A0A087WYG1_HUMAN Loading...

ADAM metallopeptidase domain 10

AlphaFold DB , UniProt , Accession A0A087WYG1, Species HUMAN (Homo sapiens, Human), Gene ADAM10, Length 59 aa.

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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1M73.4Confident84.9Confident210 Ų210125.3 Ų125.3100%1.03464%0.638SS**  0-37.30-69-177.5127.800113.9
2V83.6Confident84.3Confident113 Ų113121.3 Ų121.369%0.68563%0.63SS**Hα-helixtrans-64.8-43.6-179.6179.70000112.6L4 R5 V6V2-L4 PolarHBondContact O-N 2.99Å; V2-L4 VanDerWaalsContact C-N 3.3Å; V2-R5 PolarHBondContact O-N 3.49Å; V2-R5 VanDerWaalsContact O-N 3.09Å; V2-R5 WeakPolarHBondContact O-CB 3.43Å; V2-V6 HydrophobicContact CG1-CG2 4.35Å; V2-V6 WeakPolarHBondContact O-CG2 3.33Å; V2-V6 PolarHBondContact O-N 2.9Å; V2-V6 VanDerWaalsContact O-N 3.09Å
3L87.4Confident83.9Confident147 Ų147126.1 Ų126.177%0.7764%0.635SS**Hα-helixtrans-57.8-40.1-178.7-169.968.9000113.2R5 V6 L7L3-R5 PolarHBondContact O-N 3Å; L3-V6 PolarHBondContact O-N 3.12Å; L3-L7 PolarHBondContact O-N 3.31Å
4L87.6Confident83.4Confident114 Ų114121.6 Ų121.660%0.59763%0.627SS**Hα-helixtrans-64.7-40.1178.2-175.565.9000111.7V2 L7 I8V2-L4 PolarHBondContact O-N 2.99Å; V2-L4 VanDerWaalsContact C-N 3.3Å; L4-L7 PolarHBondContact O-N 3.22Å; L4-I8 HydrophobicContact CD1-CD1 4.5Å; L4-I8 HydrophobicContact CG-CD1 4.09Å; L4-I8 WeakPolarHBondContact O-CD1 3.06Å; L4-I8 VanDerWaalsContact O-CG1 3.27Å; L4-I8 WeakPolarHBondContact O-CG1 3.42Å; L4-I8 PolarHBondContact O-N 3.29Å
5R84Confident82.4Confident186 Ų186118.4 Ų118.470%0.70263%0.626SS**Hα-helixtrans-65.4-41.6177.4-69.9-178166.9171.5-3.5111.6V2 L3 L7 I8 L9V2-R5 PolarHBondContact O-N 3.49Å; V2-R5 VanDerWaalsContact O-N 3.09Å; V2-R5 WeakPolarHBondContact O-CB 3.43Å; L3-R5 PolarHBondContact O-N 3Å; R5-L7 VanDerWaalsContact C-N 3.34Å; R5-I8 PolarHBondContact O-N 2.74Å; R5-L9 PolarHBondContact O-N 3.41Å; R5-L9 WeakPolarHBondContact O-CG 3.44Å; R5-L9 WeakPolarHBondContact O-CB 3.35Å; R5-L9 WeakPolarHBondContact O-CD1 3.43Å
6V88.5Confident81.2Confident71 Ų71114.4 Ų114.443%0.4362%0.622SS.*Hα-helixtrans-63.5-41.9176.61760000110.9V2 L3 L9 L10V2-V6 HydrophobicContact CG1-CG2 4.35Å; V2-V6 WeakPolarHBondContact O-CG2 3.33Å; V2-V6 PolarHBondContact O-N 2.9Å; V2-V6 VanDerWaalsContact O-N 3.09Å; L3-V6 PolarHBondContact O-N 3.12Å; V6-L9 PolarHBondContact O-N 3.02Å; V6-L10 HydrophobicContact CG1-CD1 3.92Å; V6-L10 PolarHBondContact O-N 3.01Å
7L88.4Confident80Confident99 Ų99115.9 Ų115.952%0.51863%0.626SS.*Hα-helixtrans-64.1-42.9178-171.468.2000112.5L3 L4 R5 L10 L11L3-L7 PolarHBondContact O-N 3.31Å; L4-L7 PolarHBondContact O-N 3.22Å; R5-L7 VanDerWaalsContact C-N 3.34Å; L7-L10 PolarHBondContact O-N 3.49Å; L7-L11 HydrophobicContact CG-CD1 4.13Å; L7-L11 WeakPolarHBondContact O-CG 3.5Å; L7-L11 PolarHBondContact O-N 3.45Å
