A0A087X163_HUMAN Loading...

RAB18, member RAS oncogene family

AlphaFold DB , UniProt , Accession A0A087X163, Species HUMAN (Homo sapiens, Human), Gene RAB18, Length 49 aa.

>A0A087X163_HUMAN|A0A087X163|RAB18
MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGYCWSREV
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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1M42.6Very low53.1Low226 Ų226148.1 Ų148.1100%1.11378%0.775SS**  083.90-74.6-174.4175.200103.6E3M1-E3 PolarHBondContact O-N 2.87Å; M1-E3 VanDerWaalsContact C-N 3.33Å; M1-E3 VanDerWaalsContact O-N 3.1Å
2D49.9Very low53.7Low160 Ų160148.2 Ų148.286%0.85678%0.775SS**  trans-78.692.3-177.6-59.8-87.4000105.9D4D2-D4 PolarHBondContact O-N 3.33Å
3E53.5Low54.7Low176 Ų176142.7 Ų142.782%0.82275%0.746SS**  trans-55129.2178.6-82.8169.485.200109.6M1 V5M1-E3 PolarHBondContact O-N 2.87Å; M1-E3 VanDerWaalsContact C-N 3.33Å; M1-E3 VanDerWaalsContact O-N 3.1Å; E3-V5 VanDerWaalsContact C-N 3.35Å; E3-V5 PolarHBondContact O-N 3.41Å
4D53.7Low55.8Low135 Ų135143.2 Ų143.272%0.72275%0.747SS**  trans-56.982.5-171.5-57.9-92.2000112.9D2 L6D2-D4 PolarHBondContact O-N 3.33Å; D4-L6 HydrophobicContact CB-CD1 3.94Å; D4-L6 HydrophobicContact CB-CG 4.16Å; D4-L6 PolarHBondContact O-N 3.46Å
5V58.8Low56.7Low123 Ų123136.6 Ų136.675%0.74573%0.728SS**  trans-75.977.2161.8-177.10000107.6E3 T7E3-V5 VanDerWaalsContact C-N 3.35Å; E3-V5 PolarHBondContact O-N 3.41Å; V5-T7 PolarHBondContact O-N 2.8Å
6L55.8Low57Low143 Ų143138.3 Ų138.375%0.74973%0.73SS**  trans-68.1-28.2-171-98.2154.8000113.5D4D4-L6 HydrophobicContact CB-CD1 3.94Å; D4-L6 HydrophobicContact CB-CG 4.16Å; D4-L6 PolarHBondContact O-N 3.46Å
7T46.4Very low57.1Low121 Ų121137.7 Ų137.774%0.74274%0.74SS**  trans-165.8118.9174.144.20000112.3V5 L9V5-T7 PolarHBondContact O-N 2.8Å; T7-L9 PolarHBondContact O-N 3.1Å
8T53Low57.4Low118 Ų118134.2 Ų134.272%0.72474%0.742SS**  trans-80.6111.9165.1-50.50000109.6
9L52.1Low57.8Low132 Ų132132.3 Ų132.369%0.69173%0.734SS**  trans-93.8121178.9-151.884.3000110.5T7 I11T7-L9 PolarHBondContact O-N 3.1Å; L9-I11 HydrophobicContact CD2-CD1 3.98Å; L9-I11 HydrophobicContact CG-CG1 4.44Å; L9-I11 HydrophobicContact CD2-CG1 3.91Å
10K52.9Low57.9Low202 Ų202127.1 Ų127.188%0.87871%0.712SS**  trans-100.4112.2172.9-73.9-176178.3178.10109.8
11I65.6Low58.5Low93 Ų93123.2 Ų123.248%0.47769%0.687SS.*  trans-104.4128177.8-53.2176.8000109L9 I13L9-I11 HydrophobicContact CD2-CD1 3.98Å; L9-I11 HydrophobicContact CG-CG1 4.44Å; L9-I11 HydrophobicContact CD2-CG1 3.91Å; I11-I13 HydrophobicContact CG2-CD1 4.3Å; I11-I13 HydrophobicContact CG2-CG1 3.77Å
