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Presenilin-1

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein)^{1,2,3,4,5,6,7,8,9,10,11,12,13,14}. Requires the presence of the other members of the gamma-secretase complex for protease activity^{15,16,17,18,19}. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels^20,21,22,23. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin)²⁴. Under conditions of apoptosis or calcium influx, cleaves CDH1²⁵. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling^26,27. Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2^28,29. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis^30,31. Involved in the regulation of neurite outgrowth^32,33. Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity).

AlphaFold DB , UniProt , Accession P49768, Species HUMAN (Homo sapiens, Human), Gene PSEN1, Length 467 aa.

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(Predicted Aligned Error values between residue pairs)

Download Structure PDB PAE Table

Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	38.7	Very low	40.7	Very low	230 Å²	230	157.2 Å²	157.2	100%	1.133	84%	0.844	S	S	*	*				0	82.9	0	-73	172.9	-178.2	0	0	105.3
2	T	38.6	Very low	40.3	Very low	130 Å²	130	157.3 Å²	157.3	80%	0.798	84%	0.835	S	S	*	*				75.9	124.1	100.9	46.1	0	0	0	0	110.5
3	E	37.2	Very low	40	Very low	169 Å²	169	155.9 Å²	155.9	79%	0.79	83%	0.828	S	S	*	*			cis	163.3	118.5	-2.5	-102.5	-94.8	136	0	0	102.1
4	L	36.2	Very low	40	Very low	156 Å²	156	150.4 Å²	150.4	82%	0.817	82%	0.816	S	S	*	*			trans	33.7	171.4	134.8	-105.5	105.7	0	0	0	123
5	P	49.7	Very low	39.9	Very low	111 Å²	111	151.9 Å²	151.9	72%	0.721	82%	0.815	S	S	*	*				-127.7	-175.5	-121.8	31	-5.2	0	0	0	113.9
6	A	47.3	Very low	39.6	Very low	96 Å²	96	151.8 Å²	151.8	79%	0.793	81%	0.811	S	S	*	*			trans	-173.2	146.7	154.3	0	0	0	0	0	113.4
7	P	38.9	Very low	39.2	Very low	129 Å²	129	149.7 Å²	149.7	84%	0.838	81%	0.811	S	S	*	*			trans	-100.3	157.7	173.2	37.7	-29.5	0	0	0	113
8	L	43.3	Very low	39.6	Very low	165 Å²	165	151.8 Å²	151.8	86%	0.864	81%	0.814	S	S	*	*			trans	-118.7	117.6	-177.7	-98	166.1	0	0	0	113.7
9	S	40.1	Very low	39.5	Very low	98 Å²	98	151.9 Å²	151.9	69%	0.685	82%	0.815	S	S	*	*				57.4	119.7	129.2	62.7	0	0	0	0	123.2
10	Y	33.8	Very low	39.7	Very low	231 Å²	231	152.9 Å²	152.9	91%	0.906	82%	0.82	S	S	*	*			trans	-28.2	145	146.2	-90	-104.8	0	0	0	117.5
11	F	43.9	Very low	39.6	Very low	214 Å²	214	153.7 Å²	153.7	94%	0.939	82%	0.818	S	S	*	*			trans	-112.6	134.5	161.5	-123.7	-88.4	0	0	0	110.1
12	Q	35.5	Very low	39.6	Very low	159 Å²	159	149.8 Å²	149.8	74%	0.743	80%	0.801	S	S	*	*			trans	-119.8	145.8	-174.3	-172.3	-175.8	-43.9	0	0	109.9
13	N	37.5	Very low	39.6	Very low	139 Å²	139	148 Å²	148	74%	0.743	79%	0.794	S	S	*	*			trans	134.8	120.7	141.9	-75.1	-31.8	0	0	0	113.9
14	A	39.1	Very low	39.9	Very low	79 Å²	79	148.1 Å²	148.1	65%	0.653	80%	0.8	S	S	*	*				176.8	120.6	104.3	0	0	0	0	0	112.9
15	Q	38	Very low	40	Very low	172 Å²	172	147 Å²	147	80%	0.804	80%	0.799	S	S	*	*			trans	62.2	139.3	134.8	-72.5	171.6	-64.4	0	0	119.6
16	M	35.9	Very low	39.6	Very low	151 Å²	151	148 Å²	148	74%	0.744	80%	0.804	S	S	*	*			cis	-172.3	137.5	6.8	-179.6	173.2	-88.2	0	0	107.3
17	S	33.3	Very low	39.2	Very low	116 Å²	116	154.1 Å²	154.1	81%	0.811	81%	0.806	S	S	*	*			trans	-82.7	144.9	169.1	-73.2	0	0	0	0	110.9
18	E	45.4	Very low	39.5	Very low	188 Å²	188	154.1 Å²	154.1	88%	0.879	81%	0.809	S	S	*	*			trans	-155	125.2	148.6	-113.1	177.5	145.2	0	0	111
19	D	37.5	Very low	39.4	Very low	154 Å²	154	153.7 Å²	153.7	82%	0.824	80%	0.803	S	S	*	*			trans	-70.6	146.4	170.7	-70.3	-54.8	0	0	0	111.1
20	N	44.8	Very low	39.7	Very low	171 Å²	171	156.7 Å²	156.7	91%	0.914	81%	0.811	S	S	*	*			trans	-156.5	130.1	145.2	-119.8	-21.5	0	0	0	114.9
21	H	36.8	Very low	40.1	Very low	170 Å²	170	150.5 Å²	150.5	79%	0.787	79%	0.794	S	S	*	*			trans	-85.7	164.5	175.1	-104.9	-91.4	0	0	0	111.6
22	L	39	Very low	39.9	Very low	148 Å²	148	146 Å²	146	78%	0.775	78%	0.779	S	S	*	*			trans	90.1	115.7	155.8	-98.8	87.6	0	0	0	121.2
23	S	39.3	Very low	40.1	Very low	92 Å²	92	148 Å²	148	64%	0.643	78%	0.78	S	S	*	*				67	116.2	128.8	-58.7	0	0	0	0	120.5
24	N	42.1	Very low	40.3	Very low	171 Å²	171	147.8 Å²	147.8	91%	0.914	78%	0.775	S	S	*	*				-166.2	122.6	120.5	-94	-25.4	0	0	0	113.9
25	T	38.3	Very low	40.3	Very low	132 Å²	132	154.6 Å²	154.6	81%	0.81	78%	0.783	S	S	*	*			trans	-74.7	137.9	170.1	-59.2	0	0	0	0	112
26	V	42.7	Very low	40.2	Very low	133 Å²	133	155.3 Å²	155.3	81%	0.806	79%	0.787	S	S	*	*			trans	-168.3	104.1	145.7	172.1	0	0	0	0	107.8
27	R	39.1	Very low	40.5	Very low	225 Å²	225	157.7 Å²	157.7	85%	0.849	80%	0.796	S	S	*	*				86.8	106.3	87.4	-156	-176.5	-164.4	171.8	3.8	115.4
28	S	44	Very low	40.8	Very low	128 Å²	128	159.8 Å²	159.8	90%	0.895	79%	0.793	S	S	*	*				-169.6	138	124.7	-90	0	0	0	0	111.9
29	Q	41.6	Very low	40.7	Very low	157 Å²	157	158.2 Å²	158.2	73%	0.734	79%	0.79	S	S	*	*			trans	-125	139	-161.9	178.7	-174.2	2.6	0	0	107.3
30	N	46.7	Very low	40.8	Very low	161 Å²	161	156.8 Å²	156.8	86%	0.861	78%	0.782	S	S	*	*			trans	-164.2	85.8	156.7	-133.7	12.5	0	0	0	107.7
31	D	42.1	Very low	40.7	Very low	101 Å²	101	160.2 Å²	160.2	54%	0.54	78%	0.783	S	S	.	*				69.9	117.3	83.8	-98.6	13.1	0	0	0	116.7
32	N	39.1	Very low	40.8	Very low	118 Å²	118	164 Å²	164	63%	0.631	79%	0.79	S	S	*	*			trans	67.9	146.4	135.2	-68	-34.9	0	0	0	119
33	R	39.9	Very low	41	Very low	202 Å²	202	162.7 Å²	162.7	76%	0.762	79%	0.793	S	S	*	*			cis	179.8	155.3	-12.5	-130.5	177.5	166.1	155.5	-4.7	104.3
34	E	41	Very low	41.2	Very low	135 Å²	135	166.5 Å²	166.5	63%	0.631	81%	0.806	S	S	*	*			trans	83.9	127.1	143.7	-75.9	179	-156.2	0	0	123.5
35	R	40.2	Very low	41.1	Very low	222 Å²	222	161.8 Å²	161.8	84%	0.838	80%	0.797	S	S	*	*			trans	114	104.4	134	-82.8	165.7	-172	-119.6	2.1	119.3
36	Q	36.3	Very low	41.4	Very low	186 Å²	186	164.6 Å²	164.6	87%	0.869	80%	0.801	S	S	*	*			trans	-41.2	144.3	146.9	-73.6	155	-60.9	0	0	112.8
37	E	41	Very low	41.5	Very low	202 Å²	202	163.7 Å²	163.7	94%	0.944	80%	0.797	S	S	*	*				-169.5	155.2	120.2	-106.5	177	173.9	0	0	113.5
38	H	40.2	Very low	41.9	Very low	160 Å²	160	162.2 Å²	162.2	74%	0.741	80%	0.8	S	S	*	*			trans	-90	140.1	-163.8	-156.4	-52.4	0	0	0	110.8
39	N	43.2	Very low	42	Very low	154 Å²	154	161.5 Å²	161.5	82%	0.824	79%	0.793	S	S	*	*				-176	141.1	127.9	-120.9	-19.9	0	0	0	116
40	D	40.6	Very low	42	Very low	124 Å²	124	162.1 Å²	162.1	66%	0.663	80%	0.8	S	S	*	*			trans	-63.2	146.7	173.9	-70.1	-70.8	0	0	0	115
41	R	41	Very low	42	Very low	243 Å²	243	160.2 Å²	160.2	92%	0.917	80%	0.799	S	S	*	*				168.9	122.1	112	-94.9	175.6	170.2	174.2	-2.5	113.9
42	R	39.3	Very low	42.2	Very low	250 Å²	250	162.8 Å²	162.8	94%	0.943	81%	0.813	S	S	*	*			trans	1.3	127.8	150.9	-64.8	175.4	-176.3	171	0.3	118.6
43	S	43.6	Very low	42.4	Very low	120 Å²	120	160.8 Å²	160.8	84%	0.839	82%	0.82	S	S	*	*				-165.8	144.1	121.5	-159.5	0	0	0	0	112.4
44	L	43.1	Very low	42.6	Very low	173 Å²	173	162.8 Å²	162.8	91%	0.906	83%	0.828	S	S	*	*			trans	-62.5	151.5	-177.6	-88.3	69.1	0	0	0	114.8
45	G	40.1	Very low	42.7	Very low	72 Å²	72	162.1 Å²	162.1	74%	0.742	84%	0.835	S	S	*	*			trans	139	107.3	136.8	0	0	0	0	0	118.6
46	H	43.9	Very low	43.1	Very low	191 Å²	191	161.2 Å²	161.2	88%	0.884	84%	0.84	S	S	*	*			trans	71.6	129.1	153.7	-93	-59.7	0	0	0	122.9
47	P	46.8	Very low	43.7	Very low	113 Å²	113	154.6 Å²	154.6	73%	0.734	82%	0.822	S	S	*	*			trans	-107	148.8	169.2	38.2	-27.5	0	0	0	113.2
48	E	46.5	Very low	44.1	Very low	195 Å²	195	151 Å²	151	91%	0.911	81%	0.809	S	S	*	*			trans	-163.8	154.8	148.4	-88.9	-130.6	124.4	0	0	110.8
49	P	45.2	Very low	44.6	Very low	113 Å²	113	147.8 Å²	147.8	73%	0.734	81%	0.805	S	S	*	*			trans	-106.9	159.1	-137.3	38.1	-32.6	0	0	0	116.9
50	L	42.9	Very low	45	Very low	169 Å²	169	149.4 Å²	149.4	89%	0.885	80%	0.8	S	S	*	*			trans	-71.7	129.3	174.2	-77	151.7	0	0	0	112.6
51	S	45.9	Very low	45.4	Very low	121 Å²	121	150 Å²	150	85%	0.846	80%	0.798	S	S	*	*			trans	-103.1	119.3	161	177.9	0	0	0	0	108.9
52	N	46.4	Very low	46.2	Very low	156 Å²	156	142.1 Å²	142.1	83%	0.834	78%	0.777	S	S	*	*			trans	-112.5	118.8	178.7	-115.7	-1	0	0	0	109.4
53	G	43	Very low	47.3	Very low	75 Å²	75	133.8 Å²	133.8	77%	0.773	75%	0.754	S	S	*	*			trans	-77.2	144.6	173.3	0	0	0	0	0	113.3
54	R	44.5	Very low	48.1	Very low	245 Å²	245	132.7 Å²	132.7	93%	0.925	74%	0.735	S	S	*	*			trans	-140.6	152.4	167	-106.9	-179.3	172	169.8	-2.9	110.5
55	P	43.5	Very low	48.9	Very low	120 Å²	120	129.9 Å²	129.9	78%	0.779	72%	0.717	S	S	*	*			trans	-84.7	134.4	-150.5	32.4	-34.7	0	0	0	115.3	G57	P55-G57 VanDerWaalsContact C-N 3.28Å; P55-G57 PolarHBondContact O-N 3.08Å; P55-G57 VanDerWaalsContact O-N 3.08Å
56	Q	48	Very low	50	Low	203 Å²	203	130.5 Å²	130.5	95%	0.949	70%	0.704	S	S	*	*			trans	-79.5	49.4	177.7	-102.5	178.5	-5.8	0	0	113.6
57	G	49.8	Very low	51	Low	47 Å²	47	127 Å²	127	49%	0.485	69%	0.688	S	S	.	*			trans	-101.7	-33.7	-174.2	0	0	0	0	0	116.6	P55	P55-G57 VanDerWaalsContact C-N 3.28Å; P55-G57 PolarHBondContact O-N 3.08Å; P55-G57 VanDerWaalsContact O-N 3.08Å
58	N	49.1	Very low	52	Low	126 Å²	126	127.6 Å²	127.6	67%	0.674	68%	0.681	S	S	*	*	S	Bend	trans	-94.2	-19.5	-168.6	-100.5	35.7	0	0	0	115.2	R60 V62	N58-R60 VanDerWaalsContact C-N 3.27Å; N58-R60 PolarHBondContact O-N 3.4Å; N58-V62 WeakPolarHBondContact O-CG2 3.48Å
59	S	51.1	Low	52.8	Low	94 Å²	94	123.1 Å²	123.1	66%	0.657	66%	0.66	S	S	*	*	H	α-helix	trans	-73.8	-20.5	-176.6	-53.1	0	0	0	0	113	V63	S59-V63 WeakPolarHBondContact O-CG2 3.19Å; S59-V63 PolarHBondContact O-N 3.11Å
60	R	50.3	Low	53.8	Low	188 Å²	188	122.8 Å²	122.8	71%	0.709	65%	0.652	S	S	*	*	H	α-helix	trans	-83.3	-35	-177.3	-162.2	172.2	173	169.6	0.3	113.1	N58 E64	N58-R60 VanDerWaalsContact C-N 3.27Å; N58-R60 PolarHBondContact O-N 3.4Å; R60-E64 IonicContact NE-OE1 3.41Å; R60-E64 WeakPolarHBondContact O-CG 3.47Å; R60-E64 PolarHBondContact O-N 3.45Å; R60-E64 VanDerWaalsContact O-N 3.11Å
61	Q	50.5	Low	54.9	Low	135 Å²	135	121 Å²	121	63%	0.631	64%	0.639	S	S	*	*	H	α-helix	trans	-72.4	-32.7	175.3	-81.5	-176.9	-44.3	0	0	113	Q65	Q61-Q65 WeakPolarHBondContact O-CB 3.4Å; Q61-Q65 PolarHBondContact O-N 3.38Å; Q61-Q65 VanDerWaalsContact O-N 3.13Å
62	V	57.8	Low	55.9	Low	79 Å²	79	121.8 Å²	121.8	48%	0.479	63%	0.629	S	S	.	*	H	α-helix	trans	-70.6	-39.3	176.3	179	0	0	0	0	110.7	N58 Q65 D66	N58-V62 WeakPolarHBondContact O-CG2 3.48Å; V62-Q65 PolarHBondContact O-N 2.96Å; V62-D66 WeakPolarHBondContact O-CB 3.34Å; V62-D66 PolarHBondContact O-N 3.01Å
63	V	60.4	Low	56.9	Low	75 Å²	75	117.6 Å²	117.6	46%	0.455	61%	0.607	S	S	.	*	H	α-helix	trans	-68.8	-40.2	176.9	174.7	0	0	0	0	112.1	S59 Q65 D66 E67	S59-V63 WeakPolarHBondContact O-CG2 3.19Å; S59-V63 PolarHBondContact O-N 3.11Å; V63-Q65 VanDerWaalsContact C-N 3.31Å; V63-Q65 PolarHBondContact O-N 3.48Å; V63-D66 PolarHBondContact O-N 3.46Å; V63-E67 WeakPolarHBondContact O-CB 3.46Å; V63-E67 WeakPolarHBondContact O-CG 3.35Å; V63-E67 PolarHBondContact O-N 3.13Å
64	E	60.8	Low	58.2	Low	96 Å²	96	118.5 Å²	118.5	45%	0.449	60%	0.597	S	S	.	*	H	α-helix	trans	-64.8	-35.1	175.1	-76.9	173.7	175.3	0	0	111.8	R60 E68	R60-E64 IonicContact NE-OE1 3.41Å; R60-E64 WeakPolarHBondContact O-CG 3.47Å; R60-E64 PolarHBondContact O-N 3.45Å; R60-E64 VanDerWaalsContact O-N 3.11Å; E64-E68 WeakPolarHBondContact O-CG 3.5Å; E64-E68 PolarHBondContact O-N 3.45Å; E64-E68 VanDerWaalsContact O-N 3.08Å
65	Q	60	Low	59.6	Low	114 Å²	114	112.8 Å²	112.8	53%	0.533	58%	0.584	S	S	.	*	H	α-helix	trans	-74	-38.5	178.1	-162	171	2.2	0	0	112.5	Q61 V62 V63 E68 E69	Q61-Q65 WeakPolarHBondContact O-CB 3.4Å; Q61-Q65 PolarHBondContact O-N 3.38Å; Q61-Q65 VanDerWaalsContact O-N 3.13Å; V62-Q65 PolarHBondContact O-N 2.96Å; V63-Q65 VanDerWaalsContact C-N 3.31Å; V63-Q65 PolarHBondContact O-N 3.48Å; Q65-E68 PolarHBondContact O-N 3.01Å; Q65-E69 WeakPolarHBondContact O-CG 3.48Å; Q65-E69 PolarHBondContact O-N 3.08Å
66	D	64.1	Low	61	Low	85 Å²	85	114 Å²	114	46%	0.455	58%	0.577	S	S	.	*	H	α-helix	trans	-65.1	-39.2	173.6	-68.7	-23.5	0	0	0	111.3	V62 V63 E69 D70	V62-D66 WeakPolarHBondContact O-CB 3.34Å; V62-D66 PolarHBondContact O-N 3.01Å; V63-D66 PolarHBondContact O-N 3.46Å; D66-E69 PolarHBondContact O-N 3.45Å; D66-D70 WeakPolarHBondContact O-CB 3.39Å; D66-D70 PolarHBondContact O-N 3.01Å
67	E	65.5	Low	62.1	Low	117 Å²	117	106.7 Å²	106.7	55%	0.547	54%	0.541	S	S	.	.	H	α-helix	trans	-65.2	-42.1	175.5	-75.9	179.6	178.1	0	0	112.2	V63 D70 E71	V63-E67 WeakPolarHBondContact O-CB 3.46Å; V63-E67 WeakPolarHBondContact O-CG 3.35Å; V63-E67 PolarHBondContact O-N 3.13Å; E67-D70 PolarHBondContact O-N 3.46Å; E67-E71 WeakPolarHBondContact O-CG 3.36Å; E67-E71 PolarHBondContact O-N 2.99Å
68	E	65.7	Low	63.3	Low	127 Å²	127	106 Å²	106	59%	0.593	54%	0.535	S	S	*	.	H	α-helix	trans	-64.3	-41.6	175	-76.1	180	-178.7	0	0	112	E64 Q65 E71 E72	E64-E68 WeakPolarHBondContact O-CG 3.5Å; E64-E68 PolarHBondContact O-N 3.45Å; E64-E68 VanDerWaalsContact O-N 3.08Å; Q65-E68 PolarHBondContact O-N 3.01Å; E68-E71 PolarHBondContact O-N 2.9Å; E68-E72 WeakPolarHBondContact O-CB 3.21Å; E68-E72 WeakPolarHBondContact O-CG 3.49Å; E68-E72 PolarHBondContact O-N 2.7Å
69	E	63.7	Low	64.7	Low	101 Å²	101	102.5 Å²	102.5	47%	0.472	52%	0.523	S	S	.	.	H	α-helix	trans	-64.5	-41.4	176.8	-74.5	-177.2	-171.2	0	0	111.9	Q65 D66 E72 L73	Q65-E69 WeakPolarHBondContact O-CG 3.48Å; Q65-E69 PolarHBondContact O-N 3.08Å; D66-E69 PolarHBondContact O-N 3.45Å; E69-E72 PolarHBondContact O-N 2.75Å; E69-L73 VanDerWaalsContact O-CB 3.26Å; E69-L73 WeakPolarHBondContact O-CB 3.27Å; E69-L73 WeakPolarHBondContact O-CG 3.34Å; E69-L73 PolarHBondContact O-N 3.08Å
70	D	66.4	Low	66.2	Low	105 Å²	105	102.6 Å²	102.6	56%	0.561	51%	0.511	S	S	*	.	H	α-helix	trans	-63.9	-41	174.8	-80.7	-23.8	0	0	0	112	D66 E67 L73 T74	D66-D70 WeakPolarHBondContact O-CB 3.39Å; D66-D70 PolarHBondContact O-N 3.01Å; E67-D70 PolarHBondContact O-N 3.46Å; D70-L73 PolarHBondContact O-N 2.81Å; D70-T74 WeakPolarHBondContact O-CG2 3.24Å; D70-T74 PolarHBondContact O-N 3.47Å; D70-T74 PolarHBondContact O-OG1 3.02Å
71	E	66.8	Low	67.4	Low	131 Å²	131	95.6 Å²	95.6	61%	0.612	49%	0.487	S	S	*	.	H	α-helix	trans	-64.4	-45.4	174.5	-75	-170.2	178.1	0	0	111.9	E67 E68 L73 T74 L75	E67-E71 WeakPolarHBondContact O-CG 3.36Å; E67-E71 PolarHBondContact O-N 2.99Å; E68-E71 PolarHBondContact O-N 2.9Å; E71-L73 PolarHBondContact O-N 2.76Å; E71-T74 PolarHBondContact O-N 3.02Å; E71-T74 PolarHBondContact O-OG1 3.28Å; E71-L75 WeakPolarHBondContact O-CB 3.26Å; E71-L75 WeakPolarHBondContact O-CG 3.3Å; E71-L75 PolarHBondContact O-N 3.37Å
72	E	66.8	Low	68.9	Low	138 Å²	138	90.8 Å²	90.8	65%	0.645	47%	0.466	S	S	*	.	H	α-helix	trans	-62.6	-41.3	175.9	-75.9	-166.2	170.5	0	0	112.3	E68 E69 L75 K76	E68-E72 WeakPolarHBondContact O-CB 3.21Å; E68-E72 WeakPolarHBondContact O-CG 3.49Å; E68-E72 PolarHBondContact O-N 2.7Å; E69-E72 PolarHBondContact O-N 2.75Å; E72-L75 PolarHBondContact O-N 3.4Å; E72-K76 VanDerWaalsContact O-CB 3.28Å; E72-K76 WeakPolarHBondContact O-CB 3.41Å; E72-K76 PolarHBondContact O-N 3.22Å
73	L	66.4	Low	70.1	Confident	69 Å²	69	92 Å²	92	36%	0.361	47%	0.47	S	S	.	.	H	α-helix	trans	-62.2	-49.3	176	-76.7	172.1	0	0	0	110.6	E69 D70 E71 L75 K76 Y77	E69-L73 VanDerWaalsContact O-CB 3.26Å; E69-L73 WeakPolarHBondContact O-CB 3.27Å; E69-L73 WeakPolarHBondContact O-CG 3.34Å; E69-L73 PolarHBondContact O-N 3.08Å; D70-L73 PolarHBondContact O-N 2.81Å; E71-L73 PolarHBondContact O-N 2.76Å; L73-L75 VanDerWaalsContact C-N 3.31Å; L73-L75 PolarHBondContact O-N 2.89Å; L73-K76 PolarHBondContact O-N 2.93Å; L73-Y77 VanDerWaalsContact C-CD2 3.46Å; L73-Y77 HydrophobicContact CB-CD2 4.29Å; L73-Y77 HydrophobicContact CB-CE2 3.84Å; L73-Y77 HydrophobicContact CD2-CE2 4.12Å; L73-Y77 WeakPolarHBondContact O-CD2 3.14Å; L73-Y77 PolarHBondContact O-N 3.34Å
74	T	71.8	Confident	71.2	Confident	93 Å²	93	90.6 Å²	90.6	57%	0.571	46%	0.458	S	S	*	.	H	α-helix	trans	-60.9	-38.9	178.1	60.6	0	0	0	0	112.6	D70 E71 G78	D70-T74 WeakPolarHBondContact O-CG2 3.24Å; D70-T74 PolarHBondContact O-N 3.47Å; D70-T74 PolarHBondContact O-OG1 3.02Å; E71-T74 PolarHBondContact O-N 3.02Å; E71-T74 PolarHBondContact O-OG1 3.28Å; T74-G78 PolarHBondContact O-N 3.15Å
75	L	72.7	Confident	72.3	Confident	125 Å²	125	86.2 Å²	86.2	65%	0.654	44%	0.438	S	S	*	.	H	α-helix	trans	-65.3	-44.6	174	-74.4	171.3	0	0	0	112.2	E71 E72 L73 G78 A79	E71-L75 WeakPolarHBondContact O-CB 3.26Å; E71-L75 WeakPolarHBondContact O-CG 3.3Å; E71-L75 PolarHBondContact O-N 3.37Å; E72-L75 PolarHBondContact O-N 3.4Å; L73-L75 VanDerWaalsContact C-N 3.31Å; L73-L75 PolarHBondContact O-N 2.89Å; L75-G78 PolarHBondContact O-N 3.35Å; L75-A79 PolarHBondContact O-N 3.36Å
76	K	73.6	Confident	73.7	Confident	146 Å²	146	82.9 Å²	82.9	64%	0.635	42%	0.422	S	S	*	.	H	α-helix	trans	-63.7	-41.8	178.2	-174.1	179.3	179.5	-176.1	0	111.6	E72 L73 A79 K80	E72-K76 VanDerWaalsContact O-CB 3.28Å; E72-K76 WeakPolarHBondContact O-CB 3.41Å; E72-K76 PolarHBondContact O-N 3.22Å; L73-K76 PolarHBondContact O-N 2.93Å; K76-A79 PolarHBondContact O-N 2.87Å; K76-K80 WeakPolarHBondContact O-CB 3.42Å; K76-K80 PolarHBondContact O-N 3.48Å
77	Y	69.9	Low	75.1	Confident	49 Å²	49	83 Å²	83	19%	0.192	43%	0.426	C	S	.	.	H	α-helix	trans	-65.2	-42.9	174.4	-66.5	-53.8	0	0	0	111.4	L73 A79 K80 H81 P374 E375	L73-Y77 VanDerWaalsContact C-CD2 3.46Å; L73-Y77 HydrophobicContact CB-CD2 4.29Å; L73-Y77 HydrophobicContact CB-CE2 3.84Å; L73-Y77 HydrophobicContact CD2-CE2 4.12Å; L73-Y77 WeakPolarHBondContact O-CD2 3.14Å; L73-Y77 PolarHBondContact O-N 3.34Å; Y77-A79 PolarHBondContact O-N 3.31Å; Y77-K80 PolarHBondContact O-N 2.86Å; Y77-H81 VanDerWaalsContact O-CB 3.31Å; Y77-H81 WeakPolarHBondContact O-CB 3.35Å; Y77-H81 PolarHBondContact O-N 2.83Å; Y77-H81 PolarHBondContact O-ND1 3.13Å; Y77-P374 HydrophobicContact CD2-CB 4.42Å; Y77-P374 HydrophobicContact CD2-CG 4.26Å; Y77-P374 HydrophobicContact CE1-CG 4.25Å; Y77-P374 HydrophobicContact CE2-CB 4.25Å; Y77-P374 HydrophobicContact CE2-CG 3.62Å; Y77-E375 HydrophobicContact CE1-CG 3.67Å
78	G	75.6	Confident	76.3	Confident	33 Å²	33	77.7 Å²	77.7	34%	0.34	40%	0.401	S	S	.	.	H	α-helix	trans	-55.4	-50.2	172.9	0	0	0	0	0	112.3	T74 L75 H81 V82	T74-G78 PolarHBondContact O-N 3.15Å; L75-G78 PolarHBondContact O-N 3.35Å; G78-H81 PolarHBondContact O-N 3.19Å; G78-V82 WeakPolarHBondContact O-CG2 3.46Å; G78-V82 PolarHBondContact O-N 3.02Å
79	A	79.8	Confident	77.6	Confident	52 Å²	52	71.7 Å²	71.7	43%	0.43	37%	0.373	S	S	.	.	H	α-helix	trans	-63.9	-44.1	179	0	0	0	0	0	112.8	L75 K76 Y77 H81 V82 I83	L75-A79 PolarHBondContact O-N 3.36Å; K76-A79 PolarHBondContact O-N 2.87Å; Y77-A79 PolarHBondContact O-N 3.31Å; A79-H81 VanDerWaalsContact C-N 3.33Å; A79-H81 PolarHBondContact O-N 2.86Å; A79-V82 PolarHBondContact O-N 2.9Å; A79-I83 WeakPolarHBondContact O-CG1 3.26Å; A79-I83 PolarHBondContact O-N 3.46Å
80	K	80.9	Confident	79.1	Confident	96 Å²	96	68.9 Å²	68.9	42%	0.417	36%	0.363	S	S	.	.	H	α-helix	trans	-59.3	-45.3	176.3	-171.3	-177.8	-175.2	-174.1	0	110.7	K76 Y77 I83 M84 E375	K76-K80 WeakPolarHBondContact O-CB 3.42Å; K76-K80 PolarHBondContact O-N 3.48Å; Y77-K80 PolarHBondContact O-N 2.86Å; K80-I83 PolarHBondContact O-N 2.95Å; K80-M84 VanDerWaalsContact O-CB 3.28Å; K80-M84 WeakPolarHBondContact O-CB 3.13Å; K80-M84 PolarHBondContact O-N 3.48Å; K80-E375 IonicContact NZ-OE1 3.87Å; K80-E375 PolarHBondContact NZ-OE1 2.87Å; K80-E375 IonicContact NZ-OE2 2.77Å
81	H	75.6	Confident	80.5	Confident	42 Å²	42	68.1 Å²	68.1	19%	0.194	36%	0.358	C	S	.	.	H	α-helix	trans	-62.3	-42.9	176.9	-71.4	159.7	0	0	0	112.9	Y77 G78 A79 M84 L85 R377 V379	Y77-H81 VanDerWaalsContact O-CB 3.31Å; Y77-H81 WeakPolarHBondContact O-CB 3.35Å; Y77-H81 PolarHBondContact O-N 2.83Å; Y77-H81 PolarHBondContact O-ND1 3.13Å; G78-H81 PolarHBondContact O-N 3.19Å; A79-H81 VanDerWaalsContact C-N 3.33Å; A79-H81 PolarHBondContact O-N 2.86Å; H81-M84 PolarHBondContact O-N 3.44Å; H81-L85 PolarHBondContact O-N 2.88Å; H81-R377 PolarHBondContact NE2-O 2.89Å; H81-V379 HydrophobicContact CB-CG2 3.76Å
82	V	82.1	Confident	81.9	Confident	33 Å²	33	61.9 Å²	61.9	20%	0.2	33%	0.329	C	S	.	.	H	α-helix	trans	-61.7	-49.9	176.6	173.3	0	0	0	0	110.8	G78 A79 M84 L85 F86 L422	G78-V82 WeakPolarHBondContact O-CG2 3.46Å; G78-V82 PolarHBondContact O-N 3.02Å; A79-V82 PolarHBondContact O-N 2.9Å; V82-M84 VanDerWaalsContact C-N 3.27Å; V82-M84 PolarHBondContact O-N 3.46Å; V82-L85 PolarHBondContact O-N 2.94Å; V82-L85 VanDerWaalsContact O-N 3.17Å; V82-F86 HydrophobicContact CG1-CD2 3.73Å; V82-F86 HydrophobicContact CG1-CE2 3.64Å; V82-F86 HydrophobicContact CG1-CG 4.39Å; V82-F86 HydrophobicContact CG1-CZ 4.23Å; V82-F86 PolarHBondContact O-N 3.27Å; V82-L422 HydrophobicContact CB-CD1 4.15Å; V82-L422 HydrophobicContact CG1-CD1 4.11Å; V82-L422 HydrophobicContact CG2-CB 4.24Å; V82-L422 HydrophobicContact CG2-CD1 3.7Å
83	I	83.6	Confident	83.2	Confident	106 Å²	106	55.3 Å²	55.3	54%	0.544	30%	0.299	S	S	.	.	H	α-helix	trans	-60.5	-41	179.6	-67	167.9	0	0	0	110.6	A79 K80 L85 F86 V87	A79-I83 WeakPolarHBondContact O-CG1 3.26Å; A79-I83 PolarHBondContact O-N 3.46Å; K80-I83 PolarHBondContact O-N 2.95Å; I83-L85 PolarHBondContact O-N 3.04Å; I83-F86 PolarHBondContact O-N 2.86Å; I83-V87 HydrophobicContact CG2-CG2 4.32Å; I83-V87 WeakPolarHBondContact O-CG2 3.2Å; I83-V87 PolarHBondContact O-N 2.81Å; I83-V87 VanDerWaalsContact O-N 3.12Å
84	M	83.5	Confident	84.6	Confident	45 Å²	45	55.9 Å²	55.9	22%	0.222	30%	0.304	C	S	.	.	H	α-helix	trans	-64.8	-27.2	-179.2	-158	178.6	-167.2	0	0	113.5	K80 H81 V82 P88 S290	K80-M84 VanDerWaalsContact O-CB 3.28Å; K80-M84 WeakPolarHBondContact O-CB 3.13Å; K80-M84 PolarHBondContact O-N 3.48Å; H81-M84 PolarHBondContact O-N 3.44Å; V82-M84 VanDerWaalsContact C-N 3.27Å; V82-M84 PolarHBondContact O-N 3.46Å; M84-P88 WeakPolarHBondContact O-CD 3.39Å; M84-P88 WeakPolarHBondContact O-CG 3.18Å; M84-S290 WeakPolarHBondContact CE-O 3.42Å; M84-S290 WeakPolarHBondContact SD-CB 3.41Å; M84-S290 PolarHBondContact SD-OG 3.16Å
85	L	84.2	Confident	85.8	Confident	3 Å²	3	53.1 Å²	53.1	2%	0.016	29%	0.287	C	S	.	.	H	α-helix	trans	-84.9	-37.1	171.2	-72	-175.5	0	0	0	112.9	H81 V82 I83 P88 V89 V379 L381 L422	H81-L85 PolarHBondContact O-N 2.88Å; V82-L85 PolarHBondContact O-N 2.94Å; V82-L85 VanDerWaalsContact O-N 3.17Å; I83-L85 PolarHBondContact O-N 3.04Å; L85-P88 VanDerWaalsContact O-CD 3.25Å; L85-P88 WeakPolarHBondContact O-CD 3.33Å; L85-P88 VanDerWaalsContact O-CG 3.31Å; L85-P88 WeakPolarHBondContact O-CG 3.35Å; L85-V89 WeakPolarHBondContact O-CB 3.22Å; L85-V89 VanDerWaalsContact O-CG2 3.25Å; L85-V89 WeakPolarHBondContact O-CG2 3.38Å; L85-V89 PolarHBondContact O-N 3.02Å; L85-V379 HydrophobicContact CD1-CB 4.42Å; L85-V379 HydrophobicContact CD1-CG1 3.68Å; L85-V379 HydrophobicContact CD2-CB 4.28Å; L85-V379 HydrophobicContact CD2-CG1 4.02Å; L85-V379 HydrophobicContact CG-CB 4.35Å; L85-V379 HydrophobicContact CG-CG1 4.08Å; L85-L381 HydrophobicContact CD2-CB 3.9Å; L85-L381 HydrophobicContact CD2-CD2 4.14Å; L85-L422 HydrophobicContact CD1-CD1 4.1Å; L85-L422 HydrophobicContact CD1-CD2 3.9Å
86	F	90	Very high	87	Confident	44 Å²	44	47.1 Å²	47.1	19%	0.193	26%	0.256	C	S	.	.	H	α-helix	trans	-64.6	-42.2	-178.3	-88.2	-20.5	0	0	0	114.1	V82 I83 V89 T90 L415 L418 C419	V82-F86 HydrophobicContact CG1-CD2 3.73Å; V82-F86 HydrophobicContact CG1-CE2 3.64Å; V82-F86 HydrophobicContact CG1-CG 4.39Å; V82-F86 HydrophobicContact CG1-CZ 4.23Å; V82-F86 PolarHBondContact O-N 3.27Å; I83-F86 PolarHBondContact O-N 2.86Å; F86-V89 PolarHBondContact O-N 2.76Å; F86-T90 WeakPolarHBondContact O-CB 3.33Å; F86-T90 PolarHBondContact O-N 2.94Å; F86-T90 PolarHBondContact O-OG1 3.19Å; F86-L415 HydrophobicContact CD1-CD2 3.68Å; F86-L415 HydrophobicContact CE1-CB 4.13Å; F86-L415 HydrophobicContact CE1-CD2 3.74Å; F86-L415 WeakPolarHBondContact CE1-O 3.49Å; F86-L415 HydrophobicContact CG-CD2 4.46Å; F86-L415 HydrophobicContact CZ-CB 4.31Å; F86-L415 VanDerWaalsContact CZ-O 3.31Å; F86-L415 WeakPolarHBondContact CZ-O 3.27Å; F86-L418 HydrophobicContact CD1-CD2 3.45Å; F86-L418 VanDerWaalsContact CD1-CD2 3.45Å; F86-L418 HydrophobicContact CE1-CB 4.09Å; F86-L418 HydrophobicContact CE1-CD2 3.29Å; F86-L418 HydrophobicContact CE1-CG 4.28Å; F86-L418 HydrophobicContact CZ-CD2 4.31Å; F86-C419 VanDerWaalsContact CE2-SG 3.52Å; F86-C419 HydrophobicContact CZ-CB 4.06Å; F86-C419 WeakPolarHBondContact CZ-SG 3.49Å
87	V	91.7	Very high	88	Confident	89 Å²	89	40.8 Å²	40.8	54%	0.539	23%	0.23	S	C	.	.	H	α-helix	trans	-57.4	-55.2	-178.7	173.2	0	0	0	0	112.4	I83 V89 T90 L91	I83-V87 HydrophobicContact CG2-CG2 4.32Å; I83-V87 WeakPolarHBondContact O-CG2 3.2Å; I83-V87 PolarHBondContact O-N 2.81Å; I83-V87 VanDerWaalsContact O-N 3.12Å; V87-V89 PolarHBondContact O-N 3.11Å; V87-T90 PolarHBondContact O-N 2.88Å; V87-L91 WeakPolarHBondContact O-CB 3.26Å; V87-L91 PolarHBondContact O-N 3.44Å