8I85.6Confident78.6Confident93 Ų93112.8 Ų112.848%0.47763%0.625SS.*Hα-helixtrans-62.9-44.9176.7-66.4163.2000110.5L4 R5 L10 L11 S12L4-I8 HydrophobicContact CD1-CD1 4.5Å; L4-I8 HydrophobicContact CG-CD1 4.09Å; L4-I8 WeakPolarHBondContact O-CD1 3.06Å; L4-I8 VanDerWaalsContact O-CG1 3.27Å; L4-I8 WeakPolarHBondContact O-CG1 3.42Å; L4-I8 PolarHBondContact O-N 3.29Å; R5-I8 PolarHBondContact O-N 2.74Å; I8-L10 VanDerWaalsContact C-N 3.34Å; I8-L10 PolarHBondContact O-N 2.75Å; I8-L11 PolarHBondContact O-N 3.48Å; I8-S12 WeakPolarHBondContact O-CB 3.45Å; I8-S12 PolarHBondContact O-N 3.48Å; I8-S12 PolarHBondContact O-OG 3.46Å; I8-S12 VanDerWaalsContact O-OG 3.08Å
9L85.3Confident77.3Confident125 Ų125110.6 Ų110.665%0.65462%0.624SS**Hα-helixtrans-58.7-43.8176.7-82.9156.9000112.1R5 V6 W13R5-L9 PolarHBondContact O-N 3.41Å; R5-L9 WeakPolarHBondContact O-CG 3.44Å; R5-L9 WeakPolarHBondContact O-CB 3.35Å; R5-L9 WeakPolarHBondContact O-CD1 3.43Å; V6-L9 PolarHBondContact O-N 3.02Å; L9-W13 WeakPolarHBondContact O-CB 3.45Å; L9-W13 PolarHBondContact O-N 3.12Å
10L86.4Confident75.9Confident109 Ų109109.6 Ų109.657%0.57162%0.622SS**Hα-helixtrans-64-44.7177.1-102.6138000112.5V6 L7 I8 W13 A14V6-L10 HydrophobicContact CG1-CD1 3.92Å; V6-L10 PolarHBondContact O-N 3.01Å; L7-L10 PolarHBondContact O-N 3.49Å; I8-L10 VanDerWaalsContact C-N 3.34Å; I8-L10 PolarHBondContact O-N 2.75Å; L10-W13 PolarHBondContact O-N 3.03Å; L10-A14 WeakPolarHBondContact O-CB 3.47Å; L10-A14 PolarHBondContact O-N 3.2Å
11L83.6Confident75Confident111 Ų111108.9 Ų108.958%0.58163%0.63SS**Hα-helixtrans-66.6-41.3179-73.8167.4000111.9L7 I8 W13 A14 A15L7-L11 HydrophobicContact CG-CD1 4.13Å; L7-L11 WeakPolarHBondContact O-CG 3.5Å; L7-L11 PolarHBondContact O-N 3.45Å; I8-L11 PolarHBondContact O-N 3.48Å; L11-W13 VanDerWaalsContact C-N 3.34Å; L11-A14 PolarHBondContact O-N 3.44Å; L11-A15 PolarHBondContact O-N 3.03Å; L11-A15 WeakPolarHBondContact O-CB 3.49Å
12S77.4Confident74.1Confident77 Ų77108.8 Ų108.854%0.53862%0.618SS.*Hα-helixtrans-64.7-38.4175.5-62.90000112.3I8 G16I8-S12 WeakPolarHBondContact O-CB 3.45Å; I8-S12 PolarHBondContact O-N 3.48Å; I8-S12 PolarHBondContact O-OG 3.46Å; I8-S12 VanDerWaalsContact O-OG 3.08Å; S12-G16 PolarHBondContact O-N 3.46Å
13W80.1Confident72.5Confident184 Ų184114.6 Ų114.670%0.69763%0.628SS**Hα-helixtrans-65.5-46.4175.5-174.3-94000112L9 L10 L11 A15 G16 M17L9-W13 WeakPolarHBondContact O-CB 3.45Å; L9-W13 PolarHBondContact O-N 3.12Å; L10-W13 PolarHBondContact O-N 3.03Å; L11-W13 VanDerWaalsContact C-N 3.34Å; W13-A15 VanDerWaalsContact C-N 3.34Å; W13-A15 PolarHBondContact O-N 2.88Å; W13-G16 PolarHBondContact O-N 2.97Å; W13-M17 HydrophobicContact CZ2-SD 4.39Å; W13-M17 PolarHBondContact NE1-SD 3.36Å; W13-M17 PolarHBondContact O-N 3.44Å
