A0A087WZX3_HUMAN Loading...

WD repeat and FYVE domain containing 2

AlphaFold DB , UniProt , Accession A0A087WZX3, Species HUMAN (Homo sapiens, Human), Gene WDFY2, Length 62 aa.

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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1M56.8Low66.7Low246 Ų246147.7 Ų147.7100%1.21282%0.819SS**  0119.50-168.1158.3-176.900107.2
2A67.3Low66.9Low95 Ų95153.2 Ų153.279%0.78582%0.818SS**  trans-81.2128.7179.600000109.1E4A2-E4 PolarHBondContact O-N 3.47Å
3A69.2Low67.4Low93 Ų93155.9 Ų155.977%0.76982%0.818SS**  trans-73.4123.2174.100000109I5A3-I5 PolarHBondContact O-N 3.13Å; A3-I5 VanDerWaalsContact O-N 3.13Å
4E67.6Low67.8Low189 Ų189154.1 Ų154.188%0.88382%0.82SS**  trans-66.7109.3176.7-61.5-178.4119.100109.1A2 Q6A2-E4 PolarHBondContact O-N 3.47Å; E4-Q6 PolarHBondContact O-N 3.05Å
5I69.9Low68.4Low159 Ų159153.3 Ų153.382%0.81581%0.814SS**  trans-74.199.4177.1-58.2170.5000106.9A3 P7A3-I5 PolarHBondContact O-N 3.13Å; A3-I5 VanDerWaalsContact O-N 3.13Å; I5-P7 VanDerWaalsContact O-CD 3.23Å; I5-P7 WeakPolarHBondContact O-CD 3.23Å
6Q71.5Confident68.9Low170 Ų170151.3 Ų151.379%0.79480%0.803SS**  trans-65115.9169.4-65.5-175.125.500108.2E4 K8E4-Q6 PolarHBondContact O-N 3.05Å; Q6-K8 PolarHBondContact O-N 2.91Å
7P66.5Low69.3Low118 Ų118151.9 Ų151.977%0.76681%0.805SS**  trans-66.9101.9178.426.5-31.1000107.9I5 P9I5-P7 VanDerWaalsContact O-CD 3.23Å; I5-P7 WeakPolarHBondContact O-CD 3.23Å; P7-P9 WeakPolarHBondContact O-CD 3.32Å
8K70.9Confident69.6Low185 Ų185151.9 Ų151.980%0.80480%0.8SS**  trans-60.9120.9170.2-77.5176.9177.3173.40107Q6 L10Q6-K8 PolarHBondContact O-N 2.91Å; K8-L10 PolarHBondContact O-N 2.89Å
9P66Low69.8Low109 Ų109154.4 Ų154.471%0.70880%0.798SS**  trans-60.6110.8174.121.9-28.6000107.3P7 T11P7-P9 WeakPolarHBondContact O-CD 3.32Å; P9-T11 HydrophobicContact CB-CG2 4.41Å; P9-T11 PolarHBondContact O-N 2.81Å
10L68Low70Confident143 Ų143151.1 Ų151.175%0.74978%0.779SS**  trans-68.483.7170.8-72170.4000106.6K8 R12K8-L10 PolarHBondContact O-N 2.89Å; L10-R12 PolarHBondContact O-N 2.76Å
11T59.7Low70.1Confident118 Ų118152.4 Ų152.472%0.72478%0.782SS**  trans-71.370.6173.557.30000108.4P9 K13P9-T11 HydrophobicContact CB-CG2 4.41Å; P9-T11 PolarHBondContact O-N 2.81Å; T11-K13 VanDerWaalsContact C-N 3.35Å; T11-K13 PolarHBondContact O-N 3.25Å
12R69.8Low70.8Confident213 Ų213144.2 Ų144.280%0.80476%0.76SS**  trans-67.399.4168.8-71.2-175.6172.7173-1.7106L10 P14L10-R12 PolarHBondContact O-N 2.76Å; R12-P14 WeakPolarHBondContact O-CD 3.49Å