12L60.4Low59.4Low149 Ų149116.7 Ų116.778%0.7866%0.664SS**  trans-113.5112.2171179.667000108.6I14L12-I14 HydrophobicContact CD2-CD1 4.14Å; L12-I14 HydrophobicContact CD2-CG1 4.43Å; L12-I14 HydrophobicContact CG-CD1 4.41Å; L12-I14 HydrophobicContact CG-CG1 4.16Å
13I66.3Low59.8Low77 Ų77112.7 Ų112.740%0.39565%0.649SS.*  trans-104.6119.3176.2-49.8-170.9000109.2I11 K21 L25I11-I13 HydrophobicContact CG2-CD1 4.3Å; I11-I13 HydrophobicContact CG2-CG1 3.77Å; I13-K21 HydrophobicContact CG2-CG 3.79Å; I13-K21 HydrophobicContact CG2-CD 3.64Å; I13-K21 HydrophobicContact CG2-CB 4.12Å; I13-L25 HydrophobicContact CD1-CD2 3.65Å; I13-L25 HydrophobicContact CD1-CG 3.49Å; I13-L25 VanDerWaalsContact CD1-CG 3.49Å; I13-L25 HydrophobicContact CG1-CD1 4.33Å; I13-L25 HydrophobicContact CG1-CD2 4.45Å; I13-L25 HydrophobicContact CD1-CD1 3.71Å
14I70.3Confident60.1Low150 Ų150110.4 Ų110.477%0.76964%0.641SS**  trans-110.2133.8175.2-54.6176.9000108.1L12L12-I14 HydrophobicContact CD2-CD1 4.14Å; L12-I14 HydrophobicContact CD2-CG1 4.43Å; L12-I14 HydrophobicContact CG-CD1 4.41Å; L12-I14 HydrophobicContact CG-CG1 4.16Å
15G69.4Low60.4Low44 Ų44107 Ų10745%0.45462%0.623SS.*  trans178.8169.6170.400000112.9K21G15-K21 WeakPolarHBondContact O-CE 3.46Å; G15-K21 PolarHBondContact O-NZ 3.27Å
16E61.2Low60.4Low164 Ų164106.6 Ų106.677%0.76662%0.616SS**  trans-62137.5-175-150.7173.7-162.800113.7G18 K21E16-G18 VanDerWaalsContact O-N 3.16Å; E16-G18 PolarHBondContact O-N 3.47Å; E16-K21 PolarHBondContact O-NZ 3.47Å
17S59.3Low60.5Low128 Ų128110.5 Ų110.590%0.89562%0.621SS**THydrogen-bonded Turntrans-59.9118.5-175.9-168.60000110.6
18G62Low60.9Low75 Ų75112.6 Ų112.677%0.77362%0.62SS**THydrogen-bonded Turntrans124.7-12.1177.200000117.3E16 G20E16-G18 VanDerWaalsContact O-N 3.16Å; E16-G18 PolarHBondContact O-N 3.47Å; G18-G20 VanDerWaalsContact C-N 3.35Å; G18-G20 PolarHBondContact O-N 2.94Å
19V65Low60.9Low97 Ų97110.8 Ų110.859%0.58861%0.609SS**SBendtrans-87.514.3-173.6-52.60000115.8K21V19-K21 HydrophobicContact CG2-CD 4.37Å; V19-K21 HydrophobicContact CG2-CG 3.86Å; V19-K21 VanDerWaalsContact CG2-NZ 3.3Å; V19-K21 PolarHBondContact O-N 3.26Å
20G60.2Low60.7Low29 Ų29110.8 Ų110.830%0.29961%0.609SS.*  trans70.729.7174.900000115.3G18 S22 S23 L24G18-G20 VanDerWaalsContact C-N 3.35Å; G18-G20 PolarHBondContact O-N 2.94Å; G20-S22 PolarHBondContact O-N 3.46Å; G20-S23 PolarHBondContact O-N 3.3Å; G20-S23 VanDerWaalsContact O-N 3.15Å; G20-S23 PolarHBondContact O-OG 3.18Å; G20-S23 VanDerWaalsContact CA-OG 3.28Å; G20-S23 WeakPolarHBondContact CA-OG 3.47Å; G20-S23 VanDerWaalsContact C-OG 3.31Å; G20-L24 PolarHBondContact O-N 3.49Å; G20-L24 VanDerWaalsContact O-N 3.17Å