14A76.8Confident70.8Confident64 Ų64119.5 Ų119.553%0.52964%0.636SS.*Hα-helixtrans-62.4-39.4176.700000112.4L10 L11 G18L10-A14 WeakPolarHBondContact O-CB 3.47Å; L10-A14 PolarHBondContact O-N 3.2Å; L11-A14 PolarHBondContact O-N 3.44Å; A14-G18 PolarHBondContact O-N 3Å
15A67.8Low69.2Low73 Ų73120.8 Ų120.860%0.60364%0.642SS**Hα-helixtrans-68-34175.200000112.7L11 W13L11-A15 PolarHBondContact O-N 3.03Å; L11-A15 WeakPolarHBondContact O-CB 3.49Å; W13-A15 VanDerWaalsContact C-N 3.34Å; W13-A15 PolarHBondContact O-N 2.88Å
16G64Low67.4Low55 Ų55117 Ų11757%0.56764%0.642SS**Hα-helixtrans-72.9-31.5176.800000114S12 W13S12-G16 PolarHBondContact O-N 3.46Å; W13-G16 PolarHBondContact O-N 2.97Å
17M61Low65.6Low139 Ų139123.7 Ų123.769%0.68567%0.665SS**Hα-helixtrans-78.7-20.2177.1-77.9-177.24600114W13W13-M17 HydrophobicContact CZ2-SD 4.39Å; W13-M17 PolarHBondContact NE1-SD 3.36Å; W13-M17 PolarHBondContact O-N 3.44Å
18G54.4Low64Low60 Ų60123.7 Ų123.762%0.61967%0.673SS**THydrogen-bonded Turntrans-83.8-3.6-178.400000115.6A14 P20A14-G18 PolarHBondContact O-N 3Å; G18-P20 WeakPolarHBondContact O-CD 3.48Å
19A52.8Low62.5Low72 Ų72123.9 Ų123.960%0.59568%0.683SS**  trans-101.69317900000110.4A21A19-A21 PolarHBondContact O-N 2.98Å
20P50.5Low61.1Low89 Ų89123.4 Ų123.458%0.57869%0.687SS**  trans-63.4115.4163.626.8-30.6000107G18 R22G18-P20 WeakPolarHBondContact O-CD 3.48Å; P20-R22 HydrophobicContact CB-CG 4.46Å; P20-R22 PolarHBondContact O-N 2.95Å
21A56.9Low59.7Low96 Ų96123.8 Ų123.879%0.79370%0.696SS**  trans-52.490.9163.900000109A19 W23A19-A21 PolarHBondContact O-N 2.98Å; A21-W23 PolarHBondContact O-N 3.37Å
22R54.4Low57.9Low208 Ų208124.6 Ų124.679%0.78571%0.708SS**  trans-96.585.3168.1-66.5-164.5-148.1-148.36.4108.9P20 R24P20-R22 HydrophobicContact CB-CG 4.46Å; P20-R22 PolarHBondContact O-N 2.95Å; R22-R24 PolarHBondContact O-N 3.39Å
23W49.1Very low56.6Low235 Ų235131.9 Ų131.989%0.8972%0.723SS**  trans46.773.4140.2-66.382.2000116.3A21 I25A21-W23 PolarHBondContact O-N 3.37Å; W23-I25 PolarHBondContact O-N 3.05Å
24R51.5Low55.1Low250 Ų250129.3 Ų129.394%0.94373%0.731SS**  trans-85.299.1151.5-81.1-173.3-178.8-174.41.7107.9R22R22-R24 PolarHBondContact O-N 3.39Å
25I54.5Low53.4Low140 Ų140131 Ų13172%0.71875%0.745SS**  trans-32.6135.5168.4-63150.7000110.8W23 K27W23-I25 PolarHBondContact O-N 3.05Å; I25-K27 PolarHBondContact O-N 3.31Å
26P46.9Very low52.6Low108 Ų108131.8 Ų131.870%0.70175%0.751SS**  trans-61.1113.4-179.524.3-31.7000109.1S28P26-S28 PolarHBondContact O-N 2.92Å
27K51Low51.8Low211 Ų211137.9 Ų137.992%0.91776%0.764SS**  trans-81.159.3176.7-143.8159.9-172.2169.90109I25I25-K27 PolarHBondContact O-N 3.31Å
28S54.6Low50.9Low98 Ų98136.8 Ų136.869%0.68577%0.766SS**  trans-99.672.3170.261.80000109P26P26-S28 PolarHBondContact O-N 2.92Å