88	P	92	Very high	89.2	Confident	5 Å²	5	40.9 Å²	40.9	3%	0.032	24%	0.241	C	C	.	.	H	α-helix	trans	-68.6	-35	-177.6	29.9	-39.2	0	0	0	112.7	M84 L85 L91 C92 I227 Y288 F386	M84-P88 WeakPolarHBondContact O-CD 3.39Å; M84-P88 WeakPolarHBondContact O-CG 3.18Å; L85-P88 VanDerWaalsContact O-CD 3.25Å; L85-P88 WeakPolarHBondContact O-CD 3.33Å; L85-P88 VanDerWaalsContact O-CG 3.31Å; L85-P88 WeakPolarHBondContact O-CG 3.35Å; P88-L91 PolarHBondContact O-N 2.97Å; P88-C92 WeakPolarHBondContact O-CB 3.33Å; P88-C92 PolarHBondContact O-N 3.38Å; P88-I227 HydrophobicContact CB-CD1 3.66Å; P88-I227 HydrophobicContact CB-CG1 4.09Å; P88-Y288 HydrophobicContact CB-CE1 4.23Å; P88-Y288 HydrophobicContact CB-CE2 3.91Å; P88-Y288 WeakPolarHBondContact CB-OH 3.3Å; P88-Y288 HydrophobicContact CG-CE1 3.77Å; P88-Y288 HydrophobicContact CG-CE2 4.37Å; P88-Y288 WeakPolarHBondContact CG-OH 3.21Å; P88-F386 HydrophobicContact CB-CE1 3.89Å; P88-F386 HydrophobicContact CB-CZ 4.4Å; P88-F386 HydrophobicContact CG-CE1 4.17Å; P88-F386 HydrophobicContact CG-CZ 4.31Å
89	V	92.9	Very high	90.1	Very high	1 Å²	1	39.5 Å²	39.5	1%	0.006	23%	0.226	C	C	.	.	H	α-helix	trans	-65.5	-46	177	170.3	0	0	0	0	110.4	L85 F86 V87 C92 M93 L381 F386 Y389	L85-V89 WeakPolarHBondContact O-CB 3.22Å; L85-V89 VanDerWaalsContact O-CG2 3.25Å; L85-V89 WeakPolarHBondContact O-CG2 3.38Å; L85-V89 PolarHBondContact O-N 3.02Å; F86-V89 PolarHBondContact O-N 2.76Å; V87-V89 PolarHBondContact O-N 3.11Å; V89-C92 WeakPolarHBondContact O-CB 3.09Å; V89-C92 PolarHBondContact O-N 2.99Å; V89-M93 HydrophobicContact CG1-CE 3.49Å; V89-M93 VanDerWaalsContact CG1-CE 3.49Å; V89-M93 WeakPolarHBondContact O-CG 3.33Å; V89-M93 PolarHBondContact O-N 3.41Å; V89-L381 HydrophobicContact CG2-CD2 4.03Å; V89-F386 HydrophobicContact CB-CD1 4.41Å; V89-F386 HydrophobicContact CB-CE1 4.18Å; V89-F386 HydrophobicContact CG2-CD1 3.79Å; V89-F386 HydrophobicContact CG2-CD2 4.5Å; V89-F386 HydrophobicContact CG2-CE1 3.38Å; V89-F386 HydrophobicContact CG2-CE2 4.17Å; V89-F386 HydrophobicContact CG2-CG 4.33Å; V89-F386 HydrophobicContact CG2-CZ 3.59Å; V89-Y389 HydrophobicContact CG1-CD2 3.89Å
90	T	94.9	Very high	90.8	Very high	42 Å²	42	37.3 Å²	37.3	26%	0.258	21%	0.207	S	C	.	.	H	α-helix	trans	-59.3	-47.7	174.3	-64.5	0	0	0	0	111.5	F86 V87 C92 M93 V94 F411	F86-T90 WeakPolarHBondContact O-CB 3.33Å; F86-T90 PolarHBondContact O-N 2.94Å; F86-T90 PolarHBondContact O-OG1 3.19Å; V87-T90 PolarHBondContact O-N 2.88Å; T90-C92 VanDerWaalsContact C-N 3.31Å; T90-C92 PolarHBondContact O-N 2.8Å; T90-M93 PolarHBondContact O-N 2.71Å; T90-V94 HydrophobicContact CG2-CG2 4.22Å; T90-V94 WeakPolarHBondContact O-CB 3.46Å; T90-V94 VanDerWaalsContact O-CG2 3.28Å; T90-V94 WeakPolarHBondContact O-CG2 3.29Å; T90-V94 PolarHBondContact O-N 2.93Å; T90-F411 HydrophobicContact CG2-CE2 4.12Å; T90-F411 HydrophobicContact CG2-CZ 3.63Å
91	L	95.2	Very high	91.3	Very high	89 Å²	89	35.9 Å²	35.9	47%	0.466	20%	0.2	S	C	.	.	H	α-helix	trans	-62.5	-39.7	-179.4	-165.5	133.1	0	0	0	111.6	V87 P88 V94 V95 I227	V87-L91 WeakPolarHBondContact O-CB 3.26Å; V87-L91 PolarHBondContact O-N 3.44Å; P88-L91 PolarHBondContact O-N 2.97Å; L91-V94 PolarHBondContact O-N 2.9Å; L91-V95 HydrophobicContact CD2-CG2 4.33Å; L91-V95 VanDerWaalsContact O-CG2 3.27Å; L91-V95 WeakPolarHBondContact O-CG2 3.16Å; L91-V95 PolarHBondContact O-N 3.47Å; L91-I227 HydrophobicContact CD2-CD1 4.11Å; L91-I227 HydrophobicContact CD2-CG2 3.63Å
92	C	96	Very high	92.1	Very high	0 Å²	0	36.1 Å²	36.1	0%	0	21%	0.207	C	C	.	.	H	α-helix	trans	-59.9	-50.2	174.3	-165.8	0	0	0	0	111.8	P88 V89 T90 V94 V95 V96 I227 F386 S390	P88-C92 WeakPolarHBondContact O-CB 3.33Å; P88-C92 PolarHBondContact O-N 3.38Å; V89-C92 WeakPolarHBondContact O-CB 3.09Å; V89-C92 PolarHBondContact O-N 2.99Å; T90-C92 VanDerWaalsContact C-N 3.31Å; T90-C92 PolarHBondContact O-N 2.8Å; C92-V94 PolarHBondContact O-N 3.43Å; C92-V95 PolarHBondContact O-N 2.86Å; C92-V96 WeakPolarHBondContact O-CG2 3.28Å; C92-V96 PolarHBondContact O-N 3.19Å; C92-I227 HydrophobicContact CB-CG2 3.78Å; C92-F386 HydrophobicContact CB-CD1 4.15Å; C92-S390 PolarHBondContact SG-OG 2.83Å; C92-S390 VanDerWaalsContact SG-OG 3.33Å
93	M	95.4	Very high	92.6	Very high	0 Å²	0	34.6 Å²	34.6	0%	0	20%	0.198	C	C	.	.	H	α-helix	trans	-61.2	-43	178	-73	-172.1	-77.2	0	0	112.1	V89 T90 V96 V97 V393 F411 I414 L415	V89-M93 HydrophobicContact CG1-CE 3.49Å; V89-M93 VanDerWaalsContact CG1-CE 3.49Å; V89-M93 WeakPolarHBondContact O-CG 3.33Å; V89-M93 PolarHBondContact O-N 3.41Å; T90-M93 PolarHBondContact O-N 2.71Å; M93-V96 PolarHBondContact O-N 3.46Å; M93-V97 VanDerWaalsContact O-CG2 3.32Å; M93-V97 WeakPolarHBondContact O-CG2 3.29Å; M93-V97 PolarHBondContact O-N 3.23Å; M93-V393 HydrophobicContact CB-CG1 4.01Å; M93-V393 HydrophobicContact CG-CG1 3.86Å; M93-V393 HydrophobicContact SD-CG1 4.19Å; M93-F411 HydrophobicContact CB-CD2 4.09Å; M93-F411 HydrophobicContact CB-CE2 3.99Å; M93-F411 HydrophobicContact CE-CD2 3.99Å; M93-F411 HydrophobicContact CE-CE2 3.77Å; M93-F411 HydrophobicContact SD-CD2 3.96Å; M93-F411 HydrophobicContact SD-CE2 4.27Å; M93-I414 HydrophobicContact CE-CG2 4.25Å; M93-I414 HydrophobicContact SD-CD1 4Å; M93-I414 HydrophobicContact SD-CG2 4.18Å; M93-L415 HydrophobicContact CE-CD2 4.08Å
94	V	96.3	Very high	92.9	Very high	80 Å²	80	33.5 Å²	33.5	49%	0.485	20%	0.199	S	C	.	.	H	α-helix	trans	-61.2	-45.3	177.3	169.1	0	0	0	0	111.2	T90 L91 C92 V96 V97 A98	T90-V94 HydrophobicContact CG2-CG2 4.22Å; T90-V94 WeakPolarHBondContact O-CB 3.46Å; T90-V94 VanDerWaalsContact O-CG2 3.28Å; T90-V94 WeakPolarHBondContact O-CG2 3.29Å; T90-V94 PolarHBondContact O-N 2.93Å; L91-V94 PolarHBondContact O-N 2.9Å; C92-V94 PolarHBondContact O-N 3.43Å; V94-V96 VanDerWaalsContact C-N 3.34Å; V94-V96 PolarHBondContact O-N 3.45Å; V94-V97 PolarHBondContact O-N 3.36Å; V94-A98 WeakPolarHBondContact O-CB 3.47Å; V94-A98 PolarHBondContact O-N 2.93Å
95	V	96.5	Very high	93.3	Very high	35 Å²	35	34.2 Å²	34.2	21%	0.212	20%	0.201	C	C	.	.	H	α-helix	trans	-58.6	-47.8	176.6	169.6	0	0	0	0	110.4	L91 C92 A98 T99 M228 A231	L91-V95 HydrophobicContact CD2-CG2 4.33Å; L91-V95 VanDerWaalsContact O-CG2 3.27Å; L91-V95 WeakPolarHBondContact O-CG2 3.16Å; L91-V95 PolarHBondContact O-N 3.47Å; C92-V95 PolarHBondContact O-N 2.86Å; V95-A98 PolarHBondContact O-N 2.87Å; V95-T99 WeakPolarHBondContact O-CB 2.85Å; V95-T99 PolarHBondContact O-N 3.11Å; V95-T99 PolarHBondContact O-OG1 2.86Å; V95-M228 HydrophobicContact CG1-SD 4.47Å; V95-A231 HydrophobicContact CB-CB 4.45Å; V95-A231 HydrophobicContact CG1-CB 3.88Å
96	V	96.6	Very high	93.5	Very high	0 Å²	0	34.9 Å²	34.9	0%	0	20%	0.204	C	C	.	.	H	α-helix	trans	-65.1	-45.3	-178.8	172.7	0	0	0	0	112.1	C92 M93 V94 T99 I100 A231 A234 L235 I238	C92-V96 WeakPolarHBondContact O-CG2 3.28Å; C92-V96 PolarHBondContact O-N 3.19Å; M93-V96 PolarHBondContact O-N 3.46Å; V94-V96 VanDerWaalsContact C-N 3.34Å; V94-V96 PolarHBondContact O-N 3.45Å; V96-T99 PolarHBondContact O-N 2.98Å; V96-I100 HydrophobicContact CG1-CD1 3.69Å; V96-I100 WeakPolarHBondContact O-CD1 3.03Å; V96-I100 VanDerWaalsContact O-CG1 3.25Å; V96-I100 WeakPolarHBondContact O-CG1 3.39Å; V96-I100 PolarHBondContact O-N 3.41Å; V96-A231 HydrophobicContact CG2-CB 3.63Å; V96-A234 HydrophobicContact CG2-CB 4.12Å; V96-L235 HydrophobicContact CG1-CD2 4.23Å; V96-I238 HydrophobicContact CG1-CD1 3.77Å
97	V	95.1	Very high	93.4	Very high	13 Å²	13	35.8 Å²	35.8	8%	0.079	21%	0.213	C	C	.	.	H	α-helix	trans	-63.7	-45.6	177.2	173.1	0	0	0	0	110.9	M93 V94 T99 I100 K101 V393 W404 T407	M93-V97 VanDerWaalsContact O-CG2 3.32Å; M93-V97 WeakPolarHBondContact O-CG2 3.29Å; M93-V97 PolarHBondContact O-N 3.23Å; V94-V97 PolarHBondContact O-N 3.36Å; V97-T99 VanDerWaalsContact C-N 3.32Å; V97-T99 PolarHBondContact O-N 3.47Å; V97-I100 PolarHBondContact O-N 2.84Å; V97-K101 HydrophobicContact CG1-CG 4.38Å; V97-K101 WeakPolarHBondContact O-CG 3.39Å; V97-K101 PolarHBondContact O-N 3.36Å; V97-V393 HydrophobicContact CG2-CB 4.47Å; V97-V393 HydrophobicContact CG2-CG1 3.98Å; V97-V393 HydrophobicContact CG2-CG2 3.77Å; V97-W404 HydrophobicContact CG1-CH2 4.34Å; V97-W404 HydrophobicContact CG1-CZ3 3.96Å; V97-T407 HydrophobicContact CG1-CG2 4.02Å; V97-T407 HydrophobicContact CG2-CG2 3.96Å
98	A	94.8	Very high	93.1	Very high	51 Å²	51	39 Å²	39	42%	0.421	22%	0.215	S	C	.	.	H	α-helix	trans	-60.4	-42.1	177.5	0	0	0	0	0	111.6	V94 V95 S102	V94-A98 WeakPolarHBondContact O-CB 3.47Å; V94-A98 PolarHBondContact O-N 2.93Å; V95-A98 PolarHBondContact O-N 2.87Å; A98-S102 VanDerWaalsContact O-CB 3.3Å; A98-S102 WeakPolarHBondContact O-CB 3.5Å; A98-S102 PolarHBondContact O-N 3.5Å; A98-S102 PolarHBondContact O-OG 3.45Å
99	T	95.3	Very high	92.3	Very high	4 Å²	4	46.2 Å²	46.2	3%	0.025	25%	0.246	C	C	.	.	H	α-helix	trans	-62.1	-46.8	174.2	-64.3	0	0	0	0	111.7	V95 V96 V97 K101 S102 V103 Y106 Y181 L235	V95-T99 WeakPolarHBondContact O-CB 2.85Å; V95-T99 PolarHBondContact O-N 3.11Å; V95-T99 PolarHBondContact O-OG1 2.86Å; V96-T99 PolarHBondContact O-N 2.98Å; V97-T99 VanDerWaalsContact C-N 3.32Å; V97-T99 PolarHBondContact O-N 3.47Å; T99-K101 VanDerWaalsContact C-N 3.3Å; T99-K101 PolarHBondContact O-N 2.91Å; T99-S102 PolarHBondContact O-N 3.25Å; T99-S102 PolarHBondContact O-OG 3.42Å; T99-V103 HydrophobicContact CG2-CB 4.35Å; T99-V103 HydrophobicContact CG2-CG2 4.46Å; T99-V103 WeakPolarHBondContact O-CA 3.35Å; T99-V103 WeakPolarHBondContact O-CB 3.35Å; T99-V103 PolarHBondContact O-N 2.79Å; T99-Y106 HydrophobicContact CG2-CD2 3.81Å; T99-Y106 HydrophobicContact CG2-CE2 3.76Å; T99-Y181 HydrophobicContact CG2-CD2 4.36Å; T99-Y181 HydrophobicContact CG2-CE2 3.62Å; T99-Y181 PolarHBondContact OG1-OH 3.36Å; T99-L235 HydrophobicContact CG2-CD1 3.71Å; T99-L235 HydrophobicContact CG2-CD2 3.61Å; T99-L235 HydrophobicContact CG2-CG 4.33Å
100	I	93.8	Very high	91.1	Very high	6 Å²	6	50.6 Å²	50.6	3%	0.031	27%	0.27	C	S	.	.	H	α-helix	trans	-64.7	-37.2	-177.5	-70.3	164.1	0	0	0	111.6	V96 V97 T107 L235 I238 G394 A398	V96-I100 HydrophobicContact CG1-CD1 3.69Å; V96-I100 WeakPolarHBondContact O-CD1 3.03Å; V96-I100 VanDerWaalsContact O-CG1 3.25Å; V96-I100 WeakPolarHBondContact O-CG1 3.39Å; V96-I100 PolarHBondContact O-N 3.41Å; V97-I100 PolarHBondContact O-N 2.84Å; I100-T107 HydrophobicContact CG2-CG2 3.98Å; I100-L235 HydrophobicContact CD1-CD2 4.44Å; I100-L235 HydrophobicContact CG1-CD2 3.97Å; I100-I238 HydrophobicContact CD1-CD1 3.55Å; I100-I238 HydrophobicContact CD1-CG2 4.22Å; I100-G394 WeakPolarHBondContact CD1-O 3.4Å; I100-A398 HydrophobicContact CG2-CB 3.87Å
101	K	91.7	Very high	89.6	Confident	66 Å²	66	51.3 Å²	51.3	29%	0.287	29%	0.285	S	S	.	.	H	α-helix	trans	-75	-33.5	177.5	-67.1	-63	-166.5	-166.1	0	113	V97 T99 S397 G402 W404	V97-K101 HydrophobicContact CG1-CG 4.38Å; V97-K101 WeakPolarHBondContact O-CG 3.39Å; V97-K101 PolarHBondContact O-N 3.36Å; T99-K101 VanDerWaalsContact C-N 3.3Å; T99-K101 PolarHBondContact O-N 2.91Å; K101-S397 WeakPolarHBondContact CE-OG 3.37Å; K101-S397 PolarHBondContact NZ-O 3.5Å; K101-S397 VanDerWaalsContact NZ-O 3.09Å; K101-G402 VanDerWaalsContact NZ-CA 3.34Å; K101-G402 PolarHBondContact NZ-O 2.98Å; K101-W404 HydrophobicContact CD-CZ2 4.36Å; K101-W404 HydrophobicContact CG-CH2 4.01Å; K101-W404 HydrophobicContact CG-CZ2 4.05Å
102	S	92.7	Very high	88	Confident	47 Å²	47	52.3 Å²	52.3	33%	0.329	29%	0.287	S	S	.	.	H	α-helix	trans	-85.3	-43	-179.3	54.9	0	0	0	0	112.8	A98 T99 T188	A98-S102 VanDerWaalsContact O-CB 3.3Å; A98-S102 WeakPolarHBondContact O-CB 3.5Å; A98-S102 PolarHBondContact O-N 3.5Å; A98-S102 PolarHBondContact O-OG 3.45Å; T99-S102 PolarHBondContact O-N 3.25Å; T99-S102 PolarHBondContact O-OG 3.42Å; S102-T188 WeakPolarHBondContact O-CG2 3.49Å
103	V	93.3	Very high	86.4	Confident	1 Å²	1	54.6 Å²	54.6	1%	0.006	30%	0.299	C	S	.	.			trans	-106.7	97.2	-172.6	-177.6	0	0	0	0	110.1	T99 F105 Y106 E184 V185	T99-V103 HydrophobicContact CG2-CB 4.35Å; T99-V103 HydrophobicContact CG2-CG2 4.46Å; T99-V103 WeakPolarHBondContact O-CA 3.35Å; T99-V103 WeakPolarHBondContact O-CB 3.35Å; T99-V103 PolarHBondContact O-N 2.79Å; V103-F105 HydrophobicContact CG1-CB 3.96Å; V103-F105 PolarHBondContact O-N 3.27Å; V103-F105 VanDerWaalsContact O-N 3.1Å; V103-Y106 HydrophobicContact CB-CD2 4.11Å; V103-Y106 HydrophobicContact CB-CE2 4.39Å; V103-Y106 HydrophobicContact CG1-CD2 3.82Å; V103-Y106 HydrophobicContact CG1-CE2 3.91Å; V103-Y106 PolarHBondContact O-N 3.35Å; V103-E184 HydrophobicContact CG1-CB 3.92Å; V103-V185 HydrophobicContact CG2-CG2 4.02Å
104	S	89.5	Confident	85.1	Confident	83 Å²	83	62.1 Å²	62.1	58%	0.58	34%	0.338	S	S	*	.	G	3₁₀ helix	trans	-64.4	-16.7	-176.4	61.5	0	0	0	0	114.4	Y106 T107 R108	S104-Y106 PolarHBondContact O-N 2.99Å; S104-T107 PolarHBondContact O-N 2.85Å; S104-T107 PolarHBondContact O-OG1 3.49Å; S104-R108 PolarHBondContact O-N 3.24Å
105	F	90.8	Very high	83.7	Confident	60 Å²	60	64.4 Å²	64.4	26%	0.263	34%	0.339	S	S	.	.	G	3₁₀ helix	trans	-52.1	-40.2	176.4	176.4	-97.2	0	0	0	113.1	V103 T107 R108 E184 K239	V103-F105 HydrophobicContact CG1-CB 3.96Å; V103-F105 PolarHBondContact O-N 3.27Å; V103-F105 VanDerWaalsContact O-N 3.1Å; F105-T107 PolarHBondContact O-N 3.25Å; F105-R108 PolarHBondContact O-N 2.89Å; F105-E184 HydrophobicContact CB-CB 4.34Å; F105-E184 HydrophobicContact CB-CG 4.12Å; F105-E184 WeakPolarHBondContact CB-OE2 3.01Å; F105-E184 HydrophobicContact CD1-CG 3.72Å; F105-E184 VanDerWaalsContact CD2-CD 3.49Å; F105-E184 HydrophobicContact CD2-CG 4.08Å; F105-E184 VanDerWaalsContact CD2-OE2 3.26Å; F105-E184 WeakPolarHBondContact CD2-OE2 3.44Å; F105-E184 HydrophobicContact CE1-CG 4.1Å; F105-E184 HydrophobicContact CE2-CG 4.44Å; F105-E184 HydrophobicContact CG-CB 4.43Å; F105-E184 HydrophobicContact CG-CG 3.7Å; F105-E184 WeakPolarHBondContact CG-OE2 3.46Å; F105-E184 HydrophobicContact CZ-CG 4.45Å; F105-K239 HydrophobicContact CD1-CD 4.22Å; F105-K239 HydrophobicContact CE1-CD 3.97Å; F105-K239 HydrophobicContact CE1-CG 4.29Å; F105-K239 HydrophobicContact CZ-CD 4.48Å; F105-K239 WeakPolarHBondContact O-CD 3.47Å; F105-K239 WeakPolarHBondContact O-CE 3.48Å
106	Y	89.7	Confident	82.8	Confident	16 Å²	16	62.8 Å²	62.8	6%	0.063	33%	0.329	C	S	.	.	G	3₁₀ helix	trans	-70.3	-19.3	-178.2	-69.5	-79.1	0	0	0	113.7	T99 V103 S104 Y181 L235 K239	T99-Y106 HydrophobicContact CG2-CD2 3.81Å; T99-Y106 HydrophobicContact CG2-CE2 3.76Å; V103-Y106 HydrophobicContact CB-CD2 4.11Å; V103-Y106 HydrophobicContact CB-CE2 4.39Å; V103-Y106 HydrophobicContact CG1-CD2 3.82Å; V103-Y106 HydrophobicContact CG1-CE2 3.91Å; V103-Y106 PolarHBondContact O-N 3.35Å; S104-Y106 PolarHBondContact O-N 2.99Å; Y106-Y181 HydrophobicContact CE2-CD2 4.24Å; Y106-Y181 WeakPolarHBondContact OH-CD2 3.39Å; Y106-L235 HydrophobicContact CD1-CB 3.99Å; Y106-L235 HydrophobicContact CD1-CD2 4.08Å; Y106-L235 HydrophobicContact CD2-CD2 4.35Å; Y106-L235 HydrophobicContact CE1-CB 3.68Å; Y106-L235 HydrophobicContact CE1-CD2 4.34Å; Y106-L235 HydrophobicContact CE1-CG 4.43Å; Y106-L235 HydrophobicContact CG-CD2 4.12Å; Y106-K239 HydrophobicContact CD1-CB 3.93Å; Y106-K239 HydrophobicContact CE1-CB 4.49Å
107	T	87.3	Confident	81.9	Confident	63 Å²	63	66 Å²	66	39%	0.387	35%	0.35	S	S	.	.	G	3₁₀ helix	trans	-92.5	-13.9	178	66.7	0	0	0	0	113.1	I100 S104 F105 A398	I100-T107 HydrophobicContact CG2-CG2 3.98Å; S104-T107 PolarHBondContact O-N 2.85Å; S104-T107 PolarHBondContact O-OG1 3.49Å; F105-T107 PolarHBondContact O-N 3.25Å; T107-A398 HydrophobicContact CG2-CB 4.12Å
108	R	85.5	Confident	81.2	Confident	157 Å²	157	68.8 Å²	68.8	59%	0.592	36%	0.361	S	S	*	.			trans	-77.1	129.1	-176.2	-169.3	171.1	174.9	177.7	-5.9	111.1	S104 F105 D110 K239	S104-R108 PolarHBondContact O-N 3.24Å; F105-R108 PolarHBondContact O-N 2.89Å; R108-D110 HydrophobicContact CG-CB 4.29Å; R108-D110 IonicContact CZ-OD2 3.06Å; R108-D110 IonicContact NE-OD2 3.55Å; R108-D110 PolarHBondContact NE-OD2 2.91Å; R108-D110 IonicContact NH2-OD2 2.73Å; R108-D110 PolarHBondContact NH2-OD2 3.24Å; R108-D110 PolarHBondContact O-N 3.01Å; R108-D110 VanDerWaalsContact O-N 3.12Å; R108-K239 WeakPolarHBondContact O-CE 3.25Å; R108-K239 PolarHBondContact O-NZ 3.35Å
109	K	76.1	Confident	80.5	Confident	156 Å²	156	69.6 Å²	69.6	68%	0.678	36%	0.361	S	S	*	.			trans	-79	14.7	-175	-63	-174.2	176.8	-175.6	0	115	E243	K109-E243 WeakPolarHBondContact CE-OE1 3.46Å; K109-E243 IonicContact NZ-OE1 2.66Å; K109-E243 PolarHBondContact NZ-OE1 2.86Å; K109-E243 IonicContact NZ-OE2 2.73Å
110	D	67.3	Low	79.6	Confident	94 Å²	94	70.4 Å²	70.4	50%	0.503	36%	0.364	S	S	.	.			trans	-89	120.4	-177.2	-61.7	-5.1	0	0	0	110.1	R108 K239	R108-D110 HydrophobicContact CG-CB 4.29Å; R108-D110 IonicContact CZ-OD2 3.06Å; R108-D110 IonicContact NE-OD2 3.55Å; R108-D110 PolarHBondContact NE-OD2 2.91Å; R108-D110 IonicContact NH2-OD2 2.73Å; R108-D110 PolarHBondContact NH2-OD2 3.24Å; R108-D110 PolarHBondContact O-N 3.01Å; R108-D110 VanDerWaalsContact O-N 3.12Å; D110-K239 PolarHBondContact O-NZ 3.46Å
111	G	63.2	Low	78.9	Confident	56 Å²	56	77 Å²	77	58%	0.577	40%	0.4	S	S	*	.			trans	113.4	115.9	177	0	0	0	0	0	113.1
112	Q	60.3	Low	78.5	Confident	110 Å²	110	75 Å²	75	51%	0.514	39%	0.393	S	S	.	.			trans	-95.7	130.8	175.5	-169.7	173.6	-8.3	0	0	109.4	T116 P117	Q112-T116 VanDerWaalsContact CG-O 3.29Å; Q112-T116 WeakPolarHBondContact CG-O 3.5Å; Q112-T116 PolarHBondContact NE2-O 2.99Å; Q112-P117 PolarHBondContact NE2-O 3.24Å
113	L	63.7	Low	78	Confident	48 Å²	48	81.9 Å²	81.9	25%	0.251	42%	0.42	S	S	.	.			trans	-69.3	145.7	168.8	-93.8	170.1	0	0	0	109.9	Y115 T116 Y240	L113-Y115 HydrophobicContact CD2-CD2 4.27Å; L113-Y115 PolarHBondContact O-N 3.43Å; L113-Y115 VanDerWaalsContact O-N 3.12Å; L113-T116 PolarHBondContact O-N 3.47Å; L113-T116 PolarHBondContact O-OG1 3.28Å; L113-Y240 HydrophobicContact CD1-CD2 4.48Å; L113-Y240 HydrophobicContact CD1-CG 3.93Å; L113-Y240 HydrophobicContact CD2-CG 4.36Å; L113-Y240 HydrophobicContact CG-CD1 4.08Å; L113-Y240 HydrophobicContact CG-CG 3.87Å
114	I	67	Low	77.9	Confident	159 Å²	159	85.1 Å²	85.1	82%	0.815	44%	0.44	S	S	*	.	T	Hydrogen-bonded Turn	trans	-55.6	-29.3	169.9	-63.4	169.8	0	0	0	111.1	T116	I114-T116 VanDerWaalsContact C-N 3.34Å; I114-T116 PolarHBondContact O-N 2.88Å
115	Y	67.9	Low	78	Confident	127 Å²	127	85.8 Å²	85.8	50%	0.498	44%	0.44	S	S	.	.	T	Hydrogen-bonded Turn	trans	-80.2	-7.4	-180	-59	-68.2	0	0	0	115	L113 P117 V142	L113-Y115 HydrophobicContact CD2-CD2 4.27Å; L113-Y115 PolarHBondContact O-N 3.43Å; L113-Y115 VanDerWaalsContact O-N 3.12Å; Y115-P117 VanDerWaalsContact C-CD 3.47Å; Y115-P117 WeakPolarHBondContact O-CD 3.41Å; Y115-V142 HydrophobicContact CD1-CG2 4.46Å
116	T	77.7	Confident	78.1	Confident	2 Å²	2	85.4 Å²	85.4	1%	0.012	45%	0.453	C	S	.	.			trans	-122.4	73.9	176.8	53.8	0	0	0	0	109	Q112 L113 I114 F118 N135 M139 L241	Q112-T116 VanDerWaalsContact CG-O 3.29Å; Q112-T116 WeakPolarHBondContact CG-O 3.5Å; Q112-T116 PolarHBondContact NE2-O 2.99Å; L113-T116 PolarHBondContact O-N 3.47Å; L113-T116 PolarHBondContact O-OG1 3.28Å; I114-T116 VanDerWaalsContact C-N 3.34Å; I114-T116 PolarHBondContact O-N 2.88Å; T116-F118 VanDerWaalsContact C-N 3.28Å; T116-F118 PolarHBondContact O-N 2.92Å; T116-N135 WeakPolarHBondContact CA-OD1 3.33Å; T116-N135 HydrophobicContact CG2-CB 4.37Å; T116-M139 HydrophobicContact CG2-CE 4.29Å; T116-L241 HydrophobicContact CG2-CD2 4.47Å
117	P	78.2	Confident	78.1	Confident	67 Å²	67	89.1 Å²	89.1	44%	0.435	47%	0.471	S	S	.	.			trans	-69.7	-21	-171.7	25.7	-33.7	0	0	0	114.1	Q112 Y115 N135 I138	Q112-P117 PolarHBondContact NE2-O 3.24Å; Y115-P117 VanDerWaalsContact C-CD 3.47Å; Y115-P117 WeakPolarHBondContact O-CD 3.41Å; P117-N135 WeakPolarHBondContact CD-OD1 3.35Å; P117-I138 HydrophobicContact CG-CD1 3.79Å
118	F	79.8	Confident	78.3	Confident	71 Å²	71	89.8 Å²	89.8	31%	0.311	47%	0.467	S	S	.	.	S	Bend	trans	-99.1	130.6	-179.1	-55.7	-78.1	0	0	0	111	T116 H131 L134 N135 I138	T116-F118 VanDerWaalsContact C-N 3.28Å; T116-F118 PolarHBondContact O-N 2.92Å; F118-H131 HydrophobicContact CB-CB 3.68Å; F118-H131 AromaticContact CD1-CE1 3.89Å; F118-H131 AromaticContact CD1-ND1 3.57Å; F118-H131 AromaticContact CG-ND1 3.7Å; F118-L134 HydrophobicContact CD2-CB 4.16Å; F118-L134 HydrophobicContact CD2-CD2 3.6Å; F118-L134 HydrophobicContact CD2-CG 3.75Å; F118-L134 HydrophobicContact CE1-CD2 4.08Å; F118-L134 HydrophobicContact CE2-CB 4.33Å; F118-L134 HydrophobicContact CE2-CD2 3.08Å; F118-L134 HydrophobicContact CE2-CG 3.43Å; F118-L134 VanDerWaalsContact CE2-CG 3.43Å; F118-L134 HydrophobicContact CG-CD2 4.32Å; F118-L134 HydrophobicContact CZ-CD2 3.35Å; F118-L134 HydrophobicContact CZ-CG 4.2Å; F118-N135 WeakPolarHBondContact CD2-OD1 3.31Å; F118-N135 PolarHBondContact N-OD1 3.27Å; F118-N135 VanDerWaalsContact N-OD1 3.11Å; F118-N135 PolarHBondContact O-ND2 2.87Å; F118-I138 HydrophobicContact CE2-CD1 4.15Å
119	T	79.2	Confident	78.7	Confident	69 Å²	69	83.7 Å²	83.7	42%	0.423	45%	0.45	S	S	.	.			trans	-81.4	145.2	177.3	58.3	0	0	0	0	110.6	D121	T119-D121 VanDerWaalsContact C-N 3.3Å
120	E	77.8	Confident	79.5	Confident	20 Å²	20	81.7 Å²	81.7	9%	0.093	45%	0.446	C	S	.	.	S	Bend	trans	-84.6	-6.3	176.3	-70.8	-174.8	179.1	0	0	112.8	T122 R128 S132 P242 E243 W244 T245	E120-T122 PolarHBondContact O-N 2.87Å; E120-R128 HydrophobicContact CB-CG 4.06Å; E120-R128 HydrophobicContact CG-CG 4.42Å; E120-R128 WeakPolarHBondContact O-CG 3.24Å; E120-R128 PolarHBondContact O-NE 3.02Å; E120-S132 WeakPolarHBondContact OE1-CB 3.28Å; E120-P242 HydrophobicContact CG-CB 3.92Å; E120-P242 VanDerWaalsContact OE1-CB 3.28Å; E120-P242 WeakPolarHBondContact OE1-CB 3.36Å; E120-P242 WeakPolarHBondContact OE2-CB 3.34Å; E120-E243 PolarHBondContact OE2-N 3.38Å; E120-W244 WeakPolarHBondContact OE1-CB 3.27Å; E120-W244 PolarHBondContact OE2-N 3.45Å; E120-W244 VanDerWaalsContact OE2-N 3.08Å; E120-T245 WeakPolarHBondContact OE1-CB 3.39Å; E120-T245 PolarHBondContact OE1-N 3.45Å; E120-T245 PolarHBondContact OE1-OG1 2.88Å
121	D	79.1	Confident	80.6	Confident	145 Å²	145	79.3 Å²	79.3	78%	0.775	43%	0.432	S	S	*	.			trans	-77.8	59.8	179.1	-60.1	-36.2	0	0	0	111.7	T119	T119-D121 VanDerWaalsContact C-N 3.3Å
122	T	83.5	Confident	82	Confident	24 Å²	24	76.7 Å²	76.7	15%	0.147	41%	0.405	C	S	.	.			trans	-108.1	153.7	175.5	51.5	0	0	0	0	111.7	E120 Q127 R128	E120-T122 PolarHBondContact O-N 2.87Å; T122-Q127 HydrophobicContact CG2-CB 4.24Å; T122-R128 PolarHBondContact O-NH2 3.4Å; T122-R128 VanDerWaalsContact OG1-CA 3.27Å; T122-R128 WeakPolarHBondContact OG1-CA 3.41Å; T122-R128 WeakPolarHBondContact OG1-CB 3.37Å; T122-R128 PolarHBondContact OG1-N 2.77Å
123	E	81.2	Confident	83.6	Confident	192 Å²	192	76.2 Å²	76.2	90%	0.897	41%	0.405	S	S	*	.	S	Bend	trans	-67.8	-34.1	-175.1	-63.4	-177.3	175.4	0	0	112.8
124	T	91.3	Very high	84.9	Confident	68 Å²	68	77.3 Å²	77.3	42%	0.417	41%	0.41	S	S	.	.	S	Bend	trans	-109.2	139.8	-176	65.9	0	0	0	0	111.9	G126 Q127 R128	T124-G126 PolarHBondContact O-N 2.94Å; T124-Q127 PolarHBondContact O-N 3.4Å; T124-Q127 WeakPolarHBondContact OG1-CB 3.5Å; T124-Q127 VanDerWaalsContact OG1-CD 3.28Å; T124-Q127 WeakPolarHBondContact OG1-CG 3.3Å; T124-Q127 PolarHBondContact OG1-N 2.91Å; T124-Q127 PolarHBondContact OG1-OE1 3.46Å; T124-R128 PolarHBondContact O-N 3.38Å
125	V	91.6	Very high	86.1	Confident	97 Å²	97	69.8 Å²	69.8	59%	0.588	37%	0.372	S	S	*	.	H	α-helix	trans	-57.3	-36.1	176.1	-179.8	0	0	0	0	111.3	R128 A129	V125-R128 PolarHBondContact O-N 3.45Å; V125-A129 WeakPolarHBondContact O-CB 3.33Å; V125-A129 PolarHBondContact O-N 2.87Å
126	G	91.8	Very high	87.2	Confident	52 Å²	52	63.9 Å²	63.9	54%	0.536	35%	0.35	S	S	.	.	H	α-helix	trans	-63.6	-43.6	177.7	0	0	0	0	0	113.3	T124 A129 L130	T124-G126 PolarHBondContact O-N 2.94Å; G126-A129 PolarHBondContact O-N 2.77Å; G126-L130 WeakPolarHBondContact O-CB 3.28Å; G126-L130 PolarHBondContact O-N 2.86Å
127	Q	91.4	Very high	87.9	Confident	95 Å²	95	66 Å²	66	44%	0.444	37%	0.367	S	S	.	.	H	α-helix	trans	-67.6	-40.3	175.3	-74.5	171.3	-30.6	0	0	111.6	T122 T124 A129 L130 H131	T122-Q127 HydrophobicContact CG2-CB 4.24Å; T124-Q127 PolarHBondContact O-N 3.4Å; T124-Q127 WeakPolarHBondContact OG1-CB 3.5Å; T124-Q127 VanDerWaalsContact OG1-CD 3.28Å; T124-Q127 WeakPolarHBondContact OG1-CG 3.3Å; T124-Q127 PolarHBondContact OG1-N 2.91Å; T124-Q127 PolarHBondContact OG1-OE1 3.46Å; Q127-A129 VanDerWaalsContact C-N 3.35Å; Q127-A129 PolarHBondContact O-N 3.38Å; Q127-L130 PolarHBondContact O-N 3.47Å; Q127-H131 WeakPolarHBondContact O-CB 3.34Å; Q127-H131 PolarHBondContact O-CD2 3.41Å; Q127-H131 VanDerWaalsContact O-CD2 3.28Å; Q127-H131 PolarHBondContact O-N 3.49Å
128	R	91.2	Very high	88.5	Confident	76 Å²	76	65.6 Å²	65.6	29%	0.287	36%	0.361	S	S	.	.	H	α-helix	trans	-58.4	-48.2	175.2	-172.9	175.8	-58.8	153.6	9.9	111.3	E120 T122 T124 V125 H131 S132 W244	E120-R128 HydrophobicContact CB-CG 4.06Å; E120-R128 HydrophobicContact CG-CG 4.42Å; E120-R128 WeakPolarHBondContact O-CG 3.24Å; E120-R128 PolarHBondContact O-NE 3.02Å; T122-R128 PolarHBondContact O-NH2 3.4Å; T122-R128 VanDerWaalsContact OG1-CA 3.27Å; T122-R128 WeakPolarHBondContact OG1-CA 3.41Å; T122-R128 WeakPolarHBondContact OG1-CB 3.37Å; T122-R128 PolarHBondContact OG1-N 2.77Å; T124-R128 PolarHBondContact O-N 3.38Å; V125-R128 PolarHBondContact O-N 3.45Å; R128-H131 PolarHBondContact O-N 3.45Å; R128-S132 WeakPolarHBondContact O-CB 3.29Å; R128-S132 PolarHBondContact O-N 3.37Å; R128-S132 PolarHBondContact O-OG 2.96Å; R128-W244 HydrophobicContact CG-CG 4.48Å
