A0A087WYT4_HUMAN Loading...

Serine/threonine kinase 4

AlphaFold DB , UniProt , Accession A0A087WYT4, Species HUMAN (Homo sapiens, Human), Gene STK4, Length 64 aa.

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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1M45.5Very low58.6Low240 Ų240165.6 Ų165.6100%1.18283%0.826SS**  0113.50-62-174.4-165.700106.3
2E50.4Low59.5Low197 Ų197171.3 Ų171.392%0.92183%0.831SS**  trans-72.1128.4-179.9-69.2-177.4157.800109.5V4E2-V4 PolarHBondContact O-N 2.56Å
3T56.3Low60.8Low128 Ų128171.8 Ų171.879%0.78583%0.831SS**  trans-79.5115.5179.646.30000109Q5T3-Q5 PolarHBondContact O-N 3.2Å
4V62.4Low61.8Low132 Ų132172.1 Ų172.180%0.884%0.837SS**  trans-64.8107.5173.2-179.50000107.8E2 L6E2-V4 PolarHBondContact O-N 2.56Å; V4-L6 PolarHBondContact O-N 3.45Å
5Q59.6Low63Low176 Ų176173.8 Ų173.882%0.82284%0.839SS**  trans-68.5104.5175-64.8-143.261.800108.9T3 R7T3-Q5 PolarHBondContact O-N 3.2Å; Q5-R7 PolarHBondContact O-N 3.29Å
6L60.1Low64.5Low156 Ų156175.8 Ų175.882%0.81784%0.842SS**  trans-62.889.4164.9-122.783.9000106.8V4 N8V4-L6 PolarHBondContact O-N 3.45Å; L6-N8 VanDerWaalsContact C-N 3.35Å; L6-N8 PolarHBondContact O-N 3.4Å
7R60.5Low65.7Low234 Ų234169.9 Ų169.988%0.88382%0.816SS**  trans-54107.3164.6-95.2178.1163.4-177.2-4.1105.1Q5 P9Q5-R7 PolarHBondContact O-N 3.29Å; R7-P9 WeakPolarHBondContact O-CD 3.03Å
8N59Low67.1Low129 Ų129165.4 Ų165.469%0.6980%0.797SS**  trans-78.695176.6-156.939.8000105.3L6L6-N8 VanDerWaalsContact C-N 3.35Å; L6-N8 PolarHBondContact O-N 3.4Å
9P62.8Low68.4Low93 Ų93165.5 Ų165.560%0.60480%0.796SS**  trans-58.8148.6177.129.8-35.7000107.5R7 R11R7-P9 WeakPolarHBondContact O-CD 3.03Å; P9-R11 PolarHBondContact O-N 3.32Å
10P62.6Low69.5Low116 Ų116162.8 Ų162.875%0.75379%0.786SS**  trans-49.7120.5172.520.4-30.4000107.1R12P10-R12 VanDerWaalsContact C-N 3.3Å; P10-R12 PolarHBondContact O-N 2.84Å
11R64.9Low70.3Confident221 Ų221156 Ų15683%0.83476%0.756SS**  trans-53.2100-177.6-78.4-176.1176.6172.3-0.9107P9 Q13P9-R11 PolarHBondContact O-N 3.32Å; R11-Q13 PolarHBondContact O-N 3.29Å
12R70.1Confident72.4Confident234 Ų234150.5 Ų150.588%0.88373%0.73SS**  trans-61.6104.7175.5-80.8178152.2159.5-7.6105.1P10 L14P10-R12 VanDerWaalsContact C-N 3.3Å; P10-R12 PolarHBondContact O-N 2.84Å; R12-L14 PolarHBondContact O-N 3.2Å
13Q75.9Confident74.2Confident178 Ų178146.8 Ų146.883%0.83272%0.721SS**PPolyproline II helixtrans-61.7122.1174-66.8-175.2-2.500106.7R11 K15R11-Q13 PolarHBondContact O-N 3.29Å; Q13-K15 PolarHBondContact O-N 3.25Å
14L74.7Confident75.8Confident175 Ų175145.7 Ų145.792%0.91671%0.706SS**PPolyproline II helixtrans-62.1125.4176.2-68.5171.2000108.1R12R12-L14 PolarHBondContact O-N 3.2Å