13K73.4Confident71Confident189 Ų189142 Ų14282%0.82274%0.74SS**PPolyproline II helixtrans-59.1123.9173.4-71.7-176.3177.8179.50107.2T11 I15T11-K13 VanDerWaalsContact C-N 3.35Å; T11-K13 PolarHBondContact O-N 3.25Å; K13-I15 PolarHBondContact O-N 2.98Å
14P72Confident71.1Confident131 Ų131147.6 Ų147.685%0.85175%0.75SS**PPolyproline II helixtrans-61.6127.4174.825.4-32000108R12R12-P14 WeakPolarHBondContact O-CD 3.49Å
15I77.5Confident71.5Confident141 Ų141143.1 Ų143.172%0.72373%0.729SS**PPolyproline II helixtrans-100131.1172.4-151166000107.4K13 L17K13-I15 PolarHBondContact O-N 2.98Å; I15-L17 HydrophobicContact CG2-CD2 3.66Å; I15-L17 HydrophobicContact CG2-CG 4.17Å; I15-L17 PolarHBondContact O-N 3.2Å
16L76.2Confident71.9Confident122 Ų122141.1 Ų141.164%0.63972%0.723SS**  trans-75.4108.2174.8-176.6128.7000107.8R19L16-R19 HydrophobicContact CD1-CG 4.36Å; L16-R19 HydrophobicContact CD2-CG 3.66Å
17L76.4Confident72.4Confident161 Ų161136.1 Ų136.184%0.84371%0.705SS**  trans-77.4-45-179.9-64.8174.8000111.4I15I15-L17 HydrophobicContact CG2-CD2 3.66Å; I15-L17 HydrophobicContact CG2-CG 4.17Å; I15-L17 PolarHBondContact O-N 3.2Å
18Q73.9Confident73.1Confident153 Ų153134.8 Ų134.872%0.71569%0.691SS**  trans-149.3145.6-177.6-173.6162.3-77.700110.1
19R72.9Confident73.7Confident199 Ų199131.5 Ų131.575%0.75168%0.68SS**  trans-92.3133.7166.9-64.9-168.5177.8178.7-0.9108.5L16L16-R19 HydrophobicContact CD1-CG 4.36Å; L16-R19 HydrophobicContact CD2-CG 3.66Å
20M74.3Confident74.5Confident88 Ų88129.3 Ų129.343%0.43367%0.671SS.*  trans-97.4125.8177.2-47.4-174.681.100108V39 L61M20-V39 HydrophobicContact SD-CG2 4.31Å; M20-V39 HydrophobicContact SD-CG1 4.17Å; M20-V39 HydrophobicContact CE-CG2 4.12Å; M20-V39 HydrophobicContact CE-CB 3.84Å; M20-V39 HydrophobicContact SD-CB 4.09Å; M20-L61 HydrophobicContact CB-CD1 4.23Å; M20-L61 HydrophobicContact CE-CB 3.37Å; M20-L61 HydrophobicContact CE-CD1 3.99Å; M20-L61 HydrophobicContact CE-CG 4.31Å; M20-L61 HydrophobicContact SD-CD1 4.25Å
21E72.9Confident75.3Confident179 Ų179126 Ų12684%0.83666%0.657SS**  trans-112.8138.2177.3-62.8-179.1-176.100108.3
22G70.8Confident76.6Confident73 Ų73126.6 Ų126.675%0.75365%0.654SS**  trans141.8-11.6-179.700000115.6
23S70.6Confident77.3Confident50 Ų50118 Ų11835%0.3563%0.625SS.*  trans-109.6127169.4-1740000110.6E25S23-E25 VanDerWaalsContact C-N 3.25Å; S23-E25 PolarHBondContact OG-N 3Å
24Q72.1Confident77.7Confident210 Ų210114 Ų11498%0.98162%0.619SS**  trans-86.5-0.5172.6-64.9-172.392.500112