129	A	92.7	Very high	89	Confident	30 Å²	30	63 Å²	63	25%	0.248	35%	0.35	C	S	.	.	H	α-helix	trans	-62.5	-42.9	177.7	0	0	0	0	0	112.1	V125 G126 Q127 S132 I133	V125-A129 WeakPolarHBondContact O-CB 3.33Å; V125-A129 PolarHBondContact O-N 2.87Å; G126-A129 PolarHBondContact O-N 2.77Å; Q127-A129 VanDerWaalsContact C-N 3.35Å; Q127-A129 PolarHBondContact O-N 3.38Å; A129-S132 WeakPolarHBondContact CA-OG 3.47Å; A129-S132 PolarHBondContact O-N 3.43Å; A129-S132 PolarHBondContact O-OG 3.18Å; A129-I133 WeakPolarHBondContact O-CB 3.48Å; A129-I133 WeakPolarHBondContact O-CD1 3.28Å; A129-I133 WeakPolarHBondContact O-CG1 3.15Å; A129-I133 PolarHBondContact O-N 3.37Å
130	L	93	Very high	89.5	Confident	113 Å²	113	61.1 Å²	61.1	59%	0.592	34%	0.337	S	S	*	.	H	α-helix	trans	-60.6	-47.9	176.7	-173.1	82.9	0	0	0	111.3	G126 Q127 I133 L134	G126-L130 WeakPolarHBondContact O-CB 3.28Å; G126-L130 PolarHBondContact O-N 2.86Å; Q127-L130 PolarHBondContact O-N 3.47Å; L130-I133 PolarHBondContact O-N 3.23Å; L130-L134 WeakPolarHBondContact O-CB 3.47Å; L130-L134 PolarHBondContact O-N 2.86Å
131	H	91.6	Very high	90.2	Very high	45 Å²	45	63.3 Å²	63.3	21%	0.208	36%	0.355	C	S	.	.	H	α-helix	trans	-65.7	-40.8	178.8	-72.2	-37.1	0	0	0	112.4	F118 Q127 R128 L134 N135	F118-H131 HydrophobicContact CB-CB 3.68Å; F118-H131 AromaticContact CD1-CE1 3.89Å; F118-H131 AromaticContact CD1-ND1 3.57Å; F118-H131 AromaticContact CG-ND1 3.7Å; Q127-H131 WeakPolarHBondContact O-CB 3.34Å; Q127-H131 PolarHBondContact O-CD2 3.41Å; Q127-H131 VanDerWaalsContact O-CD2 3.28Å; Q127-H131 PolarHBondContact O-N 3.49Å; R128-H131 PolarHBondContact O-N 3.45Å; H131-L134 PolarHBondContact O-N 3.45Å; H131-N135 WeakPolarHBondContact O-CB 3.25Å; H131-N135 PolarHBondContact O-N 2.98Å; H131-N135 PolarHBondContact O-ND2 3.29Å
132	S	91.6	Very high	90.7	Very high	1 Å²	1	58.9 Å²	58.9	1%	0.007	33%	0.333	C	S	.	.	H	α-helix	trans	-65.8	-40	176.7	65.2	0	0	0	0	112.1	E120 R128 A129 L134 N135 A136 L248	E120-S132 WeakPolarHBondContact OE1-CB 3.28Å; R128-S132 WeakPolarHBondContact O-CB 3.29Å; R128-S132 PolarHBondContact O-N 3.37Å; R128-S132 PolarHBondContact O-OG 2.96Å; A129-S132 WeakPolarHBondContact CA-OG 3.47Å; A129-S132 PolarHBondContact O-N 3.43Å; A129-S132 PolarHBondContact O-OG 3.18Å; S132-L134 VanDerWaalsContact C-N 3.34Å; S132-N135 PolarHBondContact O-N 3.47Å; S132-A136 VanDerWaalsContact O-CB 3.29Å; S132-A136 WeakPolarHBondContact O-CB 3.14Å; S132-A136 PolarHBondContact O-N 3.04Å; S132-L248 WeakPolarHBondContact OG-CD1 3.33Å
133	I	93.8	Very high	91	Very high	99 Å²	99	60.6 Å²	60.6	51%	0.508	34%	0.34	S	S	.	.	H	α-helix	trans	-62.3	-44	174.5	-71.4	165.3	0	0	0	110.2	A129 L130 A136 A137 L248	A129-I133 WeakPolarHBondContact O-CB 3.48Å; A129-I133 WeakPolarHBondContact O-CD1 3.28Å; A129-I133 WeakPolarHBondContact O-CG1 3.15Å; A129-I133 PolarHBondContact O-N 3.37Å; L130-I133 PolarHBondContact O-N 3.23Å; I133-A136 PolarHBondContact O-N 2.99Å; I133-A137 WeakPolarHBondContact O-CB 3.44Å; I133-A137 PolarHBondContact O-N 3.35Å; I133-L248 HydrophobicContact CG1-CD1 3.77Å
134	L	92.4	Very high	91.3	Very high	72 Å²	72	53.2 Å²	53.2	38%	0.377	31%	0.308	S	S	.	.	H	α-helix	trans	-66.7	-42.6	-179.6	-172.9	54.1	0	0	0	112.1	F118 L130 H131 S132 A137 I138	F118-L134 HydrophobicContact CD2-CB 4.16Å; F118-L134 HydrophobicContact CD2-CD2 3.6Å; F118-L134 HydrophobicContact CD2-CG 3.75Å; F118-L134 HydrophobicContact CE1-CD2 4.08Å; F118-L134 HydrophobicContact CE2-CB 4.33Å; F118-L134 HydrophobicContact CE2-CD2 3.08Å; F118-L134 HydrophobicContact CE2-CG 3.43Å; F118-L134 VanDerWaalsContact CE2-CG 3.43Å; F118-L134 HydrophobicContact CG-CD2 4.32Å; F118-L134 HydrophobicContact CZ-CD2 3.35Å; F118-L134 HydrophobicContact CZ-CG 4.2Å; L130-L134 WeakPolarHBondContact O-CB 3.47Å; L130-L134 PolarHBondContact O-N 2.86Å; H131-L134 PolarHBondContact O-N 3.45Å; S132-L134 VanDerWaalsContact C-N 3.34Å; L134-A137 PolarHBondContact O-N 2.77Å; L134-I138 HydrophobicContact CG-CD1 4.35Å; L134-I138 VanDerWaalsContact O-CG1 3.3Å; L134-I138 WeakPolarHBondContact O-CG1 3.36Å; L134-I138 PolarHBondContact O-N 3.36Å
135	N	91.1	Very high	91.4	Very high	0 Å²	0	54 Å²	54	0%	0	31%	0.312	C	S	.	.	H	α-helix	trans	-60.4	-46.9	172.5	-74.8	-24.8	0	0	0	111.9	T116 P117 F118 H131 S132 A137 I138 M139 T245	T116-N135 WeakPolarHBondContact CA-OD1 3.33Å; T116-N135 HydrophobicContact CG2-CB 4.37Å; P117-N135 WeakPolarHBondContact CD-OD1 3.35Å; F118-N135 WeakPolarHBondContact CD2-OD1 3.31Å; F118-N135 PolarHBondContact N-OD1 3.27Å; F118-N135 VanDerWaalsContact N-OD1 3.11Å; F118-N135 PolarHBondContact O-ND2 2.87Å; H131-N135 WeakPolarHBondContact O-CB 3.25Å; H131-N135 PolarHBondContact O-N 2.98Å; H131-N135 PolarHBondContact O-ND2 3.29Å; S132-N135 PolarHBondContact O-N 3.47Å; N135-A137 VanDerWaalsContact C-N 3.33Å; N135-A137 PolarHBondContact O-N 3.37Å; N135-I138 PolarHBondContact O-N 2.8Å; N135-M139 PolarHBondContact O-N 3.35Å; N135-T245 HydrophobicContact CB-CG2 3.8Å
136	A	91.2	Very high	91.3	Very high	4 Å²	4	53.4 Å²	53.4	3%	0.033	30%	0.304	C	S	.	.	H	α-helix	trans	-60.4	-44.2	178.1	0	0	0	0	0	111	S132 I133 I138 M139 I140 T245 L248 I249	S132-A136 VanDerWaalsContact O-CB 3.29Å; S132-A136 WeakPolarHBondContact O-CB 3.14Å; S132-A136 PolarHBondContact O-N 3.04Å; I133-A136 PolarHBondContact O-N 2.99Å; A136-I138 PolarHBondContact O-N 3.12Å; A136-M139 PolarHBondContact O-N 3.05Å; A136-I140 HydrophobicContact CB-CD1 4.47Å; A136-I140 WeakPolarHBondContact O-CB 3.34Å; A136-I140 VanDerWaalsContact O-CD1 3.32Å; A136-I140 WeakPolarHBondContact O-CD1 3.31Å; A136-I140 VanDerWaalsContact O-CG1 3.24Å; A136-I140 WeakPolarHBondContact O-CG1 3.32Å; A136-I140 PolarHBondContact O-N 3.42Å; A136-T245 HydrophobicContact CB-CG2 4.34Å; A136-L248 HydrophobicContact CB-CB 4.08Å; A136-I249 HydrophobicContact CB-CG1 3.97Å
137	A	92.5	Very high	91.1	Very high	47 Å²	47	52.5 Å²	52.5	39%	0.388	29%	0.289	S	S	.	.	H	α-helix	trans	-61	-43.6	177.4	0	0	0	0	0	112.4	I133 L134 N135 S141	I133-A137 WeakPolarHBondContact O-CB 3.44Å; I133-A137 PolarHBondContact O-N 3.35Å; L134-A137 PolarHBondContact O-N 2.77Å; N135-A137 VanDerWaalsContact C-N 3.33Å; N135-A137 PolarHBondContact O-N 3.37Å; A137-S141 VanDerWaalsContact O-CB 3.27Å; A137-S141 WeakPolarHBondContact O-CB 3.26Å; A137-S141 PolarHBondContact O-N 3.39Å; A137-S141 PolarHBondContact O-OG 3.49Å
138	I	91.7	Very high	90.9	Very high	57 Å²	57	51.7 Å²	51.7	29%	0.292	29%	0.287	S	S	.	.	H	α-helix	trans	-61.8	-48.9	176.2	-68.3	164.7	0	0	0	110.2	P117 F118 L134 N135 A136 S141 V142	P117-I138 HydrophobicContact CG-CD1 3.79Å; F118-I138 HydrophobicContact CE2-CD1 4.15Å; L134-I138 HydrophobicContact CG-CD1 4.35Å; L134-I138 VanDerWaalsContact O-CG1 3.3Å; L134-I138 WeakPolarHBondContact O-CG1 3.36Å; L134-I138 PolarHBondContact O-N 3.36Å; N135-I138 PolarHBondContact O-N 2.8Å; A136-I138 PolarHBondContact O-N 3.12Å; I138-S141 WeakPolarHBondContact O-CB 3.38Å; I138-S141 PolarHBondContact O-N 3.08Å; I138-V142 WeakPolarHBondContact O-CG2 3.32Å; I138-V142 PolarHBondContact O-N 2.94Å
139	M	89.9	Confident	90.9	Very high	18 Å²	18	51.7 Å²	51.7	9%	0.089	29%	0.292	C	S	.	.	H	α-helix	trans	-63.3	-46.9	-178.3	-176.3	170.5	-67.1	0	0	112.2	T116 N135 A136 S141 V142 I143 L241 I249	T116-M139 HydrophobicContact CG2-CE 4.29Å; N135-M139 PolarHBondContact O-N 3.35Å; A136-M139 PolarHBondContact O-N 3.05Å; M139-S141 VanDerWaalsContact C-N 3.29Å; M139-S141 PolarHBondContact O-N 3.03Å; M139-V142 PolarHBondContact O-N 3.25Å; M139-I143 HydrophobicContact CG-CD1 4.12Å; M139-I143 WeakPolarHBondContact O-CG1 3.42Å; M139-I143 PolarHBondContact O-N 3.38Å; M139-L241 HydrophobicContact CE-CD2 3.27Å; M139-L241 HydrophobicContact CE-CG 4.36Å; M139-L241 HydrophobicContact SD-CD1 4.46Å; M139-L241 HydrophobicContact SD-CD2 3.66Å; M139-I249 HydrophobicContact CB-CD1 4.26Å; M139-I249 HydrophobicContact CE-CD1 4.48Å; M139-I249 HydrophobicContact CG-CD1 4.26Å; M139-I249 HydrophobicContact SD-CD1 3.46Å; M139-I249 WeakPolarHBondContact SD-CD1 3.38Å
140	I	89.8	Confident	90.7	Very high	28 Å²	28	52 Å²	52	14%	0.144	29%	0.289	C	S	.	.	H	α-helix	trans	-61.8	-40.4	177.7	-69	158.9	0	0	0	110.4	A136 V142 I143 V144 V252	A136-I140 HydrophobicContact CB-CD1 4.47Å; A136-I140 WeakPolarHBondContact O-CB 3.34Å; A136-I140 VanDerWaalsContact O-CD1 3.32Å; A136-I140 WeakPolarHBondContact O-CD1 3.31Å; A136-I140 VanDerWaalsContact O-CG1 3.24Å; A136-I140 WeakPolarHBondContact O-CG1 3.32Å; A136-I140 PolarHBondContact O-N 3.42Å; I140-V142 VanDerWaalsContact C-N 3.32Å; I140-V142 PolarHBondContact O-N 3.02Å; I140-I143 PolarHBondContact O-N 3.4Å; I140-V144 HydrophobicContact CG2-CG2 4.14Å; I140-V144 WeakPolarHBondContact O-CB 3.27Å; I140-V144 VanDerWaalsContact O-CG2 3.29Å; I140-V144 WeakPolarHBondContact O-CG2 3.32Å; I140-V144 PolarHBondContact O-N 3.26Å; I140-V252 HydrophobicContact CD1-CB 3.67Å; I140-V252 HydrophobicContact CD1-CG1 3.53Å; I140-V252 HydrophobicContact CD1-CG2 4.26Å
141	S	91	Very high	90.3	Very high	67 Å²	67	47.3 Å²	47.3	47%	0.469	27%	0.265	S	S	.	.	H	α-helix	trans	-59.1	-43.8	176.2	-61.1	0	0	0	0	111.7	A137 I138 M139 V144 V145	A137-S141 VanDerWaalsContact O-CB 3.27Å; A137-S141 WeakPolarHBondContact O-CB 3.26Å; A137-S141 PolarHBondContact O-N 3.39Å; A137-S141 PolarHBondContact O-OG 3.49Å; I138-S141 WeakPolarHBondContact O-CB 3.38Å; I138-S141 PolarHBondContact O-N 3.08Å; M139-S141 VanDerWaalsContact C-N 3.29Å; M139-S141 PolarHBondContact O-N 3.03Å; S141-V144 PolarHBondContact O-N 3.39Å; S141-V145 WeakPolarHBondContact O-CB 3.02Å; S141-V145 VanDerWaalsContact O-CG2 3.23Å; S141-V145 WeakPolarHBondContact O-CG2 3.5Å; S141-V145 PolarHBondContact O-N 3Å
142	V	91.4	Very high	90.2	Very high	52 Å²	52	48 Å²	48	32%	0.315	27%	0.272	S	S	.	.	H	α-helix	trans	-63.2	-45.4	175.9	175.3	0	0	0	0	111	Y115 I138 M139 I140 V144 V145 M146	Y115-V142 HydrophobicContact CD1-CG2 4.46Å; I138-V142 WeakPolarHBondContact O-CG2 3.32Å; I138-V142 PolarHBondContact O-N 2.94Å; M139-V142 PolarHBondContact O-N 3.25Å; I140-V142 VanDerWaalsContact C-N 3.32Å; I140-V142 PolarHBondContact O-N 3.02Å; V142-V144 PolarHBondContact O-N 2.87Å; V142-V145 PolarHBondContact O-N 2.93Å; V142-M146 HydrophobicContact CG1-CG 4.31Å; V142-M146 WeakPolarHBondContact O-CB 3.3Å; V142-M146 VanDerWaalsContact O-CG 3.22Å; V142-M146 WeakPolarHBondContact O-CG 3.48Å; V142-M146 PolarHBondContact O-N 2.88Å
143	I	88.5	Confident	90.1	Very high	60 Å²	60	49.3 Å²	49.3	31%	0.308	28%	0.279	S	S	.	.	H	α-helix	trans	-58.9	-49.2	177.7	-66.9	169.1	0	0	0	110.6	M139 I140 V145 M146 T147 I253	M139-I143 HydrophobicContact CG-CD1 4.12Å; M139-I143 WeakPolarHBondContact O-CG1 3.42Å; M139-I143 PolarHBondContact O-N 3.38Å; I140-I143 PolarHBondContact O-N 3.4Å; I143-V145 PolarHBondContact O-N 3.37Å; I143-M146 PolarHBondContact O-N 3.25Å; I143-T147 PolarHBondContact O-N 3.02Å; I143-T147 PolarHBondContact O-OG1 3.36Å; I143-I253 HydrophobicContact CD1-CD1 4.32Å
144	V	88.7	Confident	89.6	Confident	36 Å²	36	45 Å²	45	22%	0.218	26%	0.256	C	S	.	.	H	α-helix	trans	-61.2	-45.4	179.5	171.3	0	0	0	0	111.3	I140 S141 V142 M146 T147 I148 Y256	I140-V144 HydrophobicContact CG2-CG2 4.14Å; I140-V144 WeakPolarHBondContact O-CB 3.27Å; I140-V144 VanDerWaalsContact O-CG2 3.29Å; I140-V144 WeakPolarHBondContact O-CG2 3.32Å; I140-V144 PolarHBondContact O-N 3.26Å; S141-V144 PolarHBondContact O-N 3.39Å; V142-V144 PolarHBondContact O-N 2.87Å; V144-M146 PolarHBondContact O-N 3.5Å; V144-T147 PolarHBondContact O-N 3.49Å; V144-I148 HydrophobicContact CG1-CD1 3.78Å; V144-I148 HydrophobicContact CG1-CG1 4.44Å; V144-I148 VanDerWaalsContact O-CG1 3.3Å; V144-I148 WeakPolarHBondContact O-CG1 3.37Å; V144-I148 PolarHBondContact O-N 3.5Å; V144-Y256 HydrophobicContact CG2-CE2 4Å
145	V	91.9	Very high	89.3	Confident	84 Å²	84	47.6 Å²	47.6	51%	0.509	27%	0.265	S	S	.	.	H	α-helix	trans	-61.6	-43.2	177.1	169.3	0	0	0	0	111.1	S141 V142 I143 I148 L149	S141-V145 WeakPolarHBondContact O-CB 3.02Å; S141-V145 VanDerWaalsContact O-CG2 3.23Å; S141-V145 WeakPolarHBondContact O-CG2 3.5Å; S141-V145 PolarHBondContact O-N 3Å; V142-V145 PolarHBondContact O-N 2.93Å; I143-V145 PolarHBondContact O-N 3.37Å; V145-I148 PolarHBondContact O-N 2.66Å; V145-L149 WeakPolarHBondContact O-CB 3.18Å; V145-L149 PolarHBondContact O-N 3.25Å
146	M	89.3	Confident	89.2	Confident	85 Å²	85	56 Å²	56	42%	0.419	30%	0.298	S	S	.	.	H	α-helix	trans	-65.2	-39.3	176.8	-67.7	-61.4	145	0	0	112	V142 I143 V144 L149 L150 W165	V142-M146 HydrophobicContact CG1-CG 4.31Å; V142-M146 WeakPolarHBondContact O-CB 3.3Å; V142-M146 VanDerWaalsContact O-CG 3.22Å; V142-M146 WeakPolarHBondContact O-CG 3.48Å; V142-M146 PolarHBondContact O-N 2.88Å; I143-M146 PolarHBondContact O-N 3.25Å; V144-M146 PolarHBondContact O-N 3.5Å; M146-L149 PolarHBondContact O-N 2.91Å; M146-L149 HydrophobicContact SD-CD2 4.46Å; M146-L150 WeakPolarHBondContact O-CB 3.41Å; M146-L150 PolarHBondContact O-N 2.97Å; M146-W165 HydrophobicContact SD-CH2 3.89Å; M146-W165 HydrophobicContact SD-CZ2 4.17Å
147	T	87.5	Confident	88.8	Confident	34 Å²	34	63.8 Å²	63.8	21%	0.209	33%	0.326	C	S	.	.	H	α-helix	trans	-63.1	-46.2	173.9	-56.7	0	0	0	0	111.5	I143 V144 L149 L150 V151 P267 L268	I143-T147 PolarHBondContact O-N 3.02Å; I143-T147 PolarHBondContact O-OG1 3.36Å; V144-T147 PolarHBondContact O-N 3.49Å; T147-L149 VanDerWaalsContact C-N 3.34Å; T147-L149 PolarHBondContact O-N 3.47Å; T147-L150 PolarHBondContact O-N 2.98Å; T147-V151 VanDerWaalsContact O-CG2 3.31Å; T147-V151 WeakPolarHBondContact O-CG2 3.37Å; T147-V151 PolarHBondContact O-N 3.29Å; T147-P267 HydrophobicContact CG2-CB 4.24Å; T147-L268 HydrophobicContact CG2-CD2 4.4Å
148	I	88.8	Confident	88.5	Confident	78 Å²	78	63.7 Å²	63.7	40%	0.4	32%	0.322	S	S	.	.	H	α-helix	trans	-61.7	-44.5	176.9	-67.8	166.6	0	0	0	110.3	V144 V145 L150 V151 V152 P267	V144-I148 HydrophobicContact CG1-CD1 3.78Å; V144-I148 HydrophobicContact CG1-CG1 4.44Å; V144-I148 VanDerWaalsContact O-CG1 3.3Å; V144-I148 WeakPolarHBondContact O-CG1 3.37Å; V144-I148 PolarHBondContact O-N 3.5Å; V145-I148 PolarHBondContact O-N 2.66Å; I148-L150 VanDerWaalsContact C-N 3.31Å; I148-L150 PolarHBondContact O-N 3.36Å; I148-V151 PolarHBondContact O-N 3.48Å; I148-V152 HydrophobicContact CG2-CG2 4.07Å; I148-V152 WeakPolarHBondContact O-CB 3.31Å; I148-V152 WeakPolarHBondContact O-CG2 3.39Å; I148-V152 PolarHBondContact O-N 3.24Å; I148-P267 HydrophobicContact CG1-CG 4.44Å
149	L	91.5	Very high	88.1	Confident	75 Å²	75	64.6 Å²	64.6	39%	0.393	32%	0.323	S	S	.	.	H	α-helix	trans	-58.9	-43.2	177.4	-177.8	62.6	0	0	0	111.5	V145 M146 T147 V152 L153 W165	V145-L149 WeakPolarHBondContact O-CB 3.18Å; V145-L149 PolarHBondContact O-N 3.25Å; M146-L149 PolarHBondContact O-N 2.91Å; M146-L149 HydrophobicContact SD-CD2 4.46Å; T147-L149 VanDerWaalsContact C-N 3.34Å; T147-L149 PolarHBondContact O-N 3.47Å; L149-V152 PolarHBondContact O-N 3.33Å; L149-L153 HydrophobicContact CD1-CD1 4.44Å; L149-L153 HydrophobicContact CD1-CG 4.44Å; L149-L153 HydrophobicContact CG-CD1 4.16Å; L149-L153 WeakPolarHBondContact O-CB 3.42Å; L149-L153 VanDerWaalsContact O-CG 3.25Å; L149-L153 WeakPolarHBondContact O-CG 3.34Å; L149-L153 PolarHBondContact O-N 2.85Å; L149-W165 HydrophobicContact CD2-CH2 3.91Å; L149-W165 HydrophobicContact CD2-CZ3 3.81Å; L149-W165 HydrophobicContact CG-CZ3 4.2Å
150	L	86.9	Confident	88.1	Confident	37 Å²	37	72.7 Å²	72.7	19%	0.194	36%	0.357	C	S	.	.	H	α-helix	trans	-62.4	-46.9	175.9	-171	157.6	0	0	0	111.4	M146 T147 I148 V152 L153 Y154 L271	M146-L150 WeakPolarHBondContact O-CB 3.41Å; M146-L150 PolarHBondContact O-N 2.97Å; T147-L150 PolarHBondContact O-N 2.98Å; I148-L150 VanDerWaalsContact C-N 3.31Å; I148-L150 PolarHBondContact O-N 3.36Å; L150-V152 VanDerWaalsContact C-N 3.33Å; L150-V152 PolarHBondContact O-N 3.31Å; L150-L153 PolarHBondContact O-N 3.43Å; L150-Y154 WeakPolarHBondContact O-CB 3.42Å; L150-Y154 PolarHBondContact O-N 3.14Å; L150-L271 HydrophobicContact CD2-CD1 3.43Å; L150-L271 VanDerWaalsContact CD2-CD1 3.43Å
151	V	85.9	Confident	88.2	Confident	15 Å²	15	74.9 Å²	74.9	9%	0.091	37%	0.372	C	S	.	.	H	α-helix	trans	-61.5	-42.4	177.7	172.5	0	0	0	0	111.3	T147 I148 Y154 K155 P267 M270 L271	T147-V151 VanDerWaalsContact O-CG2 3.31Å; T147-V151 WeakPolarHBondContact O-CG2 3.37Å; T147-V151 PolarHBondContact O-N 3.29Å; I148-V151 PolarHBondContact O-N 3.48Å; V151-Y154 PolarHBondContact O-N 3.16Å; V151-K155 WeakPolarHBondContact O-CB 3.34Å; V151-K155 PolarHBondContact O-N 2.87Å; V151-P267 HydrophobicContact CG2-CB 3.96Å; V151-P267 WeakPolarHBondContact CG2-O 3.48Å; V151-M270 HydrophobicContact CG1-SD 4.14Å; V151-L271 HydrophobicContact CG2-CB 4.32Å; V151-L271 HydrophobicContact CG2-CD1 4.05Å
152	V	88.9	Confident	87.9	Confident	58 Å²	58	72 Å²	72	35%	0.352	35%	0.351	S	S	.	.	H	α-helix	trans	-63.6	-48.5	177.2	169.9	0	0	0	0	110.8	I148 L149 L150 Y154 K155 Y156	I148-V152 HydrophobicContact CG2-CG2 4.07Å; I148-V152 WeakPolarHBondContact O-CB 3.31Å; I148-V152 WeakPolarHBondContact O-CG2 3.39Å; I148-V152 PolarHBondContact O-N 3.24Å; L149-V152 PolarHBondContact O-N 3.33Å; L150-V152 VanDerWaalsContact C-N 3.33Å; L150-V152 PolarHBondContact O-N 3.31Å; V152-Y154 VanDerWaalsContact C-N 3.27Å; V152-Y154 PolarHBondContact O-N 3.17Å; V152-K155 WeakPolarHBondContact O-CB 3.26Å; V152-K155 PolarHBondContact O-N 3.28Å; V152-Y156 HydrophobicContact CG1-CD2 3.54Å; V152-Y156 HydrophobicContact CG1-CE2 3.47Å; V152-Y156 VanDerWaalsContact CG1-CE2 3.47Å; V152-Y156 WeakPolarHBondContact O-CD2 3.1Å; V152-Y156 PolarHBondContact O-N 3.32Å
153	L	89.4	Confident	87.6	Confident	30 Å²	30	74.7 Å²	74.7	16%	0.157	36%	0.36	C	S	.	.	H	α-helix	trans	-59.1	-38.7	175.8	-74.1	171	0	0	0	112.1	L149 L150 Y156 R157 C158 V161 I162 W165	L149-L153 HydrophobicContact CD1-CD1 4.44Å; L149-L153 HydrophobicContact CD1-CG 4.44Å; L149-L153 HydrophobicContact CG-CD1 4.16Å; L149-L153 WeakPolarHBondContact O-CB 3.42Å; L149-L153 VanDerWaalsContact O-CG 3.25Å; L149-L153 WeakPolarHBondContact O-CG 3.34Å; L149-L153 PolarHBondContact O-N 2.85Å; L150-L153 PolarHBondContact O-N 3.43Å; L153-Y156 PolarHBondContact O-N 2.97Å; L153-R157 PolarHBondContact O-N 2.81Å; L153-C158 HydrophobicContact CB-CB 4.45Å; L153-C158 HydrophobicContact CD2-CB 3.94Å; L153-C158 PolarHBondContact O-N 3.33Å; L153-V161 HydrophobicContact CD1-CG1 4.16Å; L153-V161 HydrophobicContact CD2-CG1 4.37Å; L153-I162 HydrophobicContact CB-CD1 4.23Å; L153-I162 HydrophobicContact CB-CG1 4.07Å; L153-W165 HydrophobicContact CD1-CE3 4.18Å; L153-W165 HydrophobicContact CD1-CZ3 4.03Å
154	Y	84	Confident	87.7	Confident	7 Å²	7	74.1 Å²	74.1	3%	0.027	36%	0.364	C	S	.	.	H	α-helix	trans	-66.6	-42.5	176.7	-171.9	-109.9	0	0	0	111.6	L150 V151 V152 Y156 R157 Y159 I162 L271 T274 E280 F283	L150-Y154 WeakPolarHBondContact O-CB 3.42Å; L150-Y154 PolarHBondContact O-N 3.14Å; V151-Y154 PolarHBondContact O-N 3.16Å; V152-Y154 VanDerWaalsContact C-N 3.27Å; V152-Y154 PolarHBondContact O-N 3.17Å; Y154-Y156 PolarHBondContact O-N 3.08Å; Y154-R157 PolarHBondContact O-N 3.33Å; Y154-R157 VanDerWaalsContact O-N 3.15Å; Y154-Y159 HydrophobicContact CD2-CE1 4.32Å; Y154-Y159 AromaticContact CE2-CE1 3.87Å; Y154-Y159 HydrophobicContact CE2-CE1 3.87Å; Y154-I162 HydrophobicContact CD2-CD1 4.04Å; Y154-L271 HydrophobicContact CD1-CG 4.43Å; Y154-T274 HydrophobicContact CD1-CG2 4.18Å; Y154-T274 HydrophobicContact CE1-CG2 3.66Å; Y154-E280 PolarHBondContact OH-OE2 2.9Å; Y154-F283 HydrophobicContact CD2-CE2 4.28Å; Y154-F283 AromaticContact CD2-CZ 3.95Å; Y154-F283 HydrophobicContact CD2-CZ 3.95Å; Y154-F283 HydrophobicContact CE2-CZ 4.2Å
155	K	85.5	Confident	87.8	Confident	128 Å²	128	76.5 Å²	76.5	56%	0.557	37%	0.369	S	S	*	.	H	α-helix	trans	-61.1	-43.1	175.3	-168.7	178.1	-173.5	175.7	0	112	V151 V152 R157 M270	V151-K155 WeakPolarHBondContact O-CB 3.34Å; V151-K155 PolarHBondContact O-N 2.87Å; V152-K155 WeakPolarHBondContact O-CB 3.26Å; V152-K155 PolarHBondContact O-N 3.28Å; K155-R157 PolarHBondContact O-N 3.5Å; K155-M270 HydrophobicContact CD-CE 3.78Å
156	Y	88.1	Confident	87.6	Confident	176 Å²	176	73.9 Å²	73.9	69%	0.69	35%	0.352	S	S	*	.	T	Hydrogen-bonded Turn	trans	-76.7	7.3	177.6	-73.6	-66.4	0	0	0	114.5	V152 L153 Y154 C158	V152-Y156 HydrophobicContact CG1-CD2 3.54Å; V152-Y156 HydrophobicContact CG1-CE2 3.47Å; V152-Y156 VanDerWaalsContact CG1-CE2 3.47Å; V152-Y156 WeakPolarHBondContact O-CD2 3.1Å; V152-Y156 PolarHBondContact O-N 3.32Å; L153-Y156 PolarHBondContact O-N 2.97Å; Y154-Y156 PolarHBondContact O-N 3.08Å; Y156-C158 PolarHBondContact O-N 3.21Å
157	R	83.8	Confident	87.7	Confident	167 Å²	167	72 Å²	72	63%	0.63	34%	0.343	S	S	*	.	T	Hydrogen-bonded Turn	trans	56.6	30.1	179.9	-65	-173.5	172.8	-175.9	-1.1	113.5	L153 Y154 K155 Y159	L153-R157 PolarHBondContact O-N 2.81Å; Y154-R157 PolarHBondContact O-N 3.33Å; Y154-R157 VanDerWaalsContact O-N 3.15Å; K155-R157 PolarHBondContact O-N 3.5Å; R157-Y159 HydrophobicContact CB-CD2 4.02Å; R157-Y159 HydrophobicContact CB-CE2 3.6Å; R157-Y159 HydrophobicContact CG-CE2 3.79Å; R157-Y159 VanDerWaalsContact O-CD2 3.23Å; R157-Y159 WeakPolarHBondContact O-CD2 2.85Å; R157-Y159 PolarHBondContact O-N 3.24Å
158	C	85.8	Confident	87.9	Confident	46 Å²	46	75.6 Å²	75.6	31%	0.311	36%	0.36	S	S	.	.			trans	-77.1	50.6	175.8	-63.4	0	0	0	0	111.9	L153 Y156 K160 V161 I162	L153-C158 HydrophobicContact CB-CB 4.45Å; L153-C158 HydrophobicContact CD2-CB 3.94Å; L153-C158 PolarHBondContact O-N 3.33Å; Y156-C158 PolarHBondContact O-N 3.21Å; C158-K160 VanDerWaalsContact C-N 3.26Å; C158-K160 PolarHBondContact O-N 2.92Å; C158-V161 HydrophobicContact CB-CB 4.25Å; C158-V161 HydrophobicContact CB-CG2 4.23Å; C158-V161 WeakPolarHBondContact O-CB 3.45Å; C158-V161 PolarHBondContact O-N 3.43Å; C158-I162 PolarHBondContact O-N 2.88Å; C158-I162 VanDerWaalsContact O-N 3.16Å
159	Y	83.5	Confident	88	Confident	75 Å²	75	74.3 Å²	74.3	29%	0.294	36%	0.358	S	S	.	.	H	α-helix	trans	-57.8	-35.4	-173	-63.2	-76.9	0	0	0	113.4	Y154 R157 V161 I162 H163 R278 E280	Y154-Y159 HydrophobicContact CD2-CE1 4.32Å; Y154-Y159 AromaticContact CE2-CE1 3.87Å; Y154-Y159 HydrophobicContact CE2-CE1 3.87Å; R157-Y159 HydrophobicContact CB-CD2 4.02Å; R157-Y159 HydrophobicContact CB-CE2 3.6Å; R157-Y159 HydrophobicContact CG-CE2 3.79Å; R157-Y159 VanDerWaalsContact O-CD2 3.23Å; R157-Y159 WeakPolarHBondContact O-CD2 2.85Å; R157-Y159 PolarHBondContact O-N 3.24Å; Y159-V161 VanDerWaalsContact C-N 3.33Å; Y159-V161 PolarHBondContact O-N 3.49Å; Y159-I162 PolarHBondContact O-N 3.49Å; Y159-H163 VanDerWaalsContact O-CB 3.3Å; Y159-H163 WeakPolarHBondContact O-CB 3.37Å; Y159-H163 PolarHBondContact O-N 2.9Å; Y159-R278 PolarHBondContact OH-NH1 3.48Å; Y159-E280 WeakPolarHBondContact CE1-OE2 3.17Å; Y159-E280 PolarHBondContact OH-OE1 3.14Å; Y159-E280 PolarHBondContact OH-OE2 3.24Å
160	K	89.7	Confident	87.9	Confident	188 Å²	188	71.1 Å²	71.1	82%	0.817	34%	0.342	S	S	*	.	H	α-helix	trans	-60.5	-41.3	175.3	-72.4	-176.5	179.1	169.2	0	112.3	C158 A164	C158-K160 VanDerWaalsContact C-N 3.26Å; C158-K160 PolarHBondContact O-N 2.92Å; K160-A164 VanDerWaalsContact O-CB 3.24Å; K160-A164 WeakPolarHBondContact O-CB 3.41Å; K160-A164 PolarHBondContact O-N 3.3Å
161	V	91.3	Very high	88.2	Confident	75 Å²	75	73.4 Å²	73.4	46%	0.455	35%	0.354	S	S	.	.	H	α-helix	trans	-68.9	-44	179.5	179.3	0	0	0	0	110	L153 C158 Y159 A164 W165	L153-V161 HydrophobicContact CD1-CG1 4.16Å; L153-V161 HydrophobicContact CD2-CG1 4.37Å; C158-V161 HydrophobicContact CB-CB 4.25Å; C158-V161 HydrophobicContact CB-CG2 4.23Å; C158-V161 WeakPolarHBondContact O-CB 3.45Å; C158-V161 PolarHBondContact O-N 3.43Å; Y159-V161 VanDerWaalsContact C-N 3.33Å; Y159-V161 PolarHBondContact O-N 3.49Å; V161-A164 PolarHBondContact O-N 3.23Å; V161-W165 VanDerWaalsContact O-CB 3.26Å; V161-W165 WeakPolarHBondContact O-CB 3.47Å; V161-W165 PolarHBondContact O-N 3.12Å
162	I	86.5	Confident	88.6	Confident	5 Å²	5	76.9 Å²	76.9	3%	0.026	37%	0.372	C	S	.	.	H	α-helix	trans	-65.4	-45.1	179.9	-55.7	168.6	0	0	0	110.6	L153 Y154 C158 Y159 W165 L166 F283	L153-I162 HydrophobicContact CB-CD1 4.23Å; L153-I162 HydrophobicContact CB-CG1 4.07Å; Y154-I162 HydrophobicContact CD2-CD1 4.04Å; C158-I162 PolarHBondContact O-N 2.88Å; C158-I162 VanDerWaalsContact O-N 3.16Å; Y159-I162 PolarHBondContact O-N 3.49Å; I162-W165 PolarHBondContact O-N 3.01Å; I162-L166 HydrophobicContact CG2-CD1 4.08Å; I162-L166 HydrophobicContact CG2-CG 4.28Å; I162-L166 WeakPolarHBondContact O-CB 3.45Å; I162-L166 WeakPolarHBondContact O-CG 3.28Å; I162-L166 PolarHBondContact O-N 3.2Å; I162-F283 HydrophobicContact CB-CE1 4.28Å; I162-F283 HydrophobicContact CB-CZ 4.22Å; I162-F283 HydrophobicContact CD1-CZ 4.08Å; I162-F283 HydrophobicContact CG2-CD1 4.19Å; I162-F283 HydrophobicContact CG2-CE1 3.42Å; I162-F283 VanDerWaalsContact CG2-CE1 3.42Å; I162-F283 HydrophobicContact CG2-CE2 3.97Å; I162-F283 HydrophobicContact CG2-CZ 3.31Å