29S53.6Low50.5Low98 Ų98145.8 Ų145.869%0.68578%0.781SS**SBendtrans-177.5134.6146.238.90000109.2
30P56.2Low50.1Low115 Ų115145.2 Ų145.275%0.74778%0.783SS**PPolyproline II helixtrans-63.8146.2172.727.3-32000109.7
31P56.1Low50.1Low117 Ų117150.3 Ų150.376%0.7680%0.796SS**PPolyproline II helixtrans-61.8131.2176.726.2-32.7000109.1R33P31-R33 PolarHBondContact O-N 2.99Å
32P46.9Very low49.7Very low127 Ų127150.2 Ų150.283%0.82578%0.781SS**PPolyproline II helixtrans-64.1125.3166.826.7-29.1000107.2
33R49Very low49.4Very low230 Ų230145.5 Ų145.587%0.86878%0.779SS**PPolyproline II helixtrans-48.3151.1170.3-78.7178.2174.5167.9-2.3110.4P31 A35P31-R33 PolarHBondContact O-N 2.99Å; R33-A35 PolarHBondContact O-N 3.43Å
34P49.5Very low49.5Very low131 Ų131138 Ų13885%0.85176%0.762SS**  trans-71.5104.3-175.730.6-31.7000109A36P34-A36 PolarHBondContact O-N 3.36Å
35A41.5Very low49.4Very low100 Ų100133.4 Ų133.483%0.82676%0.755SS**  trans-78.7118.3161.800000107.3R33R33-A35 PolarHBondContact O-N 3.43Å
36A49.1Very low49.1Very low88 Ų88134.8 Ų134.873%0.72776%0.758SS**  trans-55165.1177.900000113.4P34P34-A36 PolarHBondContact O-N 3.36Å
37Q47.8Very low49.1Very low183 Ų183137.1 Ų137.186%0.85576%0.764SS**  trans76.4122.4170.9-63.7175.2-17.100113.6
38T42.5Very low49.6Very low117 Ų117130.9 Ų130.972%0.71876%0.759SS**  -166.6134.368.3-59.40000111.4
39R45.6Very low49.5Very low248 Ų248132.2 Ų132.294%0.93677%0.769SS**  trans56.2103.2154.1-75.8175.2168.6-174.5-3.3119.4
40G44.1Very low49Very low61 Ų61131.9 Ų131.963%0.62977%0.766SS**  trans150.5105.3147.500000109.4L42G40-L42 PolarHBondContact O-N 3.01Å
41K51.3Low48.9Very low196 Ų196132.3 Ų132.385%0.85276%0.76SS**  trans-64.778.8169.8-81.4179.8174.1-176.80108.6A56K41-A56 WeakPolarHBondContact O-CB 3.27Å
42L47.8Very low48.7Very low94 Ų94130 Ų13049%0.49274%0.744SS.*  trans-100.2101162.2-82.8149.4000105G40 C44 L53G40-L42 PolarHBondContact O-N 3.01Å; L42-C44 VanDerWaalsContact C-N 3.35Å; L42-C44 PolarHBondContact O-N 3.28Å; L42-L53 HydrophobicContact CD2-CD2 4.39Å
43C48.7Very low49Very low109 Ų109129.5 Ų129.574%0.73673%0.733SS**  trans-6997.5170.5-78.40000107.6L45C43-L45 PolarHBondContact O-N 3.08Å
44C51Low49.3Very low78 Ų78126.3 Ų126.353%0.52772%0.723SS.*  trans-82.6111171.8-64.70000108.9L42L42-C44 VanDerWaalsContact C-N 3.35Å; L42-C44 PolarHBondContact O-N 3.28Å
45L50.5Low49.3Very low152 Ų152125.7 Ų125.780%0.79672%0.719SS**  trans-91.4111.1162.7-76.7164.9000107.6C43 L47C43-L45 PolarHBondContact O-N 3.08Å; L45-L47 PolarHBondContact O-N 3.09Å
46Q48.1Very low50Low170 Ų170124 Ų12479%0.79470%0.704SS**EExtended strand (participates in β ladder)trans-78.5113.8171.5-86.7-177-44.300109.4
47L45.6Very low49.9Very low157 Ų157131.3 Ų131.382%0.82271%0.713SS**EExtended strand (participates in β ladder)trans-110.796.8164.2-142.785.2000108.4L45 S49 C50L45-L47 PolarHBondContact O-N 3.09Å; L47-S49 PolarHBondContact O-N 3.09Å; L47-C50 PolarHBondContact O-N 3.37Å