25E75.4Confident78.4Confident95 Ų95118.3 Ų118.344%0.44462%0.624SS.*SBendtrans-102.6155.9-176.2-66.4160-168.800110.9S23 V27 S43S23-E25 VanDerWaalsContact C-N 3.25Å; S23-E25 PolarHBondContact OG-N 3Å; E25-V27 PolarHBondContact O-N 3.41Å; E25-S43 WeakPolarHBondContact OE2-CB 3.34Å; E25-S43 PolarHBondContact OE2-OG 3.45Å
26V80Confident78.6Confident116 Ų116117.7 Ų117.770%0.70362%0.618SS**  trans-68.4119.6171.31780000108.1N28 S43V26-N28 PolarHBondContact O-N 3.19Å; V26-N28 PolarHBondContact O-OD1 2.91Å; V26-S43 WeakPolarHBondContact O-CB 3.25Å
27V80.7Confident78.7Confident66 Ų66121.4 Ų121.440%0.463%0.632SS.*EExtended strand (participates in β ladder)trans-82.9113.1175.2179.30000108.6E25 M29E25-V27 PolarHBondContact O-N 3.41Å; V27-M29 VanDerWaalsContact CG1-O 3.25Å; V27-M29 WeakPolarHBondContact CG1-O 3.4Å
28N82.4Confident78.6Confident90 Ų90114.3 Ų114.348%0.48160%0.598SS.*EExtended strand (participates in β ladder)trans-81-32.2179.2-62.373.5000111.6V26 V42 E44V26-N28 PolarHBondContact O-N 3.19Å; V26-N28 PolarHBondContact O-OD1 2.91Å; N28-V42 PolarHBondContact N-O 3.18Å; N28-E44 PolarHBondContact ND2-OE1 3.26Å; N28-E44 PolarHBondContact OD1-N 3.48Å
29M82.8Confident79Confident115 Ų115108.6 Ų108.657%0.56757%0.573SS**EExtended strand (participates in β ladder)trans-149.4148-175.8-169.2-175-47.200111.1V27 V31 V42V27-M29 VanDerWaalsContact CG1-O 3.25Å; V27-M29 WeakPolarHBondContact CG1-O 3.4Å; M29-V31 HydrophobicContact SD-CG2 4.47Å; M29-V42 HydrophobicContact CB-CB 4.13Å; M29-V42 PolarHBondContact N-O 2.81Å; M29-V42 PolarHBondContact O-N 3.24Å
30A83.4Confident79.6Confident64 Ų64101.5 Ų101.553%0.52955%0.55SS..EExtended strand (participates in β ladder)trans-134.9139.9171.500000109.8V39 I40A30-V39 HydrophobicContact CB-CG1 3.92Å; A30-I40 VanDerWaalsContact CA-O 3.25Å; A30-I40 WeakPolarHBondContact CA-O 3.25Å; A30-I40 CarbonylContact C-O 3.57Å
31V85.1Confident79.9Confident74 Ų7497.6 Ų97.645%0.44853%0.531SS..EExtended strand (participates in β ladder)trans-126131.7179.1-175.70000109.4M29 I40M29-V31 HydrophobicContact SD-CG2 4.47Å; V31-I40 PolarHBondContact N-O 2.94Å; V31-I40 PolarHBondContact O-N 3.16Å
32I85.6Confident80.5Confident130 Ų13090.7 Ų90.767%0.66750%0.501SS*.EExtended strand (participates in β ladder)trans-87.3124.8173.6-59.9165.4000107.5P34 V39I32-P34 WeakPolarHBondContact O-CD 3.32Å; I32-V39 HydrophobicContact CG1-CG2 4.49Å
33V84.4Confident80.9Confident33 Ų3387.7 Ų87.720%0.247%0.469CS..PPolyproline II helixtrans-82.2118.9176.5-1760000108.7K35 E36 G38 I40V33-K35 PolarHBondContact O-N 3.39Å; V33-E36 VanDerWaalsContact O-O 3.12Å; V33-E36 PolarHBondContact O-N 2.61Å; V33-E36 WeakPolarHBondContact CG1-OE2 3.37Å; V33-E36 HydrophobicContact CG1-CG 4.03Å; V33-E36 HydrophobicContact CG1-CB 4.08Å; V33-E36 HydrophobicContact CB-CB 4.09Å; V33-G38 PolarHBondContact N-O 3.44Å; V33-I40 HydrophobicContact CG2-CD1 3.54Å; V33-I40 HydrophobicContact CG2-CG1 3.92Å