163	H	84.5	Confident	88.8	Confident	110 Å²	110	74.9 Å²	74.9	51%	0.509	36%	0.359	S	S	.	.	H	α-helix	trans	-61.9	-46	177	-169.8	-85	0	0	0	111.4	Y159 L166 I167	Y159-H163 VanDerWaalsContact O-CB 3.3Å; Y159-H163 WeakPolarHBondContact O-CB 3.37Å; Y159-H163 PolarHBondContact O-N 2.9Å; H163-L166 PolarHBondContact O-N 3.47Å; H163-I167 WeakPolarHBondContact O-CB 3.36Å; H163-I167 WeakPolarHBondContact O-CG1 3.41Å; H163-I167 PolarHBondContact O-N 3.05Å
164	A	90.7	Very high	89	Confident	47 Å²	47	73.5 Å²	73.5	39%	0.388	35%	0.352	S	S	.	.	H	α-helix	trans	-62.1	-43.7	176.3	0	0	0	0	0	112.1	K160 V161 I167 I168	K160-A164 VanDerWaalsContact O-CB 3.24Å; K160-A164 WeakPolarHBondContact O-CB 3.41Å; K160-A164 PolarHBondContact O-N 3.3Å; V161-A164 PolarHBondContact O-N 3.23Å; A164-I167 PolarHBondContact O-N 3.17Å; A164-I168 WeakPolarHBondContact O-CB 3.35Å; A164-I168 WeakPolarHBondContact O-CD1 3.2Å; A164-I168 WeakPolarHBondContact O-CG1 3.4Å; A164-I168 PolarHBondContact O-N 3.34Å
165	W	91.1	Very high	89.6	Confident	87 Å²	87	75.3 Å²	75.3	33%	0.33	36%	0.36	S	S	.	.	H	α-helix	trans	-58	-54.9	175.6	-177	-31.1	0	0	0	110.3	M146 L149 L153 V161 I162 I167 I168 S169	M146-W165 HydrophobicContact SD-CH2 3.89Å; M146-W165 HydrophobicContact SD-CZ2 4.17Å; L149-W165 HydrophobicContact CD2-CH2 3.91Å; L149-W165 HydrophobicContact CD2-CZ3 3.81Å; L149-W165 HydrophobicContact CG-CZ3 4.2Å; L153-W165 HydrophobicContact CD1-CE3 4.18Å; L153-W165 HydrophobicContact CD1-CZ3 4.03Å; V161-W165 VanDerWaalsContact O-CB 3.26Å; V161-W165 WeakPolarHBondContact O-CB 3.47Å; V161-W165 PolarHBondContact O-N 3.12Å; I162-W165 PolarHBondContact O-N 3.01Å; W165-I167 VanDerWaalsContact C-N 3.31Å; W165-I167 PolarHBondContact O-N 3.17Å; W165-I168 PolarHBondContact O-N 3.15Å; W165-I168 VanDerWaalsContact O-N 3.14Å; W165-S169 PolarHBondContact NE1-OG 3.28Å; W165-S169 WeakPolarHBondContact O-CB 3.4Å; W165-S169 PolarHBondContact O-N 3.03Å; W165-S169 PolarHBondContact O-OG 2.96Å; W165-S169 VanDerWaalsContact O-OG 3.05Å
166	L	87.1	Confident	90	Very high	28 Å²	28	74.6 Å²	74.6	15%	0.147	36%	0.357	C	S	.	.	H	α-helix	trans	-60.3	-40.8	-177.5	-70.9	-178.9	0	0	0	112	I162 H163 S169 S170 F283	I162-L166 HydrophobicContact CG2-CD1 4.08Å; I162-L166 HydrophobicContact CG2-CG 4.28Å; I162-L166 WeakPolarHBondContact O-CB 3.45Å; I162-L166 WeakPolarHBondContact O-CG 3.28Å; I162-L166 PolarHBondContact O-N 3.2Å; H163-L166 PolarHBondContact O-N 3.47Å; L166-S169 PolarHBondContact O-N 3.23Å; L166-S170 VanDerWaalsContact O-CB 3.31Å; L166-S170 WeakPolarHBondContact O-CB 3.43Å; L166-S170 PolarHBondContact O-N 2.63Å; L166-F283 HydrophobicContact CD1-CB 3.64Å; L166-F283 HydrophobicContact CD1-CD1 3.37Å; L166-F283 HydrophobicContact CD1-CD2 4.24Å; L166-F283 HydrophobicContact CD1-CE1 4.11Å; L166-F283 HydrophobicContact CD1-CG 3.47Å; L166-F283 VanDerWaalsContact CD1-CG 3.47Å
167	I	90.9	Very high	90.3	Very high	45 Å²	45	68 Å²	68	23%	0.231	33%	0.332	C	S	.	.	H	α-helix	trans	-60.4	-49.2	173.9	-69.3	-81.8	0	0	0	110.8	H163 A164 W165 S169 S170 L171 M210 H214	H163-I167 WeakPolarHBondContact O-CB 3.36Å; H163-I167 WeakPolarHBondContact O-CG1 3.41Å; H163-I167 PolarHBondContact O-N 3.05Å; A164-I167 PolarHBondContact O-N 3.17Å; W165-I167 VanDerWaalsContact C-N 3.31Å; W165-I167 PolarHBondContact O-N 3.17Å; I167-S169 VanDerWaalsContact C-N 3.33Å; I167-S169 PolarHBondContact O-N 2.94Å; I167-S170 PolarHBondContact O-N 3.27Å; I167-L171 VanDerWaalsContact O-CB 3.24Å; I167-L171 WeakPolarHBondContact O-CB 3.27Å; I167-L171 PolarHBondContact O-N 3.18Å; I167-M210 HydrophobicContact CB-CE 4.44Å; I167-M210 HydrophobicContact CD1-CE 3.84Å; I167-M210 HydrophobicContact CG2-CE 3.88Å; I167-H214 HydrophobicContact CD1-CB 3.76Å; I167-H214 WeakPolarHBondContact CD1-CD2 3.41Å
168	I	92.9	Very high	90.9	Very high	110 Å²	110	60.3 Å²	60.3	56%	0.564	30%	0.304	S	S	*	.	H	α-helix	trans	-62.1	-43	179.5	-70.2	165.2	0	0	0	110.6	A164 W165 L171 L172	A164-I168 WeakPolarHBondContact O-CB 3.35Å; A164-I168 WeakPolarHBondContact O-CD1 3.2Å; A164-I168 WeakPolarHBondContact O-CG1 3.4Å; A164-I168 PolarHBondContact O-N 3.34Å; W165-I168 PolarHBondContact O-N 3.15Å; W165-I168 VanDerWaalsContact O-N 3.14Å; I168-L171 PolarHBondContact O-N 3.23Å; I168-L172 WeakPolarHBondContact O-CB 3.49Å; I168-L172 PolarHBondContact O-N 2.83Å
169	S	90.4	Very high	91.3	Very high	51 Å²	51	63.3 Å²	63.3	36%	0.357	31%	0.312	S	S	.	.	H	α-helix	trans	-64.7	-45.1	179.3	-62.5	0	0	0	0	111.3	W165 L166 I167 L172 L173	W165-S169 PolarHBondContact NE1-OG 3.28Å; W165-S169 WeakPolarHBondContact O-CB 3.4Å; W165-S169 PolarHBondContact O-N 3.03Å; W165-S169 PolarHBondContact O-OG 2.96Å; W165-S169 VanDerWaalsContact O-OG 3.05Å; L166-S169 PolarHBondContact O-N 3.23Å; I167-S169 VanDerWaalsContact C-N 3.33Å; I167-S169 PolarHBondContact O-N 2.94Å; S169-L172 PolarHBondContact O-N 3.34Å; S169-L173 VanDerWaalsContact O-CB 3.31Å; S169-L173 WeakPolarHBondContact O-CB 3.15Å; S169-L173 PolarHBondContact O-N 3.24Å
170	S	89.9	Confident	91.8	Very high	9 Å²	9	61.6 Å²	61.6	6%	0.063	31%	0.307	C	S	.	.	H	α-helix	trans	-65.6	-39.3	176.4	-175.7	0	0	0	0	112.3	L166 I167 L173 L174 M210 H214	L166-S170 VanDerWaalsContact O-CB 3.31Å; L166-S170 WeakPolarHBondContact O-CB 3.43Å; L166-S170 PolarHBondContact O-N 2.63Å; I167-S170 PolarHBondContact O-N 3.27Å; S170-L173 PolarHBondContact O-N 3.39Å; S170-L174 WeakPolarHBondContact O-CB 3.24Å; S170-L174 WeakPolarHBondContact O-CG 3.35Å; S170-L174 PolarHBondContact O-N 3.33Å; S170-M210 PolarHBondContact OG-SD 3.18Å; S170-M210 VanDerWaalsContact OG-SD 3.37Å; S170-H214 VanDerWaalsContact CB-CE1 3.47Å; S170-H214 WeakPolarHBondContact CB-CE1 3.14Å; S170-H214 PolarHBondContact OG-CE1 3.21Å
171	L	93.2	Very high	92.1	Very high	84 Å²	84	55.2 Å²	55.2	44%	0.44	28%	0.279	S	S	.	.	H	α-helix	trans	-64.4	-50.5	177.2	-171.5	168.9	0	0	0	110	I167 I168 L173 L174 F175 M210	I167-L171 VanDerWaalsContact O-CB 3.24Å; I167-L171 WeakPolarHBondContact O-CB 3.27Å; I167-L171 PolarHBondContact O-N 3.18Å; I168-L171 PolarHBondContact O-N 3.23Å; L171-L173 PolarHBondContact O-N 3.25Å; L171-L174 PolarHBondContact O-N 3.44Å; L171-F175 HydrophobicContact CD2-CB 4.45Å; L171-F175 HydrophobicContact CD2-CD2 3.87Å; L171-F175 HydrophobicContact CD2-CE2 4.48Å; L171-F175 HydrophobicContact CD2-CG 4.36Å; L171-F175 HydrophobicContact CG-CD2 3.83Å; L171-F175 HydrophobicContact CG-CE2 4.06Å; L171-F175 WeakPolarHBondContact O-CB 3.47Å; L171-F175 WeakPolarHBondContact O-CD2 3.23Å; L171-F175 PolarHBondContact O-N 3.06Å; L171-M210 HydrophobicContact CB-CE 4.43Å; L171-M210 HydrophobicContact CB-SD 4.31Å
172	L	93.4	Very high	92.3	Very high	89 Å²	89	52.9 Å²	52.9	47%	0.466	26%	0.263	S	S	.	.	I	π-helix	trans	-54.2	-46	176.5	-174.6	152.2	0	0	0	110	I168 S169 F176 F177	I168-L172 WeakPolarHBondContact O-CB 3.49Å; I168-L172 PolarHBondContact O-N 2.83Å; S169-L172 PolarHBondContact O-N 3.34Å; L172-F176 WeakPolarHBondContact O-CA 3.29Å; L172-F176 WeakPolarHBondContact O-CB 3.46Å; L172-F176 PolarHBondContact O-N 3.13Å; L172-F177 HydrophobicContact CD2-CD2 3.95Å; L172-F177 HydrophobicContact CD2-CE2 3.56Å; L172-F177 HydrophobicContact CD2-CZ 4.49Å
173	L	92.4	Very high	92.6	Very high	16 Å²	16	53.8 Å²	53.8	8%	0.084	27%	0.274	C	S	.	.	I	π-helix	trans	-67.7	-50.3	-177.6	-162.2	168.5	0	0	0	113.2	S169 S170 L171 F175 F177 S178 I229 L232 M233	S169-L173 VanDerWaalsContact O-CB 3.31Å; S169-L173 WeakPolarHBondContact O-CB 3.15Å; S169-L173 PolarHBondContact O-N 3.24Å; S170-L173 PolarHBondContact O-N 3.39Å; L171-L173 PolarHBondContact O-N 3.25Å; L173-F175 PolarHBondContact O-N 2.82Å; L173-F177 HydrophobicContact CG-CD2 4.33Å; L173-F177 WeakPolarHBondContact O-CB 3.12Å; L173-F177 PolarHBondContact O-N 2.99Å; L173-S178 PolarHBondContact O-N 2.88Å; L173-I229 HydrophobicContact CD1-CG2 3.7Å; L173-I229 HydrophobicContact CD2-CB 4.2Å; L173-I229 HydrophobicContact CD2-CG1 3.94Å; L173-I229 HydrophobicContact CD2-CG2 4.03Å; L173-L232 HydrophobicContact CD2-CB 4Å; L173-L232 HydrophobicContact CD2-CD1 3.97Å; L173-M233 HydrophobicContact CD1-CG 3.52Å; L173-M233 HydrophobicContact CD1-SD 3.38Å; L173-M233 WeakPolarHBondContact CD1-SD 3.3Å; L173-M233 HydrophobicContact CG-CG 4.39Å; L173-M233 HydrophobicContact CG-SD 4.06Å
174	L	94.5	Very high	93.1	Very high	0 Å²	0	49.7 Å²	49.7	0%	0	26%	0.255	C	S	.	.	I	π-helix	trans	-69.1	-33	-177.6	-76.6	176.3	0	0	0	113.8	S170 L171 S178 F205 M210 I213 Y225 I229	S170-L174 WeakPolarHBondContact O-CB 3.24Å; S170-L174 WeakPolarHBondContact O-CG 3.35Å; S170-L174 PolarHBondContact O-N 3.33Å; L171-L174 PolarHBondContact O-N 3.44Å; L174-S178 WeakPolarHBondContact O-CB 3.24Å; L174-S178 PolarHBondContact O-OG 3.44Å; L174-F205 HydrophobicContact CD2-CE1 3.74Å; L174-F205 HydrophobicContact CD2-CZ 4.21Å; L174-M210 HydrophobicContact CD1-CG 4.23Å; L174-M210 HydrophobicContact CD1-SD 3.96Å; L174-I213 HydrophobicContact CD1-CD1 4.02Å; L174-Y225 HydrophobicContact CD2-CD1 4.14Å; L174-I229 HydrophobicContact CD1-CD1 4.42Å; L174-I229 HydrophobicContact CD2-CD1 3.95Å; L174-I229 HydrophobicContact CD2-CG1 3.8Å; L174-I229 HydrophobicContact CG-CD1 4.08Å; L174-I229 HydrophobicContact CG-CG1 4.35Å
175	F	96.1	Very high	93.3	Very high	46 Å²	46	48.7 Å²	48.7	20%	0.202	24%	0.244	C	C	.	.	I	π-helix	trans	-92.5	-55.7	-179.6	-72.7	-94.7	0	0	0	111.6	L171 L173 F179 I202 W203 G206 V207 M210	L171-F175 HydrophobicContact CD2-CB 4.45Å; L171-F175 HydrophobicContact CD2-CD2 3.87Å; L171-F175 HydrophobicContact CD2-CE2 4.48Å; L171-F175 HydrophobicContact CD2-CG 4.36Å; L171-F175 HydrophobicContact CG-CD2 3.83Å; L171-F175 HydrophobicContact CG-CE2 4.06Å; L171-F175 WeakPolarHBondContact O-CB 3.47Å; L171-F175 WeakPolarHBondContact O-CD2 3.23Å; L171-F175 PolarHBondContact O-N 3.06Å; L173-F175 PolarHBondContact O-N 2.82Å; F175-F179 WeakPolarHBondContact O-CB 3.44Å; F175-F179 PolarHBondContact O-N 2.98Å; F175-I202 HydrophobicContact CD1-CG2 4.08Å; F175-W203 HydrophobicContact CE1-CE3 4.29Å; F175-G206 VanDerWaalsContact CZ-C 3.45Å; F175-G206 VanDerWaalsContact CZ-CA 3.49Å; F175-V207 HydrophobicContact CZ-CG2 4.12Å; F175-M210 HydrophobicContact CE2-CG 4.16Å
176	F	95	Very high	93.5	Very high	113 Å²	113	47 Å²	47	50%	0.496	24%	0.239	S	C	.	.	I	π-helix	trans	-73.5	-51.3	-171.5	-178.8	-102.3	0	0	0	112.4	L172 F179 I180	L172-F176 WeakPolarHBondContact O-CA 3.29Å; L172-F176 WeakPolarHBondContact O-CB 3.46Å; L172-F176 PolarHBondContact O-N 3.13Å; F176-F179 WeakPolarHBondContact O-CB 3.44Å; F176-F179 PolarHBondContact O-N 3.08Å; F176-I180 HydrophobicContact CD1-CD1 3.93Å; F176-I180 HydrophobicContact CE1-CD1 3.43Å; F176-I180 VanDerWaalsContact CE1-CD1 3.43Å; F176-I180 HydrophobicContact CE2-CD1 4.28Å; F176-I180 HydrophobicContact CZ-CD1 3.64Å; F176-I180 WeakPolarHBondContact O-CG1 3.1Å; F176-I180 PolarHBondContact O-N 2.89Å; F176-I180 VanDerWaalsContact O-N 3.08Å
177	F	94.3	Very high	93.9	Very high	37 Å²	37	52.2 Å²	52.2	16%	0.162	26%	0.261	C	S	.	.	I	π-helix	trans	-70.7	-34.5	-179.4	-74.3	-62.7	0	0	0	112.3	L172 L173 F179 I180 Y181 V236	L172-F177 HydrophobicContact CD2-CD2 3.95Å; L172-F177 HydrophobicContact CD2-CE2 3.56Å; L172-F177 HydrophobicContact CD2-CZ 4.49Å; L173-F177 HydrophobicContact CG-CD2 4.33Å; L173-F177 WeakPolarHBondContact O-CB 3.12Å; L173-F177 PolarHBondContact O-N 2.99Å; F177-F179 VanDerWaalsContact C-N 3.34Å; F177-I180 HydrophobicContact CD1-CD1 4.43Å; F177-I180 PolarHBondContact O-N 3.31Å; F177-Y181 WeakPolarHBondContact O-CB 3.36Å; F177-Y181 PolarHBondContact O-N 2.69Å; F177-V236 HydrophobicContact CD1-CG2 3.4Å; F177-V236 HydrophobicContact CD2-CG2 4.21Å; F177-V236 HydrophobicContact CE1-CB 4.47Å; F177-V236 HydrophobicContact CE1-CG1 4.17Å; F177-V236 HydrophobicContact CE1-CG2 3.39Å; F177-V236 HydrophobicContact CE2-CG2 4.22Å; F177-V236 HydrophobicContact CG-CG2 3.85Å; F177-V236 HydrophobicContact CZ-CG1 4.07Å; F177-V236 HydrophobicContact CZ-CG2 3.83Å
178	S	95.1	Very high	94	Very high	6 Å²	6	52.7 Å²	52.7	4%	0.042	27%	0.266	C	S	.	.	H	α-helix	trans	-65.9	-36.3	172.6	-49.5	0	0	0	0	112.6	L173 L174 Y181 L182 F205 L232	L173-S178 PolarHBondContact O-N 2.88Å; L174-S178 WeakPolarHBondContact O-CB 3.24Å; L174-S178 PolarHBondContact O-OG 3.44Å; S178-Y181 PolarHBondContact O-N 3.05Å; S178-L182 VanDerWaalsContact O-CB 3.25Å; S178-L182 WeakPolarHBondContact O-CB 3.34Å; S178-L182 PolarHBondContact O-N 2.82Å; S178-F205 VanDerWaalsContact OG-CE1 3.27Å; S178-F205 WeakPolarHBondContact OG-CE1 3.44Å; S178-L232 WeakPolarHBondContact OG-CD1 3.23Å
179	F	95.6	Very high	94.1	Very high	108 Å²	108	54.4 Å²	54.4	47%	0.474	27%	0.266	S	S	.	.	H	α-helix	trans	-61.5	-46.6	173.5	170.8	-100.1	0	0	0	111.4	F175 F176 F177 G183 V198 I202	F175-F179 WeakPolarHBondContact O-CB 3.44Å; F175-F179 PolarHBondContact O-N 2.98Å; F176-F179 WeakPolarHBondContact O-CB 3.44Å; F176-F179 PolarHBondContact O-N 3.08Å; F177-F179 VanDerWaalsContact C-N 3.34Å; F179-G183 PolarHBondContact O-N 3.25Å; F179-V198 HydrophobicContact CD2-CG1 3.97Å; F179-V198 HydrophobicContact CE2-CG1 3.96Å; F179-I202 HydrophobicContact CB-CD1 4.43Å; F179-I202 HydrophobicContact CB-CG1 4.43Å; F179-I202 HydrophobicContact CD2-CG1 4.49Å
180	I	93.7	Very high	94.3	Very high	40 Å²	40	59.2 Å²	59.2	21%	0.205	29%	0.288	C	S	.	.	H	α-helix	trans	-61.8	-49.6	175.6	-65.8	170.9	0	0	0	110.3	F176 F177 L182 G183 E184	F176-I180 HydrophobicContact CD1-CD1 3.93Å; F176-I180 HydrophobicContact CE1-CD1 3.43Å; F176-I180 VanDerWaalsContact CE1-CD1 3.43Å; F176-I180 HydrophobicContact CE2-CD1 4.28Å; F176-I180 HydrophobicContact CZ-CD1 3.64Å; F176-I180 WeakPolarHBondContact O-CG1 3.1Å; F176-I180 PolarHBondContact O-N 2.89Å; F176-I180 VanDerWaalsContact O-N 3.08Å; F177-I180 HydrophobicContact CD1-CD1 4.43Å; F177-I180 PolarHBondContact O-N 3.31Å; I180-L182 PolarHBondContact O-N 3.44Å; I180-G183 PolarHBondContact O-N 2.96Å; I180-E184 HydrophobicContact CG2-CG 4.43Å; I180-E184 WeakPolarHBondContact O-CG 3.27Å; I180-E184 PolarHBondContact O-N 3.22Å
181	Y	95.1	Very high	94.6	Very high	54 Å²	54	62.5 Å²	62.5	21%	0.212	31%	0.308	C	S	.	.	H	α-helix	trans	-55.2	-52.6	179.9	172.6	-107.2	0	0	0	111.7	T99 Y106 F177 S178 G183 E184 V185 L232 L235	T99-Y181 HydrophobicContact CG2-CD2 4.36Å; T99-Y181 HydrophobicContact CG2-CE2 3.62Å; T99-Y181 PolarHBondContact OG1-OH 3.36Å; Y106-Y181 HydrophobicContact CE2-CD2 4.24Å; Y106-Y181 WeakPolarHBondContact OH-CD2 3.39Å; F177-Y181 WeakPolarHBondContact O-CB 3.36Å; F177-Y181 PolarHBondContact O-N 2.69Å; S178-Y181 PolarHBondContact O-N 3.05Å; Y181-G183 VanDerWaalsContact C-N 3.3Å; Y181-G183 PolarHBondContact O-N 3.06Å; Y181-E184 PolarHBondContact O-N 3.35Å; Y181-V185 HydrophobicContact CD1-CG2 4.48Å; Y181-V185 HydrophobicContact CD2-CG2 4.39Å; Y181-V185 HydrophobicContact CE1-CG2 4.09Å; Y181-V185 HydrophobicContact CE2-CG2 3.98Å; Y181-V185 WeakPolarHBondContact O-CG2 3.43Å; Y181-V185 PolarHBondContact O-N 3.37Å; Y181-L232 HydrophobicContact CD1-CD2 4.43Å; Y181-L232 HydrophobicContact CD2-CD2 4.39Å; Y181-L232 HydrophobicContact CG-CD2 3.95Å; Y181-L235 HydrophobicContact CD2-CD1 4.25Å; Y181-L235 HydrophobicContact CE2-CD1 4.25Å
182	L	95.2	Very high	94.6	Very high	25 Å²	25	63.5 Å²	63.5	13%	0.131	33%	0.328	C	S	.	.	H	α-helix	trans	-62.8	-38.6	179.7	-173.1	67.8	0	0	0	111.8	S178 I180 V185 F186 V198 L201 I202	S178-L182 VanDerWaalsContact O-CB 3.25Å; S178-L182 WeakPolarHBondContact O-CB 3.34Å; S178-L182 PolarHBondContact O-N 2.82Å; I180-L182 PolarHBondContact O-N 3.44Å; L182-V185 PolarHBondContact O-N 2.86Å; L182-F186 HydrophobicContact CD1-CD2 4.44Å; L182-F186 HydrophobicContact CD1-CE1 4.3Å; L182-F186 HydrophobicContact CD1-CE2 3.75Å; L182-F186 HydrophobicContact CD1-CZ 3.66Å; L182-F186 HydrophobicContact CD2-CE2 3.78Å; L182-F186 HydrophobicContact CD2-CZ 4.27Å; L182-F186 HydrophobicContact CG-CD2 3.99Å; L182-F186 HydrophobicContact CG-CE2 3.43Å; L182-F186 VanDerWaalsContact CG-CE2 3.43Å; L182-F186 HydrophobicContact CG-CZ 3.9Å; L182-F186 WeakPolarHBondContact O-CD2 3.45Å; L182-F186 WeakPolarHBondContact O-CG 3.39Å; L182-F186 PolarHBondContact O-N 2.63Å; L182-V198 HydrophobicContact CD2-CG1 4.34Å; L182-L201 HydrophobicContact CD2-CD2 3.79Å; L182-I202 HydrophobicContact CB-CD1 4.33Å; L182-I202 HydrophobicContact CD2-CD1 3.83Å; L182-I202 HydrophobicContact CD2-CG1 4.15Å
183	G	94.1	Very high	94.6	Very high	25 Å²	25	61.6 Å²	61.6	26%	0.258	32%	0.32	S	S	.	.	H	α-helix	trans	-61.1	-43.1	174.7	0	0	0	0	0	112.9	F179 I180 Y181 F186 K187	F179-G183 PolarHBondContact O-N 3.25Å; I180-G183 PolarHBondContact O-N 2.96Å; Y181-G183 VanDerWaalsContact C-N 3.3Å; Y181-G183 PolarHBondContact O-N 3.06Å; G183-F186 PolarHBondContact O-N 2.82Å; G183-K187 VanDerWaalsContact O-CG 3.31Å; G183-K187 WeakPolarHBondContact O-CG 3.45Å; G183-K187 PolarHBondContact O-N 3.27Å
184	E	94.5	Very high	94.7	Very high	24 Å²	24	64.8 Å²	64.8	11%	0.112	34%	0.337	C	S	.	.	H	α-helix	trans	-70.1	-34.7	176.4	-66.1	-53.3	131.8	0	0	112.5	V103 F105 I180 Y181 K187 T188	V103-E184 HydrophobicContact CG1-CB 3.92Å; F105-E184 HydrophobicContact CB-CB 4.34Å; F105-E184 HydrophobicContact CB-CG 4.12Å; F105-E184 WeakPolarHBondContact CB-OE2 3.01Å; F105-E184 HydrophobicContact CD1-CG 3.72Å; F105-E184 VanDerWaalsContact CD2-CD 3.49Å; F105-E184 HydrophobicContact CD2-CG 4.08Å; F105-E184 VanDerWaalsContact CD2-OE2 3.26Å; F105-E184 WeakPolarHBondContact CD2-OE2 3.44Å; F105-E184 HydrophobicContact CE1-CG 4.1Å; F105-E184 HydrophobicContact CE2-CG 4.44Å; F105-E184 HydrophobicContact CG-CB 4.43Å; F105-E184 HydrophobicContact CG-CG 3.7Å; F105-E184 WeakPolarHBondContact CG-OE2 3.46Å; F105-E184 HydrophobicContact CZ-CG 4.45Å; I180-E184 HydrophobicContact CG2-CG 4.43Å; I180-E184 WeakPolarHBondContact O-CG 3.27Å; I180-E184 PolarHBondContact O-N 3.22Å; Y181-E184 PolarHBondContact O-N 3.35Å; E184-K187 PolarHBondContact O-N 2.94Å; E184-K187 IonicContact OE1-NZ 2.68Å; E184-K187 PolarHBondContact OE1-NZ 2.85Å; E184-T188 WeakPolarHBondContact O-CB 3.18Å; E184-T188 PolarHBondContact O-N 3.29Å; E184-T188 PolarHBondContact O-OG1 3.08Å
185	V	95.5	Very high	94.7	Very high	25 Å²	25	74.3 Å²	74.3	15%	0.152	37%	0.374	C	S	.	.	H	α-helix	trans	-60.2	-50.3	171.9	170.4	0	0	0	0	110.4	V103 Y181 L182 K187 T188 Y189	V103-V185 HydrophobicContact CG2-CG2 4.02Å; Y181-V185 HydrophobicContact CD1-CG2 4.48Å; Y181-V185 HydrophobicContact CD2-CG2 4.39Å; Y181-V185 HydrophobicContact CE1-CG2 4.09Å; Y181-V185 HydrophobicContact CE2-CG2 3.98Å; Y181-V185 WeakPolarHBondContact O-CG2 3.43Å; Y181-V185 PolarHBondContact O-N 3.37Å; L182-V185 PolarHBondContact O-N 2.86Å; V185-K187 PolarHBondContact O-N 2.93Å; V185-T188 WeakPolarHBondContact O-CB 3.28Å; V185-T188 PolarHBondContact O-N 3.18Å; V185-T188 VanDerWaalsContact O-N 3.17Å; V185-Y189 HydrophobicContact CG1-CD2 3.92Å; V185-Y189 HydrophobicContact CG1-CE2 4.02Å; V185-Y189 VanDerWaalsContact O-CD2 3.28Å; V185-Y189 WeakPolarHBondContact O-CD2 3.46Å; V185-Y189 PolarHBondContact O-N 3.28Å; V185-Y189 VanDerWaalsContact O-N 3.09Å
186	F	95.2	Very high	94.7	Very high	52 Å²	52	77.9 Å²	77.9	23%	0.228	39%	0.394	C	S	.	.	H	α-helix	trans	-64.1	-38.1	179.3	-68.1	-39.9	0	0	0	113.4	L182 G183 T188 Y189 N190 V191 V193 V198	L182-F186 HydrophobicContact CD1-CD2 4.44Å; L182-F186 HydrophobicContact CD1-CE1 4.3Å; L182-F186 HydrophobicContact CD1-CE2 3.75Å; L182-F186 HydrophobicContact CD1-CZ 3.66Å; L182-F186 HydrophobicContact CD2-CE2 3.78Å; L182-F186 HydrophobicContact CD2-CZ 4.27Å; L182-F186 HydrophobicContact CG-CD2 3.99Å; L182-F186 HydrophobicContact CG-CE2 3.43Å; L182-F186 VanDerWaalsContact CG-CE2 3.43Å; L182-F186 HydrophobicContact CG-CZ 3.9Å; L182-F186 WeakPolarHBondContact O-CD2 3.45Å; L182-F186 WeakPolarHBondContact O-CG 3.39Å; L182-F186 PolarHBondContact O-N 2.63Å; G183-F186 PolarHBondContact O-N 2.82Å; F186-T188 VanDerWaalsContact C-N 3.33Å; F186-T188 PolarHBondContact O-N 3.2Å; F186-Y189 PolarHBondContact O-N 3.05Å; F186-N190 PolarHBondContact O-N 2.79Å; F186-N190 VanDerWaalsContact O-N 3.08Å; F186-V191 PolarHBondContact O-N 2.88Å; F186-V193 HydrophobicContact CD1-CG2 3.8Å; F186-V193 HydrophobicContact CD2-CB 4.2Å; F186-V193 HydrophobicContact CD2-CG2 3.93Å; F186-V193 HydrophobicContact CE1-CG2 3.84Å; F186-V193 HydrophobicContact CE2-CB 4.19Å; F186-V193 HydrophobicContact CE2-CG1 4.18Å; F186-V193 HydrophobicContact CE2-CG2 3.95Å; F186-V193 HydrophobicContact CG-CG2 3.86Å; F186-V193 HydrophobicContact CZ-CG1 4.43Å; F186-V193 HydrophobicContact CZ-CG2 3.92Å; F186-V198 HydrophobicContact CD2-CG2 4.43Å; F186-V198 HydrophobicContact CE2-CG2 4.03Å
187	K	94	Very high	94.8	Very high	138 Å²	138	75.7 Å²	75.7	60%	0.6	39%	0.39	S	S	*	.	H	α-helix	trans	-61.5	-41.7	172.9	-73.2	173.2	-164.8	160.9	0	112	G183 E184 V185 N190	G183-K187 VanDerWaalsContact O-CG 3.31Å; G183-K187 WeakPolarHBondContact O-CG 3.45Å; G183-K187 PolarHBondContact O-N 3.27Å; E184-K187 PolarHBondContact O-N 2.94Å; E184-K187 IonicContact OE1-NZ 2.68Å; E184-K187 PolarHBondContact OE1-NZ 2.85Å; V185-K187 PolarHBondContact O-N 2.93Å; K187-N190 PolarHBondContact O-N 3.18Å
188	T	94.4	Very high	94.9	Very high	54 Å²	54	74.8 Å²	74.8	33%	0.331	39%	0.388	S	S	.	.	H	α-helix	trans	-63.5	-44.2	-179.2	-60.3	0	0	0	0	111.7	S102 E184 V185 F186 N190	S102-T188 WeakPolarHBondContact O-CG2 3.49Å; E184-T188 WeakPolarHBondContact O-CB 3.18Å; E184-T188 PolarHBondContact O-N 3.29Å; E184-T188 PolarHBondContact O-OG1 3.08Å; V185-T188 WeakPolarHBondContact O-CB 3.28Å; V185-T188 PolarHBondContact O-N 3.18Å; V185-T188 VanDerWaalsContact O-N 3.17Å; F186-T188 VanDerWaalsContact C-N 3.33Å; F186-T188 PolarHBondContact O-N 3.2Å; T188-N190 PolarHBondContact O-N 2.84Å
189	Y	94.6	Very high	94.9	Very high	146 Å²	146	77.4 Å²	77.4	57%	0.573	41%	0.41	S	S	*	.	T	Hydrogen-bonded Turn	trans	-83.6	2.5	177.6	-69.1	-73.8	0	0	0	113.8	V185 F186 V191	V185-Y189 HydrophobicContact CG1-CD2 3.92Å; V185-Y189 HydrophobicContact CG1-CE2 4.02Å; V185-Y189 VanDerWaalsContact O-CD2 3.28Å; V185-Y189 WeakPolarHBondContact O-CD2 3.46Å; V185-Y189 PolarHBondContact O-N 3.28Å; V185-Y189 VanDerWaalsContact O-N 3.09Å; F186-Y189 PolarHBondContact O-N 3.05Å; Y189-V191 PolarHBondContact O-N 3.47Å
190	N	95.3	Very high	95	Very high	152 Å²	152	77.1 Å²	77.1	81%	0.813	41%	0.412	S	S	*	.	T	Hydrogen-bonded Turn	trans	50.6	39.2	-177.4	-163.3	26.6	0	0	0	113.1	F186 K187 T188	F186-N190 PolarHBondContact O-N 2.79Å; F186-N190 VanDerWaalsContact O-N 3.08Å; K187-N190 PolarHBondContact O-N 3.18Å; T188-N190 PolarHBondContact O-N 2.84Å
191	V	94.5	Very high	95.1	Very high	79 Å²	79	79.4 Å²	79.4	48%	0.479	43%	0.425	S	S	.	.			trans	-96.4	120.2	179.4	-179.1	0	0	0	0	108.9	F186 Y189 V193	F186-V191 PolarHBondContact O-N 2.88Å; Y189-V191 PolarHBondContact O-N 3.47Å; V191-V193 HydrophobicContact CG1-CG2 3.8Å; V191-V193 PolarHBondContact O-N 3.25Å
192	A	93.8	Very high	95.2	Very high	105 Å²	105	77.7 Å²	77.7	87%	0.868	42%	0.419	S	S	*	.			trans	-76	113.3	172.1	0	0	0	0	0	109.8
193	V	93.5	Very high	95.2	Very high	49 Å²	49	84.1 Å²	84.1	30%	0.297	44%	0.441	S	S	.	.			trans	-118.8	137.8	176.1	-173.7	0	0	0	0	108.6	F186 V191 T197 V198	F186-V193 HydrophobicContact CD1-CG2 3.8Å; F186-V193 HydrophobicContact CD2-CB 4.2Å; F186-V193 HydrophobicContact CD2-CG2 3.93Å; F186-V193 HydrophobicContact CE1-CG2 3.84Å; F186-V193 HydrophobicContact CE2-CB 4.19Å; F186-V193 HydrophobicContact CE2-CG1 4.18Å; F186-V193 HydrophobicContact CE2-CG2 3.95Å; F186-V193 HydrophobicContact CG-CG2 3.86Å; F186-V193 HydrophobicContact CZ-CG1 4.43Å; F186-V193 HydrophobicContact CZ-CG2 3.92Å; V191-V193 HydrophobicContact CG1-CG2 3.8Å; V191-V193 PolarHBondContact O-N 3.25Å; V193-T197 HydrophobicContact CG1-CG2 3.87Å; V193-V198 HydrophobicContact CB-CG2 4.35Å; V193-V198 HydrophobicContact CG1-CG2 3.81Å
194	D	95.1	Very high	95.4	Very high	82 Å²	82	87.4 Å²	87.4	44%	0.439	45%	0.453	S	S	.	.			trans	-75.8	153.7	177.6	66.5	-68.8	0	0	0	112.1	I196 T197 V198	D194-I196 PolarHBondContact O-N 3.21Å; D194-I196 WeakPolarHBondContact OD2-CB 3.25Å; D194-I196 PolarHBondContact OD2-N 3.49Å; D194-T197 VanDerWaalsContact CG-OG1 3.26Å; D194-T197 PolarHBondContact O-N 2.87Å; D194-T197 VanDerWaalsContact OD1-CB 3.22Å; D194-T197 WeakPolarHBondContact OD1-CB 3.48Å; D194-T197 PolarHBondContact OD1-OG1 3.37Å; D194-T197 PolarHBondContact OD2-N 2.88Å; D194-T197 PolarHBondContact OD2-OG1 2.9Å; D194-V198 PolarHBondContact O-N 3.42Å
195	Y	94.8	Very high	95.5	Very high	201 Å²	201	88.6 Å²	88.6	79%	0.788	46%	0.458	S	S	*	.	H	α-helix	trans	-62.2	-29.1	-179.3	-71.1	-75.3	0	0	0	113.6	A199	Y195-A199 VanDerWaalsContact O-CB 3.22Å; Y195-A199 WeakPolarHBondContact O-CB 3.47Å; Y195-A199 PolarHBondContact O-N 2.98Å