15K79.9Confident77.1Confident198 Ų198145.1 Ų145.186%0.86169%0.694SS**PPolyproline II helixtrans-78.1140.5173.9-65.5-178.3-179.1179.40108.5Q13Q13-K15 PolarHBondContact O-N 3.25Å
16K86.9Confident78.3Confident206 Ų206139.8 Ų139.890%0.89668%0.675SS**PPolyproline II helixtrans-66136.6168.1-65.6-175.9179.1-176.60108.2
17L85.4Confident79.6Confident75 Ų75138.4 Ų138.439%0.39366%0.664SS.*PPolyproline II helixtrans-71147.1169-67.3173.6000109.3L22 F30L17-L22 HydrophobicContact CB-CD2 4.03Å; L17-L22 HydrophobicContact CB-CG 4.19Å; L17-L22 HydrophobicContact CD1-CD2 3.93Å; L17-F30 HydrophobicContact CD1-CE2 4.49Å; L17-F30 HydrophobicContact CD1-CZ 3.93Å
18D90.5Very high80.8Confident89 Ų89133.9 Ų133.948%0.47665%0.653SS.*PPolyproline II helixtrans-72.3160.5165.957.8-29.6000111D20 S21 L22D18-D20 PolarHBondContact O-N 2.9Å; D18-D20 VanDerWaalsContact C-N 3.26Å; D18-S21 PolarHBondContact O-N 2.95Å; D18-S21 WeakPolarHBondContact OD1-CB 3.49Å; D18-S21 PolarHBondContact OD1-OG 3.2Å; D18-L22 PolarHBondContact O-N 3.29Å
19E92.4Very high82.2Confident167 Ų167129.7 Ų129.778%0.7863%0.632SS**Hα-helixtrans-60.3-37.4-175.8-64.4-175.7174.400112.1S21 L22E19-S21 PolarHBondContact O-N 2.72Å; E19-L22 WeakPolarHBondContact O-CB 3.38Å; E19-L22 PolarHBondContact O-N 3.4Å
20D89.8Confident83.3Confident111 Ų111130.9 Ų130.959%0.59463%0.628SS**Hα-helixtrans-62.8-41.8178.3-69.1-14.2000111.9D18 L22 T23D18-D20 PolarHBondContact O-N 2.9Å; D18-D20 VanDerWaalsContact C-N 3.26Å; D20-L22 VanDerWaalsContact C-N 3.28Å; D20-L22 PolarHBondContact O-N 3.32Å; D20-T23 PolarHBondContact O-N 2.8Å; D20-T23 PolarHBondContact O-OG1 3.49Å
21S87Confident84.4Confident21 Ų21132.3 Ų132.315%0.14763%0.629CS.*Hα-helixtrans-69.7-24.1178.1-64.10000113.3D18 E19 T23 K24D18-S21 PolarHBondContact O-N 2.95Å; D18-S21 WeakPolarHBondContact OD1-CB 3.49Å; D18-S21 PolarHBondContact OD1-OG 3.2Å; E19-S21 PolarHBondContact O-N 2.72Å; S21-T23 PolarHBondContact O-N 3.28Å; S21-K24 PolarHBondContact O-N 3.41Å
22L88.8Confident85.2Confident124 Ų124127.5 Ų127.565%0.64962%0.624SS**Hα-helixtrans-72.8-16.8176.5-68.5173.8000113.3L17 D18 E19 D20L17-L22 HydrophobicContact CB-CD2 4.03Å; L17-L22 HydrophobicContact CB-CG 4.19Å; L17-L22 HydrophobicContact CD1-CD2 3.93Å; D18-L22 PolarHBondContact O-N 3.29Å; E19-L22 WeakPolarHBondContact O-CB 3.38Å; E19-L22 PolarHBondContact O-N 3.4Å; D20-L22 VanDerWaalsContact C-N 3.28Å; D20-L22 PolarHBondContact O-N 3.32Å
23T89.3Confident85.6Confident120 Ų120122.9 Ų122.974%0.73662%0.616SS**THydrogen-bonded Turntrans-94.1-11.3178.867.10000113.7D20 S21D20-T23 PolarHBondContact O-N 2.8Å; D20-T23 PolarHBondContact O-OG1 3.49Å; S21-T23 PolarHBondContact O-N 3.28Å