34P82.5Confident81.4Confident104 Ų10491.3 Ų91.368%0.67548%0.48SS*.THydrogen-bonded Turntrans-62.3136.9179.3-20.932.9000110.7I32 E36I32-P34 WeakPolarHBondContact O-CD 3.32Å; P34-E36 PolarHBondContact O-N 3.11Å
35K86.3Confident81.2Confident222 Ų22284.9 Ų84.997%0.96545%0.452SS*.THydrogen-bonded Turntrans72.16.7-179.4-46.2171.9-179.7176.30115.1V33V33-K35 PolarHBondContact O-N 3.39Å
36E81.9Confident80.7Confident127 Ų12789.7 Ų89.759%0.59347%0.466SS*.SBendtrans-121.6141.2171.6-66.6176.9-170.200109.1V33 P34 G38V33-E36 VanDerWaalsContact O-O 3.12Å; V33-E36 PolarHBondContact O-N 2.61Å; V33-E36 WeakPolarHBondContact CG1-OE2 3.37Å; V33-E36 HydrophobicContact CG1-CG 4.03Å; V33-E36 HydrophobicContact CG1-CB 4.08Å; V33-E36 HydrophobicContact CB-CB 4.09Å; P34-E36 PolarHBondContact O-N 3.11Å; E36-G38 PolarHBondContact O-N 3.47Å; E36-G38 VanDerWaalsContact O-N 3.08Å
37E77.4Confident79.7Confident200 Ų20086.9 Ų86.994%0.93545%0.452SS*.SBendtrans-8274.4165.8-75.9-167.4162.800108.3
38G75.5Confident78.7Confident12 Ų1291.9 Ų91.912%0.12448%0.476CS..  trans-154.5146.2-178.700000112.4V33 E36V33-G38 PolarHBondContact N-O 3.44Å; E36-G38 PolarHBondContact O-N 3.47Å; E36-G38 VanDerWaalsContact O-N 3.08Å
39V82.5Confident77Confident34 Ų3490 Ų9021%0.20648%0.478CS..EExtended strand (participates in β ladder)trans-121.6127.4172.1-177.30000108.5M20 A30 I32 L61M20-V39 HydrophobicContact SD-CG2 4.31Å; M20-V39 HydrophobicContact SD-CG1 4.17Å; M20-V39 HydrophobicContact CE-CG2 4.12Å; M20-V39 HydrophobicContact CE-CB 3.84Å; M20-V39 HydrophobicContact SD-CB 4.09Å; A30-V39 HydrophobicContact CB-CG1 3.92Å; I32-V39 HydrophobicContact CG1-CG2 4.49Å; V39-L61 PolarHBondContact O-N 3.47Å; V39-L61 VanDerWaalsContact O-N 3.13Å
40I84.9Confident75.5Confident50 Ų5093.6 Ų93.626%0.25649%0.49SS..EExtended strand (participates in β ladder)trans-89115.5172.7-61.3173000107.3A30 V31 V33 V42 A58A30-I40 VanDerWaalsContact CA-O 3.25Å; A30-I40 WeakPolarHBondContact CA-O 3.25Å; A30-I40 CarbonylContact C-O 3.57Å; V31-I40 PolarHBondContact N-O 2.94Å; V31-I40 PolarHBondContact O-N 3.16Å; V33-I40 HydrophobicContact CG2-CD1 3.54Å; V33-I40 HydrophobicContact CG2-CG1 3.92Å; I40-V42 HydrophobicContact CG2-CG2 4.4Å; I40-A58 HydrophobicContact CG2-CB 3.74Å