48G63.1Low50.2Low79 Ų79134.6 Ų134.681%0.81472%0.718SS**THydrogen-bonded Turntrans66.4-87.6173.200000115.2
49S52.5Low50.3Low126 Ų126138 Ų13888%0.88175%0.746SS**THydrogen-bonded Turntrans-13811.6-171.5-76.20000115.2L47L47-S49 PolarHBondContact O-N 3.09Å
50C41.9Very low50.5Low92 Ų92132.5 Ų132.562%0.62274%0.736SS**EExtended strand (participates in β ladder)trans-119.8122.9173.3-69.60000110.4L47 V52L47-C50 PolarHBondContact O-N 3.37Å; C50-V52 PolarHBondContact O-N 2.99Å
51I55.2Low50.9Low124 Ų124136.2 Ų136.264%0.63674%0.742SS**EExtended strand (participates in β ladder)trans-87.6105.1169.9-56.7174.6000106.6L53I51-L53 HydrophobicContact CG2-CD2 4.11Å; I51-L53 HydrophobicContact CG2-CG 4.2Å
52V52.1Low50.9Low68 Ų68132.9 Ų132.941%0.41274%0.736SS.*  trans-95.7111.3173.1-164.90000108.4C50 Y54C50-V52 PolarHBondContact O-N 2.99Å; V52-Y54 HydrophobicContact CB-CD2 4.32Å; V52-Y54 WeakPolarHBondContact CG1-OH 3.37Å; V52-Y54 HydrophobicContact CG1-CE2 3.23Å; V52-Y54 HydrophobicContact CG1-CE1 4.04Å; V52-Y54 HydrophobicContact CG1-CD2 3.93Å; V52-Y54 HydrophobicContact CB-CE2 3.67Å
53L53Low51Low116 Ų116135.2 Ų135.261%0.60775%0.75SS**  trans-87.3111.6177.9-66.2168.8000108.8L42 I51L42-L53 HydrophobicContact CD2-CD2 4.39Å; I51-L53 HydrophobicContact CG2-CD2 4.11Å; I51-L53 HydrophobicContact CG2-CG 4.2Å
54Y54.9Low51.2Low164 Ų164136.8 Ų136.864%0.64375%0.751SS**  trans-106136.1171-63.9-82.6000110.1V52 A56V52-Y54 HydrophobicContact CB-CD2 4.32Å; V52-Y54 WeakPolarHBondContact CG1-OH 3.37Å; V52-Y54 HydrophobicContact CG1-CE2 3.23Å; V52-Y54 HydrophobicContact CG1-CE1 4.04Å; V52-Y54 HydrophobicContact CG1-CD2 3.93Å; V52-Y54 HydrophobicContact CB-CE2 3.67Å; Y54-A56 PolarHBondContact O-N 3.36Å
55P49.6Very low51.2Low118 Ų118140.7 Ų140.777%0.76677%0.766SS**  trans-66.7122.4168.626.7-30.5000108.9R57P55-R57 PolarHBondContact O-N 3.49Å
56A55Low51.2Low63 Ų63139.9 Ų139.952%0.52176%0.764SS.*  trans-65.3105.1172.300000108.8K41 Y54 R58K41-A56 WeakPolarHBondContact O-CB 3.27Å; Y54-A56 PolarHBondContact O-N 3.36Å; A56-R58 PolarHBondContact O-N 3.43Å; A56-R58 VanDerWaalsContact O-N 3.12Å
57R48.9Very low51.5Low243 Ų243137.6 Ų137.692%0.91776%0.762SS**  trans-65.3111.7175.1-147.7-178.4-154-1415.9107.7P55 S59P55-R57 PolarHBondContact O-N 3.49Å; R57-S59 PolarHBondContact O-N 3.05Å
58R53Low52Low252 Ų252136 Ų13695%0.95176%0.757SS**  trans-67.2115.7169.2-99.9179.6174.5165.7-3.2108.2A56A56-R58 PolarHBondContact O-N 3.43Å; A56-R58 VanDerWaalsContact O-N 3.12Å
59S44.8Very low51Low187 Ų187141.2 Ų141.2100%1.30875%0.751SS**  trans-143.10152.1-173.20000108.7R57R57-S59 PolarHBondContact O-N 3.05Å

Retrieved 59 of 59 residues in 96.8 ms (Link to these results)