196	I	96.5	Very high	95.5	Very high	121 Å²	121	87.4 Å²	87.4	62%	0.621	45%	0.451	S	S	*	.	H	α-helix	trans	-69	-45.7	-179	-54.9	-59.5	0	0	0	109.8	D194 V198 A199 L200	D194-I196 PolarHBondContact O-N 3.21Å; D194-I196 WeakPolarHBondContact OD2-CB 3.25Å; D194-I196 PolarHBondContact OD2-N 3.49Å; I196-V198 PolarHBondContact O-N 3.23Å; I196-A199 PolarHBondContact O-N 3.39Å; I196-L200 HydrophobicContact CG2-CD1 4.16Å; I196-L200 WeakPolarHBondContact O-CB 3.45Å; I196-L200 WeakPolarHBondContact O-CG 3.4Å; I196-L200 PolarHBondContact O-N 3.46Å
197	T	95.9	Very high	95.5	Very high	66 Å²	66	87 Å²	87	41%	0.405	45%	0.453	S	S	.	.	H	α-helix	trans	-58.9	-47.2	174.7	-61.6	0	0	0	0	112	V193 D194 L200 L201	V193-T197 HydrophobicContact CG1-CG2 3.87Å; D194-T197 VanDerWaalsContact CG-OG1 3.26Å; D194-T197 PolarHBondContact O-N 2.87Å; D194-T197 VanDerWaalsContact OD1-CB 3.22Å; D194-T197 WeakPolarHBondContact OD1-CB 3.48Å; D194-T197 PolarHBondContact OD1-OG1 3.37Å; D194-T197 PolarHBondContact OD2-N 2.88Å; D194-T197 PolarHBondContact OD2-OG1 2.9Å; T197-L200 PolarHBondContact O-N 2.99Å; T197-L201 WeakPolarHBondContact O-CB 3.17Å; T197-L201 PolarHBondContact O-N 2.97Å
198	V	95.8	Very high	95.6	Very high	19 Å²	19	83.1 Å²	83.1	12%	0.115	44%	0.44	C	S	.	.	H	α-helix	trans	-62.3	-45.8	178.3	177.3	0	0	0	0	111.4	F179 L182 F186 V193 D194 I196 L200 L201 I202	F179-V198 HydrophobicContact CD2-CG1 3.97Å; F179-V198 HydrophobicContact CE2-CG1 3.96Å; L182-V198 HydrophobicContact CD2-CG1 4.34Å; F186-V198 HydrophobicContact CD2-CG2 4.43Å; F186-V198 HydrophobicContact CE2-CG2 4.03Å; V193-V198 HydrophobicContact CB-CG2 4.35Å; V193-V198 HydrophobicContact CG1-CG2 3.81Å; D194-V198 PolarHBondContact O-N 3.42Å; I196-V198 PolarHBondContact O-N 3.23Å; V198-L200 PolarHBondContact O-N 3.4Å; V198-L201 PolarHBondContact O-N 3.46Å; V198-I202 HydrophobicContact CG1-CG1 4.18Å; V198-I202 WeakPolarHBondContact O-CB 3.39Å; V198-I202 WeakPolarHBondContact O-CG1 3.25Å; V198-I202 PolarHBondContact O-N 2.89Å
199	A	96	Very high	95.5	Very high	61 Å²	61	80.6 Å²	80.6	50%	0.504	43%	0.425	S	S	.	.	H	α-helix	trans	-61.2	-44.2	179.6	0	0	0	0	0	111.7	Y195 I196 W203	Y195-A199 VanDerWaalsContact O-CB 3.22Å; Y195-A199 WeakPolarHBondContact O-CB 3.47Å; Y195-A199 PolarHBondContact O-N 2.98Å; I196-A199 PolarHBondContact O-N 3.39Å; A199-W203 WeakPolarHBondContact O-CB 3.31Å; A199-W203 PolarHBondContact O-N 3.28Å
200	L	96.9	Very high	95.5	Very high	101 Å²	101	75 Å²	75	53%	0.529	40%	0.404	S	S	.	.	H	α-helix	trans	-64.4	-42.6	176.4	-74.9	174.5	0	0	0	112	I196 T197 V198 W203 N204	I196-L200 HydrophobicContact CG2-CD1 4.16Å; I196-L200 WeakPolarHBondContact O-CB 3.45Å; I196-L200 WeakPolarHBondContact O-CG 3.4Å; I196-L200 PolarHBondContact O-N 3.46Å; T197-L200 PolarHBondContact O-N 2.99Å; V198-L200 PolarHBondContact O-N 3.4Å; L200-W203 PolarHBondContact O-N 2.8Å; L200-N204 WeakPolarHBondContact O-CB 3.47Å; L200-N204 PolarHBondContact O-N 3.45Å; L200-N204 PolarHBondContact O-ND2 3.08Å
201	L	96.4	Very high	95.3	Very high	89 Å²	89	71.8 Å²	71.8	47%	0.466	39%	0.386	S	S	.	.	H	α-helix	trans	-66.9	-47.7	-178.6	-165.1	149.2	0	0	0	111.5	L182 T197 V198 W203 N204 F205	L182-L201 HydrophobicContact CD2-CD2 3.79Å; T197-L201 WeakPolarHBondContact O-CB 3.17Å; T197-L201 PolarHBondContact O-N 2.97Å; V198-L201 PolarHBondContact O-N 3.46Å; L201-W203 VanDerWaalsContact C-N 3.34Å; L201-W203 PolarHBondContact O-N 3.46Å; L201-N204 PolarHBondContact O-N 2.9Å; L201-F205 WeakPolarHBondContact O-CB 3.37Å; L201-F205 PolarHBondContact O-N 3.29Å
202	I	96.6	Very high	95.1	Very high	17 Å²	17	68.2 Å²	68.2	9%	0.087	36%	0.364	C	S	.	.	H	α-helix	trans	-65.2	-38.3	177.3	-64.6	-62.6	0	0	0	111.2	F175 F179 L182 V198 G206	F175-I202 HydrophobicContact CD1-CG2 4.08Å; F179-I202 HydrophobicContact CB-CD1 4.43Å; F179-I202 HydrophobicContact CB-CG1 4.43Å; F179-I202 HydrophobicContact CD2-CG1 4.49Å; L182-I202 HydrophobicContact CB-CD1 4.33Å; L182-I202 HydrophobicContact CD2-CD1 3.83Å; L182-I202 HydrophobicContact CD2-CG1 4.15Å; V198-I202 HydrophobicContact CG1-CG1 4.18Å; V198-I202 WeakPolarHBondContact O-CB 3.39Å; V198-I202 WeakPolarHBondContact O-CG1 3.25Å; V198-I202 PolarHBondContact O-N 2.89Å; I202-G206 PolarHBondContact O-N 2.94Å
203	W	96.9	Very high	94.8	Very high	160 Å²	160	63.3 Å²	63.3	61%	0.606	32%	0.324	S	S	*	.	H	α-helix	trans	-60.3	-50.3	174.7	177	-97.2	0	0	0	111.8	F175 A199 L200 L201 G206 V207	F175-W203 HydrophobicContact CE1-CE3 4.29Å; A199-W203 WeakPolarHBondContact O-CB 3.31Å; A199-W203 PolarHBondContact O-N 3.28Å; L200-W203 PolarHBondContact O-N 2.8Å; L201-W203 VanDerWaalsContact C-N 3.34Å; L201-W203 PolarHBondContact O-N 3.46Å; W203-G206 PolarHBondContact O-N 3.48Å; W203-V207 HydrophobicContact CD2-CG2 3.91Å; W203-V207 HydrophobicContact CE3-CG2 4.27Å; W203-V207 HydrophobicContact CG-CG2 4.41Å; W203-V207 HydrophobicContact CH2-CG2 4.23Å; W203-V207 HydrophobicContact CZ2-CG2 3.86Å; W203-V207 HydrophobicContact CZ3-CG2 4.41Å; W203-V207 WeakPolarHBondContact O-CB 3.27Å; W203-V207 VanDerWaalsContact O-CG2 3.28Å; W203-V207 WeakPolarHBondContact O-CG2 3.48Å; W203-V207 PolarHBondContact O-N 3.48Å
204	N	97.1	Very high	94.5	Very high	94 Å²	94	63 Å²	63	50%	0.503	32%	0.319	S	S	.	.	H	α-helix	trans	-62.3	-47	178.3	-79.1	-72.2	0	0	0	111.6	L200 L201 V208	L200-N204 WeakPolarHBondContact O-CB 3.47Å; L200-N204 PolarHBondContact O-N 3.45Å; L200-N204 PolarHBondContact O-ND2 3.08Å; L201-N204 PolarHBondContact O-N 2.9Å; N204-V208 VanDerWaalsContact O-CB 3.28Å; N204-V208 WeakPolarHBondContact O-CB 3.29Å; N204-V208 WeakPolarHBondContact O-CG2 3.3Å; N204-V208 PolarHBondContact O-N 3.38Å
205	F	96.4	Very high	94	Very high	49 Å²	49	68.2 Å²	68.2	22%	0.215	33%	0.333	C	S	.	.	H	α-helix	trans	-60.4	-47.4	178.1	-179.2	-99.1	0	0	0	112	L174 S178 L201 G209 Y225	L174-F205 HydrophobicContact CD2-CE1 3.74Å; L174-F205 HydrophobicContact CD2-CZ 4.21Å; S178-F205 VanDerWaalsContact OG-CE1 3.27Å; S178-F205 WeakPolarHBondContact OG-CE1 3.44Å; L201-F205 WeakPolarHBondContact O-CB 3.37Å; L201-F205 PolarHBondContact O-N 3.29Å; F205-G209 PolarHBondContact O-N 3.4Å; F205-Y225 AromaticContact CD2-CE1 3.81Å; F205-Y225 HydrophobicContact CD2-CE1 3.81Å; F205-Y225 HydrophobicContact CE1-CE1 4.38Å; F205-Y225 HydrophobicContact CE2-CD1 4.14Å; F205-Y225 AromaticContact CE2-CE1 3.52Å; F205-Y225 HydrophobicContact CE2-CE1 3.52Å; F205-Y225 HydrophobicContact CG-CE1 4.37Å; F205-Y225 HydrophobicContact CZ-CD1 4.12Å; F205-Y225 AromaticContact CZ-CE1 3.84Å; F205-Y225 HydrophobicContact CZ-CE1 3.84Å; F205-Y225 WeakPolarHBondContact O-CE1 3.48Å; F205-Y225 PolarHBondContact O-OH 2.87Å
206	G	95.7	Very high	93.5	Very high	0 Å²	0	65.4 Å²	65.4	0%	0	33%	0.325	C	S	.	.	H	α-helix	trans	-67	-47.5	-178.9	0	0	0	0	0	112.8	F175 I202 W203 G209 M210	F175-G206 VanDerWaalsContact CZ-C 3.45Å; F175-G206 VanDerWaalsContact CZ-CA 3.49Å; I202-G206 PolarHBondContact O-N 2.94Å; W203-G206 PolarHBondContact O-N 3.48Å; G206-G209 PolarHBondContact O-N 3.44Å; G206-M210 WeakPolarHBondContact O-CB 3.48Å; G206-M210 VanDerWaalsContact O-CG 3.25Å; G206-M210 WeakPolarHBondContact O-CG 3.45Å; G206-M210 PolarHBondContact O-N 3.36Å
207	V	95.7	Very high	92.7	Very high	45 Å²	45	61 Å²	61	27%	0.273	31%	0.309	S	S	.	.	H	α-helix	trans	-66.6	-47	-179.3	173.5	0	0	0	0	111.4	F175 W203 G209 M210 I211	F175-V207 HydrophobicContact CZ-CG2 4.12Å; W203-V207 HydrophobicContact CD2-CG2 3.91Å; W203-V207 HydrophobicContact CE3-CG2 4.27Å; W203-V207 HydrophobicContact CG-CG2 4.41Å; W203-V207 HydrophobicContact CH2-CG2 4.23Å; W203-V207 HydrophobicContact CZ2-CG2 3.86Å; W203-V207 HydrophobicContact CZ3-CG2 4.41Å; W203-V207 WeakPolarHBondContact O-CB 3.27Å; W203-V207 VanDerWaalsContact O-CG2 3.28Å; W203-V207 WeakPolarHBondContact O-CG2 3.48Å; W203-V207 PolarHBondContact O-N 3.48Å; V207-G209 VanDerWaalsContact C-N 3.3Å; V207-G209 PolarHBondContact O-N 2.99Å; V207-M210 PolarHBondContact O-N 2.89Å; V207-I211 HydrophobicContact CG1-CD1 3.82Å; V207-I211 HydrophobicContact CG1-CG1 4.49Å; V207-I211 VanDerWaalsContact O-CG1 3.31Å; V207-I211 WeakPolarHBondContact O-CG1 3.49Å; V207-I211 PolarHBondContact O-N 2.9Å
208	V	95.3	Very high	92.4	Very high	56 Å²	56	61.9 Å²	61.9	34%	0.339	32%	0.316	S	S	.	.	H	α-helix	trans	-64.8	-37.1	178.1	176.8	0	0	0	0	110.8	N204 I211 S212 L221 Y225	N204-V208 VanDerWaalsContact O-CB 3.28Å; N204-V208 WeakPolarHBondContact O-CB 3.29Å; N204-V208 WeakPolarHBondContact O-CG2 3.3Å; N204-V208 PolarHBondContact O-N 3.38Å; V208-I211 PolarHBondContact O-N 3.35Å; V208-S212 VanDerWaalsContact O-CB 3.3Å; V208-S212 WeakPolarHBondContact O-CB 3.32Å; V208-S212 PolarHBondContact O-N 2.96Å; V208-S212 PolarHBondContact O-OG 3.45Å; V208-L221 HydrophobicContact CG1-CD2 4.02Å; V208-Y225 WeakPolarHBondContact CB-OH 3.31Å; V208-Y225 HydrophobicContact CG1-CE2 3.99Å; V208-Y225 WeakPolarHBondContact CG1-OH 3.46Å
209	G	93.8	Very high	91.9	Very high	0 Å²	0	63.6 Å²	63.6	0%	0	32%	0.324	C	S	.	.	H	α-helix	trans	-62.5	-46.1	173.2	0	0	0	0	0	112.7	F205 G206 V207 I211 S212 I213 Y225	F205-G209 PolarHBondContact O-N 3.4Å; G206-G209 PolarHBondContact O-N 3.44Å; V207-G209 VanDerWaalsContact C-N 3.3Å; V207-G209 PolarHBondContact O-N 2.99Å; G209-I211 PolarHBondContact O-N 3.31Å; G209-S212 PolarHBondContact O-N 3.41Å; G209-I213 WeakPolarHBondContact O-CB 3.3Å; G209-I213 WeakPolarHBondContact O-CD1 3.39Å; G209-I213 VanDerWaalsContact O-CG1 3.27Å; G209-I213 WeakPolarHBondContact O-CG1 3.31Å; G209-I213 PolarHBondContact O-N 2.83Å; G209-Y225 VanDerWaalsContact CA-CZ 3.49Å
210	M	92.7	Very high	91.6	Very high	30 Å²	30	69 Å²	69	15%	0.148	33%	0.331	C	S	.	.	H	α-helix	trans	-62	-43.1	177.1	-71.7	-57.2	-65.1	0	0	112.2	I167 S170 L171 L174 F175 G206 V207 I213 H214	I167-M210 HydrophobicContact CB-CE 4.44Å; I167-M210 HydrophobicContact CD1-CE 3.84Å; I167-M210 HydrophobicContact CG2-CE 3.88Å; S170-M210 PolarHBondContact OG-SD 3.18Å; S170-M210 VanDerWaalsContact OG-SD 3.37Å; L171-M210 HydrophobicContact CB-CE 4.43Å; L171-M210 HydrophobicContact CB-SD 4.31Å; L174-M210 HydrophobicContact CD1-CG 4.23Å; L174-M210 HydrophobicContact CD1-SD 3.96Å; F175-M210 HydrophobicContact CE2-CG 4.16Å; G206-M210 WeakPolarHBondContact O-CB 3.48Å; G206-M210 VanDerWaalsContact O-CG 3.25Å; G206-M210 WeakPolarHBondContact O-CG 3.45Å; G206-M210 PolarHBondContact O-N 3.36Å; V207-M210 PolarHBondContact O-N 2.89Å; M210-I213 PolarHBondContact O-N 3.34Å; M210-H214 PolarHBondContact O-N 3.46Å
211	I	92	Very high	91.4	Very high	84 Å²	84	67.2 Å²	67.2	43%	0.431	32%	0.322	S	S	.	.	H	α-helix	trans	-63.1	-43.8	175	-66.2	167.8	0	0	0	110.4	V207 V208 G209 I213 W215	V207-I211 HydrophobicContact CG1-CD1 3.82Å; V207-I211 HydrophobicContact CG1-CG1 4.49Å; V207-I211 VanDerWaalsContact O-CG1 3.31Å; V207-I211 WeakPolarHBondContact O-CG1 3.49Å; V207-I211 PolarHBondContact O-N 2.9Å; V208-I211 PolarHBondContact O-N 3.35Å; G209-I211 PolarHBondContact O-N 3.31Å; I211-I213 VanDerWaalsContact C-N 3.32Å; I211-I213 PolarHBondContact O-N 3.47Å; I211-W215 HydrophobicContact CG2-CB 4.22Å; I211-W215 CarbonylContact O-C 3.53Å; I211-W215 VanDerWaalsContact O-C 3.25Å; I211-W215 VanDerWaalsContact O-CA 3.22Å; I211-W215 WeakPolarHBondContact O-CA 3.2Å; I211-W215 WeakPolarHBondContact O-CB 3.16Å; I211-W215 PolarHBondContact O-N 3.23Å
212	S	90.2	Very high	91.1	Very high	3 Å²	3	65.1 Å²	65.1	2%	0.021	31%	0.31	C	S	.	.	H	α-helix	trans	-68.8	-28	-177.2	-57.2	0	0	0	0	113.6	V208 G209 L221 Q222	V208-S212 VanDerWaalsContact O-CB 3.3Å; V208-S212 WeakPolarHBondContact O-CB 3.32Å; V208-S212 PolarHBondContact O-N 2.96Å; V208-S212 PolarHBondContact O-OG 3.45Å; G209-S212 PolarHBondContact O-N 3.41Å; S212-L221 WeakPolarHBondContact OG-CD2 3.33Å; S212-Q222 WeakPolarHBondContact O-CG 3.41Å
213	I	88.2	Confident	90.8	Very high	3 Å²	3	64.8 Å²	64.8	2%	0.015	31%	0.308	C	S	.	.	H	α-helix	trans	-92.9	-43.6	-176.5	-64.7	165.6	0	0	0	112.3	L174 G209 M210 I211 I229 A285	L174-I213 HydrophobicContact CD1-CD1 4.02Å; G209-I213 WeakPolarHBondContact O-CB 3.3Å; G209-I213 WeakPolarHBondContact O-CD1 3.39Å; G209-I213 VanDerWaalsContact O-CG1 3.27Å; G209-I213 WeakPolarHBondContact O-CG1 3.31Å; G209-I213 PolarHBondContact O-N 2.83Å; M210-I213 PolarHBondContact O-N 3.34Å; I211-I213 VanDerWaalsContact C-N 3.32Å; I211-I213 PolarHBondContact O-N 3.47Å; I213-I229 HydrophobicContact CD1-CD1 3.3Å; I213-A285 HydrophobicContact CG2-CB 3.62Å
214	H	87.2	Confident	90.6	Very high	41 Å²	41	59.4 Å²	59.4	19%	0.19	30%	0.297	C	S	.	.	H	α-helix	trans	-102.6	-12.8	-173.1	-62.5	87.6	0	0	0	113.3	I167 S170 M210	I167-H214 HydrophobicContact CD1-CB 3.76Å; I167-H214 WeakPolarHBondContact CD1-CD2 3.41Å; S170-H214 VanDerWaalsContact CB-CE1 3.47Å; S170-H214 WeakPolarHBondContact CB-CE1 3.14Å; S170-H214 PolarHBondContact OG-CE1 3.21Å; M210-H214 PolarHBondContact O-N 3.46Å
215	W	84.9	Confident	90.5	Very high	193 Å²	193	56 Å²	56	73%	0.731	28%	0.277	S	S	*	.	S	Bend	trans	-120.9	-178.2	175.6	-153.7	-93.2	0	0	0	110.3	I211 G217	I211-W215 HydrophobicContact CG2-CB 4.22Å; I211-W215 CarbonylContact O-C 3.53Å; I211-W215 VanDerWaalsContact O-C 3.25Å; I211-W215 VanDerWaalsContact O-CA 3.22Å; I211-W215 WeakPolarHBondContact O-CA 3.2Å; I211-W215 WeakPolarHBondContact O-CB 3.16Å; I211-W215 PolarHBondContact O-N 3.23Å; W215-G217 PolarHBondContact O-N 3.03Å
216	K	82.7	Confident	90.3	Very high	142 Å²	142	53.7 Å²	53.7	62%	0.617	27%	0.268	S	S	*	.			trans	-66.8	114.9	172.5	-68.4	155.2	179.8	168.6	0	109.4
217	G	80.8	Confident	90.2	Very high	29 Å²	29	54.3 Å²	54.3	30%	0.299	27%	0.271	S	S	.	.			trans	-134.5	164.6	173.2	0	0	0	0	0	111.6	W215 L219	W215-G217 PolarHBondContact O-N 3.03Å; G217-L219 PolarHBondContact O-N 3.43Å
218	P	90	Very high	90.1	Very high	83 Å²	83	54.8 Å²	54.8	54%	0.539	27%	0.271	S	S	.	.			trans	-65.6	134.6	175.7	21.4	-24.6	0	0	0	110.5	R220 L221 Q222	P218-R220 VanDerWaalsContact C-N 3.3Å; P218-R220 PolarHBondContact O-N 3.34Å; P218-L221 HydrophobicContact CB-CB 4.45Å; P218-L221 HydrophobicContact CG-CB 3.72Å; P218-L221 HydrophobicContact CG-CD2 3.95Å; P218-L221 WeakPolarHBondContact O-CB 2.96Å; P218-L221 PolarHBondContact O-N 2.87Å; P218-Q222 PolarHBondContact O-N 3.37Å
219	L	85.3	Confident	90	Very high	55 Å²	55	53 Å²	53	29%	0.288	26%	0.259	S	S	.	.	H	α-helix	trans	-54.3	-43	-171.2	-179.6	153.5	0	0	0	113	G217 L221 Q222 Q223 M292	G217-L219 PolarHBondContact O-N 3.43Å; L219-L221 VanDerWaalsContact C-N 3.32Å; L219-L221 PolarHBondContact O-N 3.43Å; L219-Q222 PolarHBondContact O-N 2.97Å; L219-Q223 VanDerWaalsContact CD2-CD 3.44Å; L219-Q223 HydrophobicContact CD2-CG 4.22Å; L219-Q223 VanDerWaalsContact CD2-NE2 3.27Å; L219-Q223 WeakPolarHBondContact O-CG 3.39Å; L219-Q223 PolarHBondContact O-N 3.28Å; L219-M292 HydrophobicContact CD1-CB 3.81Å
220	R	89.3	Confident	90	Very high	176 Å²	176	53 Å²	53	66%	0.664	26%	0.259	S	S	*	.	H	α-helix	trans	-64.8	-35	178.5	-63.6	-57.8	-173.7	179.1	3.5	113	P218 Q223 A224	P218-R220 VanDerWaalsContact C-N 3.3Å; P218-R220 PolarHBondContact O-N 3.34Å; R220-Q223 VanDerWaalsContact NH1-OE1 3.14Å; R220-Q223 PolarHBondContact O-N 2.91Å; R220-A224 WeakPolarHBondContact O-CB 3.25Å; R220-A224 PolarHBondContact O-N 3.2Å
221	L	91.6	Very high	90.2	Very high	63 Å²	63	51.6 Å²	51.6	33%	0.33	25%	0.253	S	S	.	.	H	α-helix	trans	-72	-42.4	178.1	-172.2	62.7	0	0	0	110.6	V208 S212 P218 L219 Q223 A224 Y225	V208-L221 HydrophobicContact CG1-CD2 4.02Å; S212-L221 WeakPolarHBondContact OG-CD2 3.33Å; P218-L221 HydrophobicContact CB-CB 4.45Å; P218-L221 HydrophobicContact CG-CB 3.72Å; P218-L221 HydrophobicContact CG-CD2 3.95Å; P218-L221 WeakPolarHBondContact O-CB 2.96Å; P218-L221 PolarHBondContact O-N 2.87Å; L219-L221 VanDerWaalsContact C-N 3.32Å; L219-L221 PolarHBondContact O-N 3.43Å; L221-Q223 VanDerWaalsContact C-N 3.33Å; L221-Q223 PolarHBondContact O-N 3.26Å; L221-A224 PolarHBondContact O-N 2.92Å; L221-Y225 HydrophobicContact CD1-CD2 4.08Å; L221-Y225 HydrophobicContact CD1-CE2 3.66Å; L221-Y225 HydrophobicContact CD2-CE2 4.25Å; L221-Y225 HydrophobicContact CG-CD2 3.91Å; L221-Y225 HydrophobicContact CG-CE2 3.7Å; L221-Y225 VanDerWaalsContact O-CD2 3.27Å; L221-Y225 WeakPolarHBondContact O-CD2 3.25Å; L221-Y225 PolarHBondContact O-N 2.81Å
222	Q	90.7	Very high	90.3	Very high	44 Å²	44	47.9 Å²	47.9	21%	0.206	23%	0.234	C	C	.	.	H	α-helix	trans	-57.7	-47	172.5	-175.3	-177.7	-9.4	0	0	110.8	S212 P218 L219 A224 Y225 L226	S212-Q222 WeakPolarHBondContact O-CG 3.41Å; P218-Q222 PolarHBondContact O-N 3.37Å; L219-Q222 PolarHBondContact O-N 2.97Å; Q222-A224 PolarHBondContact O-N 2.84Å; Q222-Y225 PolarHBondContact O-N 3.01Å; Q222-L226 HydrophobicContact CG-CD1 4.02Å; Q222-L226 HydrophobicContact CG-CG 4.44Å; Q222-L226 WeakPolarHBondContact O-CB 3.35Å; Q222-L226 VanDerWaalsContact O-CG 3.23Å; Q222-L226 WeakPolarHBondContact O-CG 3.28Å; Q222-L226 PolarHBondContact O-N 2.96Å
223	Q	90.9	Very high	90.4	Very high	10 Å²	10	50 Å²	50	5%	0.047	24%	0.243	C	C	.	.	H	α-helix	trans	-57.7	-44.7	175.2	-72.3	178.1	-17.3	0	0	112.2	L219 R220 L221 L226 I227 Y288 S289 S290	L219-Q223 VanDerWaalsContact CD2-CD 3.44Å; L219-Q223 HydrophobicContact CD2-CG 4.22Å; L219-Q223 VanDerWaalsContact CD2-NE2 3.27Å; L219-Q223 WeakPolarHBondContact O-CG 3.39Å; L219-Q223 PolarHBondContact O-N 3.28Å; R220-Q223 VanDerWaalsContact NH1-OE1 3.14Å; R220-Q223 PolarHBondContact O-N 2.91Å; L221-Q223 VanDerWaalsContact C-N 3.33Å; L221-Q223 PolarHBondContact O-N 3.26Å; Q223-L226 PolarHBondContact O-N 2.7Å; Q223-I227 VanDerWaalsContact O-CG1 3.27Å; Q223-I227 WeakPolarHBondContact O-CG1 3.46Å; Q223-I227 PolarHBondContact O-N 3.15Å; Q223-Y288 HydrophobicContact CB-CE2 3.71Å; Q223-Y288 HydrophobicContact CG-CD2 4.46Å; Q223-Y288 HydrophobicContact CG-CE2 3.57Å; Q223-Y288 WeakPolarHBondContact CG-OH 3.4Å; Q223-Y288 PolarHBondContact NE2-OH 2.88Å; Q223-Y288 PolarHBondContact OE1-OH 2.97Å; Q223-S289 PolarHBondContact NE2-O 3.34Å; Q223-S290 PolarHBondContact NE2-O 3.18Å
224	A	93.1	Very high	90.8	Very high	47 Å²	47	49.8 Å²	49.8	39%	0.388	24%	0.243	S	C	.	.	H	α-helix	trans	-61.5	-44.9	177.3	0	0	0	0	0	112.3	R220 L221 Q222 I227 M228	R220-A224 WeakPolarHBondContact O-CB 3.25Å; R220-A224 PolarHBondContact O-N 3.2Å; L221-A224 PolarHBondContact O-N 2.92Å; Q222-A224 PolarHBondContact O-N 2.84Å; A224-I227 PolarHBondContact O-N 3.1Å; A224-M228 WeakPolarHBondContact O-CG 3.37Å; A224-M228 PolarHBondContact O-N 3.4Å
225	Y	93.6	Very high	91.1	Very high	22 Å²	22	48 Å²	48	9%	0.086	23%	0.234	C	C	.	.	H	α-helix	trans	-64.1	-40	175.4	-83.4	-72.3	0	0	0	112.3	L174 F205 V208 G209 L221 Q222 I227 M228 I229	L174-Y225 HydrophobicContact CD2-CD1 4.14Å; F205-Y225 AromaticContact CD2-CE1 3.81Å; F205-Y225 HydrophobicContact CD2-CE1 3.81Å; F205-Y225 HydrophobicContact CE1-CE1 4.38Å; F205-Y225 HydrophobicContact CE2-CD1 4.14Å; F205-Y225 AromaticContact CE2-CE1 3.52Å; F205-Y225 HydrophobicContact CE2-CE1 3.52Å; F205-Y225 HydrophobicContact CG-CE1 4.37Å; F205-Y225 HydrophobicContact CZ-CD1 4.12Å; F205-Y225 AromaticContact CZ-CE1 3.84Å; F205-Y225 HydrophobicContact CZ-CE1 3.84Å; F205-Y225 WeakPolarHBondContact O-CE1 3.48Å; F205-Y225 PolarHBondContact O-OH 2.87Å; V208-Y225 WeakPolarHBondContact CB-OH 3.31Å; V208-Y225 HydrophobicContact CG1-CE2 3.99Å; V208-Y225 WeakPolarHBondContact CG1-OH 3.46Å; G209-Y225 VanDerWaalsContact CA-CZ 3.49Å; L221-Y225 HydrophobicContact CD1-CD2 4.08Å; L221-Y225 HydrophobicContact CD1-CE2 3.66Å; L221-Y225 HydrophobicContact CD2-CE2 4.25Å; L221-Y225 HydrophobicContact CG-CD2 3.91Å; L221-Y225 HydrophobicContact CG-CE2 3.7Å; L221-Y225 VanDerWaalsContact O-CD2 3.27Å; L221-Y225 WeakPolarHBondContact O-CD2 3.25Å; L221-Y225 PolarHBondContact O-N 2.81Å; Q222-Y225 PolarHBondContact O-N 3.01Å; Y225-I227 VanDerWaalsContact C-N 3.34Å; Y225-I227 PolarHBondContact O-N 3Å; Y225-M228 PolarHBondContact O-N 3.39Å; Y225-I229 WeakPolarHBondContact O-CB 3.28Å; Y225-I229 VanDerWaalsContact O-CG1 3.28Å; Y225-I229 WeakPolarHBondContact O-CG1 3.45Å; Y225-I229 PolarHBondContact O-N 3.08Å
226	L	91.8	Very high	91.4	Very high	2 Å²	2	39.8 Å²	39.8	1%	0.01	21%	0.206	C	C	.	.	H	α-helix	trans	-62.7	-40.2	176.5	-70.7	169.2	0	0	0	112	Q222 Q223 S230 Y288 L383	Q222-L226 HydrophobicContact CG-CD1 4.02Å; Q222-L226 HydrophobicContact CG-CG 4.44Å; Q222-L226 WeakPolarHBondContact O-CB 3.35Å; Q222-L226 VanDerWaalsContact O-CG 3.23Å; Q222-L226 WeakPolarHBondContact O-CG 3.28Å; Q222-L226 PolarHBondContact O-N 2.96Å; Q223-L226 PolarHBondContact O-N 2.7Å; L226-S230 WeakPolarHBondContact O-CB 3.34Å; L226-S230 PolarHBondContact O-N 3.33Å; L226-S230 PolarHBondContact O-OG 3.3Å; L226-Y288 HydrophobicContact CB-CD2 4.31Å; L226-Y288 HydrophobicContact CD1-CD2 4.16Å; L226-L383 HydrophobicContact CB-CD2 3.99Å; L226-L383 HydrophobicContact CD2-CD1 3.63Å; L226-L383 HydrophobicContact CD2-CD2 4.1Å; L226-L383 HydrophobicContact CD2-CG 4.45Å; L226-L383 HydrophobicContact CG-CD2 4.5Å
227	I	93.9	Very high	91.9	Very high	13 Å²	13	35.5 Å²	35.5	7%	0.067	19%	0.187	C	C	.	.	H	α-helix	trans	-64.9	-44.6	174.7	-65.7	163.3	0	0	0	110.6	P88 L91 C92 Q223 A224 Y225 S230 A231 Y288	P88-I227 HydrophobicContact CB-CD1 3.66Å; P88-I227 HydrophobicContact CB-CG1 4.09Å; L91-I227 HydrophobicContact CD2-CD1 4.11Å; L91-I227 HydrophobicContact CD2-CG2 3.63Å; C92-I227 HydrophobicContact CB-CG2 3.78Å; Q223-I227 VanDerWaalsContact O-CG1 3.27Å; Q223-I227 WeakPolarHBondContact O-CG1 3.46Å; Q223-I227 PolarHBondContact O-N 3.15Å; A224-I227 PolarHBondContact O-N 3.1Å; Y225-I227 VanDerWaalsContact C-N 3.34Å; Y225-I227 PolarHBondContact O-N 3Å; I227-S230 PolarHBondContact O-N 3.47Å; I227-A231 WeakPolarHBondContact O-CB 3.47Å; I227-A231 PolarHBondContact O-N 2.92Å; I227-Y288 HydrophobicContact CG1-CE2 4.47Å
228	M	93.9	Very high	92.4	Very high	54 Å²	54	34.4 Å²	34.4	27%	0.266	17%	0.174	S	C	.	.	H	α-helix	trans	-63.6	-42.1	177.2	-74	-59.3	-59.6	0	0	112.7	V95 A224 Y225 S230 A231 L232	V95-M228 HydrophobicContact CG1-SD 4.47Å; A224-M228 WeakPolarHBondContact O-CG 3.37Å; A224-M228 PolarHBondContact O-N 3.4Å; Y225-M228 PolarHBondContact O-N 3.39Å; M228-S230 VanDerWaalsContact C-N 3.33Å; M228-A231 PolarHBondContact O-N 3.26Å; M228-L232 WeakPolarHBondContact O-CB 3.5Å; M228-L232 WeakPolarHBondContact O-CG 3.2Å; M228-L232 PolarHBondContact O-N 3.14Å
229	I	93.4	Very high	92.4	Very high	18 Å²	18	31.3 Å²	31.3	9%	0.092	15%	0.152	C	C	.	.	H	α-helix	trans	-61.4	-44.4	175.1	-75.3	-177.5	0	0	0	110.6	L173 L174 I213 Y225 A231 L232 M233	L173-I229 HydrophobicContact CD1-CG2 3.7Å; L173-I229 HydrophobicContact CD2-CB 4.2Å; L173-I229 HydrophobicContact CD2-CG1 3.94Å; L173-I229 HydrophobicContact CD2-CG2 4.03Å; L174-I229 HydrophobicContact CD1-CD1 4.42Å; L174-I229 HydrophobicContact CD2-CD1 3.95Å; L174-I229 HydrophobicContact CD2-CG1 3.8Å; L174-I229 HydrophobicContact CG-CD1 4.08Å; L174-I229 HydrophobicContact CG-CG1 4.35Å; I213-I229 HydrophobicContact CD1-CD1 3.3Å; Y225-I229 WeakPolarHBondContact O-CB 3.28Å; Y225-I229 VanDerWaalsContact O-CG1 3.28Å; Y225-I229 WeakPolarHBondContact O-CG1 3.45Å; Y225-I229 PolarHBondContact O-N 3.08Å; I229-A231 VanDerWaalsContact C-N 3.34Å; I229-A231 PolarHBondContact O-N 2.8Å; I229-L232 PolarHBondContact O-N 3.36Å; I229-M233 WeakPolarHBondContact O-CG 3.24Å; I229-M233 PolarHBondContact O-N 2.95Å
230	S	94	Very high	92.5	Very high	0 Å²	0	32 Å²	32	0%	0	15%	0.152	C	C	.	.	H	α-helix	trans	-63	-42.2	177.8	-56.1	0	0	0	0	111.2	L226 I227 M228 M233 A234	L226-S230 WeakPolarHBondContact O-CB 3.34Å; L226-S230 PolarHBondContact O-N 3.33Å; L226-S230 PolarHBondContact O-OG 3.3Å; I227-S230 PolarHBondContact O-N 3.47Å; M228-S230 VanDerWaalsContact C-N 3.33Å; S230-M233 PolarHBondContact O-N 2.91Å; S230-A234 WeakPolarHBondContact O-CB 3.24Å; S230-A234 PolarHBondContact O-N 3.42Å
231	A	95.8	Very high	92.4	Very high	2 Å²	2	24.2 Å²	24.2	2%	0.017	12%	0.123	C	C	.	.	H	α-helix	trans	-64.2	-45.7	175.9	0	0	0	0	0	112.2	V95 V96 I227 M228 I229 M233 A234 L235	V95-A231 HydrophobicContact CB-CB 4.45Å; V95-A231 HydrophobicContact CG1-CB 3.88Å; V96-A231 HydrophobicContact CG2-CB 3.63Å; I227-A231 WeakPolarHBondContact O-CB 3.47Å; I227-A231 PolarHBondContact O-N 2.92Å; M228-A231 PolarHBondContact O-N 3.26Å; I229-A231 VanDerWaalsContact C-N 3.34Å; I229-A231 PolarHBondContact O-N 2.8Å; A231-M233 PolarHBondContact O-N 3.38Å; A231-A234 PolarHBondContact O-N 3.23Å; A231-L235 WeakPolarHBondContact O-CB 3.32Å; A231-L235 VanDerWaalsContact O-CG 3.27Å; A231-L235 WeakPolarHBondContact O-CG 3.41Å; A231-L235 PolarHBondContact O-N 3.35Å
