-OE2 3.99Å; R35-E37 HydrophobicContact CG-CB 4.33Å; R35-E37 IonicContact NE-OE2 3.59Å
36	Q	52.6	Low	52.7	Low	206 Å²	206	134.2 Å²	134.2	96%	0.963	80%	0.795	S	S	*	*	S	Bend	trans	-64.8	84.6	166.6	-81.1	-155.2	76.6	0	0	110	V34	V34-Q36 PolarHBondContact O-N 2.87Å
37	E	53	Low	52.5	Low	138 Å²	138	134.5 Å²	134.5	65%	0.645	80%	0.797	S	S	*	*			trans	-156.4	86.8	165.7	-159.6	-178.3	126	0	0	107.6	R35	R35-E37 PolarHBondContact O-N 2.87Å; R35-E37 PolarHBondContact NH2-OE2 3.05Å; R35-E37 IonicContact NH2-OE2 3.49Å; R35-E37 IonicContact CZ-OE2 3.99Å; R35-E37 HydrophobicContact CG-CB 4.33Å; R35-E37 IonicContact NE-OE2 3.59Å
38	T	41.3	Very low	52.4	Low	128 Å²	128	130.9 Å²	130.9	79%	0.785	79%	0.787	S	S	*	*			trans	-171	103.5	144.3	-70.6	0	0	0	0	108.7	S40	T38-S40 PolarHBondContact O-N 2.94Å
39	K	58.5	Low	52.3	Low	192 Å²	192	136.3 Å²	136.3	84%	0.835	79%	0.794	S	S	*	*			trans	-22.1	123.1	151	176.1	-176.1	176.8	-164	0	113.2
40	S	51.3	Low	52.2	Low	109 Å²	109	144.2 Å²	144.2	76%	0.762	80%	0.801	S	S	*	*			trans	-145	122.8	152.6	-80.1	0	0	0	0	109.8	T38	T38-S40 PolarHBondContact O-N 2.94Å
41	P	56.6	Low	51.9	Low	124 Å²	124	142.5 Å²	142.5	81%	0.805	79%	0.794	S	S	*	*			trans	-88.3	129.6	178.1	33.7	-27.4	0	0	0	109.5
42	G	53.7	Low	52.1	Low	86 Å²	86	135.7 Å²	135.7	89%	0.887	78%	0.784	S	S	*	*			trans	127.9	108.2	168.3	0	0	0	0	0	113.4
43	G	45.8	Very low	52	Low	72 Å²	72	136.4 Å²	136.4	74%	0.742	78%	0.784	S	S	*	*			trans	172.9	81.4	173.1	0	0	0	0	0	108.7	R45	G43-R45 PolarHBondContact O-N 3.47Å
44	A	53.1	Low	51.9	Low	88 Å²	88	142 Å²	142	73%	0.727	79%	0.789	S	S	*	*			trans	-49.4	125.9	-178.5	0	0	0	0	0	111.2	T46	A44-T46 PolarHBondContact O-N 3.11Å
45	R	55.9	Low	52.5	Low	254 Å²	254	143.2 Å²	143.2	96%	0.958	79%	0.785	S	S	*	*			trans	-67.7	96.3	170.1	-68	-158.2	-93.5	-169.3	-5.5	108.2	G43	G43-R45 PolarHBondContact O-N 3.47Å
46	T	54.1	Low	53.2	Low	126 Å²	126	139.9 Å²	139.9	77%	0.773	79%	0.787	S	S	*	*			trans	-106	91	161.9	58.6	0	0	0	0	107.2	A44 G48	A44-T46 PolarHBondContact O-N 3.11Å; T46-G48 VanDerWaalsContact C-N 3.29Å; T46-G48 PolarHBondContact O-N 2.91Å
47	S	54.3	Low	53	Low	106 Å²	106	139.2 Å²	139.2	74%	0.741	78%	0.784	S	S	*	*			trans	-66.8	94.7	164.2	163.5	0	0	0	0	106.4	H49	S47-H49 PolarHBondContact O-N 3.31Å