41S81.2Confident73.8Confident5 Ų599.4 Ų99.44%0.03551%0.506CS..EExtended strand (participates in β ladder)trans-88.9141.1170.763.10000110.5S59S41-S59 PolarHBondContact N-O 2.91Å; S41-S59 VanDerWaalsContact OG-O 3.11Å; S41-S59 PolarHBondContact OG-O 3.42Å; S41-S59 VanDerWaalsContact N-O 3.16Å; S41-S59 PolarHBondContact O-N 3.26Å
42V83.9Confident71.7Confident35 Ų35100.7 Ų100.721%0.21252%0.517CS..EExtended strand (participates in β ladder)trans-126.3115.4177.8-1780000108.5N28 M29 I40 P56N28-V42 PolarHBondContact N-O 3.18Å; M29-V42 HydrophobicContact CB-CB 4.13Å; M29-V42 PolarHBondContact N-O 2.81Å; M29-V42 PolarHBondContact O-N 3.24Å; I40-V42 HydrophobicContact CG2-CG2 4.4Å; V42-P56 HydrophobicContact CG1-CB 4.27Å
43S81.2Confident69.7Low10 Ų10103.5 Ų103.57%0.0753%0.525CS..EExtended strand (participates in β ladder)trans-111.8160.3172.150.10000110.8E25 V26 D45E25-S43 WeakPolarHBondContact OE2-CB 3.34Å; E25-S43 PolarHBondContact OE2-OG 3.45Å; V26-S43 WeakPolarHBondContact O-CB 3.25Å; S43-D45 PolarHBondContact O-N 3.34Å
44E79.4Confident67.8Low126 Ų126111.2 Ų111.259%0.58956%0.558SS**  trans-70.3121.1168.7-75.8167.4-168.200110.5N28 R46N28-E44 PolarHBondContact ND2-OE1 3.26Å; N28-E44 PolarHBondContact OD1-N 3.48Å; E44-R46 PolarHBondContact O-N 3.41Å
45D68.9Low66.1Low74 Ų74111 Ų11140%0.39656%0.555SS.*  trans-66.9124.9176.3-171.13.8000110.7S43 S47 V57S43-D45 PolarHBondContact O-N 3.34Å; D45-S47 VanDerWaalsContact OD1-CB 3.23Å; D45-S47 WeakPolarHBondContact OD1-CB 3.23Å; D45-S47 PolarHBondContact OD1-N 3.13Å; D45-S47 PolarHBondContact OD1-OG 2.9Å; D45-S47 PolarHBondContact OD2-OG 2.69Å; D45-V57 HydrophobicContact CB-CG2 4Å
46R64.3Low64.5Low196 Ų196104.5 Ų104.574%0.7454%0.535SS*.  trans-104.928.4175.9-65-173.4177.8-163.9-0.2112.5E44 N48E44-R46 PolarHBondContact O-N 3.41Å; R46-N48 PolarHBondContact O-N 2.95Å
47S59.7Low63.2Low57 Ų57101.3 Ų101.340%0.39953%0.525SS..  trans-66.294.1179.150.80000112.1D45 G49D45-S47 VanDerWaalsContact OD1-CB 3.23Å; D45-S47 WeakPolarHBondContact OD1-CB 3.23Å; D45-S47 PolarHBondContact OD1-N 3.13Å; D45-S47 PolarHBondContact OD1-OG 2.9Å; D45-S47 PolarHBondContact OD2-OG 2.69Å; S47-G49 PolarHBondContact O-N 3.08Å
48N58.8Low62.2Low171 Ų17194.5 Ų94.591%0.91450%0.503SS*.  trans-73.751.8175.4-65.3-37.4000113.2R46R46-N48 PolarHBondContact O-N 2.95Å
49G46.4Very low61.4Low50 Ų5096.9 Ų96.952%0.51552%0.517SS..SBendtrans-171.4100.4-174.800000113.2S47S47-G49 PolarHBondContact O-N 3.08Å
50K52Low60.3Low191 Ų191101.1 Ų101.183%0.8354%0.537SS*.SBendtrans23.2124.1154.6-47-158.6-178.7-1710115.6
51H48.5Very low59.1Low187 Ų187100.4 Ų100.487%0.86653%0.534SS*.  trans98.453178.1-45.795.8000115.5K53H51-K53 PolarHBondContact O-N 2.9Å