21K69.7Low60.5Low45 Ų45108.6 Ų108.620%0.19661%0.607CS.*Hα-helixtrans-55.5-39.8172.5-69.4175.9-73.9-73.10112I13 G15 E16 V19 L24 L25I13-K21 HydrophobicContact CG2-CG 3.79Å; I13-K21 HydrophobicContact CG2-CD 3.64Å; I13-K21 HydrophobicContact CG2-CB 4.12Å; G15-K21 WeakPolarHBondContact O-CE 3.46Å; G15-K21 PolarHBondContact O-NZ 3.27Å; E16-K21 PolarHBondContact O-NZ 3.47Å; V19-K21 HydrophobicContact CG2-CD 4.37Å; V19-K21 HydrophobicContact CG2-CG 3.86Å; V19-K21 VanDerWaalsContact CG2-NZ 3.3Å; V19-K21 PolarHBondContact O-N 3.26Å; K21-L24 PolarHBondContact O-N 3.34Å; K21-L25 PolarHBondContact O-N 2.89Å
22S61.3Low59.7Low89 Ų89110.3 Ų110.362%0.62262%0.622SS**Hα-helixtrans-67.3-36177.5-47.40000112.7G20 L24 L25 L26G20-S22 PolarHBondContact O-N 3.46Å; S22-L24 VanDerWaalsContact C-N 3.32Å; S22-L24 PolarHBondContact O-N 3.17Å; S22-L25 PolarHBondContact O-N 2.97Å; S22-L26 WeakPolarHBondContact O-CG 3.32Å; S22-L26 PolarHBondContact O-N 3.01Å; S22-L26 VanDerWaalsContact O-CG 3.28Å; S22-L26 WeakPolarHBondContact O-CD1 3.28Å; S22-L26 WeakPolarHBondContact O-CB 3.43Å
23S58.9Low59Low76 Ų76111.5 Ų111.553%0.53162%0.621SS.*Hα-helixtrans-71.1-25.8175.842.30000113.6G20 R27G20-S23 PolarHBondContact O-N 3.3Å; G20-S23 VanDerWaalsContact O-N 3.15Å; G20-S23 PolarHBondContact O-OG 3.18Å; G20-S23 VanDerWaalsContact CA-OG 3.28Å; G20-S23 WeakPolarHBondContact CA-OG 3.47Å; G20-S23 VanDerWaalsContact C-OG 3.31Å; S23-R27 PolarHBondContact O-N 2.94Å
24L60.3Low58Low128 Ų128112.7 Ų112.767%0.6763%0.629SS**Hα-helixtrans-75.7-38.9175-114144.1000111.7G20 K21 S22 F28G20-L24 PolarHBondContact O-N 3.49Å; G20-L24 VanDerWaalsContact O-N 3.17Å; K21-L24 PolarHBondContact O-N 3.34Å; S22-L24 VanDerWaalsContact C-N 3.32Å; S22-L24 PolarHBondContact O-N 3.17Å; L24-F28 WeakPolarHBondContact O-CB 3.28Å; L24-F28 PolarHBondContact O-N 2.68Å
25L60.5Low56.9Low63 Ų63110.4 Ų110.433%0.3362%0.624SS.*Hα-helixtrans-65.6-48.9172.6-77.7166.2000111.2I13 K21 S22 R27 F28 T29I13-L25 HydrophobicContact CD1-CD2 3.65Å; I13-L25 HydrophobicContact CD1-CG 3.49Å; I13-L25 VanDerWaalsContact CD1-CG 3.49Å; I13-L25 HydrophobicContact CG1-CD1 4.33Å; I13-L25 HydrophobicContact CG1-CD2 4.45Å; I13-L25 HydrophobicContact CD1-CD1 3.71Å; K21-L25 PolarHBondContact O-N 2.89Å; S22-L25 PolarHBondContact O-N 2.97Å; L25-R27 VanDerWaalsContact C-N 3.29Å; L25-R27 PolarHBondContact O-N 3.33Å; L25-F28 PolarHBondContact O-N 3.44Å; L25-T29 PolarHBondContact O-N 3.32Å; L25-T29 PolarHBondContact O-OG1 3Å
