A0A087X081_HUMAN Loading...

Transmembrane protein 185A

AlphaFold DB , UniProt , Accession A0A087X081, Species HUMAN (Homo sapiens, Human), Gene TMEM185A, Length 45 aa.

						>A0A087X081_HUMAN|A0A087X081|TMEM185A
MNLRGLFQDFNPRLCVSRCGFSCPFCAWWSSTTLCGPSCSCALWM
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	39.3	Very low	42	Very low	236 Å²	236	148.9 Å²	148.9	100%	1.163	75%	0.745	S	S	*	*				0	126.1	0	-62.4	82.7	174.7	0	0	108.8
2	N	33.1	Very low	42.2	Very low	135 Å²	135	145.5 Å²	145.5	72%	0.722	74%	0.741	S	S	*	*			trans	-93.8	102.1	-172	-156.9	-68.1	0	0	0	109.1	R4	N2-R4 VanDerWaalsContact O-N 3.17Å; N2-R4 PolarHBondContact O-N 3.25Å; N2-R4 WeakPolarHBondContact OD1-CG 3.11Å; N2-R4 WeakPolarHBondContact OD1-CD 3.31Å; N2-R4 WeakPolarHBondContact OD1-CB 3.23Å; N2-R4 VanDerWaalsContact OD1-CD 3.23Å; N2-R4 VanDerWaalsContact OD1-CB 3.31Å
3	L	42.1	Very low	42.7	Very low	129 Å²	129	141.4 Å²	141.4	68%	0.675	71%	0.711	S	S	*	*	G	3₁₀ helix	trans	-75.5	9.5	-176.2	-79.9	153.2	0	0	0	114.2	G5 L6	L3-G5 PolarHBondContact O-N 3.17Å; L3-L6 HydrophobicContact CD2-CD1 4.29Å
4	R	41.6	Very low	42.9	Very low	206 Å²	206	141.4 Å²	141.4	78%	0.777	71%	0.713	S	S	*	*	G	3₁₀ helix	trans	-77.8	-4.2	-171.1	-58.1	-179.4	87.6	-174	7.3	114.1	N2	N2-R4 VanDerWaalsContact O-N 3.17Å; N2-R4 PolarHBondContact O-N 3.25Å; N2-R4 WeakPolarHBondContact OD1-CG 3.11Å; N2-R4 WeakPolarHBondContact OD1-CD 3.31Å; N2-R4 WeakPolarHBondContact OD1-CB 3.23Å; N2-R4 VanDerWaalsContact OD1-CD 3.23Å; N2-R4 VanDerWaalsContact OD1-CB 3.31Å
5	G	38	Very low	43.3	Very low	57 Å²	57	132.7 Å²	132.7	59%	0.588	67%	0.67	S	S	*	*	G	3₁₀ helix	trans	-92.6	-11.9	-179.7	0	0	0	0	0	115.9	L3 F7	L3-G5 PolarHBondContact O-N 3.17Å; G5-F7 VanDerWaalsContact C-N 3.34Å
6	L	45.4	Very low	43.4	Very low	125 Å²	125	131.1 Å²	131.1	65%	0.654	67%	0.669	S	S	*	*	T	Hydrogen-bonded Turn	trans	-87.3	-3.9	178.8	-77.3	163.7	0	0	0	113.4	L3 F10	L3-L6 HydrophobicContact CD2-CD1 4.29Å; L6-F10 WeakPolarHBondContact O-CD2 3.14Å; L6-F10 WeakPolarHBondContact O-CE2 3.35Å
7	F	41.9	Very low	43.5	Very low	153 Å²	153	123.8 Å²	123.8	67%	0.671	63%	0.633	S	S	*	*	T	Hydrogen-bonded Turn	trans	-103.9	2.4	-175.6	-75	-81.3	0	0	0	114.3	G5 F10	G5-F7 VanDerWaalsContact C-N 3.34Å; F7-F10 HydrophobicContact CD1-CD2 4.12Å; F7-F10 HydrophobicContact CD1-CE2 4.14Å; F7-F10 HydrophobicContact CE1-CE2 4.42Å
