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E3 SUMO-protein ligase PIAS1

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor^1,2,3,4,5,6. Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2, PML and ZNF76^{7,8,9,10,11,12}. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway^13,14. In vitro, binds A/T-rich DNA¹⁵. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context^{16,17,18,19,20}. Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection²¹. Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation²². Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression²³. The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes²⁴.

AlphaFold DB , UniProt , Accession O75925, Species HUMAN (Homo sapiens, Human), Gene PIAS1, Length 651 aa.