232	L	94.6	Very high	92.2	Very high	6 Å²	6	23 Å²	23	3%	0.031	12%	0.118	C	C	.	.	H	α-helix	trans	-61	-43.6	176	-75.3	172.2	0	0	0	111.6	L173 S178 Y181 M228 I229 L235 V236	L173-L232 HydrophobicContact CD2-CB 4Å; L173-L232 HydrophobicContact CD2-CD1 3.97Å; S178-L232 WeakPolarHBondContact OG-CD1 3.23Å; Y181-L232 HydrophobicContact CD1-CD2 4.43Å; Y181-L232 HydrophobicContact CD2-CD2 4.39Å; Y181-L232 HydrophobicContact CG-CD2 3.95Å; M228-L232 WeakPolarHBondContact O-CB 3.5Å; M228-L232 WeakPolarHBondContact O-CG 3.2Å; M228-L232 PolarHBondContact O-N 3.14Å; I229-L232 PolarHBondContact O-N 3.36Å; L232-L235 PolarHBondContact O-N 3.14Å; L232-V236 VanDerWaalsContact O-CG2 3.28Å; L232-V236 WeakPolarHBondContact O-CG2 3.49Å; L232-V236 PolarHBondContact O-N 3.02Å
233	M	93.6	Very high	92	Very high	46 Å²	46	23.4 Å²	23.4	23%	0.227	12%	0.12	C	C	.	.	H	α-helix	trans	-62.6	-42.8	175.1	-75.9	-57.6	-60.2	0	0	112.6	L173 I229 S230 A231 L235 V236 F237 I387	L173-M233 HydrophobicContact CD1-CG 3.52Å; L173-M233 HydrophobicContact CD1-SD 3.38Å; L173-M233 WeakPolarHBondContact CD1-SD 3.3Å; L173-M233 HydrophobicContact CG-CG 4.39Å; L173-M233 HydrophobicContact CG-SD 4.06Å; I229-M233 WeakPolarHBondContact O-CG 3.24Å; I229-M233 PolarHBondContact O-N 2.95Å; S230-M233 PolarHBondContact O-N 2.91Å; A231-M233 PolarHBondContact O-N 3.38Å; M233-L235 VanDerWaalsContact C-N 3.34Å; M233-L235 PolarHBondContact O-N 3.08Å; M233-V236 WeakPolarHBondContact O-CB 3.27Å; M233-V236 PolarHBondContact O-N 3.05Å; M233-F237 HydrophobicContact CE-CE1 4.42Å; M233-F237 HydrophobicContact CE-CE2 4.48Å; M233-F237 HydrophobicContact CE-CZ 4.08Å; M233-F237 PolarHBondContact O-N 2.86Å; M233-I387 HydrophobicContact CB-CD1 3.84Å; M233-I387 HydrophobicContact CB-CG1 4Å; M233-I387 HydrophobicContact CB-CG2 4.27Å; M233-I387 HydrophobicContact CG-CD1 4.26Å
234	A	95	Very high	92	Very high	0 Å²	0	28.2 Å²	28.2	0%	0	14%	0.138	C	C	.	.	H	α-helix	trans	-61.4	-44.1	175.9	0	0	0	0	0	111.2	V96 S230 A231 V236 F237 I238 I387 V391	V96-A234 HydrophobicContact CG2-CB 4.12Å; S230-A234 WeakPolarHBondContact O-CB 3.24Å; S230-A234 PolarHBondContact O-N 3.42Å; A231-A234 PolarHBondContact O-N 3.23Å; A234-V236 VanDerWaalsContact C-N 3.34Å; A234-V236 PolarHBondContact O-N 3.22Å; A234-F237 PolarHBondContact O-N 3.13Å; A234-I238 WeakPolarHBondContact O-CB 3.27Å; A234-I238 WeakPolarHBondContact O-CD1 3.32Å; A234-I238 WeakPolarHBondContact O-CG1 3.49Å; A234-I238 PolarHBondContact O-N 3.48Å; A234-I387 HydrophobicContact CB-CG2 4.4Å; A234-V391 HydrophobicContact CB-CG2 3.93Å
235	L	94	Very high	92	Very high	2 Å²	2	26 Å²	26	1%	0.01	12%	0.12	C	C	.	.	H	α-helix	trans	-61.7	-39.4	176.2	-72.5	168.9	0	0	0	112.7	V96 T99 I100 Y106 Y181 A231 L232 M233 I238 K239	V96-L235 HydrophobicContact CG1-CD2 4.23Å; T99-L235 HydrophobicContact CG2-CD1 3.71Å; T99-L235 HydrophobicContact CG2-CD2 3.61Å; T99-L235 HydrophobicContact CG2-CG 4.33Å; I100-L235 HydrophobicContact CD1-CD2 4.44Å; I100-L235 HydrophobicContact CG1-CD2 3.97Å; Y106-L235 HydrophobicContact CD1-CB 3.99Å; Y106-L235 HydrophobicContact CD1-CD2 4.08Å; Y106-L235 HydrophobicContact CD2-CD2 4.35Å; Y106-L235 HydrophobicContact CE1-CB 3.68Å; Y106-L235 HydrophobicContact CE1-CD2 4.34Å; Y106-L235 HydrophobicContact CE1-CG 4.43Å; Y106-L235 HydrophobicContact CG-CD2 4.12Å; Y181-L235 HydrophobicContact CD2-CD1 4.25Å; Y181-L235 HydrophobicContact CE2-CD1 4.25Å; A231-L235 WeakPolarHBondContact O-CB 3.32Å; A231-L235 VanDerWaalsContact O-CG 3.27Å; A231-L235 WeakPolarHBondContact O-CG 3.41Å; A231-L235 PolarHBondContact O-N 3.35Å; L232-L235 PolarHBondContact O-N 3.14Å; M233-L235 VanDerWaalsContact C-N 3.34Å; M233-L235 PolarHBondContact O-N 3.08Å; L235-I238 PolarHBondContact O-N 2.72Å; L235-K239 WeakPolarHBondContact O-CB 3.5Å; L235-K239 PolarHBondContact O-N 2.75Å
236	V	92	Very high	91.9	Very high	22 Å²	22	25 Å²	25	13%	0.133	12%	0.116	C	C	.	.	H	α-helix	trans	-60.2	-49.6	173.1	168.9	0	0	0	0	110.1	F177 L232 M233 A234 I238 K239 Y240	F177-V236 HydrophobicContact CD1-CG2 3.4Å; F177-V236 HydrophobicContact CD2-CG2 4.21Å; F177-V236 HydrophobicContact CE1-CB 4.47Å; F177-V236 HydrophobicContact CE1-CG1 4.17Å; F177-V236 HydrophobicContact CE1-CG2 3.39Å; F177-V236 HydrophobicContact CE2-CG2 4.22Å; F177-V236 HydrophobicContact CG-CG2 3.85Å; F177-V236 HydrophobicContact CZ-CG1 4.07Å; F177-V236 HydrophobicContact CZ-CG2 3.83Å; L232-V236 VanDerWaalsContact O-CG2 3.28Å; L232-V236 WeakPolarHBondContact O-CG2 3.49Å; L232-V236 PolarHBondContact O-N 3.02Å; M233-V236 WeakPolarHBondContact O-CB 3.27Å; M233-V236 PolarHBondContact O-N 3.05Å; A234-V236 VanDerWaalsContact C-N 3.34Å; A234-V236 PolarHBondContact O-N 3.22Å; V236-I238 PolarHBondContact O-N 3.33Å; V236-K239 PolarHBondContact O-N 2.9Å; V236-Y240 HydrophobicContact CG1-CD2 3.8Å; V236-Y240 HydrophobicContact CG1-CE2 4.01Å; V236-Y240 WeakPolarHBondContact O-CD2 3.28Å; V236-Y240 PolarHBondContact O-N 3.49Å
237	F	91.7	Very high	92	Very high	52 Å²	52	26.1 Å²	26.1	23%	0.228	12%	0.12	C	C	.	.	H	α-helix	trans	-61.7	-41.7	176.7	-72.9	-25.1	0	0	0	112.5	M233 A234 Y240 L241 I387 V391	M233-F237 HydrophobicContact CE-CE1 4.42Å; M233-F237 HydrophobicContact CE-CE2 4.48Å; M233-F237 HydrophobicContact CE-CZ 4.08Å; M233-F237 PolarHBondContact O-N 2.86Å; A234-F237 PolarHBondContact O-N 3.13Å; F237-Y240 PolarHBondContact O-N 3.26Å; F237-L241 HydrophobicContact CB-CD1 4.01Å; F237-L241 HydrophobicContact CG-CD1 4.44Å; F237-L241 WeakPolarHBondContact O-CB 3.4Å; F237-L241 VanDerWaalsContact O-CG 3.25Å; F237-L241 WeakPolarHBondContact O-CG 3.39Å; F237-L241 PolarHBondContact O-N 3.23Å; F237-I387 HydrophobicContact CD2-CG2 3.72Å; F237-I387 HydrophobicContact CE2-CG2 3.81Å; F237-V391 HydrophobicContact CB-CG2 3.83Å; F237-V391 HydrophobicContact CD2-CG2 4.11Å
238	I	92	Very high	92	Very high	5 Å²	5	28 Å²	28	3%	0.026	13%	0.13	C	C	.	.	H	α-helix	trans	-63.9	-44.1	179.4	-68.8	166.1	0	0	0	111.8	V96 I100 A234 L235 V236 Y240 V391 K395	V96-I238 HydrophobicContact CG1-CD1 3.77Å; I100-I238 HydrophobicContact CD1-CD1 3.55Å; I100-I238 HydrophobicContact CD1-CG2 4.22Å; A234-I238 WeakPolarHBondContact O-CB 3.27Å; A234-I238 WeakPolarHBondContact O-CD1 3.32Å; A234-I238 WeakPolarHBondContact O-CG1 3.49Å; A234-I238 PolarHBondContact O-N 3.48Å; L235-I238 PolarHBondContact O-N 2.72Å; V236-I238 PolarHBondContact O-N 3.33Å; I238-Y240 VanDerWaalsContact C-N 3.33Å; I238-Y240 PolarHBondContact O-N 3.01Å; I238-V391 HydrophobicContact CG1-CG1 4.39Å; I238-V391 HydrophobicContact CG1-CG2 4.4Å; I238-K395 HydrophobicContact CB-CD 4.35Å; I238-K395 HydrophobicContact CG1-CD 4.17Å; I238-K395 HydrophobicContact CG1-CG 4.22Å; I238-K395 HydrophobicContact CG2-CD 4.07Å
239	K	90.1	Very high	91.9	Very high	18 Å²	18	25.8 Å²	25.8	8%	0.078	12%	0.119	C	C	.	.	H	α-helix	trans	-64.2	-39.1	-178.1	175.4	62.9	-164.5	81.3	0	112.8	F105 Y106 R108 D110 L235 V236	F105-K239 HydrophobicContact CD1-CD 4.22Å; F105-K239 HydrophobicContact CE1-CD 3.97Å; F105-K239 HydrophobicContact CE1-CG 4.29Å; F105-K239 HydrophobicContact CZ-CD 4.48Å; F105-K239 WeakPolarHBondContact O-CD 3.47Å; F105-K239 WeakPolarHBondContact O-CE 3.48Å; Y106-K239 HydrophobicContact CD1-CB 3.93Å; Y106-K239 HydrophobicContact CE1-CB 4.49Å; R108-K239 WeakPolarHBondContact O-CE 3.25Å; R108-K239 PolarHBondContact O-NZ 3.35Å; D110-K239 PolarHBondContact O-NZ 3.46Å; L235-K239 WeakPolarHBondContact O-CB 3.5Å; L235-K239 PolarHBondContact O-N 2.75Å; V236-K239 PolarHBondContact O-N 2.9Å
240	Y	87.4	Confident	91.9	Very high	71 Å²	71	25 Å²	25	28%	0.278	12%	0.116	S	C	.	.	H	α-helix	trans	-105.9	-12.2	-167	-65	-62.6	0	0	0	114.4	L113 V236 F237 I238	L113-Y240 HydrophobicContact CD1-CD2 4.48Å; L113-Y240 HydrophobicContact CD1-CG 3.93Å; L113-Y240 HydrophobicContact CD2-CG 4.36Å; L113-Y240 HydrophobicContact CG-CD1 4.08Å; L113-Y240 HydrophobicContact CG-CG 3.87Å; V236-Y240 HydrophobicContact CG1-CD2 3.8Å; V236-Y240 HydrophobicContact CG1-CE2 4.01Å; V236-Y240 WeakPolarHBondContact O-CD2 3.28Å; V236-Y240 PolarHBondContact O-N 3.49Å; F237-Y240 PolarHBondContact O-N 3.26Å; I238-Y240 VanDerWaalsContact C-N 3.33Å; I238-Y240 PolarHBondContact O-N 3.01Å
241	L	87.1	Confident	91.9	Very high	12 Å²	12	26.7 Å²	26.7	6%	0.063	13%	0.129	C	C	.	.	S	Bend	trans	-90.3	123.5	174.4	-72.6	174.9	0	0	0	111.9	T116 M139 F237 T245 A246 I249 K395	T116-L241 HydrophobicContact CG2-CD2 4.47Å; M139-L241 HydrophobicContact CE-CD2 3.27Å; M139-L241 HydrophobicContact CE-CG 4.36Å; M139-L241 HydrophobicContact SD-CD1 4.46Å; M139-L241 HydrophobicContact SD-CD2 3.66Å; F237-L241 HydrophobicContact CB-CD1 4.01Å; F237-L241 HydrophobicContact CG-CD1 4.44Å; F237-L241 WeakPolarHBondContact O-CB 3.4Å; F237-L241 VanDerWaalsContact O-CG 3.25Å; F237-L241 WeakPolarHBondContact O-CG 3.39Å; F237-L241 PolarHBondContact O-N 3.23Å; L241-T245 HydrophobicContact CD2-CG2 4.28Å; L241-A246 HydrophobicContact CB-CB 4Å; L241-A246 HydrophobicContact CD1-CB 4.43Å; L241-I249 HydrophobicContact CD1-CD1 4.16Å; L241-I249 HydrophobicContact CD2-CD1 3.74Å; L241-K395 PolarHBondContact O-NZ 3.44Å
242	P	87.2	Confident	91.7	Very high	36 Å²	36	29.8 Å²	29.8	23%	0.234	15%	0.148	C	C	.	.			trans	-55	159.3	165.8	-24.8	35.6	0	0	0	112.3	E120 A246	E120-P242 HydrophobicContact CG-CB 3.92Å; E120-P242 VanDerWaalsContact OE1-CB 3.28Å; E120-P242 WeakPolarHBondContact OE1-CB 3.36Å; E120-P242 WeakPolarHBondContact OE2-CB 3.34Å; P242-A246 VanDerWaalsContact O-CB 3.24Å; P242-A246 WeakPolarHBondContact O-CB 3.23Å; P242-A246 PolarHBondContact O-N 2.9Å
243	E	87.7	Confident	91.5	Very high	53 Å²	53	30.3 Å²	30.3	25%	0.248	15%	0.151	C	C	.	.	H	α-helix	trans	-65.7	-54	-171.3	-70.5	169.3	-164.5	0	0	112.5	K109 E120 T245 A246 W247	K109-E243 WeakPolarHBondContact CE-OE1 3.46Å; K109-E243 IonicContact NZ-OE1 2.66Å; K109-E243 PolarHBondContact NZ-OE1 2.86Å; K109-E243 IonicContact NZ-OE2 2.73Å; E120-E243 PolarHBondContact OE2-N 3.38Å; E243-T245 PolarHBondContact O-N 3.43Å; E243-A246 PolarHBondContact O-N 3.3Å; E243-W247 PolarHBondContact O-N 3.25Å
244	W	90.5	Very high	91.4	Very high	111 Å²	111	28.6 Å²	28.6	42%	0.42	14%	0.143	S	C	.	.	H	α-helix	trans	-65.9	-42.8	-178.2	-72.9	76.3	0	0	0	111.1	E120 R128 A246 W247 L248	E120-W244 WeakPolarHBondContact OE1-CB 3.27Å; E120-W244 PolarHBondContact OE2-N 3.45Å; E120-W244 VanDerWaalsContact OE2-N 3.08Å; R128-W244 HydrophobicContact CG-CG 4.48Å; W244-A246 VanDerWaalsContact C-N 3.32Å; W244-A246 PolarHBondContact O-N 2.81Å; W244-W247 PolarHBondContact O-N 2.84Å; W244-L248 WeakPolarHBondContact O-CB 3.36Å; W244-L248 WeakPolarHBondContact O-CG 3.46Å; W244-L248 PolarHBondContact O-N 3.35Å
245	T	92.2	Very high	91.2	Very high	0 Å²	0	32.7 Å²	32.7	0%	0	17%	0.168	C	C	.	.	H	α-helix	trans	-57.5	-43.9	175.9	-58.9	0	0	0	0	111.4	E120 N135 A136 L241 E243 L248 I249	E120-T245 WeakPolarHBondContact OE1-CB 3.39Å; E120-T245 PolarHBondContact OE1-N 3.45Å; E120-T245 PolarHBondContact OE1-OG1 2.88Å; N135-T245 HydrophobicContact CB-CG2 3.8Å; A136-T245 HydrophobicContact CB-CG2 4.34Å; L241-T245 HydrophobicContact CD2-CG2 4.28Å; E243-T245 PolarHBondContact O-N 3.43Å; T245-L248 PolarHBondContact O-N 2.98Å; T245-I249 HydrophobicContact CG2-CD1 3.68Å; T245-I249 HydrophobicContact CG2-CG1 4.38Å; T245-I249 WeakPolarHBondContact O-CB 3.15Å; T245-I249 WeakPolarHBondContact O-CD1 3.47Å; T245-I249 WeakPolarHBondContact O-CG1 3.24Å; T245-I249 PolarHBondContact O-N 3.44Å
246	A	91.8	Very high	90.9	Very high	1 Å²	1	35.6 Å²	35.6	1%	0.008	18%	0.179	C	C	.	.	H	α-helix	trans	-62.6	-46.6	178.8	0	0	0	0	0	112.4	L241 P242 E243 W244 L248 I249 L250 K395	L241-A246 HydrophobicContact CB-CB 4Å; L241-A246 HydrophobicContact CD1-CB 4.43Å; P242-A246 VanDerWaalsContact O-CB 3.24Å; P242-A246 WeakPolarHBondContact O-CB 3.23Å; P242-A246 PolarHBondContact O-N 2.9Å; E243-A246 PolarHBondContact O-N 3.3Å; W244-A246 VanDerWaalsContact C-N 3.32Å; W244-A246 PolarHBondContact O-N 2.81Å; A246-L248 VanDerWaalsContact C-N 3.35Å; A246-L248 PolarHBondContact O-N 2.98Å; A246-I249 PolarHBondContact O-N 2.98Å; A246-L250 WeakPolarHBondContact O-CG 3.41Å; A246-L250 PolarHBondContact O-N 3.46Å; A246-K395 HydrophobicContact CB-CD 4.32Å; A246-K395 HydrophobicContact CB-CG 4.4Å
247	W	93.2	Very high	90.6	Very high	27 Å²	27	35.7 Å²	35.7	10%	0.102	18%	0.179	C	C	.	.	H	α-helix	trans	-62.8	-42.1	178.2	-65.3	124	0	0	0	112	E243 W244 L250 A251 L392 K395 L443 Y446 F447	E243-W247 PolarHBondContact O-N 3.25Å; W244-W247 PolarHBondContact O-N 2.84Å; W247-L250 HydrophobicContact CE3-CD1 3.99Å; W247-L250 HydrophobicContact CZ3-CD1 4.12Å; W247-L250 PolarHBondContact O-N 3.06Å; W247-A251 WeakPolarHBondContact O-CB 3.35Å; W247-A251 PolarHBondContact O-N 3.4Å; W247-L392 HydrophobicContact CZ3-CG 4.19Å; W247-K395 HydrophobicContact CH2-CB 4.11Å; W247-K395 HydrophobicContact CZ2-CB 4Å; W247-L443 HydrophobicContact CD2-CD2 4.44Å; W247-L443 HydrophobicContact CE3-CD2 3.31Å; W247-L443 HydrophobicContact CZ3-CD2 3.6Å; W247-Y446 HydrophobicContact CD2-CE1 4.33Å; W247-Y446 AromaticContact CE2-CE1 3.53Å; W247-Y446 AromaticContact CE2-CZ 3.92Å; W247-Y446 AromaticContact CH2-CD1 3.59Å; W247-Y446 HydrophobicContact CH2-CD1 3.59Å; W247-Y446 AromaticContact CH2-CD2 3.76Å; W247-Y446 HydrophobicContact CH2-CD2 3.76Å; W247-Y446 AromaticContact CH2-CE1 3.67Å; W247-Y446 HydrophobicContact CH2-CE1 3.67Å; W247-Y446 AromaticContact CH2-CE2 3.88Å; W247-Y446 HydrophobicContact CH2-CE2 3.88Å; W247-Y446 AromaticContact CH2-CG 3.64Å; W247-Y446 HydrophobicContact CH2-CG 3.64Å; W247-Y446 AromaticContact CH2-CZ 3.83Å; W247-Y446 AromaticContact CZ2-CD1 3.65Å; W247-Y446 HydrophobicContact CZ2-CD1 3.65Å; W247-Y446 HydrophobicContact CZ2-CD2 4.05Å; W247-Y446 AromaticContact CZ2-CE1 3.19Å; W247-Y446 HydrophobicContact CZ2-CE1 3.19Å; W247-Y446 AromaticContact CZ2-CE2 3.68Å; W247-Y446 HydrophobicContact CZ2-CE2 3.68Å; W247-Y446 HydrophobicContact CZ2-CG 4.05Å; W247-Y446 AromaticContact CZ2-CZ 3.23Å; W247-Y446 HydrophobicContact CZ3-CD1 4.05Å; W247-Y446 HydrophobicContact CZ3-CE1 4.4Å; W247-Y446 HydrophobicContact CZ3-CG 4.22Å; W247-Y446 AromaticContact NE1-CE1 3.94Å; W247-F447 HydrophobicContact CD2-CZ 4.5Å; W247-F447 HydrophobicContact CG-CZ 4.37Å
248	L	93.7	Very high	90.3	Very high	53 Å²	53	36.5 Å²	36.5	28%	0.277	19%	0.185	S	C	.	.	H	α-helix	trans	-63.1	-42.4	174.9	-71.4	176.7	0	0	0	112	S132 I133 A136 W244 T245 A246 A251 V252	S132-L248 WeakPolarHBondContact OG-CD1 3.33Å; I133-L248 HydrophobicContact CG1-CD1 3.77Å; A136-L248 HydrophobicContact CB-CB 4.08Å; W244-L248 WeakPolarHBondContact O-CB 3.36Å; W244-L248 WeakPolarHBondContact O-CG 3.46Å; W244-L248 PolarHBondContact O-N 3.35Å; T245-L248 PolarHBondContact O-N 2.98Å; A246-L248 VanDerWaalsContact C-N 3.35Å; A246-L248 PolarHBondContact O-N 2.98Å; L248-A251 PolarHBondContact O-N 2.96Å; L248-V252 WeakPolarHBondContact O-CB 3.43Å; L248-V252 VanDerWaalsContact O-CG2 3.27Å; L248-V252 WeakPolarHBondContact O-CG2 3.35Å; L248-V252 PolarHBondContact O-N 3.43Å
249	I	93.1	Very high	90.1	Very high	6 Å²	6	39.9 Å²	39.9	3%	0.031	21%	0.206	C	C	.	.	H	α-helix	trans	-62.3	-46.6	177.5	-72.9	164.8	0	0	0	110.8	A136 M139 L241 T245 A246 A251 V252 I253	A136-I249 HydrophobicContact CB-CG1 3.97Å; M139-I249 HydrophobicContact CB-CD1 4.26Å; M139-I249 HydrophobicContact CE-CD1 4.48Å; M139-I249 HydrophobicContact CG-CD1 4.26Å; M139-I249 HydrophobicContact SD-CD1 3.46Å; M139-I249 WeakPolarHBondContact SD-CD1 3.38Å; L241-I249 HydrophobicContact CD1-CD1 4.16Å; L241-I249 HydrophobicContact CD2-CD1 3.74Å; T245-I249 HydrophobicContact CG2-CD1 3.68Å; T245-I249 HydrophobicContact CG2-CG1 4.38Å; T245-I249 WeakPolarHBondContact O-CB 3.15Å; T245-I249 WeakPolarHBondContact O-CD1 3.47Å; T245-I249 WeakPolarHBondContact O-CG1 3.24Å; T245-I249 PolarHBondContact O-N 3.44Å; A246-I249 PolarHBondContact O-N 2.98Å; I249-A251 VanDerWaalsContact C-N 3.33Å; I249-A251 PolarHBondContact O-N 3.5Å; I249-V252 PolarHBondContact O-N 3.13Å; I249-I253 HydrophobicContact CG2-CD1 3.5Å; I249-I253 VanDerWaalsContact CG2-CD1 3.5Å; I249-I253 HydrophobicContact CG2-CG1 4.14Å; I249-I253 VanDerWaalsContact O-CB 3.3Å; I249-I253 WeakPolarHBondContact O-CB 3.29Å; I249-I253 WeakPolarHBondContact O-CG1 3.32Å; I249-I253 PolarHBondContact O-N 3.3Å
250	L	93.3	Very high	89.7	Confident	3 Å²	3	39.2 Å²	39.2	2%	0.016	20%	0.204	C	C	.	.	H	α-helix	trans	-58.7	-45.7	177.6	-71.3	173.2	0	0	0	111.2	A246 W247 S254 F388 V391 L392 I439	A246-L250 WeakPolarHBondContact O-CG 3.41Å; A246-L250 PolarHBondContact O-N 3.46Å; W247-L250 HydrophobicContact CE3-CD1 3.99Å; W247-L250 HydrophobicContact CZ3-CD1 4.12Å; W247-L250 PolarHBondContact O-N 3.06Å; L250-S254 WeakPolarHBondContact O-CB 3.46Å; L250-S254 PolarHBondContact O-N 3.21Å; L250-F388 HydrophobicContact CD2-CB 4.19Å; L250-F388 HydrophobicContact CD2-CD1 3.9Å; L250-F388 HydrophobicContact CD2-CG 4.48Å; L250-V391 HydrophobicContact CD1-CG1 4.33Å; L250-V391 HydrophobicContact CD2-CB 4.47Å; L250-V391 HydrophobicContact CD2-CG1 4.21Å; L250-L392 HydrophobicContact CD1-CB 4.02Å; L250-L392 HydrophobicContact CD1-CG 4.3Å; L250-I439 HydrophobicContact CB-CG2 4.35Å
251	A	93.2	Very high	89.3	Confident	35 Å²	35	37.6 Å²	37.6	29%	0.289	20%	0.201	S	C	.	.	H	α-helix	trans	-62.5	-48.5	177.3	0	0	0	0	0	112	W247 L248 I249 S254 V255 L443	W247-A251 WeakPolarHBondContact O-CB 3.35Å; W247-A251 PolarHBondContact O-N 3.4Å; L248-A251 PolarHBondContact O-N 2.96Å; I249-A251 VanDerWaalsContact C-N 3.33Å; I249-A251 PolarHBondContact O-N 3.5Å; A251-S254 PolarHBondContact O-N 2.91Å; A251-S254 PolarHBondContact O-OG 3.05Å; A251-V255 PolarHBondContact O-N 3.28Å; A251-L443 HydrophobicContact CB-CD1 4.14Å
252	V	92.8	Very high	89	Confident	67 Å²	67	41.5 Å²	41.5	41%	0.406	22%	0.222	S	C	.	.	H	α-helix	trans	-70.7	-38.6	-176.9	178.2	0	0	0	0	112	I140 L248 I249 S254 V255 Y256	I140-V252 HydrophobicContact CD1-CB 3.67Å; I140-V252 HydrophobicContact CD1-CG1 3.53Å; I140-V252 HydrophobicContact CD1-CG2 4.26Å; L248-V252 WeakPolarHBondContact O-CB 3.43Å; L248-V252 VanDerWaalsContact O-CG2 3.27Å; L248-V252 WeakPolarHBondContact O-CG2 3.35Å; L248-V252 PolarHBondContact O-N 3.43Å; I249-V252 PolarHBondContact O-N 3.13Å; V252-S254 VanDerWaalsContact C-N 3.28Å; V252-S254 PolarHBondContact O-N 3.37Å; V252-V255 PolarHBondContact O-N 3.42Å; V252-Y256 WeakPolarHBondContact O-CB 3.25Å; V252-Y256 PolarHBondContact O-N 3.48Å
253	I	90.4	Very high	88.7	Confident	17 Å²	17	42.5 Å²	42.5	9%	0.087	23%	0.229	C	C	.	.	H	α-helix	trans	-63.8	-37.4	175.2	-72.2	179.7	0	0	0	110.7	I143 I249 V255 Y256 D257 F388 L435	I143-I253 HydrophobicContact CD1-CD1 4.32Å; I249-I253 HydrophobicContact CG2-CD1 3.5Å; I249-I253 VanDerWaalsContact CG2-CD1 3.5Å; I249-I253 HydrophobicContact CG2-CG1 4.14Å; I249-I253 VanDerWaalsContact O-CB 3.3Å; I249-I253 WeakPolarHBondContact O-CB 3.29Å; I249-I253 WeakPolarHBondContact O-CG1 3.32Å; I249-I253 PolarHBondContact O-N 3.3Å; I253-V255 VanDerWaalsContact C-N 3.3Å; I253-V255 PolarHBondContact O-N 2.95Å; I253-Y256 PolarHBondContact O-N 2.66Å; I253-D257 WeakPolarHBondContact O-CB 3.22Å; I253-D257 PolarHBondContact O-N 2.97Å; I253-F388 HydrophobicContact CD1-CE1 3.54Å; I253-F388 HydrophobicContact CD1-CZ 3.53Å; I253-F388 HydrophobicContact CG2-CD2 4.37Å; I253-F388 HydrophobicContact CG2-CE1 4.38Å; I253-F388 HydrophobicContact CG2-CE2 3.96Å; I253-F388 HydrophobicContact CG2-CZ 3.97Å; I253-L435 HydrophobicContact CG2-CD1 4.27Å; I253-L435 HydrophobicContact CG2-CD2 4.4Å
254	S	90.8	Very high	88.2	Confident	9 Å²	9	44.5 Å²	44.5	6%	0.063	25%	0.247	C	C	.	.	H	α-helix	trans	-59.6	-40.5	175.3	82.1	0	0	0	0	113.2	L250 A251 V252 L258 L435	L250-S254 WeakPolarHBondContact O-CB 3.46Å; L250-S254 PolarHBondContact O-N 3.21Å; A251-S254 PolarHBondContact O-N 2.91Å; A251-S254 PolarHBondContact O-OG 3.05Å; V252-S254 VanDerWaalsContact C-N 3.28Å; V252-S254 PolarHBondContact O-N 3.37Å; S254-L258 PolarHBondContact O-N 2.91Å; S254-L435 VanDerWaalsContact CA-CD2 3.43Å
255	V	90.4	Very high	87.5	Confident	87 Å²	87	48.6 Å²	48.6	53%	0.527	27%	0.267	S	S	.	.	H	α-helix	trans	-72.8	-41.4	174.7	178.9	0	0	0	0	110.9	A251 V252 I253 L258 V259	A251-V255 PolarHBondContact O-N 3.28Å; V252-V255 PolarHBondContact O-N 3.42Å; I253-V255 VanDerWaalsContact C-N 3.3Å; I253-V255 PolarHBondContact O-N 2.95Å; V255-L258 WeakPolarHBondContact O-CB 3.34Å; V255-L258 PolarHBondContact O-N 3.19Å; V255-V259 HydrophobicContact CG1-CG2 4.45Å; V255-V259 WeakPolarHBondContact O-CG2 3.43Å; V255-V259 PolarHBondContact O-N 3.19Å
256	Y	88.6	Confident	86.8	Confident	62 Å²	62	48.9 Å²	48.9	24%	0.243	27%	0.27	C	S	.	.	H	α-helix	trans	-62.1	-43.6	179.3	174.6	-98.1	0	0	0	112.1	V144 V252 I253 L258 V259 A260	V144-Y256 HydrophobicContact CG2-CE2 4Å; V252-Y256 WeakPolarHBondContact O-CB 3.25Å; V252-Y256 PolarHBondContact O-N 3.48Å; I253-Y256 PolarHBondContact O-N 2.66Å; Y256-L258 VanDerWaalsContact C-N 3.34Å; Y256-L258 PolarHBondContact O-N 2.9Å; Y256-V259 PolarHBondContact O-N 3.43Å; Y256-A260 HydrophobicContact CE1-CB 4.22Å; Y256-A260 WeakPolarHBondContact O-CB 3.46Å; Y256-A260 PolarHBondContact O-N 3.37Å
257	D	86.4	Confident	86	Confident	24 Å²	24	50.3 Å²	50.3	13%	0.128	28%	0.279	C	S	.	.	H	α-helix	trans	-62.3	-42.4	177.7	-170.9	51.4	0	0	0	111.1	I253 V259 A260 V261 P433 L435	I253-D257 WeakPolarHBondContact O-CB 3.22Å; I253-D257 PolarHBondContact O-N 2.97Å; D257-V259 PolarHBondContact O-N 2.87Å; D257-A260 PolarHBondContact O-N 2.89Å; D257-V261 WeakPolarHBondContact O-CB 3.46Å; D257-V261 VanDerWaalsContact O-CG2 3.32Å; D257-V261 WeakPolarHBondContact O-CG2 3.4Å; D257-V261 PolarHBondContact O-N 2.94Å; D257-P433 WeakPolarHBondContact OD2-CB 3.41Å; D257-L435 WeakPolarHBondContact OD2-CB 3.13Å
258	L	84.9	Confident	84.9	Confident	69 Å²	69	52 Å²	52	36%	0.361	29%	0.29	S	S	.	.	H	α-helix	trans	-56.7	-48.5	172.8	-174.4	66.2	0	0	0	112.3	S254 V255 Y256 L262 P433 P436	S254-L258 PolarHBondContact O-N 2.91Å; V255-L258 WeakPolarHBondContact O-CB 3.34Å; V255-L258 PolarHBondContact O-N 3.19Å; Y256-L258 VanDerWaalsContact C-N 3.34Å; Y256-L258 PolarHBondContact O-N 2.9Å; L258-L262 HydrophobicContact CD1-CD1 3.45Å; L258-L262 VanDerWaalsContact CD1-CD1 3.45Å; L258-L262 HydrophobicContact CD1-CG 4.16Å; L258-L262 HydrophobicContact CG-CD1 3.89Å; L258-L262 VanDerWaalsContact O-CB 3.3Å; L258-L262 WeakPolarHBondContact O-CB 3.21Å; L258-L262 WeakPolarHBondContact O-CG 3.45Å; L258-L262 PolarHBondContact O-N 3.32Å; L258-P433 HydrophobicContact CD1-CG 3.85Å; L258-P436 HydrophobicContact CB-CG 4.37Å; L258-P436 HydrophobicContact CD1-CG 4.29Å
259	V	86.6	Confident	84	Confident	76 Å²	76	53.9 Å²	53.9	46%	0.461	29%	0.293	S	S	.	.	H	α-helix	trans	-68.3	-43.2	179.7	173.5	0	0	0	0	111.4	V255 Y256 D257 V261 C263	V255-V259 HydrophobicContact CG1-CG2 4.45Å; V255-V259 WeakPolarHBondContact O-CG2 3.43Å; V255-V259 PolarHBondContact O-N 3.19Å; Y256-V259 PolarHBondContact O-N 3.43Å; D257-V259 PolarHBondContact O-N 2.87Å; V259-V261 VanDerWaalsContact C-N 3.3Å; V259-V261 PolarHBondContact O-N 3.46Å; V259-C263 WeakPolarHBondContact O-CB 3.49Å; V259-C263 PolarHBondContact O-N 3.39Å; V259-C263 PolarHBondContact O-SG 3.48Å; V259-C263 VanDerWaalsContact O-SG 3.35Å
260	A	82.7	Confident	83.1	Confident	4 Å²	4	56.7 Å²	56.7	3%	0.033	31%	0.307	C	S	.	.	H	α-helix	trans	-68.2	-28.5	-177	0	0	0	0	0	113	Y256 D257 G266 L268	Y256-A260 HydrophobicContact CE1-CB 4.22Å; Y256-A260 WeakPolarHBondContact O-CB 3.46Å; Y256-A260 PolarHBondContact O-N 3.37Å; D257-A260 PolarHBondContact O-N 2.89Å; A260-G266 WeakPolarHBondContact O-CA 3.46Å; A260-L268 HydrophobicContact CB-CD1 4.04Å
261	V	78.2	Confident	82.2	Confident	38 Å²	38	57.7 Å²	57.7	23%	0.23	31%	0.312	C	S	.	.	H	α-helix	trans	-86.4	-44.5	176.3	175.6	0	0	0	0	111.7	D257 V259 P433	D257-V261 WeakPolarHBondContact O-CB 3.46Å; D257-V261 VanDerWaalsContact O-CG2 3.32Å; D257-V261 WeakPolarHBondContact O-CG2 3.4Å; D257-V261 PolarHBondContact O-N 2.94Å; V259-V261 VanDerWaalsContact C-N 3.3Å; V259-V261 PolarHBondContact O-N 3.46Å; V261-P433 HydrophobicContact CB-CB 4.39Å; V261-P433 HydrophobicContact CB-CG 4.14Å; V261-P433 HydrophobicContact CG1-CG 4.36Å; V261-P433 HydrophobicContact CG2-CB 4.16Å; V261-P433 HydrophobicContact CG2-CG 4.45Å
262	L	81.6	Confident	81.3	Confident	93 Å²	93	59 Å²	59	49%	0.487	32%	0.317	S	S	.	.	H	α-helix	trans	-76.3	-33.5	-176.4	-68.4	177.7	0	0	0	113.2	L258 L432	L258-L262 HydrophobicContact CD1-CD1 3.45Å; L258-L262 VanDerWaalsContact CD1-CD1 3.45Å; L258-L262 HydrophobicContact CD1-CG 4.16Å; L258-L262 HydrophobicContact CG-CD1 3.89Å; L258-L262 VanDerWaalsContact O-CB 3.3Å; L258-L262 WeakPolarHBondContact O-CB 3.21Å; L258-L262 WeakPolarHBondContact O-CG 3.45Å; L258-L262 PolarHBondContact O-N 3.32Å; L262-L432 HydrophobicContact CD2-CD2 4.5Å
263	C	81.5	Confident	80.7	Confident	57 Å²	57	59.2 Å²	59.2	39%	0.385	31%	0.313	S	S	.	.	S	Bend	trans	-79.3	134.1	-179.3	-64.7	0	0	0	0	111.7	V259 K265 G266	V259-C263 WeakPolarHBondContact O-CB 3.49Å; V259-C263 PolarHBondContact O-N 3.39Å; V259-C263 PolarHBondContact O-SG 3.48Å; V259-C263 VanDerWaalsContact O-SG 3.35Å; C263-K265 PolarHBondContact O-N 3.45Å; C263-G266 PolarHBondContact O-N 2.86Å; C263-G266 VanDerWaalsContact O-N 3.08Å
