A0A096LPI4_HUMAN Loading...

Cyclin dependent kinase like 5

AlphaFold DB , UniProt , Accession A0A096LPI4, Species HUMAN (Homo sapiens, Human), Gene CDKL5, Length 17 aa.

						>A0A096LPI4_HUMAN|A0A096LPI4|CDKL5
MKIPNIGNVMNKFEILG
					

Structure Viewer

Loading PAE data...

(Predicted Aligned Error values between residue pairs)

Download Structure PDB PAE Table

Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	78.2	Confident	83.4	Confident	241 Å²	241	122.8 Å²	122.8	100%	1.187	65%	0.652	S	S	*	*				0	130.3	0	-160.6	169.4	-164.5	0	107.6
2	K	81.3	Confident	83.8	Confident	203 Å²	203	123.4 Å²	123.4	88%	0.883	65%	0.645	S	S	*	*	P	Polyproline II helix	trans	-76.4	126	175.5	-69.5	-179.6	179.6	179.7	108	P4	K2-P4 WeakPolarHBondContact O-CD 3.46Å
3	I	79.6	Confident	84.1	Confident	160 Å²	160	125.2 Å²	125.2	82%	0.821	65%	0.645	S	S	*	*	P	Polyproline II helix	trans	-71.2	124.3	176.7	-59.3	171.9	0	0	107.4	N5	I3-N5 PolarHBondContact O-N 3.25Å
4	P	76.3	Confident	84.5	Confident	94 Å²	94	127.5 Å²	127.5	61%	0.61	65%	0.651	S	S	*	*	P	Polyproline II helix	trans	-59.3	136.3	175.9	-21.4	32.3	0	0	110.8	K2 I6 V9	K2-P4 WeakPolarHBondContact O-CD 3.46Å; P4-I6 PolarHBondContact O-N 3.47Å; P4-V9 HydrophobicContact CB-CG2 4.27Å
5	N	86.3	Confident	84.7	Confident	120 Å²	120	127.2 Å²	127.2	64%	0.642	65%	0.65	S	S	*	*	P	Polyproline II helix	trans	-67.5	119	174.8	-176	-18.5	0	0	109.4	I3 G7 N8 V9	I3-N5 PolarHBondContact O-N 3.25Å; N5-G7 PolarHBondContact O-N 3.32Å; N5-G7 PolarHBondContact OD1-N 3.18Å; N5-N8 HydrophobicContact CB-CB 4.2Å; N5-N8 WeakPolarHBondContact O-CA 3.4Å; N5-N8 VanDerWaalsContact O-CB 3.24Å; N5-N8 WeakPolarHBondContact O-CB 3.35Å; N5-N8 PolarHBondContact O-N 3.45Å; N5-V9 PolarHBondContact O-N 3.25Å
6	I	84.4	Confident	84.3	Confident	131 Å²	131	128.4 Å²	128.4	67%	0.672	66%	0.657	S	S	*	*	H	α-helix	trans	-55.1	-38.3	-179.5	-75.6	153.4	0	0	111.8	P4 N8 V9 M10	P4-I6 PolarHBondContact O-N 3.47Å; I6-N8 PolarHBondContact O-N 3.1Å; I6-V9 WeakPolarHBondContact O-CB 3.09Å; I6-V9 PolarHBondContact O-N 3.21Å; I6-M10 HydrophobicContact CG2-CG 4.29Å; I6-M10 WeakPolarHBondContact O-CG 3.31Å; I6-M10 PolarHBondContact O-N 2.93Å
7	G	84.8	Confident	83.1	Confident	45 Å²	45	128.4 Å²	128.4	46%	0.464	70%	0.696	S	S	.	*	H	α-helix	trans	-60.7	-33.9	175.8	0	0	0	0	112.7	N5 V9 N11	N5-G7 PolarHBondContact O-N 3.32Å; N5-G7 PolarHBondContact OD1-N 3.18Å; G7-V9 VanDerWaalsContact C-N 3.34Å; G7-N11 WeakPolarHBondContact O-CB 3.47Å; G7-N11 PolarHBondContact O-N 3.47Å; G7-N11 VanDerWaalsContact O-N 3.14Å