52C41Very low57.9Low100 Ų100111.2 Ų111.268%0.67658%0.584SS**  trans-82.4112.1168.9-58.70000111.1
53K42.6Very low56.6Low189 Ų189115 Ų11582%0.82260%0.603SS**  trans-118.679.3156.5-63.1-88.3-172.7175.20106.8H51 T55H51-K53 PolarHBondContact O-N 2.9Å; K53-T55 PolarHBondContact O-N 3.01Å
54H45Very low55.3Low196 Ų196120.5 Ų120.591%0.90763%0.631SS**  trans32.660.4165.6-83.8-78.3000116.9P56H54-P56 WeakPolarHBondContact O-CD 3.37Å
55T47.7Very low54Low98 Ų98120.2 Ų120.260%0.60163%0.633SS**  trans-101.2103.9168.746.70000109.1K53 V57K53-T55 PolarHBondContact O-N 3.01Å; T55-V57 PolarHBondContact O-N 2.84Å
56P52.6Low53.1Low86 Ų86122.9 Ų122.956%0.55865%0.647SS**  trans-60.5127161.326.1-30.9000107.3V42 H54 A58V42-P56 HydrophobicContact CG1-CB 4.27Å; H54-P56 WeakPolarHBondContact O-CD 3.37Å; P56-A58 PolarHBondContact O-N 3.3Å
57V54.4Low52.4Low61 Ų61118.4 Ų118.437%0.3764%0.641SS.*EExtended strand (participates in β ladder)trans-73.286175.9-165.10000106.7D45 T55 S59D45-V57 HydrophobicContact CB-CG2 4Å; T55-V57 PolarHBondContact O-N 2.84Å; V57-S59 PolarHBondContact O-N 3.3Å
58A55.3Low51.9Low57 Ų57122.5 Ų122.547%0.47166%0.657SS.*EExtended strand (participates in β ladder)trans-81.299.9176.200000108.1I40 P56I40-A58 HydrophobicContact CG2-CB 3.74Å; P56-A58 PolarHBondContact O-N 3.3Å
59S59.4Low51.5Low62 Ų62119 Ų11943%0.43464%0.639SS.*EExtended strand (participates in β ladder)trans-90.3121.2169.9-65.20000109.1S41 V57 L61S41-S59 PolarHBondContact N-O 2.91Å; S41-S59 VanDerWaalsContact OG-O 3.11Å; S41-S59 PolarHBondContact OG-O 3.42Å; S41-S59 VanDerWaalsContact N-O 3.16Å; S41-S59 PolarHBondContact O-N 3.26Å; V57-S59 PolarHBondContact O-N 3.3Å; S59-L61 PolarHBondContact O-N 3.04Å
60I59.1Low51.8Low122 Ų122124.3 Ų124.363%0.62665%0.648SS**EExtended strand (participates in β ladder)trans-74.1112169.3-60170.9000106.4Q62I60-Q62 HydrophobicContact CG2-CG 4.26Å
61L60.4Low51.8Low35 Ų35118.8 Ų118.818%0.18363%0.633CS.*EExtended strand (participates in β ladder)trans-91.7115.2169.7-70161.3000106.6M20 V39 S59M20-L61 HydrophobicContact CB-CD1 4.23Å; M20-L61 HydrophobicContact CE-CB 3.37Å; M20-L61 HydrophobicContact CE-CD1 3.99Å; M20-L61 HydrophobicContact CE-CG 4.31Å; M20-L61 HydrophobicContact SD-CD1 4.25Å; V39-L61 PolarHBondContact O-N 3.47Å; V39-L61 VanDerWaalsContact O-N 3.13Å; S59-L61 PolarHBondContact O-N 3.04Å
62Q56.1Low52.1Low232 Ų232112.5 Ų112.5100%1.08461%0.612SS**  trans-87.20172.3-61.1-173.4-84.700110I60I60-Q62 HydrophobicContact CG2-CG 4.26Å

Retrieved 62 of 62 residues in 26.3 ms (Link to these results)