8	Q	40.4	Very low	43.4	Very low	176 Å²	176	130.3 Å²	130.3	82%	0.822	65%	0.648	S	S	*	*	S	Bend	trans	-89.4	-13.4	179.7	-77.7	-161.7	-14.9	0	0	114.4
9	D	46.3	Very low	43.2	Very low	144 Å²	144	128.8 Å²	128.8	77%	0.77	65%	0.65	S	S	*	*	S	Bend	trans	-104.6	8.9	177.3	-57.9	-78.3	0	0	0	113.7	N11	D9-N11 PolarHBondContact O-N 2.84Å
10	F	47.8	Very low	43.1	Very low	140 Å²	140	125.8 Å²	125.8	61%	0.614	65%	0.652	S	S	*	*			trans	-75	72.8	167	-79.9	-89.9	0	0	0	108.8	L6 F7 P12	L6-F10 WeakPolarHBondContact O-CD2 3.14Å; L6-F10 WeakPolarHBondContact O-CE2 3.35Å; F7-F10 HydrophobicContact CD1-CD2 4.12Å; F7-F10 HydrophobicContact CD1-CE2 4.14Å; F7-F10 HydrophobicContact CE1-CE2 4.42Å; F10-P12 WeakPolarHBondContact O-CD 3.5Å
11	N	46	Very low	42.9	Very low	137 Å²	137	127.5 Å²	127.5	73%	0.733	66%	0.655	S	S	*	*			trans	-68.8	107.4	155.3	-172.1	5.4	0	0	0	105.6	D9 R13	D9-N11 PolarHBondContact O-N 2.84Å; N11-R13 PolarHBondContact O-N 3.07Å
12	P	44.1	Very low	43.1	Very low	108 Å²	108	120.2 Å²	120.2	70%	0.701	63%	0.628	S	S	*	*			trans	-71.4	84	178.7	31.7	-32.3	0	0	0	106.9	F10 L14	F10-P12 WeakPolarHBondContact O-CD 3.5Å; P12-L14 VanDerWaalsContact C-N 3.31Å; P12-L14 PolarHBondContact O-N 2.84Å
13	R	48.8	Very low	43.8	Very low	92 Å²	92	115.1 Å²	115.1	35%	0.347	60%	0.602	S	S	.	*			trans	-65	100.4	173.1	-162.5	-177.8	-170.7	142.2	25.5	106.1	N11 C15 A42 L43 W44	N11-R13 PolarHBondContact O-N 3.07Å; R13-C15 PolarHBondContact O-N 2.85Å; R13-A42 PolarHBondContact NE-O 2.07Å; R13-A42 VanDerWaalsContact NE-O 3.08Å; R13-A42 PolarHBondContact NH2-O 2.81Å; R13-L43 VanDerWaalsContact NH2-CA 3.28Å; R13-L43 VanDerWaalsContact NH1-CG 3.32Å; R13-L43 VanDerWaalsContact CZ-CA 3.49Å; R13-L43 VanDerWaalsContact NH2-C 3.34Å; R13-W44 PolarHBondContact NH2-O 2.95Å
14	L	46.5	Very low	43.9	Very low	142 Å²	142	114.2 Å²	114.2	74%	0.743	60%	0.604	S	S	*	*			trans	-57.2	100.6	-180	-82.5	159.8	0	0	0	108.5	P12 V16	P12-L14 VanDerWaalsContact C-N 3.31Å; P12-L14 PolarHBondContact O-N 2.84Å; L14-V16 PolarHBondContact O-N 2.71Å; L14-V16 VanDerWaalsContact O-N 3.07Å
15	C	48.4	Very low	44.2	Very low	10 Å²	10	112.7 Å²	112.7	7%	0.068	60%	0.603	C	S	.	*	E	Extended strand (participates in β ladder)	trans	-75	94.1	171.3	-79.4	0	0	0	0	107.9	R13 S17 C23 C26	R13-C15 PolarHBondContact O-N 2.85Å; C15-S17 PolarHBondContact O-N 2.97Å; C15-C23 HydrophobicContact CB-CB 4.34Å; C15-C23 PolarHBondContact O-N 3.29Å; C15-C26 WeakPolarHBondContact SG-CB 3.06Å; C15-C26 PolarHBondContact SG-SG 3.29Å; C15-C26 CovalentContact SG-SG 2.04Å; C15-C26 WeakPolarHBondContact CB-SG 3.29Å; C15-C26 HydrophobicContact CB-CB 4.32Å
