A0A089NFM8_HUMAN Loading...

Cystic fibrosis transmembrane conductance regulator

AlphaFold DB , UniProt , Accession A0A089NFM8, Species HUMAN (Homo sapiens, Human), Gene CFTR, Length 26 aa.

						>A0A089NFM8_HUMAN|A0A089NFM8|CFTR
YKDADLYLLDSPFGYLDVLTEKEIFE
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	Y	51.3	Low	60.2	Low	293 Å²	293	153.8 Å²	153.8	100%	1.149	77%	0.774	S	S	*	*				0	73.7	0	-78.5	-85.3	0	0	108.5
2	K	60.7	Low	60.3	Low	194 Å²	194	147 Å²	147	84%	0.843	75%	0.749	S	S	*	*			trans	-135.6	28	-167.9	-142.6	-171.3	-173.8	-172.1	112.1
3	D	56.4	Low	60.2	Low	135 Å²	135	145.6 Å²	145.6	72%	0.722	74%	0.735	S	S	*	*			trans	-138	45.3	-175	-45.8	-65	0	0	109.3	D5	D3-D5 VanDerWaalsContact O-N 3.13Å; D3-D5 PolarHBondContact O-N 3.44Å
4	A	60.8	Low	60.3	Low	98 Å²	98	137.8 Å²	137.8	81%	0.81	71%	0.709	S	S	*	*			trans	-83.1	63.2	159.5	0	0	0	0	107	L6	A4-L6 PolarHBondContact O-N 3.44Å
5	D	59.3	Low	60.3	Low	133 Å²	133	140.3 Å²	140.3	71%	0.711	71%	0.707	S	S	*	*			trans	-65.6	88.4	164.3	-75.2	-32.4	0	0	105.9	D3 Y7	D3-D5 VanDerWaalsContact O-N 3.13Å; D3-D5 PolarHBondContact O-N 3.44Å; D5-Y7 PolarHBondContact O-N 3.28Å
6	L	62.5	Low	60.3	Low	142 Å²	142	137.1 Å²	137.1	74%	0.743	69%	0.693	S	S	*	*			trans	-4.1	89.7	163.9	-172.3	70.1	0	0	112.5	A4 L8	A4-L6 PolarHBondContact O-N 3.44Å; L6-L8 VanDerWaalsContact C-N 3.28Å; L6-L8 HydrophobicContact CD2-CD1 3.8Å; L6-L8 HydrophobicContact CG-CD1 4.13Å; L6-L8 PolarHBondContact O-N 3.36Å
7	Y	60	Low	60.4	Low	204 Å²	204	134.4 Å²	134.4	80%	0.8	68%	0.68	S	S	*	*			trans	-64.7	99.7	161.4	-65.1	-79.9	0	0	105.2	D5 L9	D5-Y7 PolarHBondContact O-N 3.28Å; Y7-L9 PolarHBondContact O-N 3.41Å
8	L	65.1	Low	60.4	Low	137 Å²	137	131.3 Å²	131.3	72%	0.717	67%	0.669	S	S	*	*			trans	-58.9	98.3	162.4	-112.8	95.3	0	0	104.8	L6 D10	L6-L8 VanDerWaalsContact C-N 3.28Å; L6-L8 HydrophobicContact CD2-CD1 3.8Å; L6-L8 HydrophobicContact CG-CD1 4.13Å; L6-L8 PolarHBondContact O-N 3.36Å; L8-D10 PolarHBondContact O-N 3.03Å
9	L	65.6	Low	60.6	Low	124 Å²	124	128.5 Å²	128.5	65%	0.649	66%	0.655	S	S	*	*			trans	-64.5	83.4	173.1	-82.6	159.7	0	0	106.5	Y7 S11 P12	Y7-L9 PolarHBondContact O-N 3.41Å; L9-S11 PolarHBondContact O-N 3.29Å; L9-P12 HydrophobicContact CD2-CG 3.9Å; L9-P12 HydrophobicContact CG-CG 4.34Å; L9-P12 HydrophobicContact CD2-CB 3.76Å; L9-P12 HydrophobicContact CD1-CG 4.31Å; L9-P12 HydrophobicContact CB-CG 4.09Å
10	D	60.9	Low	60.7	Low	151 Å²	151	124.6 Å²	124.6	81%	0.807	64%	0.638	S	S	*	*	S	Bend	trans	-75.6	45.4	177.2	-142.8	17.8	0	0	110.4	L8	L8-D10 PolarHBondContact O-N 3.03Å
11	S	59.4	Low	60.7	Low	81 Å²	81	124.1 Å²	124.1	57%	0.566	63%	0.633	S	S	*	*			trans	100.4	92.3	-169.7	-49.8	0	0	0	113.5	L9 F13 G14	L9-S11 PolarHBondContact O-N 3.29Å; S11-F13 PolarHBondContact O-N 2.6Å; S11-G14 PolarHBondContact O-N 3.3Å; S11-G14 VanDerWaalsContact O-N 3.15Å