26L57.8Low55.9Low116 Ų116116.6 Ų116.661%0.60764%0.641SS**Hα-helixtrans-56.3-40.4178.9-75.3164.5000112.5S22 F28 D30S22-L26 WeakPolarHBondContact O-CG 3.32Å; S22-L26 PolarHBondContact O-N 3.01Å; S22-L26 VanDerWaalsContact O-CG 3.28Å; S22-L26 WeakPolarHBondContact O-CD1 3.28Å; S22-L26 WeakPolarHBondContact O-CB 3.43Å; L26-F28 PolarHBondContact O-N 3.15Å; L26-F28 VanDerWaalsContact C-N 3.32Å; L26-D30 WeakPolarHBondContact O-CB 3.46Å; L26-D30 PolarHBondContact O-N 3.05Å
27R57.8Low55.4Low225 Ų225116.2 Ų116.285%0.84964%0.643SS**Hα-helixtrans-68-29.3175.6-171.286.393.4149.78.5113S23 L25S23-R27 PolarHBondContact O-N 2.94Å; L25-R27 VanDerWaalsContact C-N 3.29Å; L25-R27 PolarHBondContact O-N 3.33Å
28F55.3Low54.7Low165 Ų165113.9 Ų113.972%0.72463%0.632SS**Hα-helixtrans-90.2-21.9-174.2-160-97.7000113L24 L25 L26L24-F28 WeakPolarHBondContact O-CB 3.28Å; L24-F28 PolarHBondContact O-N 2.68Å; L25-F28 PolarHBondContact O-N 3.44Å; L26-F28 PolarHBondContact O-N 3.15Å; L26-F28 VanDerWaalsContact C-N 3.32Å
29T53.6Low53.8Low80 Ų80114 Ų11449%0.49163%0.625SS.*Hα-helixtrans-99.9-4.4179.850.20000114.6L25 D31L25-T29 PolarHBondContact O-N 3.32Å; L25-T29 PolarHBondContact O-OG1 3Å; T29-D31 PolarHBondContact O-N 3.33Å
30D47.9Very low52.9Low131 Ų131116 Ų11670%0.70164%0.637SS**THydrogen-bonded Turntrans-80.948.8-175.3-133.4-11.1000113.7L26L26-D30 WeakPolarHBondContact O-CB 3.46Å; L26-D30 PolarHBondContact O-N 3.05Å
31D48.3Very low52.5Low156 Ų156122.3 Ų122.383%0.83466%0.663SS**THydrogen-bonded Turntrans-137.618.1161.3-139.72.5000113.1T29T29-D31 PolarHBondContact O-N 3.33Å
32T47.8Very low51.2Low129 Ų129123 Ų12379%0.79168%0.683SS**  trans-168.194.7161.140000109.3D34T32-D34 PolarHBondContact O-N 2.7Å
33F47.1Very low50.4Low174 Ų174129.2 Ų129.276%0.76369%0.694SS**  trans-81102.1172177.3-101.3000108.6P35F33-P35 HydrophobicContact CD1-CB 4.5Å; F33-P35 HydrophobicContact CE1-CB 3.86Å; F33-P35 HydrophobicContact CZ-CB 4.41Å; F33-P35 VanDerWaalsContact O-CD 3.32Å; F33-P35 WeakPolarHBondContact O-CD 3.15Å
34D44.9Very low49.7Very low102 Ų102131.6 Ų131.655%0.54571%0.709SS.*  trans-92.2106.9170.6-138.5-44.9000108.8T32 E36 L37T32-D34 PolarHBondContact O-N 2.7Å; D34-E36 PolarHBondContact O-N 2.6Å; D34-L37 PolarHBondContact O-N 3.16Å
35P46.9Very low48.6Very low103 Ų103135.2 Ų135.267%0.66971%0.714SS**THydrogen-bonded Turntrans-65.3-7.3-176.525.2-32.9000113.7F33 L37F33-P35 HydrophobicContact CD1-CB 4.5Å; F33-P35 HydrophobicContact CE1-CB 3.86Å; F33-P35 HydrophobicContact CZ-CB 4.41Å; F33-P35 VanDerWaalsContact O-CD 3.32Å; F33-P35 WeakPolarHBondContact O-CD 3.15Å; P35-L37 VanDerWaalsContact C-N 3.3Å
