A0A087X0Z3_HUMAN Loading...

Transient receptor potential cation channel subfamily M member 4

AlphaFold DB , UniProt , Accession A0A087X0Z3, Species HUMAN (Homo sapiens, Human), Gene TRPM4, Length 31 aa.

						>A0A087X0Z3_HUMAN|A0A087X0Z3|TRPM4
MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPG
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	50.8	Low	63.6	Low	236 Å²	236	149.4 Å²	149.4	100%	1.163	74%	0.739	S	S	*	*				0	106.8	0	-68.4	173.5	-173.6	0	106.6	V3	M1-V3 VanDerWaalsContact O-N 3.15Å; M1-V3 PolarHBondContact O-N 3.18Å
2	V	57.7	Low	64.5	Low	143 Å²	143	142.8 Å²	142.8	87%	0.867	72%	0.715	S	S	*	*			trans	-74.4	102.3	172.8	164.4	0	0	0	105.8
3	V	62.6	Low	64.9	Low	88 Å²	88	146.7 Å²	146.7	53%	0.533	73%	0.725	S	S	.	*			trans	-54.5	133.4	166.5	174	0	0	0	106.2	M1 E5	M1-V3 VanDerWaalsContact O-N 3.15Å; M1-V3 PolarHBondContact O-N 3.18Å; V3-E5 PolarHBondContact O-N 3.28Å
4	P	58.6	Low	65.1	Low	71 Å²	71	146.1 Å²	146.1	46%	0.461	72%	0.724	S	S	.	*			trans	-57.6	117.5	-178.7	-15.5	27.7	0	0	107.5	K6 E7	P4-K6 PolarHBondContact O-N 3.45Å; P4-E7 WeakPolarHBondContact CD-OE2 3.47Å; P4-E7 WeakPolarHBondContact CG-OE2 3.19Å; P4-E7 PolarHBondContact O-N 2.97Å
5	E	58.5	Low	65.2	Low	185 Å²	185	147.1 Å²	147.1	86%	0.864	72%	0.722	S	S	*	*	G	3₁₀ helix	trans	-51	-25.1	-176.7	-146.9	-178.8	104.3	0	112.2	V3 E7 Q8	V3-E5 PolarHBondContact O-N 3.28Å; E5-E7 PolarHBondContact O-N 3.15Å; E5-Q8 PolarHBondContact O-N 3.38Å
6	K	60.8	Low	65.8	Low	193 Å²	193	148.9 Å²	148.9	84%	0.839	73%	0.725	S	S	*	*	G	3₁₀ helix	trans	-69.4	-21.7	176.6	-168.5	166	177.6	169.4	115.3	P4 Q8	P4-K6 PolarHBondContact O-N 3.45Å; K6-Q8 VanDerWaalsContact C-N 3.34Å
7	E	61.2	Low	66.9	Low	152 Å²	152	151.7 Å²	151.7	71%	0.71	73%	0.733	S	S	*	*	G	3₁₀ helix	trans	-81.8	-12.2	177.6	-78.8	-167.9	87.3	0	113.6	P4 E5	P4-E7 WeakPolarHBondContact CD-OE2 3.47Å; P4-E7 WeakPolarHBondContact CG-OE2 3.19Å; P4-E7 PolarHBondContact O-N 2.97Å; E5-E7 PolarHBondContact O-N 3.15Å
8	Q	62.6	Low	68	Low	140 Å²	140	155.1 Å²	155.1	65%	0.654	74%	0.744	S	S	*	*	G	3₁₀ helix	trans	-112.6	31.4	-175.3	-150.3	159.6	20.5	0	112.2	E5 K6 W10	E5-Q8 PolarHBondContact O-N 3.38Å; K6-Q8 VanDerWaalsContact C-N 3.34Å; Q8-W10 PolarHBondContact O-N 3.48Å
9	S	74	Confident	69	Low	71 Å²	71	153.1 Å²	153.1	50%	0.497	74%	0.742	S	S	.	*			trans	-67.7	128.1	170.7	-173.8	0	0	0	109.9	I11	S9-I11 PolarHBondContact OG-N 3.1Å; S9-I11 WeakPolarHBondContact OG-CG1 3.48Å; S9-I11 PolarHBondContact O-N 3.41Å
10	W	74.1	Confident	70	Confident	247 Å²	247	151.4 Å²	151.4	94%	0.936	75%	0.745	S	S	*	*			trans	-74	-4.2	175	-71.4	50.8	0	0	112.4	Q8 P12	Q8-W10 PolarHBondContact O-N 3.48Å; W10-P12 WeakPolarHBondContact O-CD 3.4Å
11	I	79.3	Confident	70.9	Confident	117 Å²	117	150.2 Å²	150.2	60%	0.6	75%	0.747	S	S	*	*	S	Bend	trans	-66.7	116.6	174.3	-60.7	173	0	0	107.5	S9 K13 F15	S9-I11 PolarHBondContact OG-N 3.1Å; S9-I11 WeakPolarHBondContact OG-CG1 3.48Å; S9-I11 PolarHBondContact O-N 3.41Å; I11-K13 PolarHBondContact O-N 2.74Å; I11-F15 HydrophobicContact CG2-CD2 3.95Å