16	V	44.3	Very low	44.8	Very low	108 Å²	108	112.1 Å²	112.1	66%	0.655	59%	0.59	S	S	*	*	E	Extended strand (participates in β ladder)	trans	-80	110.7	172	-175.6	0	0	0	0	107.7	L14	L14-V16 PolarHBondContact O-N 2.71Å; L14-V16 VanDerWaalsContact O-N 3.07Å
17	S	45.4	Very low	44.8	Very low	7 Å²	7	108.8 Å²	108.8	5%	0.049	58%	0.58	C	S	.	*			trans	-67.9	145.6	168.8	175.5	0	0	0	0	109.5	C15 C19 G20 F21 S38	C15-S17 PolarHBondContact O-N 2.97Å; S17-C19 PolarHBondContact O-N 3.05Å; S17-C19 PolarHBondContact OG-N 2.75Å; S17-G20 PolarHBondContact O-N 3.28Å; S17-F21 VanDerWaalsContact CB-O 3.31Å; S17-F21 WeakPolarHBondContact CB-O 3.02Å; S17-F21 PolarHBondContact N-O 2.04Å; S17-S38 PolarHBondContact OG-O 3.08Å
18	R	41.5	Very low	45	Very low	240 Å²	240	109.8 Å²	109.8	91%	0.906	58%	0.58	S	S	*	*	T	Hydrogen-bonded Turn	trans	-56.2	-15.7	169.8	-88.1	-175.1	174.6	-169.7	-1.2	113
19	C	39.7	Very low	45	Very low	102 Å²	102	111.3 Å²	111.3	69%	0.689	58%	0.578	S	S	*	*	T	Hydrogen-bonded Turn	trans	-89.8	7.3	177.2	-57.2	0	0	0	0	113.9	S17 F21	S17-C19 PolarHBondContact O-N 3.05Å; S17-C19 PolarHBondContact OG-N 2.75Å; C19-F21 PolarHBondContact O-N 3.42Å; C19-F21 VanDerWaalsContact C-N 3.26Å
20	G	40.8	Very low	44.8	Very low	68 Å²	68	109.6 Å²	109.6	70%	0.701	58%	0.577	S	S	*	*	S	Bend	trans	75.9	8.1	177	0	0	0	0	0	115	S17	S17-G20 PolarHBondContact O-N 3.28Å
21	F	39.9	Very low	44.5	Very low	163 Å²	163	108.5 Å²	108.5	72%	0.715	59%	0.587	S	S	*	*			trans	-100.1	126.8	177	-138.9	-95.7	0	0	0	110.3	S17 C19 C23	S17-F21 VanDerWaalsContact CB-O 3.31Å; S17-F21 WeakPolarHBondContact CB-O 3.02Å; S17-F21 PolarHBondContact N-O 2.04Å; C19-F21 PolarHBondContact O-N 3.42Å; C19-F21 VanDerWaalsContact C-N 3.26Å; F21-C23 PolarHBondContact O-N 3.2Å
22	S	43.8	Very low	44.1	Very low	83 Å²	83	106.5 Å²	106.5	58%	0.58	58%	0.58	S	S	*	*	E	Extended strand (participates in β ladder)	trans	-70.2	110.3	173.6	-51.8	0	0	0	0	108.8	P24	S22-P24 VanDerWaalsContact O-CD 3.29Å; S22-P24 WeakPolarHBondContact O-CD 3.31Å
