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RNA 3'-terminal phosphate cyclase

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (By similarity). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (By similarity). Likely functions in some aspects of cellular RNA processing (By similarity). Function plays an important role in a RNA repair and splicing pathway which controls axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury^1,2. In response to axotomy, negatively regulates splicing of Xbp1 which in turn activates downstream effectors which inhibit axon regeneration, including down-regulating the microtubule regulators ringer and futsch^3,4.

AlphaFold DB , UniProt , Accession O77264, Species DROME (Drosophila melanogaster, Fruit fly), Gene Rtca, Length 361 aa.