24K90.1Very high85.7Confident105 Ų105123.1 Ų123.146%0.45762%0.618SS.*SBendtrans-90.7161.4-176.4-67176.9-173.1170.60111.9S21 E28 V29S21-K24 PolarHBondContact O-N 3.41Å; K24-E28 HydrophobicContact CB-CB 4.45Å; K24-V29 HydrophobicContact CB-CG1 3.89Å; K24-V29 HydrophobicContact CD-CG1 4.03Å
25Q89.6Confident85.8Confident120 Ų120122 Ų12256%0.56161%0.605SS**  trans-65.5143173-68-62.8-16.500110.2E27 E28 V29Q25-E27 PolarHBondContact O-N 2.89Å; Q25-E28 HydrophobicContact CB-CG 4.23Å; Q25-E28 PolarHBondContact O-N 3.14Å; Q25-E28 WeakPolarHBondContact O-CB 3.49Å; Q25-V29 WeakPolarHBondContact O-CG2 3.44Å; Q25-V29 PolarHBondContact O-N 2.8Å
26P83.1Confident85.4Confident63 Ų63121 Ų12141%0.40961%0.608SS.*Hα-helixtrans-58.8-31.2-177.822.7-30.8000112.6E28 V29 F30P26-E28 PolarHBondContact O-N 3.17Å; P26-V29 PolarHBondContact O-N 2.87Å; P26-F30 HydrophobicContact CB-CD2 4.05Å; P26-F30 WeakPolarHBondContact O-CA 3.46Å; P26-F30 WeakPolarHBondContact O-CB 3.33Å; P26-F30 WeakPolarHBondContact O-CD2 2.92Å; P26-F30 PolarHBondContact O-N 3.04Å
27E87.8Confident84.4Confident128 Ų128113.6 Ų113.660%0.59859%0.591SS**Hα-helixtrans-66.4-21.7175.5-6177.3-169.100113.3Q25 V32Q25-E27 PolarHBondContact O-N 2.89Å; E27-V32 HydrophobicContact CG-CG2 4.42Å
28E86.9Confident83.7Confident139 Ų139118 Ų11865%0.6561%0.609SS**Hα-helixtrans-88-23.4177.3-63.3175.8-165.800112.7K24 Q25 P26K24-E28 HydrophobicContact CB-CB 4.45Å; Q25-E28 HydrophobicContact CB-CG 4.23Å; Q25-E28 PolarHBondContact O-N 3.14Å; Q25-E28 WeakPolarHBondContact O-CB 3.49Å; P26-E28 PolarHBondContact O-N 3.17Å
29V88.4Confident82.5Confident41 Ų41116.2 Ų116.225%0.24861%0.612CS.*Hα-helixtrans-109.6-17.4-176.7-73.50000113.9K24 Q25 P26K24-V29 HydrophobicContact CB-CG1 3.89Å; K24-V29 HydrophobicContact CD-CG1 4.03Å; Q25-V29 WeakPolarHBondContact O-CG2 3.44Å; Q25-V29 PolarHBondContact O-N 2.8Å; P26-V29 PolarHBondContact O-N 2.87Å
30F85.1Confident80.7Confident117 Ų117119.8 Ų119.851%0.51362%0.619SS.*SBendtrans-120.2139.4177-63.1-71.7000111.5L17 P26 V32L17-F30 HydrophobicContact CD1-CE2 4.49Å; L17-F30 HydrophobicContact CD1-CZ 3.93Å; P26-F30 HydrophobicContact CB-CD2 4.05Å; P26-F30 WeakPolarHBondContact O-CA 3.46Å; P26-F30 WeakPolarHBondContact O-CB 3.33Å; P26-F30 WeakPolarHBondContact O-CD2 2.92Å; P26-F30 PolarHBondContact O-N 3.04Å; F30-V32 PolarHBondContact O-N 3.01Å
31D86.1Confident79.4Confident146 Ų146122.7 Ų122.778%0.78163%0.626SS**  trans-63.6122.6168.2-63.3-34.5000109.3L33D31-L33 HydrophobicContact CB-CD2 4.46Å; D31-L33 PolarHBondContact O-N 3.42Å; D31-L33 VanDerWaalsContact O-N 3.14Å