23	C	46.9	Very low	44.4	Very low	28 Å²	28	104.7 Å²	104.7	19%	0.189	57%	0.567	C	S	.	*	E	Extended strand (participates in β ladder)	trans	-75.8	112.7	175.9	-49.6	0	0	0	0	106.8	C15 F21 F25 C39	C15-C23 HydrophobicContact CB-CB 4.34Å; C15-C23 PolarHBondContact O-N 3.29Å; F21-C23 PolarHBondContact O-N 3.2Å; C23-F25 VanDerWaalsContact C-N 3.27Å; C23-F25 PolarHBondContact O-N 3.35Å; C23-C39 HydrophobicContact CB-CB 4.41Å; C23-C39 WeakPolarHBondContact CB-SG 3.31Å; C23-C39 WeakPolarHBondContact SG-CB 3.36Å; C23-C39 CovalentContact SG-SG 2.11Å; C23-C39 PolarHBondContact SG-SG 3.25Å
24	P	45.5	Very low	44	Very low	109 Å²	109	108 Å²	108	71%	0.708	59%	0.59	S	S	*	*	S	Bend	trans	-72.3	-14.9	-162.9	25.7	-33.1	0	0	0	114.6	S22	S22-P24 VanDerWaalsContact O-CD 3.29Å; S22-P24 WeakPolarHBondContact O-CD 3.31Å
25	F	46.5	Very low	44.1	Very low	174 Å²	174	102.5 Å²	102.5	76%	0.763	56%	0.564	S	S	*	*			trans	-145.8	96.5	-178.9	-71.2	-84.1	0	0	0	111.7	C23 A27	C23-F25 VanDerWaalsContact C-N 3.27Å; C23-F25 PolarHBondContact O-N 3.35Å; F25-A27 VanDerWaalsContact C-N 3.32Å; F25-A27 PolarHBondContact O-N 3.16Å
26	C	52	Low	44	Very low	46 Å²	46	104 Å²	104	31%	0.311	58%	0.582	S	S	.	*			trans	-87.4	78.6	157.4	-75.3	0	0	0	0	107.4	C15 W28	C15-C26 WeakPolarHBondContact SG-CB 3.06Å; C15-C26 PolarHBondContact SG-SG 3.29Å; C15-C26 CovalentContact SG-SG 2.04Å; C15-C26 WeakPolarHBondContact CB-SG 3.29Å; C15-C26 HydrophobicContact CB-CB 4.32Å; C26-W28 PolarHBondContact O-N 2.98Å; C26-W28 VanDerWaalsContact O-N 3.16Å
27	A	43.5	Very low	44.2	Very low	54 Å²	54	106 Å²	106	45%	0.446	60%	0.597	S	S	.	*			trans	-69.9	111	172.6	0	0	0	0	0	107.8	F25 W29	F25-A27 VanDerWaalsContact C-N 3.32Å; F25-A27 PolarHBondContact O-N 3.16Å; A27-W29 PolarHBondContact O-N 2.83Å
28	W	46.6	Very low	44.2	Very low	174 Å²	174	109.4 Å²	109.4	66%	0.659	62%	0.621	S	S	*	*			trans	-73.4	76	175.3	-158.1	-23.8	0	0	0	108.3	C26 L43	C26-W28 PolarHBondContact O-N 2.98Å; C26-W28 VanDerWaalsContact O-N 3.16Å; W28-L43 HydrophobicContact CH2-CD2 3.53Å; W28-L43 HydrophobicContact CZ2-CD1 4.43Å; W28-L43 HydrophobicContact CZ2-CD2 3.97Å; W28-L43 HydrophobicContact CZ3-CD2 4.27Å
29	W	40.4	Very low	44.4	Very low	208 Å²	208	99.5 Å²	99.5	79%	0.788	59%	0.587	S	S	*	*			trans	-79.6	122.1	165.4	-77.7	24.5	0	0	0	106.3	A27 S31 T32	A27-W29 PolarHBondContact O-N 2.83Å; W29-S31 VanDerWaalsContact O-N 3.13Å; W29-S31 PolarHBondContact O-N 3.21Å; W29-T32 PolarHBondContact O-N 3.13Å