8	N	84.3	Confident	83.1	Confident	96 Å²	96	128.4 Å²	128.4	51%	0.513	70%	0.696	S	S	.	*	H	α-helix	trans	-76.2	-24	177.8	-147.3	58.1	0	0	112.5	N5 I6 K12	N5-N8 HydrophobicContact CB-CB 4.2Å; N5-N8 WeakPolarHBondContact O-CA 3.4Å; N5-N8 VanDerWaalsContact O-CB 3.24Å; N5-N8 WeakPolarHBondContact O-CB 3.35Å; N5-N8 PolarHBondContact O-N 3.45Å; I6-N8 PolarHBondContact O-N 3.1Å; N8-K12 VanDerWaalsContact O-CG 3.31Å; N8-K12 WeakPolarHBondContact O-CG 3.24Å
9	V	86.3	Confident	83.1	Confident	56 Å²	56	128.4 Å²	128.4	34%	0.339	70%	0.696	S	S	.	*	H	α-helix	trans	-78.5	-46.4	175.3	174.4	0	0	0	109.9	P4 N5 I6 G7 N11 K12 F13	P4-V9 HydrophobicContact CB-CG2 4.27Å; N5-V9 PolarHBondContact O-N 3.25Å; I6-V9 WeakPolarHBondContact O-CB 3.09Å; I6-V9 PolarHBondContact O-N 3.21Å; G7-V9 VanDerWaalsContact C-N 3.34Å; V9-N11 PolarHBondContact O-N 3.32Å; V9-K12 PolarHBondContact O-N 3.04Å; V9-K12 WeakPolarHBondContact O-CB 3.47Å; V9-F13 HydrophobicContact CG1-CD2 3.88Å; V9-F13 HydrophobicContact CG1-CE2 3.41Å; V9-F13 VanDerWaalsContact CG1-CE2 3.41Å; V9-F13 WeakPolarHBondContact O-CD2 3.43Å; V9-F13 PolarHBondContact O-N 2.92Å
10	M	88	Confident	83.1	Confident	123 Å²	123	128.4 Å²	128.4	61%	0.606	70%	0.696	S	S	*	*	H	α-helix	trans	-60.1	-45.5	177.5	-65.9	-54.7	-67.1	0	112.2	I6 K12 F13 E14	I6-M10 HydrophobicContact CG2-CG 4.29Å; I6-M10 WeakPolarHBondContact O-CG 3.31Å; I6-M10 PolarHBondContact O-N 2.93Å; M10-K12 VanDerWaalsContact C-N 3.29Å; M10-K12 PolarHBondContact O-N 3.22Å; M10-F13 PolarHBondContact O-N 3.26Å; M10-F13 VanDerWaalsContact O-N 3.1Å; M10-E14 PolarHBondContact O-N 3.14Å
11	N	88.2	Confident	83.1	Confident	82 Å²	82	128.4 Å²	128.4	44%	0.439	70%	0.696	S	S	.	*	H	α-helix	trans	-60.3	-36.9	177.2	-171.1	17.4	0	0	112.6	G7 V9 F13 E14 I15	G7-N11 WeakPolarHBondContact O-CB 3.47Å; G7-N11 PolarHBondContact O-N 3.47Å; G7-N11 VanDerWaalsContact O-N 3.14Å; V9-N11 PolarHBondContact O-N 3.32Å; N11-F13 VanDerWaalsContact C-N 3.33Å; N11-F13 PolarHBondContact O-N 3.27Å; N11-E14 PolarHBondContact O-N 3.01Å; N11-I15 WeakPolarHBondContact O-CG1 3.4Å; N11-I15 PolarHBondContact O-N 3.32Å; N11-I15 VanDerWaalsContact O-N 3.17Å