264	P	75.7	Confident	79.9	Confident	96 Å²	96	59.3 Å²	59.3	62%	0.623	32%	0.315	S	S	*	.	T	Hydrogen-bonded Turn	trans	-66.4	-10.9	-178.7	27.2	-35.5	0	0	0	114.2
265	K	77.3	Confident	78.9	Confident	197 Å²	197	59.1 Å²	59.1	86%	0.857	31%	0.313	S	S	*	.	T	Hydrogen-bonded Turn	trans	-103	11	177.1	-66.5	-165.2	170.2	82.8	0	113.4	C263	C263-K265 PolarHBondContact O-N 3.45Å
266	G	76.5	Confident	78	Confident	5 Å²	5	61.2 Å²	61.2	5%	0.052	32%	0.318	C	S	.	.			trans	-66.1	133.6	179.7	0	0	0	0	0	112.1	A260 C263 L268 R269 M270	A260-G266 WeakPolarHBondContact O-CA 3.46Å; C263-G266 PolarHBondContact O-N 2.86Å; C263-G266 VanDerWaalsContact O-N 3.08Å; G266-L268 PolarHBondContact O-N 3.48Å; G266-R269 PolarHBondContact O-N 3.21Å; G266-M270 PolarHBondContact O-N 3.01Å
267	P	75.7	Confident	77.5	Confident	32 Å²	32	65.9 Å²	65.9	21%	0.208	34%	0.342	C	S	.	.	H	α-helix	trans	-57.4	-37.9	177.7	-23.6	32.1	0	0	0	112.7	T147 I148 V151 L271	T147-P267 HydrophobicContact CG2-CB 4.24Å; I148-P267 HydrophobicContact CG1-CG 4.44Å; V151-P267 HydrophobicContact CG2-CB 3.96Å; V151-P267 WeakPolarHBondContact CG2-O 3.48Å; P267-L271 PolarHBondContact O-N 2.93Å; P267-L271 VanDerWaalsContact O-N 3.08Å
268	L	70.8	Confident	76.8	Confident	62 Å²	62	68 Å²	68	33%	0.325	35%	0.348	S	S	.	.	H	α-helix	trans	-67.3	-48	178.2	-70.3	172.9	0	0	0	111.5	T147 A260 G266 M270 L271 V272	T147-L268 HydrophobicContact CG2-CD2 4.4Å; A260-L268 HydrophobicContact CB-CD1 4.04Å; G266-L268 PolarHBondContact O-N 3.48Å; L268-M270 VanDerWaalsContact C-N 3.31Å; L268-M270 PolarHBondContact O-N 3.47Å; L268-L271 WeakPolarHBondContact O-CB 3.35Å; L268-L271 PolarHBondContact O-N 3.26Å; L268-L271 VanDerWaalsContact O-N 3.13Å; L268-V272 WeakPolarHBondContact O-CG2 3.23Å; L268-V272 PolarHBondContact O-N 2.87Å
269	R	73.8	Confident	75.6	Confident	92 Å²	92	72.1 Å²	72.1	35%	0.347	37%	0.37	S	S	.	.	H	α-helix	trans	-59	-43.3	176.4	-177.8	169.9	175.2	164.7	3.4	111.7	G266 L271 V272 E273	G266-R269 PolarHBondContact O-N 3.21Å; R269-L271 VanDerWaalsContact C-N 3.31Å; R269-L271 PolarHBondContact O-N 2.93Å; R269-V272 PolarHBondContact O-N 3.41Å; R269-E273 HydrophobicContact CG-CG 4.27Å; R269-E273 WeakPolarHBondContact CG-OE1 3.25Å; R269-E273 IonicContact CZ-OE1 3.96Å; R269-E273 IonicContact NE-OE1 2.77Å; R269-E273 PolarHBondContact NE-OE1 3.41Å; R269-E273 IonicContact NH2-OE1 3.91Å; R269-E273 PolarHBondContact NH2-OE1 3.2Å; R269-E273 WeakPolarHBondContact O-CB 3.24Å; R269-E273 WeakPolarHBondContact O-CG 3.42Å; R269-E273 PolarHBondContact O-N 3.29Å
270	M	73.8	Confident	74.5	Confident	65 Å²	65	72 Å²	72	32%	0.32	37%	0.365	S	S	.	.	H	α-helix	trans	-60.1	-40.4	175.6	-175.9	178.9	-178	0	0	112.4	V151 K155 G266 L268 T274	V151-M270 HydrophobicContact CG1-SD 4.14Å; K155-M270 HydrophobicContact CD-CE 3.78Å; G266-M270 PolarHBondContact O-N 3.01Å; L268-M270 VanDerWaalsContact C-N 3.31Å; L268-M270 PolarHBondContact O-N 3.47Å; M270-T274 VanDerWaalsContact O-CB 3.28Å; M270-T274 WeakPolarHBondContact O-CB 3.37Å; M270-T274 PolarHBondContact O-N 3.41Å; M270-T274 PolarHBondContact O-OG1 3.23Å
271	L	75.7	Confident	73.4	Confident	24 Å²	24	75.9 Å²	75.9	13%	0.126	39%	0.388	C	S	.	.	H	α-helix	trans	-65.5	-44.9	177.6	-167.4	157.2	0	0	0	111	L150 V151 Y154 P267 L268 R269 T274 A275 L282	L150-L271 HydrophobicContact CD2-CD1 3.43Å; L150-L271 VanDerWaalsContact CD2-CD1 3.43Å; V151-L271 HydrophobicContact CG2-CB 4.32Å; V151-L271 HydrophobicContact CG2-CD1 4.05Å; Y154-L271 HydrophobicContact CD1-CG 4.43Å; P267-L271 PolarHBondContact O-N 2.93Å; P267-L271 VanDerWaalsContact O-N 3.08Å; L268-L271 WeakPolarHBondContact O-CB 3.35Å; L268-L271 PolarHBondContact O-N 3.26Å; L268-L271 VanDerWaalsContact O-N 3.13Å; R269-L271 VanDerWaalsContact C-N 3.31Å; R269-L271 PolarHBondContact O-N 2.93Å; L271-T274 PolarHBondContact O-N 3.48Å; L271-A275 WeakPolarHBondContact O-CB 3.46Å; L271-A275 PolarHBondContact O-N 2.89Å; L271-L282 HydrophobicContact CD2-CD2 3.5Å
272	V	73.3	Confident	72.6	Confident	64 Å²	64	76.4 Å²	76.4	39%	0.388	39%	0.389	S	S	.	.	H	α-helix	trans	-63.5	-48	178.3	175.1	0	0	0	0	111	L268 R269 A275 Q276	L268-V272 WeakPolarHBondContact O-CG2 3.23Å; L268-V272 PolarHBondContact O-N 2.87Å; R269-V272 PolarHBondContact O-N 3.41Å; V272-A275 PolarHBondContact O-N 3.35Å; V272-Q276 WeakPolarHBondContact O-CB 3Å; V272-Q276 VanDerWaalsContact O-CG 3.3Å; V272-Q276 WeakPolarHBondContact O-CG 3.41Å; V272-Q276 PolarHBondContact O-N 2.99Å
273	E	79.4	Confident	71.7	Confident	71 Å²	71	73.7 Å²	73.7	33%	0.332	37%	0.374	S	S	.	.	H	α-helix	trans	-61.8	-45.2	178	-72.7	173.5	175.4	0	0	111.1	R269 A275 Q276 E277	R269-E273 HydrophobicContact CG-CG 4.27Å; R269-E273 WeakPolarHBondContact CG-OE1 3.25Å; R269-E273 IonicContact CZ-OE1 3.96Å; R269-E273 IonicContact NE-OE1 2.77Å; R269-E273 PolarHBondContact NE-OE1 3.41Å; R269-E273 IonicContact NH2-OE1 3.91Å; R269-E273 PolarHBondContact NH2-OE1 3.2Å; R269-E273 WeakPolarHBondContact O-CB 3.24Å; R269-E273 WeakPolarHBondContact O-CG 3.42Å; R269-E273 PolarHBondContact O-N 3.29Å; E273-A275 VanDerWaalsContact C-N 3.32Å; E273-A275 PolarHBondContact O-N 3.37Å; E273-Q276 PolarHBondContact O-N 3.48Å; E273-E277 WeakPolarHBondContact O-CG 3.3Å; E273-E277 PolarHBondContact O-N 3.27Å
274	T	74.6	Confident	70.6	Confident	19 Å²	19	74 Å²	74	12%	0.117	38%	0.375	C	S	.	.	H	α-helix	trans	-64.6	-35.9	178.6	-53.8	0	0	0	0	112.2	Y154 M270 L271 R278	Y154-T274 HydrophobicContact CD1-CG2 4.18Å; Y154-T274 HydrophobicContact CE1-CG2 3.66Å; M270-T274 VanDerWaalsContact O-CB 3.28Å; M270-T274 WeakPolarHBondContact O-CB 3.37Å; M270-T274 PolarHBondContact O-N 3.41Å; M270-T274 PolarHBondContact O-OG1 3.23Å; L271-T274 PolarHBondContact O-N 3.48Å; T274-R278 VanDerWaalsContact O-CG 3.32Å; T274-R278 WeakPolarHBondContact O-CG 3.5Å; T274-R278 PolarHBondContact O-N 3.4Å
275	A	69.3	Low	70	Confident	4 Å²	4	70.4 Å²	70.4	3%	0.033	35%	0.354	C	S	.	.	H	α-helix	trans	-71.8	-37.6	177.3	0	0	0	0	0	112.1	L271 V272 E273 R278 N279 E280 L282	L271-A275 WeakPolarHBondContact O-CB 3.46Å; L271-A275 PolarHBondContact O-N 2.89Å; V272-A275 PolarHBondContact O-N 3.35Å; E273-A275 VanDerWaalsContact C-N 3.32Å; E273-A275 PolarHBondContact O-N 3.37Å; A275-R278 PolarHBondContact O-N 3.48Å; A275-N279 PolarHBondContact O-N 3.34Å; A275-N279 VanDerWaalsContact O-N 3.16Å; A275-E280 PolarHBondContact O-N 3.21Å; A275-L282 HydrophobicContact CB-CD1 4.46Å; A275-L282 HydrophobicContact CB-CD2 3.3Å; A275-L282 HydrophobicContact CB-CG 3.81Å
276	Q	72.6	Confident	69.6	Low	132 Å²	132	65.5 Å²	65.5	62%	0.617	34%	0.336	S	S	*	.	H	α-helix	trans	-64.1	-44.3	173.2	-74.4	175.7	-22.8	0	0	111.4	V272 E273 R278 N279	V272-Q276 WeakPolarHBondContact O-CB 3Å; V272-Q276 VanDerWaalsContact O-CG 3.3Å; V272-Q276 WeakPolarHBondContact O-CG 3.41Å; V272-Q276 PolarHBondContact O-N 2.99Å; E273-Q276 PolarHBondContact O-N 3.48Å; Q276-R278 PolarHBondContact O-N 3.42Å; Q276-N279 PolarHBondContact O-N 3.41Å
277	E	76.8	Confident	69.5	Low	159 Å²	159	67 Å²	67	74%	0.743	34%	0.343	S	S	*	.	H	α-helix	trans	-60	-30.2	175.7	-75.7	175.7	-178.6	0	0	113.1	E273	E273-E277 WeakPolarHBondContact O-CG 3.3Å; E273-E277 PolarHBondContact O-N 3.27Å
278	R	71.7	Confident	69.3	Low	69 Å²	69	65.9 Å²	65.9	26%	0.26	33%	0.334	S	S	.	.	H	α-helix	trans	-95.5	-4.3	-177	-67.2	-178.4	-173.9	-178.6	9	114.3	Y159 T274 A275 Q276 E280	Y159-R278 PolarHBondContact OH-NH1 3.48Å; T274-R278 VanDerWaalsContact O-CG 3.32Å; T274-R278 WeakPolarHBondContact O-CG 3.5Å; T274-R278 PolarHBondContact O-N 3.4Å; A275-R278 PolarHBondContact O-N 3.48Å; Q276-R278 PolarHBondContact O-N 3.42Å; R278-E280 HydrophobicContact CB-CB 4.46Å; R278-E280 HydrophobicContact CB-CG 3.93Å; R278-E280 PolarHBondContact O-N 2.83Å; R278-E280 VanDerWaalsContact O-N 3.17Å
279	N	59.5	Low	69.4	Low	156 Å²	156	64.4 Å²	64.4	83%	0.834	33%	0.329	S	S	*	.	T	Hydrogen-bonded Turn	trans	50.1	33.3	-171.4	-79.8	-27.1	0	0	0	113.3	A275 Q276	A275-N279 PolarHBondContact O-N 3.34Å; A275-N279 VanDerWaalsContact O-N 3.16Å; Q276-N279 PolarHBondContact O-N 3.41Å
280	E	63.8	Low	68.5	Low	73 Å²	73	60.1 Å²	60.1	34%	0.341	31%	0.313	S	S	.	.			trans	-92.3	134.2	178.4	-73.1	174.8	-176.8	0	0	110.1	Y154 Y159 A275 R278 L282	Y154-E280 PolarHBondContact OH-OE2 2.9Å; Y159-E280 WeakPolarHBondContact CE1-OE2 3.17Å; Y159-E280 PolarHBondContact OH-OE1 3.14Å; Y159-E280 PolarHBondContact OH-OE2 3.24Å; A275-E280 PolarHBondContact O-N 3.21Å; R278-E280 HydrophobicContact CB-CB 4.46Å; R278-E280 HydrophobicContact CB-CG 3.93Å; R278-E280 PolarHBondContact O-N 2.83Å; R278-E280 VanDerWaalsContact O-N 3.17Å; E280-L282 PolarHBondContact O-N 3.27Å; E280-L282 VanDerWaalsContact O-N 3.08Å
281	T	60.4	Low	67.6	Low	85 Å²	85	58.3 Å²	58.3	52%	0.521	31%	0.306	S	S	.	.			trans	-65.4	113	170.1	56.8	0	0	0	0	108.8
282	L	60.5	Low	66.1	Low	50 Å²	50	62 Å²	62	26%	0.262	32%	0.324	S	S	.	.			trans	-49.8	149.2	172.4	-73.5	168.3	0	0	0	111.6	L271 A275 E280 I287	L271-L282 HydrophobicContact CD2-CD2 3.5Å; A275-L282 HydrophobicContact CB-CD1 4.46Å; A275-L282 HydrophobicContact CB-CD2 3.3Å; A275-L282 HydrophobicContact CB-CG 3.81Å; E280-L282 PolarHBondContact O-N 3.27Å; E280-L282 VanDerWaalsContact O-N 3.08Å; L282-I287 HydrophobicContact CB-CD1 3.49Å; L282-I287 VanDerWaalsContact CB-CD1 3.49Å; L282-I287 HydrophobicContact CD1-CD1 3.62Å; L282-I287 HydrophobicContact CG-CD1 4.17Å
283	F	64.1	Low	64.5	Low	36 Å²	36	61.8 Å²	61.8	16%	0.158	32%	0.322	C	S	.	.			trans	-46.9	118.5	-169	-59.9	-68.8	0	0	0	113.2	Y154 I162 L166 A285 L286	Y154-F283 HydrophobicContact CD2-CE2 4.28Å; Y154-F283 AromaticContact CD2-CZ 3.95Å; Y154-F283 HydrophobicContact CD2-CZ 3.95Å; Y154-F283 HydrophobicContact CE2-CZ 4.2Å; I162-F283 HydrophobicContact CB-CE1 4.28Å; I162-F283 HydrophobicContact CB-CZ 4.22Å; I162-F283 HydrophobicContact CD1-CZ 4.08Å; I162-F283 HydrophobicContact CG2-CD1 4.19Å; I162-F283 HydrophobicContact CG2-CE1 3.42Å; I162-F283 VanDerWaalsContact CG2-CE1 3.42Å; I162-F283 HydrophobicContact CG2-CE2 3.97Å; I162-F283 HydrophobicContact CG2-CZ 3.31Å; L166-F283 HydrophobicContact CD1-CB 3.64Å; L166-F283 HydrophobicContact CD1-CD1 3.37Å; L166-F283 HydrophobicContact CD1-CD2 4.24Å; L166-F283 HydrophobicContact CD1-CE1 4.11Å; L166-F283 HydrophobicContact CD1-CG 3.47Å; L166-F283 VanDerWaalsContact CD1-CG 3.47Å; F283-A285 PolarHBondContact O-N 2.92Å; F283-L286 HydrophobicContact CB-CB 4.42Å; F283-L286 PolarHBondContact O-N 3.28Å
284	P	57.9	Low	62.5	Low	62 Å²	62	65.9 Å²	65.9	40%	0.403	34%	0.335	S	S	.	.	T	Hydrogen-bonded Turn	trans	-63.1	-21.2	-172.1	24.6	-34.7	0	0	0	113.4
285	A	62	Low	60.5	Low	22 Å²	22	70.3 Å²	70.3	18%	0.182	36%	0.357	C	S	.	.	T	Hydrogen-bonded Turn	trans	-82.3	-10.3	178.8	0	0	0	0	0	114.5	I213 F283 L383	I213-A285 HydrophobicContact CG2-CB 3.62Å; F283-A285 PolarHBondContact O-N 2.92Å; A285-L383 WeakPolarHBondContact O-CD1 3.12Å
286	L	69.8	Low	58.7	Low	94 Å²	94	72.5 Å²	72.5	49%	0.492	37%	0.37	S	S	.	.	T	Hydrogen-bonded Turn	trans	-110.5	-17.8	-173.7	-153.1	79.2	0	0	0	113.5	F283 L383	F283-L286 HydrophobicContact CB-CB 4.42Å; F283-L286 PolarHBondContact O-N 3.28Å; L286-L383 WeakPolarHBondContact O-CG 3.41Å; L286-L383 PolarHBondContact O-N 3.05Å; L286-L383 VanDerWaalsContact O-N 3.14Å
287	I	74.4	Confident	56.8	Low	37 Å²	37	72.7 Å²	72.7	19%	0.19	38%	0.375	C	S	.	.	E	Extended strand (participates in β ladder)	trans	-122.9	129.5	-174.6	-61.4	-179.8	0	0	0	109.6	L282 S289 K380	L282-I287 HydrophobicContact CB-CD1 3.49Å; L282-I287 VanDerWaalsContact CB-CD1 3.49Å; L282-I287 HydrophobicContact CD1-CD1 3.62Å; L282-I287 HydrophobicContact CG-CD1 4.17Å; I287-S289 PolarHBondContact O-N 2.85Å; I287-K380 HydrophobicContact CG2-CB 3.64Å; I287-K380 HydrophobicContact CG2-CD 4.27Å; I287-K380 HydrophobicContact CG2-CG 3.98Å
288	Y	72.2	Confident	54.7	Low	8 Å²	8	71.4 Å²	71.4	3%	0.031	37%	0.371	C	S	.	.	E	Extended strand (participates in β ladder)	trans	-77.8	115.3	168.5	-175.5	-90.4	0	0	0	109.5	P88 Q223 L226 I227 K380 L381 F386	P88-Y288 HydrophobicContact CB-CE1 4.23Å; P88-Y288 HydrophobicContact CB-CE2 3.91Å; P88-Y288 WeakPolarHBondContact CB-OH 3.3Å; P88-Y288 HydrophobicContact CG-CE1 3.77Å; P88-Y288 HydrophobicContact CG-CE2 4.37Å; P88-Y288 WeakPolarHBondContact CG-OH 3.21Å; Q223-Y288 HydrophobicContact CB-CE2 3.71Å; Q223-Y288 HydrophobicContact CG-CD2 4.46Å; Q223-Y288 HydrophobicContact CG-CE2 3.57Å; Q223-Y288 WeakPolarHBondContact CG-OH 3.4Å; Q223-Y288 PolarHBondContact NE2-OH 2.88Å; Q223-Y288 PolarHBondContact OE1-OH 2.97Å; L226-Y288 HydrophobicContact CB-CD2 4.31Å; L226-Y288 HydrophobicContact CD1-CD2 4.16Å; I227-Y288 HydrophobicContact CG1-CE2 4.47Å; Y288-K380 WeakPolarHBondContact O-CA 3.14Å; Y288-L381 WeakPolarHBondContact CB-O 3.25Å; Y288-L381 PolarHBondContact N-O 3.32Å; Y288-L381 PolarHBondContact O-N 2.99Å; Y288-L381 VanDerWaalsContact O-N 3.08Å; Y288-F386 HydrophobicContact CD1-CZ 4.19Å; Y288-F386 HydrophobicContact CD2-CZ 4.27Å; Y288-F386 HydrophobicContact CG-CE2 4.33Å; Y288-F386 AromaticContact CG-CZ 3.95Å; Y288-F386 HydrophobicContact CG-CZ 3.95Å
289	S	71	Confident	53	Low	31 Å²	31	71.7 Å²	71.7	22%	0.217	39%	0.388	C	S	.	.	E	Extended strand (participates in β ladder)	trans	-97.8	121.2	172.4	-165.1	0	0	0	0	109.7	Q223 I287 T291	Q223-S289 PolarHBondContact NE2-O 3.34Å; I287-S289 PolarHBondContact O-N 2.85Å; S289-T291 PolarHBondContact OG-O 2.98Å
290	S	56.4	Low	51.7	Low	1 Å²	1	69.8 Å²	69.8	1%	0.007	37%	0.374	C	S	.	.	S	Bend	trans	-74.8	-40.9	179.3	78.7	0	0	0	0	111.6	M84 Q223 V379	M84-S290 WeakPolarHBondContact CE-O 3.42Å; M84-S290 WeakPolarHBondContact SD-CB 3.41Å; M84-S290 PolarHBondContact SD-OG 3.16Å; Q223-S290 PolarHBondContact NE2-O 3.18Å; S290-V379 WeakPolarHBondContact CB-O 3.35Å; S290-V379 PolarHBondContact N-O 2.91Å; S290-V379 PolarHBondContact OG-N 3.44Å; S290-V379 PolarHBondContact OG-O 2.75Å
291	T	54.5	Low	50.3	Low	28 Å²	28	69.5 Å²	69.5	17%	0.172	39%	0.391	C	S	.	.	S	Bend	trans	-117.1	156.7	-175.6	-44.6	0	0	0	0	112.3	S289 V293 G378	S289-T291 PolarHBondContact OG-O 2.98Å; T291-V293 PolarHBondContact O-N 3.04Å; T291-V293 VanDerWaalsContact O-N 3.15Å; T291-G378 VanDerWaalsContact CB-CA 3.47Å; T291-G378 VanDerWaalsContact OG1-CA 3.26Å; T291-G378 WeakPolarHBondContact OG1-CA 3.28Å
292	M	43.4	Very low	49.1	Very low	102 Å²	102	69.6 Å²	69.6	50%	0.502	39%	0.388	S	S	.	.			trans	-72	95.3	-174.4	51.4	178.4	149.4	0	0	113.2	L219 W294 L295	L219-M292 HydrophobicContact CD1-CB 3.81Å; M292-W294 PolarHBondContact O-N 3.2Å; M292-L295 HydrophobicContact CB-CB 4.31Å; M292-L295 HydrophobicContact CG-CB 4.31Å; M292-L295 HydrophobicContact SD-CB 3.6Å; M292-L295 VanDerWaalsContact SD-CB 3.6Å; M292-L295 HydrophobicContact SD-CD1 3.68Å; M292-L295 HydrophobicContact SD-CG 4.13Å
293	V	40.2	Very low	48.3	Very low	59 Å²	59	72.1 Å²	72.1	36%	0.358	41%	0.407	S	S	.	.	S	Bend	trans	-74.7	-17.9	168.6	179.9	0	0	0	0	111.7	T291	T291-V293 PolarHBondContact O-N 3.04Å; T291-V293 VanDerWaalsContact O-N 3.15Å
294	W	37	Very low	47.2	Very low	156 Å²	156	76.2 Å²	76.2	59%	0.591	43%	0.427	S	S	*	.	T	Hydrogen-bonded Turn	trans	-92.3	-15.4	-170.4	-99.2	90.3	0	0	0	116	M292	M292-W294 PolarHBondContact O-N 3.2Å
295	L	32.2	Very low	46.5	Very low	113 Å²	113	75.9 Å²	75.9	59%	0.592	43%	0.429	S	S	*	.	T	Hydrogen-bonded Turn	trans	-82.4	-28.2	-175.9	-140.3	139.9	0	0	0	112	M292 A299	M292-L295 HydrophobicContact CB-CB 4.31Å; M292-L295 HydrophobicContact CG-CB 4.31Å; M292-L295 HydrophobicContact SD-CB 3.6Å; M292-L295 VanDerWaalsContact SD-CB 3.6Å; M292-L295 HydrophobicContact SD-CD1 3.68Å; M292-L295 HydrophobicContact SD-CG 4.13Å; L295-A299 WeakPolarHBondContact O-CB 3.41Å; L295-A299 PolarHBondContact O-N 2.87Å
296	V	31.9	Very low	45.6	Very low	49 Å²	49	80.4 Å²	80.4	30%	0.297	45%	0.447	S	S	.	.	H	α-helix	trans	-77.5	-40.3	-175.1	-177.6	0	0	0	0	112.2	M298 A299 E300	V296-M298 PolarHBondContact O-N 3.36Å; V296-A299 PolarHBondContact O-N 2.89Å; V296-E300 PolarHBondContact O-N 3.34Å
297	N	33.1	Very low	44.3	Very low	136 Å²	136	85.5 Å²	85.5	73%	0.727	46%	0.459	S	S	*	.	H	α-helix	trans	-67.5	-8.7	178	-83.7	-5.1	0	0	0	115.2
298	M	33.2	Very low	42.8	Very low	133 Å²	133	92.6 Å²	92.6	66%	0.655	48%	0.484	S	S	*	.	H	α-helix	trans	-117.3	-8.9	174.9	-67.4	-142.5	147.3	0	0	113.9	V296	V296-M298 PolarHBondContact O-N 3.36Å
299	A	35.9	Very low	41.5	Very low	74 Å²	74	97.5 Å²	97.5	61%	0.612	51%	0.514	S	S	*	.	H	α-helix	trans	-84.8	-28.1	169	0	0	0	0	0	111.6	L295 V296 G301	L295-A299 WeakPolarHBondContact O-CB 3.41Å; L295-A299 PolarHBondContact O-N 2.87Å; V296-A299 PolarHBondContact O-N 2.89Å; A299-G301 PolarHBondContact O-N 3.43Å
300	E	33	Very low	40.1	Very low	116 Å²	116	100.9 Å²	100.9	54%	0.542	54%	0.538	S	S	.	.			trans	-81.7	57.2	173.2	-142.8	83.9	-179.1	0	0	111.1	V296 Q306	V296-E300 PolarHBondContact O-N 3.34Å; E300-Q306 PolarHBondContact OE1-NE2 3.13Å; E300-Q306 PolarHBondContact OE1-OE1 2.78Å
301	G	33.2	Very low	39.4	Very low	67 Å²	67	109 Å²	109	69%	0.691	57%	0.573	S	S	*	*			trans	-102.3	36.1	-174.4	0	0	0	0	0	114.4	A299	A299-G301 PolarHBondContact O-N 3.43Å
302	D	34.7	Very low	38.7	Very low	88 Å²	88	114.1 Å²	114.1	47%	0.471	60%	0.6	S	S	.	*			trans	-163.2	94.5	159.2	-153	-12.1	0	0	0	113.3	E304 A305	D302-E304 PolarHBondContact O-N 2.86Å; D302-E304 PolarHBondContact OD1-N 3.45Å; D302-A305 HydrophobicContact CB-CB 4.13Å; D302-A305 PolarHBondContact O-N 3.19Å; D302-A305 VanDerWaalsContact O-N 3.12Å
303	P	44.1	Very low	38.5	Very low	102 Å²	102	114.7 Å²	114.7	66%	0.662	61%	0.613	S	S	*	*	T	Hydrogen-bonded Turn	trans	-64.4	-7	175.8	25.5	-32.2	0	0	0	113.7
304	E	42.1	Very low	38.3	Very low	123 Å²	123	121.1 Å²	121.1	58%	0.575	64%	0.636	S	S	*	*	T	Hydrogen-bonded Turn	trans	-87.3	-21.3	173.9	-64.8	-164.3	160.4	0	0	113.9	D302 R308	D302-E304 PolarHBondContact O-N 2.86Å; D302-E304 PolarHBondContact OD1-N 3.45Å; E304-R308 WeakPolarHBondContact O-CG 3.47Å
305	A	41.8	Very low	38.1	Very low	54 Å²	54	122.8 Å²	122.8	45%	0.446	64%	0.644	S	S	.	*	H	α-helix	trans	-76.2	-41.7	-176.9	0	0	0	0	0	112.8	D302 R307 R308	D302-A305 HydrophobicContact CB-CB 4.13Å; D302-A305 PolarHBondContact O-N 3.19Å; D302-A305 VanDerWaalsContact O-N 3.12Å; A305-R307 PolarHBondContact O-N 3.42Å; A305-R308 PolarHBondContact O-N 3.39Å
306	Q	43.3	Very low	38.1	Very low	118 Å²	118	125.3 Å²	125.3	55%	0.551	66%	0.658	S	S	*	*	H	α-helix	trans	-70.5	-28.3	175.8	-91	149.1	-27.7	0	0	113.1	E300 R308 V309 S310	E300-Q306 PolarHBondContact OE1-NE2 3.13Å; E300-Q306 PolarHBondContact OE1-OE1 2.78Å; Q306-R308 VanDerWaalsContact C-N 3.29Å; Q306-R308 PolarHBondContact O-N 2.84Å; Q306-V309 PolarHBondContact O-N 3.43Å; Q306-S310 PolarHBondContact O-N 3.27Å
307	R	43.8	Very low	38.4	Very low	201 Å²	201	127.3 Å²	127.3	76%	0.758	68%	0.68	S	S	*	*	H	α-helix	trans	-68.8	-24.4	175.6	-83.1	-176.4	174.4	-173.2	-0.3	113.5	A305	A305-R307 PolarHBondContact O-N 3.42Å
308	R	42	Very low	38.6	Very low	185 Å²	185	129.5 Å²	129.5	70%	0.698	69%	0.686	S	S	*	*	H	α-helix	trans	-80.5	-27.3	178.3	-69.5	-177.6	-174.4	-161.6	4.4	112.8	E304 A305 Q306	E304-R308 WeakPolarHBondContact O-CG 3.47Å; A305-R308 PolarHBondContact O-N 3.39Å; Q306-R308 VanDerWaalsContact C-N 3.29Å; Q306-R308 PolarHBondContact O-N 2.84Å
309	V	45.2	Very low	38.5	Very low	112 Å²	112	128.1 Å²	128.1	68%	0.679	69%	0.689	S	S	*	*	H	α-helix	trans	-79.3	-35.4	179.4	-177.3	0	0	0	0	111.7	Q306	Q306-V309 PolarHBondContact O-N 3.43Å
310	S	41.1	Very low	38.4	Very low	102 Å²	102	131 Å²	131	71%	0.713	70%	0.699	S	S	*	*	H	α-helix	trans	-77.9	-16.8	176.2	-83.4	0	0	0	0	115.1	Q306	Q306-S310 PolarHBondContact O-N 3.27Å
311	K	42	Very low	38.4	Very low	170 Å²	170	132.8 Å²	132.8	74%	0.739	71%	0.708	S	S	*	*	T	Hydrogen-bonded Turn	trans	-83.4	-14.3	177.8	-102.9	-179.3	175.8	179.8	0	114.4
312	N	39.2	Very low	38.5	Very low	137 Å²	137	140.6 Å²	140.6	73%	0.733	72%	0.716	S	S	*	*	S	Bend	trans	-94.4	0.3	-177.5	-112.2	12.7	0	0	0	114.6
313	S	39.5	Very low	38.2	Very low	113 Å²	113	145.4 Å²	145.4	79%	0.79	74%	0.736	S	S	*	*	S	Bend	trans	-103.5	7.7	179.6	-158.3	0	0	0	0	113.6
314	K	36.4	Very low	37.8	Very low	194 Å²	194	146.9 Å²	146.9	84%	0.843	75%	0.749	S	S	*	*			trans	-124.4	33.3	-176.1	-136.2	176.9	-172.9	179.3	0	114.4
315	Y	33	Very low	37.3	Very low	192 Å²	192	149.1 Å²	149.1	75%	0.753	76%	0.759	S	S	*	*			trans	-101.6	95.1	164.3	-91.8	-89.7	0	0	0	108.3
316	N	32.8	Very low	36.8	Very low	165 Å²	165	152.4 Å²	152.4	88%	0.882	77%	0.769	S	S	*	*			trans	162.3	88.1	153.7	-84.3	-15.1	0	0	0	110.1
317	A	37.3	Very low	36.5	Very low	92 Å²	92	153.8 Å²	153.8	76%	0.76	79%	0.786	S	S	*	*			trans	176.2	84.6	157.1	0	0	0	0	0	107.2
318	E	36.9	Very low	35.9	Very low	182 Å²	182	150.7 Å²	150.7	85%	0.85	79%	0.789	S	S	*	*				68.1	95.7	106.5	-76.6	-175.1	159.2	0	0	115.5
319	S	31.9	Very low	35.7	Very low	104 Å²	104	146.6 Å²	146.6	73%	0.727	80%	0.795	S	S	*	*			trans	14.3	130.1	132.2	46.5	0	0	0	0	120
320	T	33.6	Very low	35.3	Very low	134 Å²	134	149.5 Å²	149.5	82%	0.822	80%	0.801	S	S	*	*				-179.8	142.2	107.2	-65	0	0	0	0	111.7
321	E	32.9	Very low	35.3	Very low	154 Å²	154	152.5 Å²	152.5	72%	0.72	81%	0.809	S	S	*	*			trans	-61.7	155	-175.4	-55.2	160.8	152.7	0	0	116.2
322	R	35	Very low	35	Very low	230 Å²	230	151.4 Å²	151.4	87%	0.868	81%	0.811	S	S	*	*				165.2	136.5	107.7	-87.7	177	-172.5	177.3	1.1	114.4
323	E	29.4	Very low	34.9	Very low	190 Å²	190	152.5 Å²	152.5	89%	0.888	82%	0.817	S	S	*	*			trans	-72.1	151.1	172.6	-64.8	164.8	128.9	0	0	113.3
324	S	34.7	Very low	34.8	Very low	133 Å²	133	150 Å²	150	93%	0.93	81%	0.809	S	S	*	*			trans	-164.7	151.4	131.8	-14.6	0	0	0	0	112.5
325	Q	30.8	Very low	35.2	Very low	170 Å²	170	144.9 Å²	144.9	79%	0.794	81%	0.811	S	S	*	*			trans	-99.4	163.1	-162.6	-118.4	173.5	-40.5	0	0	115.2
326	D	32.3	Very low	35.9	Very low	122 Å²	122	142.8 Å²	142.8	65%	0.652	81%	0.806	S	S	*	*			trans	72	123	146.3	-60.7	-21.8	0	0	0	121.8
327	T	36.2	Very low	37	Very low	147 Å²	147	138.3 Å²	138.3	90%	0.902	79%	0.788	S	S	*	*				177.1	151.8	96.3	31.2	0	0	0	0	113.5
328	V	32.7	Very low	38	Very low	137 Å²	137	142 Å²	142	83%	0.83	79%	0.789	S	S	*	*			trans	-84.5	148.2	-164.7	174.4	0	0	0	0	113.7
329	A	37.8	Very low	39.2	Very low	98 Å²	98	140.4 Å²	140.4	81%	0.81	78%	0.782	S	S	*	*			trans	-159.1	127.6	145.9	0	0	0	0	0	112.2
330	E	35.4	Very low	40.9	Very low	173 Å²	173	141.4 Å²	141.4	81%	0.808	77%	0.77	S	S	*	*			trans	-56.9	145	-178.3	-66.4	158.3	112.6	0	0	115
331	N	40.9	Very low	42.2	Very low	165 Å²	165	139.4 Å²	139.4	88%	0.882	75%	0.751	S	S	*	*				-167.2	128.2	121.3	-95	-20.8	0	0	0	113.3
332	D	35.9	Very low	43.5	Very low	147 Å²	147	135 Å²	135	79%	0.786	74%	0.741	S	S	*	*			trans	-37.8	123.7	167	-166.4	24.5	0	0	0	115.9
333	D	37.5	Very low	44.8	Very low	161 Å²	161	130 Å²	130	86%	0.861	73%	0.728	S	S	*	*			trans	179.4	113.1	135.1	-102.9	-25	0	0	0	112.4
334	G	36.7	Very low	46	Very low	59 Å²	59	125.9 Å²	125.9	61%	0.608	70%	0.704	S	S	*	*	S	Bend	trans	102.1	75.5	148.1	0	0	0	0	0	119	F336	G334-F336 PolarHBondContact O-N 2.93Å
335	G	46.5	Very low	47.1	Very low	87 Å²	87	122.6 Å²	122.6	90%	0.897	68%	0.676	S	S	*	*	S	Bend	trans	65.9	-2.9	137.2	0	0	0	0	0	120.5
336	F	47.4	Very low	48.3	Very low	149 Å²	149	118.8 Å²	118.8	65%	0.654	67%	0.668	S	S	*	*	S	Bend	trans	-119.9	113.3	169.4	-64.5	-85.4	0	0	0	106.6	G334 W340	G334-F336 PolarHBondContact O-N 2.93Å; F336-W340 HydrophobicContact CD1-CE3 4.26Å; F336-W340 HydrophobicContact CD1-CZ3 4.29Å
337	S	54.9	Low	49.3	Very low	70 Å²	70	120.6 Å²	120.6	49%	0.49	67%	0.672	S	S	.	*			trans	-66.3	144.4	-177.8	50.5	0	0	0	0	110.8	E339 W340 E341	S337-E339 PolarHBondContact O-N 2.66Å; S337-E339 VanDerWaalsContact O-N 3.13Å; S337-W340 WeakPolarHBondContact O-CA 3.4Å; S337-W340 VanDerWaalsContact O-CB 3.3Å; S337-W340 WeakPolarHBondContact O-CB 3.4Å; S337-W340 PolarHBondContact O-N 2.78Å; S337-W340 WeakPolarHBondContact OG-CB 3.47Å; S337-W340 PolarHBondContact OG-N 3.09Å; S337-E341 PolarHBondContact O-N 2.8Å
338	E	58.3	Low	50.2	Low	170 Å²	170	119.2 Å²	119.2	79%	0.794	66%	0.659	S	S	*	*	H	α-helix	trans	-54.9	-29.1	171.2	-146.5	174.9	169.9	0	0	111.2	E341 A342	E338-E341 PolarHBondContact O-N 2.94Å; E338-A342 VanDerWaalsContact O-CB 3.26Å; E338-A342 WeakPolarHBondContact O-CB 3.39Å; E338-A342 PolarHBondContact O-N 2.9Å
339	E	61.6	Low	51	Low	149 Å²	149	114.1 Å²	114.1	70%	0.696	63%	0.634	S	S	*	*	H	α-helix	trans	-66.1	-36.3	171.7	-165.3	169.2	-168.2	0	0	112.9	S337 Q343	S337-E339 PolarHBondContact O-N 2.66Å; S337-E339 VanDerWaalsContact O-N 3.13Å; E339-Q343 WeakPolarHBondContact O-CB 3.5Å; E339-Q343 PolarHBondContact O-N 3.39Å
340	W	67.4	Low	51.5	Low	124 Å²	124	115 Å²	115	47%	0.47	63%	0.631	S	S	.	*	H	α-helix	trans	-70.6	-38.5	175	-174.8	88.6	0	0	0	111.8	F336 S337 Q343 R344	F336-W340 HydrophobicContact CD1-CE3 4.26Å; F336-W340 HydrophobicContact CD1-CZ3 4.29Å; S337-W340 WeakPolarHBondContact O-CA 3.4Å; S337-W340 VanDerWaalsContact O-CB 3.3Å; S337-W340 WeakPolarHBondContact O-CB 3.4Å; S337-W340 PolarHBondContact O-N 2.78Å; S337-W340 WeakPolarHBondContact OG-CB 3.47Å; S337-W340 PolarHBondContact OG-N 3.09Å; W340-Q343 PolarHBondContact O-N 2.96Å; W340-R344 WeakPolarHBondContact O-CB 3.16Å; W340-R344 PolarHBondContact O-N 3.29Å