30	S	41.8	Very low	44.8	Very low	109 Å²	109	98.6 Å²	98.6	76%	0.762	58%	0.582	S	S	*	*	T	Hydrogen-bonded Turn	trans	-19.4	109.5	-177.2	-58.7	0	0	0	0	113.4	T32	S30-T32 VanDerWaalsContact C-N 3.31Å; S30-T32 PolarHBondContact O-N 3.33Å; S30-T32 VanDerWaalsContact O-N 3.14Å
31	S	41.3	Very low	45.3	Very low	116 Å²	116	97 Å²	97	81%	0.811	56%	0.56	S	S	*	*	T	Hydrogen-bonded Turn	trans	67.2	3.6	167.7	-51.6	0	0	0	0	119.3	W29	W29-S31 VanDerWaalsContact O-N 3.13Å; W29-S31 PolarHBondContact O-N 3.21Å
32	T	39	Very low	45.4	Very low	95 Å²	95	92.3 Å²	92.3	58%	0.583	55%	0.552	S	S	*	*			trans	-129.6	96.6	174.4	-25.8	0	0	0	0	110	W29 S30 L34	W29-T32 PolarHBondContact O-N 3.13Å; S30-T32 VanDerWaalsContact C-N 3.31Å; S30-T32 PolarHBondContact O-N 3.33Å; S30-T32 VanDerWaalsContact O-N 3.14Å; T32-L34 VanDerWaalsContact C-N 3.31Å; T32-L34 PolarHBondContact O-N 2.98Å
33	T	49.4	Very low	45.4	Very low	71 Å²	71	92.5 Å²	92.5	44%	0.436	55%	0.546	S	S	.	.			trans	-69.4	95.3	172.5	-26.3	0	0	0	0	108.3	C35 C41	T33-C35 PolarHBondContact O-N 2.99Å; T33-C41 HydrophobicContact CG2-CB 3.94Å; T33-C41 WeakPolarHBondContact CG2-SG 3.1Å
34	L	41.6	Very low	44.9	Very low	160 Å²	160	101.6 Å²	101.6	84%	0.838	58%	0.576	S	S	*	*			trans	-72.6	53	170.7	-102.5	141.8	0	0	0	109.9	T32	T32-L34 VanDerWaalsContact C-N 3.31Å; T32-L34 PolarHBondContact O-N 2.98Å
35	C	48.8	Very low	44.4	Very low	27 Å²	27	108.2 Å²	108.2	18%	0.182	60%	0.601	C	S	.	*			trans	-80.4	114.9	156.4	-76.4	0	0	0	0	104.7	T33 C39 C41	T33-C35 PolarHBondContact O-N 2.99Å; C35-C39 WeakPolarHBondContact CB-O 3.35Å; C35-C39 HydrophobicContact CB-CB 3.7Å; C35-C41 WeakPolarHBondContact CB-SG 3.12Å; C35-C41 WeakPolarHBondContact SG-CB 3.12Å; C35-C41 CovalentContact SG-SG 2.07Å; C35-C41 PolarHBondContact SG-SG 3.35Å
36	G	46.1	Very low	44.3	Very low	43 Å²	43	105 Å²	105	44%	0.443	59%	0.592	S	S	.	*			trans	-52.2	168.2	170.1	0	0	0	0	0	110.8	S38 C39	G36-S38 PolarHBondContact O-N 3.23Å; G36-C39 PolarHBondContact O-N 2.11Å
37	P	46.9	Very low	43.9	Very low	149 Å²	149	108.1 Å²	108.1	97%	0.968	61%	0.607	S	S	*	*	T	Hydrogen-bonded Turn	trans	-55.7	-7	-168.9	22	-33.8	0	0	0	115.8
38	S	46.5	Very low	43.9	Very low	79 Å²	79	111.1 Å²	111.1	55%	0.552	62%	0.616	S	S	*	*	T	Hydrogen-bonded Turn	trans	-108.8	-7.8	-179.2	-36.9	0	0	0	0	115.6	S17 G36	S17-S38 PolarHBondContact OG-O 3.08Å; G36-S38 PolarHBondContact O-N 3.23Å