12	P	73.8	Confident	72.8	Confident	70 Å²	70	143.9 Å²	143.9	46%	0.455	72%	0.722	S	S	.	*			trans	-55.7	127.1	177.6	-23.4	32.6	0	0	110.2	W10 I14 F15	W10-P12 WeakPolarHBondContact O-CD 3.4Å; P12-I14 HydrophobicContact CB-CB 4.11Å; P12-I14 HydrophobicContact CB-CG2 3.72Å; P12-I14 PolarHBondContact O-N 2.87Å; P12-F15 VanDerWaalsContact O-N 3.1Å; P12-F15 PolarHBondContact O-N 2.83Å; P12-F15 WeakPolarHBondContact O-CD2 3.45Å; P12-F15 HydrophobicContact CG-CE2 4.1Å; P12-F15 HydrophobicContact CB-CE2 4.43Å; P12-F15 HydrophobicContact CB-CD2 4.27Å; P12-F15 HydrophobicContact CG-CD2 4.39Å
13	K	69.8	Low	74	Confident	194 Å²	194	146.5 Å²	146.5	84%	0.843	72%	0.722	S	S	*	*	T	Hydrogen-bonded Turn	trans	-59.3	-4.3	168.8	-61.6	179.6	-176.8	176.7	112.7	I11 F15	I11-K13 PolarHBondContact O-N 2.74Å; K13-F15 PolarHBondContact O-N 2.86Å
14	I	68.2	Low	75.2	Confident	138 Å²	138	149.7 Å²	149.7	71%	0.708	73%	0.734	S	S	*	*	T	Hydrogen-bonded Turn	trans	-68.1	-21.4	173.7	-138.9	166.3	0	0	112.9	P12 K16	P12-I14 HydrophobicContact CB-CB 4.11Å; P12-I14 HydrophobicContact CB-CG2 3.72Å; P12-I14 PolarHBondContact O-N 2.87Å; I14-K16 PolarHBondContact O-N 3.47Å
15	F	66.7	Low	76.3	Confident	161 Å²	161	152.5 Å²	152.5	71%	0.706	75%	0.75	S	S	*	*			trans	-70.4	72.4	170.7	-71.8	-71.1	0	0	109.4	I11 P12 K13	I11-F15 HydrophobicContact CG2-CD2 3.95Å; P12-F15 VanDerWaalsContact O-N 3.1Å; P12-F15 PolarHBondContact O-N 2.83Å; P12-F15 WeakPolarHBondContact O-CD2 3.45Å; P12-F15 HydrophobicContact CG-CE2 4.1Å; P12-F15 HydrophobicContact CB-CE2 4.43Å; P12-F15 HydrophobicContact CB-CD2 4.27Å; P12-F15 HydrophobicContact CG-CD2 4.39Å; K13-F15 PolarHBondContact O-N 2.86Å
16	K	74.8	Confident	77.2	Confident	177 Å²	177	148.2 Å²	148.2	77%	0.77	73%	0.733	S	S	*	*	P	Polyproline II helix	trans	-82.8	139.5	172.7	-65	-176.5	-179.9	179.4	108.4	I14 K18	I14-K16 PolarHBondContact O-N 3.47Å; K16-K18 PolarHBondContact O-N 3.41Å
17	K	84.8	Confident	77.7	Confident	196 Å²	196	144.9 Å²	144.9	85%	0.852	73%	0.734	S	S	*	*	P	Polyproline II helix	trans	-59	138.8	170.9	-69.8	-177.5	178.1	-179.1	108.8	T19	K17-T19 PolarHBondContact O-N 3.49Å
18	K	86.2	Confident	78.3	Confident	213 Å²	213	143 Å²	143	93%	0.926	73%	0.733	S	S	*	*	P	Polyproline II helix	trans	-68.8	126.8	168.7	-67.3	-173.9	179.2	-173.3	107.8	K16	K16-K18 PolarHBondContact O-N 3.41Å
19	T	86.8	Confident	78.6	Confident	116 Å²	116	142.2 Å²	142.2	71%	0.712	73%	0.733	S	S	*	*			trans	-107.3	125	174.6	-62.5	0	0	0	107.8	K17 T21	K17-T19 PolarHBondContact O-N 3.49Å; T19-T21 PolarHBondContact O-N 3.32Å
20	C	88.7	Confident	78.1	Confident	119 Å²	119	144.4 Å²	144.4	80%	0.804	75%	0.745	S	S	*	*			trans	-65	123.9	171.4	-57.7	0	0	0	108.7
21	T	89.9	Confident	77.5	Confident	128 Å²	128	139.3 Å²	139.3	79%	0.785	77%	0.77	S	S	*	*			trans	-100.6	-15.4	-178.2	53.3	0	0	0	113	T19	T19-T21 PolarHBondContact O-N 3.32Å