12	P	62	Low	61.3	Low	72 Å²	72	117 Å²	117	47%	0.468	61%	0.608	S	S	.	*	T	Hydrogen-bonded Turn	trans	-55.3	-19.5	168.6	-4.8	12	0	0	112.9	L9	L9-P12 HydrophobicContact CD2-CG 3.9Å; L9-P12 HydrophobicContact CG-CG 4.34Å; L9-P12 HydrophobicContact CD2-CB 3.76Å; L9-P12 HydrophobicContact CD1-CG 4.31Å; L9-P12 HydrophobicContact CB-CG 4.09Å
13	F	58.8	Low	61.3	Low	129 Å²	129	115.4 Å²	115.4	57%	0.566	60%	0.604	S	S	*	*	T	Hydrogen-bonded Turn	trans	-98.4	-10.3	-174	-54.3	-69.7	0	0	113.3	S11 Y15 L16 D17	S11-F13 PolarHBondContact O-N 2.6Å; F13-Y15 VanDerWaalsContact C-N 3.31Å; F13-Y15 PolarHBondContact O-N 2.85Å; F13-L16 HydrophobicContact CD1-CD2 4.21Å; F13-L16 CarbonylContact O-C 3.55Å; F13-L16 PolarHBondContact O-N 3.29Å; F13-D17 PolarHBondContact O-N 3.47Å
14	G	61	Low	61.8	Low	36 Å²	36	114.5 Å²	114.5	37%	0.371	60%	0.598	S	S	.	*	H	α-helix	trans	-64.9	-32.3	-176.3	0	0	0	0	114	S11	S11-G14 PolarHBondContact O-N 3.3Å; S11-G14 VanDerWaalsContact O-N 3.15Å
15	Y	60.2	Low	61.9	Low	175 Å²	175	118.3 Å²	118.3	69%	0.686	60%	0.596	S	S	*	*	H	α-helix	trans	-78.3	-33.6	171.6	179.3	-106	0	0	112.3	F13 L19	F13-Y15 VanDerWaalsContact C-N 3.31Å; F13-Y15 PolarHBondContact O-N 2.85Å; Y15-L19 PolarHBondContact O-N 3.32Å; Y15-L19 HydrophobicContact CE2-CD1 4.48Å; Y15-L19 HydrophobicContact CE1-CD1 3.34Å; Y15-L19 HydrophobicContact CD1-CD1 3.98Å; Y15-L19 HydrophobicContact CE1-CG 4.31Å
16	L	61.1	Low	61.5	Low	90 Å²	90	123.2 Å²	123.2	47%	0.471	62%	0.615	S	S	.	*	H	α-helix	trans	-70.1	-36.2	179.4	-161.8	68.6	0	0	110.7	F13 V18 L19 T20	F13-L16 HydrophobicContact CD1-CD2 4.21Å; F13-L16 CarbonylContact O-C 3.55Å; F13-L16 PolarHBondContact O-N 3.29Å; L16-V18 PolarHBondContact O-N 2.77Å; L16-L19 PolarHBondContact O-N 3.42Å; L16-T20 WeakPolarHBondContact O-CB 3.21Å; L16-T20 PolarHBondContact O-N 3.16Å; L16-T20 PolarHBondContact O-OG1 2.9Å
17	D	61.1	Low	61.4	Low	91 Å²	91	122.3 Å²	122.3	49%	0.487	61%	0.608	S	S	.	*	H	α-helix	trans	-60.1	-45.3	176	-78.4	-20.7	0	0	111.1	F13 L19 T20 E21	F13-D17 PolarHBondContact O-N 3.47Å; D17-L19 VanDerWaalsContact C-N 3.3Å; D17-L19 PolarHBondContact O-N 3.31Å; D17-T20 PolarHBondContact O-N 3.13Å; D17-E21 WeakPolarHBondContact O-CB 3.21Å; D17-E21 WeakPolarHBondContact O-CG 3.33Å; D17-E21 PolarHBondContact O-N 2.79Å
18	V	61.8	Low	61.5	Low	79 Å²	79	117.9 Å²	117.9	48%	0.479	60%	0.598	S	S	.	*	H	α-helix	trans	-65.6	-32.6	-179.9	178.3	0	0	0	112.8	L16	L16-V18 PolarHBondContact O-N 2.77Å