48	G	53.2	Low	52.6	Low	62 Å²	62	139.4 Å²	139.4	64%	0.639	82%	0.823	S	S	*	*			trans	-54	120	177.8	0	0	0	0	0	111.5	T46	T46-G48 VanDerWaalsContact C-N 3.29Å; T46-G48 PolarHBondContact O-N 2.91Å
49	H	52.4	Low	53.1	Low	181 Å²	181	140 Å²	140	84%	0.838	83%	0.825	S	S	*	*			trans	-13.8	117.4	167.4	-69.2	-91.2	0	0	0	117.2	S47 A51	S47-H49 PolarHBondContact O-N 3.31Å; H49-A51 PolarHBondContact O-N 3.39Å
50	W	50	Low	52.9	Low	241 Å²	241	137.3 Å²	137.3	91%	0.913	83%	0.825	S	S	*	*			trans	-73.6	113.2	155.9	-61.7	91.4	0	0	0	108.6
51	A	54.6	Low	52.9	Low	82 Å²	82	138.8 Å²	138.8	68%	0.678	83%	0.828	S	S	*	*			trans	-142	70.9	167.6	0	0	0	0	0	109.7	H49 V53	H49-A51 PolarHBondContact O-N 3.39Å; A51-V53 PolarHBondContact O-N 3.23Å
52	S	55.6	Low	52.7	Low	100 Å²	100	139.7 Å²	139.7	70%	0.699	83%	0.83	S	S	*	*			trans	-92.7	78.4	161.3	-64.7	0	0	0	0	108.1	W54	S52-W54 PolarHBondContact O-N 3.11Å
53	V	53.8	Low	52.7	Low	113 Å²	113	143.1 Å²	143.1	69%	0.685	83%	0.826	S	S	*	*			trans	-79.3	95.8	168.5	170.2	0	0	0	0	107	A51 Q55	A51-V53 PolarHBondContact O-N 3.23Å; V53-Q55 VanDerWaalsContact C-N 3.34Å; V53-Q55 HydrophobicContact CG1-CB 4.44Å; V53-Q55 HydrophobicContact CG1-CG 3.38Å; V53-Q55 PolarHBondContact O-N 3.45Å
54	W	49.5	Very low	53.1	Low	228 Å²	228	147.8 Å²	147.8	86%	0.864	83%	0.832	S	S	*	*			trans	-80.2	89.4	163.7	-67.3	93.7	0	0	0	107.5	S52 V56	S52-W54 PolarHBondContact O-N 3.11Å; W54-V56 PolarHBondContact O-N 2.85Å
55	Q	58.6	Low	53.1	Low	170 Å²	170	152.1 Å²	152.1	79%	0.794	84%	0.839	S	S	*	*			trans	-76.8	98	164.3	-70.9	-95.9	41.4	0	0	107	V53 Q57	V53-Q55 VanDerWaalsContact C-N 3.34Å; V53-Q55 HydrophobicContact CG1-CB 4.44Å; V53-Q55 HydrophobicContact CG1-CG 3.38Å; V53-Q55 PolarHBondContact O-N 3.45Å; Q55-Q57 PolarHBondContact O-N 3.41Å
56	V	59	Low	52.9	Low	131 Å²	131	144.2 Å²	144.2	79%	0.794	83%	0.83	S	S	*	*			trans	-78.1	109.5	160.2	169.9	0	0	0	0	106.2	W54 G58	W54-V56 PolarHBondContact O-N 2.85Å; V56-G58 PolarHBondContact O-N 3.49Å
57	Q	47.8	Very low	52.8	Low	192 Å²	192	145.8 Å²	145.8	90%	0.897	84%	0.835	S	S	*	*			trans	-61.8	124.2	171.5	-177.8	161.3	70.9	0	0	109.1	Q55	Q55-Q57 PolarHBondContact O-N 3.41Å
58	G	45.1	Very low	52.7	Low	143 Å²	143	149.4 Å²	149.4	100%	1.474	84%	0.843	S	S	*	*			trans	-111.3	0	164.8	0	0	0	0	0	109.6	V56	V56-G58 PolarHBondContact O-N 3.49Å

Retrieved 58 of 58 residues in 12.3 ms (Link to these results)

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