39	C	45.9	Very low	43.7	Very low	31 Å²	31	107.4 Å²	107.4	21%	0.209	61%	0.614	C	S	.	*			trans	-104.7	122.9	174.6	-54.5	0	0	0	0	108.1	C23 C35 G36	C23-C39 HydrophobicContact CB-CB 4.41Å; C23-C39 WeakPolarHBondContact CB-SG 3.31Å; C23-C39 WeakPolarHBondContact SG-CB 3.36Å; C23-C39 CovalentContact SG-SG 2.11Å; C23-C39 PolarHBondContact SG-SG 3.25Å; C35-C39 WeakPolarHBondContact CB-O 3.35Å; C35-C39 HydrophobicContact CB-CB 3.7Å; G36-C39 PolarHBondContact O-N 2.11Å
40	S	48.1	Very low	43.9	Very low	83 Å²	83	101.1 Å²	101.1	58%	0.58	60%	0.603	S	S	*	*			trans	-109.1	110	171.2	-54.7	0	0	0	0	107.4	A42	S40-A42 PolarHBondContact O-N 2.8Å
41	C	50.4	Low	44.1	Very low	35 Å²	35	100.5 Å²	100.5	24%	0.236	59%	0.592	C	S	.	*			trans	-88.5	98.8	-172.5	-0.5	0	0	0	0	106.5	T33 C35 L43	T33-C41 HydrophobicContact CG2-CB 3.94Å; T33-C41 WeakPolarHBondContact CG2-SG 3.1Å; C35-C41 WeakPolarHBondContact CB-SG 3.12Å; C35-C41 WeakPolarHBondContact SG-CB 3.12Å; C35-C41 CovalentContact SG-SG 2.07Å; C35-C41 PolarHBondContact SG-SG 3.35Å; C41-L43 PolarHBondContact O-N 3.14Å
42	A	42.7	Very low	44.3	Very low	65 Å²	65	99.4 Å²	99.4	54%	0.537	58%	0.577	S	S	.	*			trans	-69.4	100.5	-176.2	0	0	0	0	0	110.4	R13 S40 W44	R13-A42 PolarHBondContact NE-O 2.07Å; R13-A42 VanDerWaalsContact NE-O 3.08Å; R13-A42 PolarHBondContact NH2-O 2.81Å; S40-A42 PolarHBondContact O-N 2.8Å; A42-W44 PolarHBondContact O-N 2.86Å
43	L	43.5	Very low	44.7	Very low	87 Å²	87	99.8 Å²	99.8	46%	0.455	58%	0.576	S	S	.	*			trans	-73.3	77.4	167.5	-101.7	142.5	0	0	0	109.3	R13 W28 C41 M45	R13-L43 VanDerWaalsContact NH2-CA 3.28Å; R13-L43 VanDerWaalsContact NH1-CG 3.32Å; R13-L43 VanDerWaalsContact CZ-CA 3.49Å; R13-L43 VanDerWaalsContact NH2-C 3.34Å; W28-L43 HydrophobicContact CH2-CD2 3.53Å; W28-L43 HydrophobicContact CZ2-CD1 4.43Å; W28-L43 HydrophobicContact CZ2-CD2 3.97Å; W28-L43 HydrophobicContact CZ3-CD2 4.27Å; C41-L43 PolarHBondContact O-N 3.14Å; L43-M45 PolarHBondContact O-N 2.67Å
44	W	36	Very low	44.3	Very low	219 Å²	219	102.2 Å²	102.2	83%	0.83	59%	0.588	S	S	*	*			trans	-55.5	107.8	157	-76.7	58.8	0	0	0	108.1	R13 A42	R13-W44 PolarHBondContact NH2-O 2.95Å; A42-W44 PolarHBondContact O-N 2.86Å
45	M	34.9	Very low	44.5	Very low	248 Å²	248	96.9 Å²	96.9	100%	1.222	57%	0.565	S	S	*	*			trans	-73.7	0	164.4	-58.9	-172.7	-174	0	0	109	L43	L43-M45 PolarHBondContact O-N 2.67Å

Retrieved 45 of 45 residues in 70.4 ms (Link to these results)

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