32V80.4Confident77.9Confident120 Ų120128.9 Ų128.973%0.72766%0.657SS**  trans-73.3107.1172.6-177.90000107.8E27 F30E27-V32 HydrophobicContact CG-CG2 4.42Å; F30-V32 PolarHBondContact O-N 3.01Å
33L79.6Confident76Confident138 Ų138128.8 Ų128.872%0.72366%0.662SS**  trans-89.6153.8176.3-60178.3000110.9D31D31-L33 HydrophobicContact CB-CD2 4.46Å; D31-L33 PolarHBondContact O-N 3.42Å; D31-L33 VanDerWaalsContact O-N 3.14Å
34E77.7Confident74.2Confident183 Ų183131.8 Ų131.886%0.85567%0.673SS**  trans-57.1145.1173.2-68.3-177.117800111.2L36E34-L36 PolarHBondContact O-N 3.09Å
35K77.7Confident71.8Confident152 Ų152136.8 Ų136.866%0.66169%0.689SS**  trans-67.2107.8-175.7-173.6177173.7-169.50110.3G37 E38K35-G37 VanDerWaalsContact C-N 3.3Å; K35-G37 PolarHBondContact O-N 2.91Å; K35-E38 VanDerWaalsContact NZ-CG 3.31Å; K35-E38 PolarHBondContact NZ-OE1 3.04Å; K35-E38 IonicContact NZ-OE1 2.69Å
36L71.6Confident69.6Low175 Ų175138.3 Ų138.392%0.91670%0.701SS**  trans-78.7-8.5-179.8-63.4176.4000114.3E34E34-L36 PolarHBondContact O-N 3.09Å
37G65.4Low68Low52 Ų52138.8 Ų138.854%0.53670%0.704SS.*  trans162.1179.8179.900000112.6K35K35-G37 VanDerWaalsContact C-N 3.3Å; K35-G37 PolarHBondContact O-N 2.91Å
38E70.8Confident66.3Low166 Ų166136.9 Ų136.978%0.77671%0.71SS**  trans-107.8112.5177.2-71.1178.9170.100109.9K35K35-E38 VanDerWaalsContact NZ-CG 3.31Å; K35-E38 PolarHBondContact NZ-OE1 3.04Å; K35-E38 IonicContact NZ-OE1 2.69Å
39G64.7Low64.6Low52 Ų52140.8 Ų140.854%0.53672%0.719SS.*  trans-75.3147.2173.400000111.5K41G39-K41 VanDerWaalsContact C-N 3.33Å; G39-K41 PolarHBondContact O-N 2.77Å
40W55.6Low62.9Low242 Ų242145.5 Ų145.592%0.91774%0.743SS**SBendtrans-79.61.5-164.764-79000116.8
41K61Low61.1Low172 Ų172148.7 Ų148.775%0.74876%0.759SS**  trans167.798.7165.3-96.4153.1-173.1-174.90108.5G39 T43G39-K41 VanDerWaalsContact C-N 3.33Å; G39-K41 PolarHBondContact O-N 2.77Å; K41-T43 PolarHBondContact O-N 3.45Å
42N56.2Low59.3Low151 Ų151145.6 Ų145.681%0.80775%0.754SS**  trans-88.792.2170.9-68.6-9.8000108.6
43T49.3Very low58Low122 Ų122147.3 Ų147.375%0.74875%0.754SS**  trans-135.599.4164.1-24.90000108.7K41K41-T43 PolarHBondContact O-N 3.45Å
44L51.2Low56.8Low183 Ų183149.1 Ų149.196%0.95876%0.756SS**  trans-106.4111.3169.6-15382000107.3
45W40.3Very low55.5Low210 Ų210144.2 Ų144.280%0.79576%0.755SS**  trans-113.5115.6-179.3179.2-91.5000109.2
46N42.7Very low54.3Low152 Ų152142.5 Ų142.581%0.81376%0.762SS**  trans-115110171.7-167.712.8000110.5A48N46-A48 PolarHBondContact O-N 2.69Å; N46-A48 VanDerWaalsContact O-N 3.09Å