22	T	89.7	Confident	77.4	Confident	103 Å²	103	140.5 Å²	140.5	63%	0.632	78%	0.778	S	S	*	*			trans	-142.8	130.8	-171.6	-52.1	0	0	0	108.7
23	F	83.6	Confident	77.6	Confident	198 Å²	198	144.2 Å²	144.2	87%	0.868	80%	0.796	S	S	*	*	P	Polyproline II helix	trans	-86.3	124.6	170.5	-65.1	-87.9	0	0	107.8
24	I	87.1	Confident	78	Confident	154 Å²	154	141.4 Å²	141.4	79%	0.79	79%	0.793	S	S	*	*	P	Polyproline II helix	trans	-96.2	122.1	172.6	-57.8	-179.4	0	0	105.8	D26	I24-D26 PolarHBondContact O-N 3.14Å
25	V	81.9	Confident	78.6	Confident	131 Å²	131	141.6 Å²	141.6	79%	0.794	80%	0.798	S	S	*	*	P	Polyproline II helix	trans	-68.8	120.9	168.9	178.4	0	0	0	106.3	S27	V25-S27 PolarHBondContact O-N 3.33Å
26	D	78.1	Confident	79.3	Confident	95 Å²	95	140.4 Å²	140.4	51%	0.508	80%	0.804	S	S	.	*	P	Polyproline II helix	trans	-65.6	117.7	177.8	-171.9	-81.6	0	0	108.7	I24 T28 D29	I24-D26 PolarHBondContact O-N 3.14Å; D26-T28 VanDerWaalsContact O-N 3.14Å; D26-T28 PolarHBondContact OD1-OG1 3.28Å; D26-T28 PolarHBondContact OD1-N 3.42Å; D26-T28 WeakPolarHBondContact OD1-CB 3.28Å; D26-T28 VanDerWaalsContact OD1-CB 3.27Å; D26-T28 WeakPolarHBondContact OD1-CA 3.27Å; D26-T28 VanDerWaalsContact OD1-CA 3.28Å; D26-T28 PolarHBondContact O-N 2.51Å; D26-D29 WeakPolarHBondContact O-CB 3.44Å; D26-D29 PolarHBondContact O-N 2.84Å; D26-D29 PolarHBondContact OD1-N 3.2Å
27	S	70.6	Confident	79.6	Confident	123 Å²	123	137.9 Å²	137.9	86%	0.86	81%	0.806	S	S	*	*	T	Hydrogen-bonded Turn	trans	-71.5	-2.6	-177.3	56.8	0	0	0	113.4	V25	V25-S27 PolarHBondContact O-N 3.33Å
28	T	74.3	Confident	79.3	Confident	112 Å²	112	133.8 Å²	133.8	69%	0.687	80%	0.803	S	S	*	*	T	Hydrogen-bonded Turn	trans	-99.5	-1.6	174.9	73.2	0	0	0	113	D26 P30	D26-T28 VanDerWaalsContact O-N 3.14Å; D26-T28 PolarHBondContact OD1-OG1 3.28Å; D26-T28 PolarHBondContact OD1-N 3.42Å; D26-T28 WeakPolarHBondContact OD1-CB 3.28Å; D26-T28 VanDerWaalsContact OD1-CB 3.27Å; D26-T28 WeakPolarHBondContact OD1-CA 3.27Å; D26-T28 VanDerWaalsContact OD1-CA 3.28Å; D26-T28 PolarHBondContact O-N 2.51Å; T28-P30 WeakPolarHBondContact O-CD 3.12Å
29	D	67.9	Low	78.7	Confident	124 Å²	124	127.7 Å²	127.7	66%	0.663	79%	0.793	S	S	*	*			trans	-68.2	107.4	172.6	-167.8	-119.7	0	0	109.9	D26 G31	D26-D29 WeakPolarHBondContact O-CB 3.44Å; D26-D29 PolarHBondContact O-N 2.84Å; D26-D29 PolarHBondContact OD1-N 3.2Å; D29-G31 PolarHBondContact O-N 3.19Å
30	P	64.1	Low	78.1	Confident	116 Å²	116	128.7 Å²	128.7	75%	0.753	80%	0.8	S	S	*	*			trans	-85.9	98.5	176.5	29.8	-16.1	0	0	107	T28	T28-P30 WeakPolarHBondContact O-CD 3.12Å
31	G	61.2	Low	77.1	Confident	141 Å²	141	129.5 Å²	129.5	100%	1.454	80%	0.8	S	S	*	*			trans	-57.7	0	170.7	0	0	0	0	113.3	D29	D29-G31 PolarHBondContact O-N 3.19Å

Retrieved 31 of 31 residues in 18 ms (Link to these results)

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