19	L	62.9	Low	61.3	Low	77 Å²	77	116.9 Å²	116.9	40%	0.403	59%	0.592	S	S	.	*	H	α-helix	trans	-77	-43.2	176	-73.5	174.2	0	0	111.5	Y15 L16 D17 K22 E23	Y15-L19 PolarHBondContact O-N 3.32Å; Y15-L19 HydrophobicContact CE2-CD1 4.48Å; Y15-L19 HydrophobicContact CE1-CD1 3.34Å; Y15-L19 HydrophobicContact CD1-CD1 3.98Å; Y15-L19 HydrophobicContact CE1-CG 4.31Å; L16-L19 PolarHBondContact O-N 3.42Å; D17-L19 VanDerWaalsContact C-N 3.3Å; D17-L19 PolarHBondContact O-N 3.31Å; L19-K22 PolarHBondContact O-N 3.4Å; L19-E23 PolarHBondContact O-N 2.99Å
20	T	63.8	Low	61	Low	50 Å²	50	116.5 Å²	116.5	31%	0.307	59%	0.588	S	S	.	*	H	α-helix	trans	-73	-33.9	-176.9	-41	0	0	0	111.3	L16 D17 K22 E23 I24	L16-T20 WeakPolarHBondContact O-CB 3.21Å; L16-T20 PolarHBondContact O-N 3.16Å; L16-T20 PolarHBondContact O-OG1 2.9Å; D17-T20 PolarHBondContact O-N 3.13Å; T20-K22 VanDerWaalsContact C-N 3.3Å; T20-K22 PolarHBondContact O-N 3.15Å; T20-E23 PolarHBondContact O-N 2.79Å; T20-I24 HydrophobicContact CG2-CD1 3.91Å; T20-I24 WeakPolarHBondContact O-CG1 3.24Å; T20-I24 PolarHBondContact O-N 2.9Å; T20-I24 VanDerWaalsContact O-N 3.16Å
21	E	61.1	Low	61	Low	116 Å²	116	114.3 Å²	114.3	54%	0.542	58%	0.575	S	S	.	*	H	α-helix	trans	-59.4	-41	173	-81.4	179.6	174.6	0	111.5	D17 E23 I24 F25	D17-E21 WeakPolarHBondContact O-CB 3.21Å; D17-E21 WeakPolarHBondContact O-CG 3.33Å; D17-E21 PolarHBondContact O-N 2.79Å; E21-E23 VanDerWaalsContact C-N 3.34Å; E21-E23 PolarHBondContact O-N 2.81Å; E21-I24 PolarHBondContact O-N 2.8Å; E21-F25 VanDerWaalsContact O-CD2 3.24Å; E21-F25 WeakPolarHBondContact O-CD2 3.34Å; E21-F25 PolarHBondContact O-N 2.78Å
22	K	62.2	Low	61.2	Low	144 Å²	144	116.5 Å²	116.5	63%	0.626	58%	0.575	S	S	*	*	H	α-helix	trans	-67	-34.3	178.9	-72.3	-176.9	178.5	-175.3	113.1	L19 T20	L19-K22 PolarHBondContact O-N 3.4Å; T20-K22 VanDerWaalsContact C-N 3.3Å; T20-K22 PolarHBondContact O-N 3.15Å
23	E	62.6	Low	61.1	Low	160 Å²	160	119.7 Å²	119.7	75%	0.748	58%	0.583	S	S	*	*	H	α-helix	trans	-78.3	-20.9	179.1	-74.5	-176.3	139.5	0	113.8	L19 T20 E21	L19-E23 PolarHBondContact O-N 2.99Å; T20-E23 PolarHBondContact O-N 2.79Å; E21-E23 VanDerWaalsContact C-N 3.34Å; E21-E23 PolarHBondContact O-N 2.81Å
24	I	65.6	Low	61.3	Low	116 Å²	116	119 Å²	119	60%	0.595	58%	0.584	S	S	*	*	H	α-helix	trans	-88.2	-27.7	-179.6	-69	170.6	0	0	112.2	T20 E21	T20-I24 HydrophobicContact CG2-CD1 3.91Å; T20-I24 WeakPolarHBondContact O-CG1 3.24Å; T20-I24 PolarHBondContact O-N 2.9Å; T20-I24 VanDerWaalsContact O-N 3.16Å; E21-I24 PolarHBondContact O-N 2.8Å
25	F	63.3	Low	61.3	Low	178 Å²	178	125.9 Å²	125.9	78%	0.781	60%	0.602	S	S	*	*	H	α-helix	trans	-106.4	-0.3	-172.7	-68.9	-72.5	0	0	115.3	E21	E21-F25 VanDerWaalsContact O-CD2 3.24Å; E21-F25 WeakPolarHBondContact O-CD2 3.34Å; E21-F25 PolarHBondContact O-N 2.78Å
26	E	50	Low	61.4	Low	235 Å²	235	121.5 Å²	121.5	100%	1.098	59%	0.594	S	S	*	*			trans	-95	0	162.7	-78.2	-170.7	165.4	0	111.6

Retrieved 26 of 26 residues in 50.1 ms (Link to these results)

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