12	K	87.7	Confident	83.4	Confident	130 Å²	130	121.3 Å²	121.3	57%	0.565	67%	0.665	S	S	*	*	H	α-helix	trans	-64.9	-35.7	175.6	-78.5	178.1	-179.8	-168.5	112.9	N8 V9 M10 E14 L16	N8-K12 VanDerWaalsContact O-CG 3.31Å; N8-K12 WeakPolarHBondContact O-CG 3.24Å; V9-K12 PolarHBondContact O-N 3.04Å; V9-K12 WeakPolarHBondContact O-CB 3.47Å; M10-K12 VanDerWaalsContact C-N 3.29Å; M10-K12 PolarHBondContact O-N 3.22Å; K12-E14 VanDerWaalsContact C-N 3.34Å; K12-L16 WeakPolarHBondContact O-CD1 3.39Å; K12-L16 WeakPolarHBondContact O-CG 3.35Å
13	F	87.6	Confident	83.6	Confident	146 Å²	146	115.9 Å²	115.9	64%	0.64	65%	0.651	S	S	*	*	H	α-helix	trans	-71.7	-30.9	177.6	-74.9	-68.3	0	0	112.3	V9 M10 N11	V9-F13 HydrophobicContact CG1-CD2 3.88Å; V9-F13 HydrophobicContact CG1-CE2 3.41Å; V9-F13 VanDerWaalsContact CG1-CE2 3.41Å; V9-F13 WeakPolarHBondContact O-CD2 3.43Å; V9-F13 PolarHBondContact O-N 2.92Å; M10-F13 PolarHBondContact O-N 3.26Å; M10-F13 VanDerWaalsContact O-N 3.1Å; N11-F13 VanDerWaalsContact C-N 3.33Å; N11-F13 PolarHBondContact O-N 3.27Å
14	E	90.4	Very high	83.9	Confident	158 Å²	158	112.7 Å²	112.7	74%	0.738	64%	0.638	S	S	*	*	H	α-helix	trans	-73.2	-39.1	177.7	-168.9	172.1	-176.7	0	112.8	M10 N11 K12 L16 G17	M10-E14 PolarHBondContact O-N 3.14Å; N11-E14 PolarHBondContact O-N 3.01Å; K12-E14 VanDerWaalsContact C-N 3.34Å; E14-L16 PolarHBondContact O-N 3.24Å; E14-G17 PolarHBondContact O-N 3.17Å
15	I	86.8	Confident	84.4	Confident	123 Å²	123	114.2 Å²	114.2	63%	0.631	64%	0.641	S	S	*	*	H	α-helix	trans	-67.8	-23.7	178.4	-65.7	163.9	0	0	112.7	N11 G17	N11-I15 WeakPolarHBondContact O-CG1 3.4Å; N11-I15 PolarHBondContact O-N 3.32Å; N11-I15 VanDerWaalsContact O-N 3.17Å; I15-G17 VanDerWaalsContact C-N 3.32Å
16	L	78.8	Confident	84.3	Confident	147 Å²	147	113.7 Å²	113.7	77%	0.77	64%	0.641	S	S	*	*	T	Hydrogen-bonded Turn	trans	-88	-0.9	179.6	-70	169.9	0	0	113.2	K12 E14	K12-L16 WeakPolarHBondContact O-CD1 3.39Å; K12-L16 WeakPolarHBondContact O-CG 3.35Å; E14-L16 PolarHBondContact O-N 3.24Å
17	G	64.3	Low	84.3	Confident	127 Å²	127	112.1 Å²	112.1	100%	1.309	64%	0.638	S	S	*	*			trans	-74.2	0	170.9	0	0	0	0	113.2	E14 I15	E14-G17 PolarHBondContact O-N 3.17Å; I15-G17 VanDerWaalsContact C-N 3.32Å

Retrieved 17 of 17 residues in 138.6 ms (Link to these results)

U.S. Privacy Notice - Disclaimer / Registrations / Copyright Statement - Linking Policy - Notice of Privacy Practices (HIPAA) - Notice of Non‑Discrimination
© Copyright 2026 St. Jude Children's Research Hospital, a not-for-profit, section 501(c)(3).