47P50.1Low53.9Low73 Ų73143 Ų14347%0.47476%0.757SS.*  trans-85.573-171.435.8-36000111.9R49P47-R49 HydrophobicContact CB-CB 4.17Å; P47-R49 PolarHBondContact O-N 3.34Å
48A51Low53.6Low88 Ų88147.3 Ų147.373%0.72777%0.767SS**  trans-70.266.3150.500000107.9N46 N50N46-A48 PolarHBondContact O-N 2.69Å; N46-A48 VanDerWaalsContact O-N 3.09Å; A48-N50 VanDerWaalsContact C-N 3.29Å; A48-N50 PolarHBondContact O-N 3.23Å
49R52.6Low53.1Low222 Ų222147 Ų14784%0.83877%0.771SS**  trans-76.180.3-169.9-170.5179.2174.7134.1-0.1108.4P47P47-R49 HydrophobicContact CB-CB 4.17Å; P47-R49 PolarHBondContact O-N 3.34Å
50N52.1Low53Low140 Ų140150.1 Ų150.175%0.74978%0.78SS**  trans-90.6120164.8-78-46.1000109.5A48A48-N50 VanDerWaalsContact C-N 3.29Å; A48-N50 PolarHBondContact O-N 3.23Å
51Q46.3Very low53.2Low184 Ų184143.7 Ų143.786%0.8677%0.77SS**  170.8111.3129.9-93172.952.600107.2
52A49.6Very low53.2Low81 Ų81140.5 Ų140.567%0.66978%0.775SS**  97.5129.772.400000110.2
53E53Low53.3Low155 Ų155139.2 Ų139.272%0.72477%0.773SS**  trans73.5143.6154.2-67.1-176.9175.900117.4
54K53.8Low53.6Low176 Ų176145.3 Ų145.377%0.76580%0.799SS**  cis-165.9142.516.9-115.1152.6-175.6155.60107.9
55G51.4Low53.7Low81 Ų81143.4 Ų143.484%0.83579%0.791SS**  trans42.3113.3151.700000121.4
56S52.5Low54.4Low116 Ų116139.9 Ų139.981%0.81179%0.791SS**  trans-120.992.8146-1720000108.4
57K62.4Low55Low186 Ų186139.2 Ų139.281%0.80979%0.79SS**  trans-97.3105.7159.7-72.8178.9-177.4168.90105.8
58N59.1Low55.3Low141 Ų141143.1 Ų143.175%0.75481%0.808SS**  trans-139.579.6156-80.2-31.2000106.4T60N58-T60 VanDerWaalsContact C-N 3.32Å; N58-T60 PolarHBondContact O-N 3.15Å; N58-T60 VanDerWaalsContact O-N 3.15Å
59D59.9Low55.6Low159 Ų159146.6 Ų146.685%0.8581%0.813SS**  trans-67.296.1156.5-66.5-49.9000107P61D59-P61 WeakPolarHBondContact O-CD 3.46Å
60T62Low55.8Low119 Ų119141.5 Ų141.573%0.7381%0.812SS**  trans-98.2107.4165.6-43.40000107.1N58 A62N58-T60 VanDerWaalsContact C-N 3.32Å; N58-T60 PolarHBondContact O-N 3.15Å; N58-T60 VanDerWaalsContact O-N 3.15Å; T60-A62 PolarHBondContact O-N 3.2Å
61P61.4Low56.1Low107 Ų107141.6 Ų141.670%0.69582%0.816SS**  trans-71115169.728.4-30.5000108.1D59 V63D59-P61 WeakPolarHBondContact O-CD 3.46Å; P61-V63 PolarHBondContact O-N 3.04Å
62A59.6Low56.8Low105 Ų105138.4 Ų138.487%0.86881%0.813SS**  trans-69.798.416700000108.2T60T60-A62 PolarHBondContact O-N 3.2Å
63V59Low57.4Low124 Ų124143.2 Ų143.275%0.75283%0.825SS**  trans-122.2104.2164.5-176.70000107.3P61P61-V63 PolarHBondContact O-N 3.04Å
64L54.9Low57.8Low249 Ų249142.1 Ų142.1100%1.30483%0.834SS**  trans-140.70149.2-80.5179.6000107.5

Retrieved 64 of 64 residues in 9.9 ms (Link to these results)