36E48.3Very low48.2Very low173 Ų173136.1 Ų136.181%0.80873%0.726SS**THydrogen-bonded Turntrans-81.4-2.5170.5-74.2-167.4107.300113.9D34 A38D34-E36 PolarHBondContact O-N 2.6Å; E36-A38 PolarHBondContact O-N 2.81Å
37L49.9Very low47.6Very low157 Ų157139.8 Ų139.882%0.82273%0.731SS**SBendtrans-71.577.3170-148.596.2000109.3D34 P35 A39D34-L37 PolarHBondContact O-N 3.16Å; P35-L37 VanDerWaalsContact C-N 3.3Å; L37-A39 PolarHBondContact O-N 3.07Å
38A45.2Very low47.2Very low79 Ų79137.5 Ų137.565%0.65373%0.73SS**  trans-39.7113.9177.200000109.6E36 T40E36-A38 PolarHBondContact O-N 2.81Å; A38-T40 PolarHBondContact O-N 3.05Å
39A43.2Very low46.8Very low76 Ų76139.1 Ų139.163%0.62875%0.753SS**  trans-46.1120.816600000108.3L37 I41 G42L37-A39 PolarHBondContact O-N 3.07Å; A39-I41 PolarHBondContact O-N 2.73Å; A39-G42 PolarHBondContact O-N 3.27Å
40T45.7Very low46.5Very low139 Ų139142.1 Ų142.185%0.85377%0.766SS**THydrogen-bonded Turntrans-72.146.8177.1-25.20000111.2A38A38-T40 PolarHBondContact O-N 3.05Å
41I51.8Low46.4Very low163 Ų163142.6 Ų142.684%0.83677%0.77SS**THydrogen-bonded Turntrans-127.99.9169.2-42.8-178.8000108.9A39A39-I41 PolarHBondContact O-N 2.73Å
42G42.3Very low46.3Very low59 Ų59141.9 Ų141.961%0.60877%0.766SS**  trans-100.7-9.3-17800000116.1A39 C44A39-G42 PolarHBondContact O-N 3.27Å; G42-C44 PolarHBondContact O-N 2.92Å
43Y43.8Very low46.2Very low220 Ų220142.6 Ų142.686%0.86377%0.765SS**  trans-86.572.6169.2-76.5-82.2000109.6W45Y43-W45 VanDerWaalsContact C-N 3.27Å; Y43-W45 PolarHBondContact O-N 3.05Å
44C45.3Very low46.2Very low126 Ų126140.7 Ų140.785%0.85177%0.765SS**  trans-51.593.2153-176.90000108.2G42G42-C44 PolarHBondContact O-N 2.92Å
45W36.2Very low46.3Very low204 Ų204143.3 Ų143.377%0.77378%0.779SS**  trans-87.2113169.4-171.277.9000108.5Y43 R47Y43-W45 VanDerWaalsContact C-N 3.27Å; Y43-W45 PolarHBondContact O-N 3.05Å; W45-R47 HydrophobicContact CZ3-CB 4.49Å; W45-R47 HydrophobicContact CZ3-CG 4.43Å
46S52.8Low46.2Very low81 Ų81146.1 Ų146.157%0.56679%0.787SS**  trans-50.8132.3176.4178.30000112
47R46.3Very low46.1Very low193 Ų193144.1 Ų144.173%0.72879%0.786SS**  trans-135.399.2142-138.8-177.8163.2933.1108.9W45 V49W45-R47 HydrophobicContact CZ3-CB 4.49Å; W45-R47 HydrophobicContact CZ3-CG 4.43Å; R47-V49 PolarHBondContact O-N 3.22Å
48E47.8Very low45.7Very low177 Ų177143 Ų14383%0.82778%0.783SS**  trans-53.5111.5154.6-170.8154174.100108.9
49V48.6Very low45.8Very low199 Ų199148.8 Ų148.8100%1.20680%0.795SS**  trans-1500147.2-77.30000108.6R47R47-V49 PolarHBondContact O-N 3.22Å

Retrieved 49 of 49 residues in 9.1 ms (Link to these results)