341	E	60.9	Low	51.9	Low	93 Å²	93	114.8 Å²	114.8	44%	0.435	63%	0.63	S	S	.	*	H	α-helix	trans	-69.6	-41.6	174.6	-68	-164.4	146.6	0	0	111.9	S337 E338 Q343 R344 D345	S337-E341 PolarHBondContact O-N 2.8Å; E338-E341 PolarHBondContact O-N 2.94Å; E341-Q343 VanDerWaalsContact C-N 3.34Å; E341-Q343 PolarHBondContact O-N 2.88Å; E341-R344 PolarHBondContact O-N 3.5Å; E341-D345 WeakPolarHBondContact O-CB 3.13Å; E341-D345 PolarHBondContact O-N 3.32Å
342	A	61.8	Low	52	Low	62 Å²	62	117 Å²	117	51%	0.512	63%	0.626	S	S	.	*	H	α-helix	trans	-66	-34.6	174.1	0	0	0	0	0	112.4	E338 S346	E338-A342 VanDerWaalsContact O-CB 3.26Å; E338-A342 WeakPolarHBondContact O-CB 3.39Å; E338-A342 PolarHBondContact O-N 2.9Å; A342-S346 WeakPolarHBondContact O-CB 3.27Å; A342-S346 PolarHBondContact O-N 3.38Å; A342-S346 PolarHBondContact O-OG 3.01Å
343	Q	62	Low	52.5	Low	124 Å²	124	114.4 Å²	114.4	58%	0.579	62%	0.619	S	S	*	*	H	α-helix	trans	-73.2	-34.7	175.1	-167	172.8	0.1	0	0	112.1	E339 W340 E341 S346 H347	E339-Q343 WeakPolarHBondContact O-CB 3.5Å; E339-Q343 PolarHBondContact O-N 3.39Å; W340-Q343 PolarHBondContact O-N 2.96Å; E341-Q343 VanDerWaalsContact C-N 3.34Å; E341-Q343 PolarHBondContact O-N 2.88Å; Q343-S346 WeakPolarHBondContact CA-OG 3.3Å; Q343-S346 PolarHBondContact O-OG 2.79Å; Q343-S346 VanDerWaalsContact O-OG 3.11Å; Q343-H347 WeakPolarHBondContact O-CB 3.45Å; Q343-H347 PolarHBondContact O-N 3.43Å
344	R	54.6	Low	53.3	Low	103 Å²	103	109 Å²	109	39%	0.389	59%	0.592	S	S	.	*	H	α-helix	trans	-65.7	-48.8	171.3	-172.5	-166.8	71.5	-169.6	-6.7	110.8	W340 E341 S346 H347 L348	W340-R344 WeakPolarHBondContact O-CB 3.16Å; W340-R344 PolarHBondContact O-N 3.29Å; E341-R344 PolarHBondContact O-N 3.5Å; R344-S346 VanDerWaalsContact C-N 3.34Å; R344-S346 PolarHBondContact O-N 2.82Å; R344-H347 PolarHBondContact O-N 3.31Å; R344-L348 HydrophobicContact CG-CD1 3.85Å; R344-L348 VanDerWaalsContact O-CB 3.3Å; R344-L348 WeakPolarHBondContact O-CB 3.44Å; R344-L348 PolarHBondContact O-N 2.99Å
345	D	57.1	Low	54.2	Low	64 Å²	64	111.5 Å²	111.5	34%	0.342	60%	0.598	S	S	.	*	H	α-helix	trans	-74.9	-23.9	-174.2	-70.8	4.9	0	0	0	112.3	E341 G349	E341-D345 WeakPolarHBondContact O-CB 3.13Å; E341-D345 PolarHBondContact O-N 3.32Å; D345-G349 VanDerWaalsContact O-CA 3.26Å; D345-G349 WeakPolarHBondContact O-CA 3.37Å; D345-G349 PolarHBondContact O-N 2.91Å
346	S	57.3	Low	54.5	Low	90 Å²	90	114.6 Å²	114.6	63%	0.629	59%	0.589	S	S	*	*	H	α-helix	trans	-77.1	-27.3	170.1	57.2	0	0	0	0	114.1	A342 Q343 R344	A342-S346 WeakPolarHBondContact O-CB 3.27Å; A342-S346 PolarHBondContact O-N 3.38Å; A342-S346 PolarHBondContact O-OG 3.01Å; Q343-S346 WeakPolarHBondContact CA-OG 3.3Å; Q343-S346 PolarHBondContact O-OG 2.79Å; Q343-S346 VanDerWaalsContact O-OG 3.11Å; R344-S346 VanDerWaalsContact C-N 3.34Å; R344-S346 PolarHBondContact O-N 2.82Å
347	H	52.3	Low	54.7	Low	160 Å²	160	110.2 Å²	110.2	74%	0.741	58%	0.577	S	S	*	*	H	α-helix	trans	-93.6	-24.2	176.8	-108.9	-84.9	0	0	0	114.2	Q343 R344	Q343-H347 WeakPolarHBondContact O-CB 3.45Å; Q343-H347 PolarHBondContact O-N 3.43Å; R344-H347 PolarHBondContact O-N 3.31Å
348	L	54.9	Low	54.4	Low	118 Å²	118	115.5 Å²	115.5	62%	0.618	59%	0.586	S	S	*	*	H	α-helix	trans	-123.4	-1.3	-171.7	-70.8	142.7	0	0	0	114.2	R344	R344-L348 HydrophobicContact CG-CD1 3.85Å; R344-L348 VanDerWaalsContact O-CB 3.3Å; R344-L348 WeakPolarHBondContact O-CB 3.44Å; R344-L348 PolarHBondContact O-N 2.99Å
349	G	49.2	Very low	54.2	Low	30 Å²	30	109.8 Å²	109.8	31%	0.309	57%	0.568	S	S	.	*			trans	67	165.3	-175.3	0	0	0	0	0	112.6	D345 H351	D345-G349 VanDerWaalsContact O-CA 3.26Å; D345-G349 WeakPolarHBondContact O-CA 3.37Å; D345-G349 PolarHBondContact O-N 2.91Å; G349-H351 VanDerWaalsContact C-N 3.34Å; G349-H351 PolarHBondContact O-N 2.98Å
350	P	48.3	Very low	53.7	Low	117 Å²	117	105 Å²	105	76%	0.76	55%	0.554	S	S	*	*			trans	-69.8	87.7	-179.2	27	-32.6	0	0	0	110.8	R352	P350-R352 VanDerWaalsContact C-N 3.26Å; P350-R352 PolarHBondContact O-N 3.22Å
351	H	44.6	Very low	52.9	Low	169 Å²	169	104.1 Å²	104.1	78%	0.782	56%	0.562	S	S	*	*			trans	-81.7	71	173	-101.1	-49.5	0	0	0	110.8	G349 S353	G349-H351 VanDerWaalsContact C-N 3.34Å; G349-H351 PolarHBondContact O-N 2.98Å; H351-S353 PolarHBondContact O-N 3.42Å
352	R	42.5	Very low	52.2	Low	212 Å²	212	106.7 Å²	106.7	80%	0.8	57%	0.574	S	S	*	*			trans	-80	105.1	161.5	-139.9	176.9	-172.3	-178.2	3.3	106.8	P350 T354	P350-R352 VanDerWaalsContact C-N 3.26Å; P350-R352 PolarHBondContact O-N 3.22Å; R352-T354 HydrophobicContact CB-CG2 4.49Å; R352-T354 PolarHBondContact O-N 3.44Å
353	S	46	Very low	51.4	Low	91 Å²	91	110.3 Å²	110.3	64%	0.636	58%	0.58	S	S	*	*			trans	-68.9	74	173.6	49.5	0	0	0	0	109.9	H351	H351-S353 PolarHBondContact O-N 3.42Å
354	T	55.4	Low	50.5	Low	49 Å²	49	109.5 Å²	109.5	30%	0.301	58%	0.579	S	S	.	*			trans	-62.4	150	173.5	54	0	0	0	0	109.5	R352 E356 S357 R358	R352-T354 HydrophobicContact CB-CG2 4.49Å; R352-T354 PolarHBondContact O-N 3.44Å; T354-E356 PolarHBondContact O-N 3.03Å; T354-E356 VanDerWaalsContact O-N 3.08Å; T354-S357 PolarHBondContact O-N 2.87Å; T354-S357 PolarHBondContact OG1-N 2.91Å; T354-S357 VanDerWaalsContact OG1-N 3.15Å; T354-S357 PolarHBondContact OG1-OG 3.46Å; T354-R358 PolarHBondContact O-N 3.46Å
355	P	55.3	Low	49.7	Very low	110 Å²	110	107.9 Å²	107.9	71%	0.714	58%	0.584	S	S	*	*	H	α-helix	trans	-53.5	-27.9	172	19.9	-30.4	0	0	0	111.7	R358 A359	P355-R358 PolarHBondContact O-N 2.96Å; P355-A359 VanDerWaalsContact O-CB 3.27Å; P355-A359 WeakPolarHBondContact O-CB 3.13Å; P355-A359 PolarHBondContact O-N 3.37Å
356	E	51.9	Low	48.6	Very low	152 Å²	152	107.9 Å²	107.9	71%	0.71	59%	0.589	S	S	*	*	H	α-helix	trans	-69.9	-38	171.8	-67.7	172.5	159	0	0	113.7	T354 A359 A360	T354-E356 PolarHBondContact O-N 3.03Å; T354-E356 VanDerWaalsContact O-N 3.08Å; E356-A359 PolarHBondContact O-N 3.06Å; E356-A360 VanDerWaalsContact O-CB 3.24Å; E356-A360 WeakPolarHBondContact O-CB 3.22Å; E356-A360 PolarHBondContact O-N 2.98Å
357	S	51.5	Low	47.5	Very low	57 Å²	57	106.6 Å²	106.6	40%	0.399	58%	0.58	S	S	.	*	H	α-helix	trans	-70.4	-32.4	172.1	-75.3	0	0	0	0	112.1	T354 V361	T354-S357 PolarHBondContact O-N 2.87Å; T354-S357 PolarHBondContact OG1-N 2.91Å; T354-S357 VanDerWaalsContact OG1-N 3.15Å; T354-S357 PolarHBondContact OG1-OG 3.46Å; S357-V361 WeakPolarHBondContact O-CB 3.4Å; S357-V361 WeakPolarHBondContact O-CG2 3.34Å; S357-V361 PolarHBondContact O-N 3.47Å
358	R	50.5	Low	46.7	Very low	181 Å²	181	104.4 Å²	104.4	68%	0.683	57%	0.572	S	S	*	*	H	α-helix	trans	-67.5	-41.9	169.3	-105.3	-177.8	-176.9	146.7	1.1	111.5	T354 P355 V361 Q362	T354-R358 PolarHBondContact O-N 3.46Å; P355-R358 PolarHBondContact O-N 2.96Å; R358-V361 PolarHBondContact O-N 3.35Å; R358-Q362 WeakPolarHBondContact O-CB 3.43Å; R358-Q362 PolarHBondContact O-N 2.95Å
359	A	52.8	Low	45.8	Very low	51 Å²	51	103.1 Å²	103.1	42%	0.421	57%	0.566	S	S	.	*	H	α-helix	trans	-64.7	-41.1	175.4	0	0	0	0	0	111.2	P355 E356 Q362 E363	P355-A359 VanDerWaalsContact O-CB 3.27Å; P355-A359 WeakPolarHBondContact O-CB 3.13Å; P355-A359 PolarHBondContact O-N 3.37Å; E356-A359 PolarHBondContact O-N 3.06Å; A359-Q362 CarbonylContact O-C 3.53Å; A359-Q362 PolarHBondContact O-N 3.3Å; A359-E363 WeakPolarHBondContact O-CB 3.27Å; A359-E363 PolarHBondContact O-N 3.27Å
360	A	51.8	Low	45.2	Very low	49 Å²	49	105.7 Å²	105.7	41%	0.405	58%	0.584	S	S	.	*	H	α-helix	trans	-69.5	-36.2	177	0	0	0	0	0	112.6	E356 Q362 E363 L364	E356-A360 VanDerWaalsContact O-CB 3.24Å; E356-A360 WeakPolarHBondContact O-CB 3.22Å; E356-A360 PolarHBondContact O-N 2.98Å; A360-Q362 VanDerWaalsContact C-N 3.34Å; A360-E363 PolarHBondContact O-N 3.27Å; A360-L364 VanDerWaalsContact O-CB 3.29Å; A360-L364 WeakPolarHBondContact O-CB 3.3Å; A360-L364 PolarHBondContact O-N 3.49Å
361	V	50.9	Low	44.4	Very low	104 Å²	104	103.1 Å²	103.1	63%	0.63	58%	0.579	S	S	*	*	H	α-helix	trans	-70	-34	172.1	170.8	0	0	0	0	111.2	S357 R358 S365	S357-V361 WeakPolarHBondContact O-CB 3.4Å; S357-V361 WeakPolarHBondContact O-CG2 3.34Å; S357-V361 PolarHBondContact O-N 3.47Å; R358-V361 PolarHBondContact O-N 3.35Å; V361-S365 WeakPolarHBondContact O-CB 3.2Å; V361-S365 PolarHBondContact O-N 3.02Å
362	Q	46.4	Very low	44	Very low	147 Å²	147	99.2 Å²	99.2	69%	0.687	56%	0.561	S	S	*	*	H	α-helix	trans	-72.3	-36.9	174.1	-165.3	154.4	-11.8	0	0	111.4	R358 A359 A360 S365 S366	R358-Q362 WeakPolarHBondContact O-CB 3.43Å; R358-Q362 PolarHBondContact O-N 2.95Å; A359-Q362 CarbonylContact O-C 3.53Å; A359-Q362 PolarHBondContact O-N 3.3Å; A360-Q362 VanDerWaalsContact C-N 3.34Å; Q362-S365 PolarHBondContact O-N 3.23Å; Q362-S366 PolarHBondContact O-N 3.24Å; Q362-S366 PolarHBondContact O-OG 3.28Å
363	E	44	Very low	43.7	Very low	139 Å²	139	94.5 Å²	94.5	65%	0.65	55%	0.552	S	S	*	*	H	α-helix	trans	-66	-42.3	171.6	-113.5	-175.9	164.9	0	0	111.4	A359 A360 S365 S366 S367	A359-E363 WeakPolarHBondContact O-CB 3.27Å; A359-E363 PolarHBondContact O-N 3.27Å; A360-E363 PolarHBondContact O-N 3.27Å; E363-S365 VanDerWaalsContact C-N 3.32Å; E363-S365 PolarHBondContact O-N 2.88Å; E363-S366 WeakPolarHBondContact CA-OG 3.32Å; E363-S366 CarbonylContact O-C 3.25Å; E363-S366 PolarHBondContact O-N 2.99Å; E363-S366 PolarHBondContact O-OG 2.97Å; E363-S367 WeakPolarHBondContact O-CB 3.47Å; E363-S367 PolarHBondContact O-N 2.96Å; E363-S367 PolarHBondContact O-OG 3.38Å
364	L	42.3	Very low	43.6	Very low	106 Å²	106	92.8 Å²	92.8	56%	0.555	54%	0.539	S	S	*	.	H	α-helix	trans	-64.4	-37.4	175.6	-143.3	87.1	0	0	0	111	A360 S367 I368	A360-L364 VanDerWaalsContact O-CB 3.29Å; A360-L364 WeakPolarHBondContact O-CB 3.3Å; A360-L364 PolarHBondContact O-N 3.49Å; L364-S367 WeakPolarHBondContact CA-OG 3.42Å; L364-S367 PolarHBondContact O-N 3.47Å; L364-S367 PolarHBondContact O-OG 2.92Å; L364-S367 VanDerWaalsContact O-OG 3.11Å; L364-I368 HydrophobicContact CD2-CD1 4.36Å; L364-I368 HydrophobicContact CG-CD1 4.4Å; L364-I368 VanDerWaalsContact O-CB 3.29Å; L364-I368 WeakPolarHBondContact O-CB 3.4Å; L364-I368 WeakPolarHBondContact O-CD1 3.43Å; L364-I368 WeakPolarHBondContact O-CG1 3.4Å; L364-I368 PolarHBondContact O-N 3.18Å
365	S	37.8	Very low	43	Very low	69 Å²	69	95.4 Å²	95.4	48%	0.483	55%	0.547	S	S	.	.	H	α-helix	trans	-69.1	-36	174.3	-170.9	0	0	0	0	111.8	V361 Q362 E363 L369	V361-S365 WeakPolarHBondContact O-CB 3.2Å; V361-S365 PolarHBondContact O-N 3.02Å; Q362-S365 PolarHBondContact O-N 3.23Å; E363-S365 VanDerWaalsContact C-N 3.32Å; E363-S365 PolarHBondContact O-N 2.88Å; S365-L369 WeakPolarHBondContact O-CB 3.27Å; S365-L369 WeakPolarHBondContact O-CD1 3.44Å; S365-L369 VanDerWaalsContact O-CG 3.25Å; S365-L369 WeakPolarHBondContact O-CG 3.48Å; S365-L369 PolarHBondContact O-N 2.72Å
366	S	35.4	Very low	42.6	Very low	64 Å²	64	94.3 Å²	94.3	45%	0.448	53%	0.533	S	S	.	.	H	α-helix	trans	-76.9	-26.4	173.1	40.6	0	0	0	0	113.4	Q362 E363 L369 A370	Q362-S366 PolarHBondContact O-N 3.24Å; Q362-S366 PolarHBondContact O-OG 3.28Å; E363-S366 WeakPolarHBondContact CA-OG 3.32Å; E363-S366 CarbonylContact O-C 3.25Å; E363-S366 PolarHBondContact O-N 2.99Å; E363-S366 PolarHBondContact O-OG 2.97Å; S366-L369 CarbonylContact O-C 3.49Å; S366-L369 PolarHBondContact O-N 3.34Å; S366-A370 WeakPolarHBondContact O-CB 3.33Å; S366-A370 PolarHBondContact O-N 3.48Å
367	S	33.1	Very low	42.6	Very low	64 Å²	64	94 Å²	94	45%	0.448	53%	0.525	S	S	.	.	H	α-helix	trans	-80.1	-32	175.3	76.3	0	0	0	0	111.8	E363 L364 L369 A370 G371	E363-S367 WeakPolarHBondContact O-CB 3.47Å; E363-S367 PolarHBondContact O-N 2.96Å; E363-S367 PolarHBondContact O-OG 3.38Å; L364-S367 WeakPolarHBondContact CA-OG 3.42Å; L364-S367 PolarHBondContact O-N 3.47Å; L364-S367 PolarHBondContact O-OG 2.92Å; L364-S367 VanDerWaalsContact O-OG 3.11Å; S367-L369 VanDerWaalsContact C-N 3.27Å; S367-A370 PolarHBondContact O-N 3.38Å; S367-G371 PolarHBondContact O-N 3.28Å
368	I	35.9	Very low	42.8	Very low	113 Å²	113	92.1 Å²	92.1	58%	0.579	51%	0.514	S	S	*	.	H	α-helix	trans	-66.5	-32	168.2	-69.5	164.6	0	0	0	110.5	L364	L364-I368 HydrophobicContact CD2-CD1 4.36Å; L364-I368 HydrophobicContact CG-CD1 4.4Å; L364-I368 VanDerWaalsContact O-CB 3.29Å; L364-I368 WeakPolarHBondContact O-CB 3.4Å; L364-I368 WeakPolarHBondContact O-CD1 3.43Å; L364-I368 WeakPolarHBondContact O-CG1 3.4Å; L364-I368 PolarHBondContact O-N 3.18Å
369	L	35.9	Very low	43.3	Very low	92 Å²	92	85.3 Å²	85.3	48%	0.482	49%	0.493	S	S	.	.	T	Hydrogen-bonded Turn	trans	-83.2	-11.4	172	-71.3	168.6	0	0	0	114.4	S365 S366 S367 R377	S365-L369 WeakPolarHBondContact O-CB 3.27Å; S365-L369 WeakPolarHBondContact O-CD1 3.44Å; S365-L369 VanDerWaalsContact O-CG 3.25Å; S365-L369 WeakPolarHBondContact O-CG 3.48Å; S365-L369 PolarHBondContact O-N 2.72Å; S366-L369 CarbonylContact O-C 3.49Å; S366-L369 PolarHBondContact O-N 3.34Å; S367-L369 VanDerWaalsContact C-N 3.27Å; L369-R377 PolarHBondContact O-NH2 3.37Å
370	A	37	Very low	44.1	Very low	83 Å²	83	88.1 Å²	88.1	69%	0.686	50%	0.496	S	S	*	.	T	Hydrogen-bonded Turn	trans	-103.8	-13.7	178.7	0	0	0	0	0	113.1	S366 S367	S366-A370 WeakPolarHBondContact O-CB 3.33Å; S366-A370 PolarHBondContact O-N 3.48Å; S367-A370 PolarHBondContact O-N 3.38Å
371	G	31.9	Very low	45.1	Very low	64 Å²	64	86.6 Å²	86.6	66%	0.66	48%	0.48	S	S	*	.	S	Bend	trans	-95	-0	171.3	0	0	0	0	0	114.4	S367 D373	S367-G371 PolarHBondContact O-N 3.28Å; G371-D373 PolarHBondContact O-N 3.43Å
372	E	35.7	Very low	46.3	Very low	86 Å²	86	83.1 Å²	83.1	40%	0.402	47%	0.465	S	S	.	.	S	Bend	trans	-73.2	118.7	168.1	-78.9	175.6	128.7	0	0	108.7	P374	E372-P374 VanDerWaalsContact O-N 3.14Å
373	D	37.3	Very low	48	Very low	113 Å²	113	76.6 Å²	76.6	60%	0.604	44%	0.435	S	S	*	.			trans	-48.7	123	172	-78.7	-43.1	0	0	0	109	G371 E375 E376	G371-D373 PolarHBondContact O-N 3.43Å; D373-E375 PolarHBondContact O-N 2.89Å; D373-E376 PolarHBondContact O-N 2.99Å
374	P	43.1	Very low	50	Low	56 Å²	56	71.4 Å²	71.4	36%	0.364	42%	0.419	S	S	.	.	G	3₁₀ helix	trans	-59.4	-12.8	-177.5	21.4	-32.4	0	0	0	113	Y77 E372 E376 R377	Y77-P374 HydrophobicContact CD2-CB 4.42Å; Y77-P374 HydrophobicContact CD2-CG 4.26Å; Y77-P374 HydrophobicContact CE1-CG 4.25Å; Y77-P374 HydrophobicContact CE2-CB 4.25Å; Y77-P374 HydrophobicContact CE2-CG 3.62Å; E372-P374 VanDerWaalsContact O-N 3.14Å; P374-E376 PolarHBondContact O-N 3.3Å; P374-R377 PolarHBondContact O-N 3.05Å
375	E	41.5	Very low	52.1	Low	103 Å²	103	67.3 Å²	67.3	48%	0.481	40%	0.398	S	S	.	.	G	3₁₀ helix	trans	-63.6	-22.4	170.8	-65.4	-149.7	130.2	0	0	114.5	Y77 K80 D373	Y77-E375 HydrophobicContact CE1-CG 3.67Å; K80-E375 IonicContact NZ-OE1 3.87Å; K80-E375 PolarHBondContact NZ-OE1 2.87Å; K80-E375 IonicContact NZ-OE2 2.77Å; D373-E375 PolarHBondContact O-N 2.89Å
376	E	48.3	Very low	54.7	Low	88 Å²	88	64.1 Å²	64.1	41%	0.411	38%	0.375	S	S	.	.	G	3₁₀ helix	trans	-86.1	-13.1	-179.8	-59.8	-160.4	156.8	0	0	113.5	D373 P374 G378	D373-E376 PolarHBondContact O-N 2.99Å; P374-E376 PolarHBondContact O-N 3.3Å; E376-G378 PolarHBondContact O-N 3.03Å
377	R	51.2	Low	57.4	Low	146 Å²	146	62.1 Å²	62.1	55%	0.551	36%	0.359	S	S	*	.			trans	-75.6	72.8	175.8	-71.5	-173.4	177.1	171.1	4.7	111	H81 L369 P374 V379	H81-R377 PolarHBondContact NE2-O 2.89Å; L369-R377 PolarHBondContact O-NH2 3.37Å; P374-R377 PolarHBondContact O-N 3.05Å; R377-V379 PolarHBondContact O-N 2.9Å
378	G	55.4	Low	60.3	Low	17 Å²	17	60.6 Å²	60.6	18%	0.175	35%	0.345	C	S	.	.			trans	-57.3	136.5	172.7	0	0	0	0	0	112.2	T291 E376	T291-G378 VanDerWaalsContact CB-CA 3.47Å; T291-G378 VanDerWaalsContact OG1-CA 3.26Å; T291-G378 WeakPolarHBondContact OG1-CA 3.28Å; E376-G378 PolarHBondContact O-N 3.03Å
379	V	61.5	Low	63.2	Low	37 Å²	37	55.2 Å²	55.2	22%	0.224	32%	0.317	C	S	.	.			trans	-77.9	131	174.4	-173.7	0	0	0	0	109.2	H81 L85 S290 R377	H81-V379 HydrophobicContact CB-CG2 3.76Å; L85-V379 HydrophobicContact CD1-CB 4.42Å; L85-V379 HydrophobicContact CD1-CG1 3.68Å; L85-V379 HydrophobicContact CD2-CB 4.28Å; L85-V379 HydrophobicContact CD2-CG1 4.02Å; L85-V379 HydrophobicContact CG-CB 4.35Å; L85-V379 HydrophobicContact CG-CG1 4.08Å; S290-V379 WeakPolarHBondContact CB-O 3.35Å; S290-V379 PolarHBondContact N-O 2.91Å; S290-V379 PolarHBondContact OG-N 3.44Å; S290-V379 PolarHBondContact OG-O 2.75Å; R377-V379 PolarHBondContact O-N 2.9Å
380	K	70.4	Confident	66	Low	111 Å²	111	50.9 Å²	50.9	48%	0.483	30%	0.295	S	S	.	.	E	Extended strand (participates in β ladder)	trans	-104.5	124.1	177.7	-71.7	177.3	-172.9	172.5	0	108.7	I287 Y288	I287-K380 HydrophobicContact CG2-CB 3.64Å; I287-K380 HydrophobicContact CG2-CD 4.27Å; I287-K380 HydrophobicContact CG2-CG 3.98Å; Y288-K380 WeakPolarHBondContact O-CA 3.14Å
381	L	71.2	Confident	68.8	Low	16 Å²	16	47.2 Å²	47.2	8%	0.084	26%	0.263	C	S	.	.	E	Extended strand (participates in β ladder)	trans	-120.5	139.2	176.5	-168.9	64.9	0	0	0	109.3	L85 V89 Y288 D385 F386	L85-L381 HydrophobicContact CD2-CB 3.9Å; L85-L381 HydrophobicContact CD2-CD2 4.14Å; V89-L381 HydrophobicContact CG2-CD2 4.03Å; Y288-L381 WeakPolarHBondContact CB-O 3.25Å; Y288-L381 PolarHBondContact N-O 3.32Å; Y288-L381 PolarHBondContact O-N 2.99Å; Y288-L381 VanDerWaalsContact O-N 3.08Å; L381-D385 WeakPolarHBondContact CD1-OD2 3.1Å; L381-D385 HydrophobicContact CG-CB 4.42Å; L381-F386 HydrophobicContact CB-CE2 3.98Å; L381-F386 HydrophobicContact CD2-CD2 4.19Å; L381-F386 HydrophobicContact CD2-CE2 3.46Å; L381-F386 VanDerWaalsContact CD2-CE2 3.46Å; L381-F386 HydrophobicContact CD2-CZ 3.94Å; L381-F386 HydrophobicContact CG-CD2 4.47Å; L381-F386 HydrophobicContact CG-CE2 3.79Å
382	G	77.6	Confident	71.8	Confident	31 Å²	31	44.1 Å²	44.1	32%	0.32	23%	0.232	S	C	.	.	E	Extended strand (participates in β ladder)	trans	-68.4	137.3	177.6	0	0	0	0	0	110.3	G384 D385 F386	G382-G384 PolarHBondContact O-N 3.5Å; G382-D385 PolarHBondContact O-N 3.02Å; G382-F386 WeakPolarHBondContact O-CD2 3.46Å
383	L	81.8	Confident	74.6	Confident	10 Å²	10	40 Å²	40	5%	0.052	21%	0.213	C	C	.	.	H	α-helix	trans	-63.1	-23.1	175.2	-62.1	173.5	0	0	0	112.5	L226 A285 L286 D385 F386 I387	L226-L383 HydrophobicContact CB-CD2 3.99Å; L226-L383 HydrophobicContact CD2-CD1 3.63Å; L226-L383 HydrophobicContact CD2-CD2 4.1Å; L226-L383 HydrophobicContact CD2-CG 4.45Å; L226-L383 HydrophobicContact CG-CD2 4.5Å; A285-L383 WeakPolarHBondContact O-CD1 3.12Å; L286-L383 WeakPolarHBondContact O-CG 3.41Å; L286-L383 PolarHBondContact O-N 3.05Å; L286-L383 VanDerWaalsContact O-N 3.14Å; L383-D385 VanDerWaalsContact C-N 3.26Å; L383-D385 PolarHBondContact O-N 2.92Å; L383-F386 WeakPolarHBondContact O-CB 3.26Å; L383-F386 PolarHBondContact O-N 3.08Å; L383-I387 VanDerWaalsContact O-CG1 3.31Å; L383-I387 WeakPolarHBondContact O-CG1 3.44Å; L383-I387 PolarHBondContact O-N 2.73Å; L383-I387 VanDerWaalsContact O-N 3.08Å
384	G	85.2	Confident	77.3	Confident	30 Å²	30	34.7 Å²	34.7	31%	0.309	18%	0.184	S	C	.	.	H	α-helix	trans	-53.5	-43.7	173.3	0	0	0	0	0	112.2	G382 F386 I387 F388	G382-G384 PolarHBondContact O-N 3.5Å; G384-F386 PolarHBondContact O-N 3.35Å; G384-I387 WeakPolarHBondContact O-CB 3.18Å; G384-I387 PolarHBondContact O-N 2.95Å; G384-I387 VanDerWaalsContact O-N 3.14Å; G384-F388 WeakPolarHBondContact O-CD2 3.19Å; G384-F388 PolarHBondContact O-N 3.35Å
385	D	87.4	Confident	79.7	Confident	21 Å²	21	32.6 Å²	32.6	11%	0.112	17%	0.169	C	C	.	.	H	α-helix	trans	-61.1	-45.4	-179.7	-61.2	-19.7	0	0	0	111	L381 G382 L383 I387 F388 Y389	L381-D385 WeakPolarHBondContact CD1-OD2 3.1Å; L381-D385 HydrophobicContact CG-CB 4.42Å; G382-D385 PolarHBondContact O-N 3.02Å; L383-D385 VanDerWaalsContact C-N 3.26Å; L383-D385 PolarHBondContact O-N 2.92Å; D385-I387 VanDerWaalsContact C-N 3.31Å; D385-I387 PolarHBondContact O-N 2.59Å; D385-F388 PolarHBondContact O-N 3.05Å; D385-Y389 HydrophobicContact CB-CD2 4.4Å; D385-Y389 HydrophobicContact CB-CE2 3.77Å; D385-Y389 WeakPolarHBondContact O-CB 3.49Å; D385-Y389 WeakPolarHBondContact O-CD2 3.49Å; D385-Y389 PolarHBondContact O-N 3.37Å
386	F	91.6	Very high	82.2	Confident	1 Å²	1	27.7 Å²	27.7	0%	0.004	15%	0.146	C	C	.	.	H	α-helix	trans	-58.4	-44	175.9	-68.4	-109.3	0	0	0	111.7	P88 V89 C92 Y288 L381 G382 L383 G384 S390	P88-F386 HydrophobicContact CB-CE1 3.89Å; P88-F386 HydrophobicContact CB-CZ 4.4Å; P88-F386 HydrophobicContact CG-CE1 4.17Å; P88-F386 HydrophobicContact CG-CZ 4.31Å; V89-F386 HydrophobicContact CB-CD1 4.41Å; V89-F386 HydrophobicContact CB-CE1 4.18Å; V89-F386 HydrophobicContact CG2-CD1 3.79Å; V89-F386 HydrophobicContact CG2-CD2 4.5Å; V89-F386 HydrophobicContact CG2-CE1 3.38Å; V89-F386 HydrophobicContact CG2-CE2 4.17Å; V89-F386 HydrophobicContact CG2-CG 4.33Å; V89-F386 HydrophobicContact CG2-CZ 3.59Å; C92-F386 HydrophobicContact CB-CD1 4.15Å; Y288-F386 HydrophobicContact CD1-CZ 4.19Å; Y288-F386 HydrophobicContact CD2-CZ 4.27Å; Y288-F386 HydrophobicContact CG-CE2 4.33Å; Y288-F386 AromaticContact CG-CZ 3.95Å; Y288-F386 HydrophobicContact CG-CZ 3.95Å; L381-F386 HydrophobicContact CB-CE2 3.98Å; L381-F386 HydrophobicContact CD2-CD2 4.19Å; L381-F386 HydrophobicContact CD2-CE2 3.46Å; L381-F386 VanDerWaalsContact CD2-CE2 3.46Å; L381-F386 HydrophobicContact CD2-CZ 3.94Å; L381-F386 HydrophobicContact CG-CD2 4.47Å; L381-F386 HydrophobicContact CG-CE2 3.79Å; G382-F386 WeakPolarHBondContact O-CD2 3.46Å; L383-F386 WeakPolarHBondContact O-CB 3.26Å; L383-F386 PolarHBondContact O-N 3.08Å; G384-F386 PolarHBondContact O-N 3.35Å; F386-S390 WeakPolarHBondContact O-CB 3.42Å; F386-S390 PolarHBondContact O-N 3.44Å; F386-S390 PolarHBondContact O-OG 2.92Å
387	I	93.2	Very high	84.3	Confident	23 Å²	23	23.6 Å²	23.6	12%	0.118	13%	0.128	C	C	.	.	H	α-helix	trans	-63	-50.3	179.8	-64.6	164.5	0	0	0	109.5	M233 A234 F237 L383 G384 D385 S390 V391	M233-I387 HydrophobicContact CB-CD1 3.84Å; M233-I387 HydrophobicContact CB-CG1 4Å; M233-I387 HydrophobicContact CB-CG2 4.27Å; M233-I387 HydrophobicContact CG-CD1 4.26Å; A234-I387 HydrophobicContact CB-CG2 4.4Å; F237-I387 HydrophobicContact CD2-CG2 3.72Å; F237-I387 HydrophobicContact CE2-CG2 3.81Å; L383-I387 VanDerWaalsContact O-CG1 3.31Å; L383-I387 WeakPolarHBondContact O-CG1 3.44Å; L383-I387 PolarHBondContact O-N 2.73Å; L383-I387 VanDerWaalsContact O-N 3.08Å; G384-I387 WeakPolarHBondContact O-CB 3.18Å; G384-I387 PolarHBondContact O-N 2.95Å; G384-I387 VanDerWaalsContact O-N 3.14Å; D385-I387 VanDerWaalsContact C-N 3.31Å; D385-I387 PolarHBondContact O-N 2.59Å; I387-S390 PolarHBondContact O-N 2.93Å; I387-V391 HydrophobicContact CG2-CG2 4.29Å; I387-V391 VanDerWaalsContact O-CG2 3.25Å; I387-V391 WeakPolarHBondContact O-CG2 3.24Å; I387-V391 PolarHBondContact O-N 3.5Å
388	F	94	Very high	86.2	Confident	32 Å²	32	18.2 Å²	18.2	14%	0.14	11%	0.114	C	C	.	.	H	α-helix	trans	-69.9	-37.8	-176.3	-66.6	-60.6	0	0	0	113.3	L250 I253 G384 D385 S390 V391 L392 L435 I439	L250-F388 HydrophobicContact CD2-CB 4.19Å; L250-F388 HydrophobicContact CD2-CD1 3.9Å; L250-F388 HydrophobicContact CD2-CG 4.48Å; I253-F388 HydrophobicContact CD1-CE1 3.54Å; I253-F388 HydrophobicContact CD1-CZ 3.53Å; I253-F388 HydrophobicContact CG2-CD2 4.37Å; I253-F388 HydrophobicContact CG2-CE1 4.38Å; I253-F388 HydrophobicContact CG2-CE2 3.96Å; I253-F388 HydrophobicContact CG2-CZ 3.97Å; G384-F388 WeakPolarHBondContact O-CD2 3.19Å; G384-F388 PolarHBondContact O-N 3.35Å; D385-F388 PolarHBondContact O-N 3.05Å; F388-S390 VanDerWaalsContact C-N 3.3Å; F388-S390 PolarHBondContact O-N 2.82Å; F388-V391 PolarHBondContact O-N 3.14Å; F388-L392 PolarHBondContact O-N 3.41Å; F388-L435 HydrophobicContact CB-CD1 4.26Å; F388-L435 HydrophobicContact CD2-CD1 3.5Å; F388-L435 VanDerWaalsContact CD2-CD1 3.5Å; F388-L435 HydrophobicContact CE2-CD1 4.22Å; F388-L435 HydrophobicContact CG-CD1 4.16Å; F388-I439 HydrophobicContact CB-CD1 4.41Å
389	Y	95	Very high	87.6	Confident	0 Å²	0	19.1 Å²	19.1	0%	0	12%	0.116	C	C	.	.	H	α-helix	trans	-59.7	-44.5	171.3	-62.1	-24.8	0	0	0	111.2	V89 D385 L392 V393 I414 L418 A434 I439	V89-Y389 HydrophobicContact CG1-CD2 3.89Å; D385-Y389 HydrophobicContact CB-CD2 4.4Å; D385-Y389 HydrophobicContact CB-CE2 3.77Å; D385-Y389 WeakPolarHBondContact O-CB 3.49Å; D385-Y389 WeakPolarHBondContact O-CD2 3.49Å; D385-Y389 PolarHBondContact O-N 3.37Å; Y389-L392 PolarHBondContact O-N 2.95Å; Y389-V393 WeakPolarHBondContact O-CG1 3.12Å; Y389-V393 PolarHBondContact O-N 3.44Å; Y389-V393 VanDerWaalsContact O-N 3.08Å; Y389-I414 HydrophobicContact CD1-CG2 3.79Å; Y389-I414 HydrophobicContact CD2-CG2 4.08Å; Y389-I414 HydrophobicContact CE1-CG2 4.32Å; Y389-I414 HydrophobicContact CG-CG2 3.68Å; Y389-L418 HydrophobicContact CE2-CD1 3.75Å; Y389-A434 VanDerWaalsContact OH-C 3.31Å; Y389-A434 PolarHBondContact OH-O 3.44Å; Y389-A434 VanDerWaalsContact OH-O 3.08Å; Y389-I439 HydrophobicContact CD1-CD1 3.93Å; Y389-I439 HydrophobicContact CD1-CG1 4.49Å; Y389-I439 HydrophobicContact CE1-CD1 4.29Å; Y389-I439 HydrophobicContact CE1-CG1 4.35Å
390	S	95.7	Very high	88.1	Confident	1 Å²	1	17.3 Å²	17.3	1%	0.007	11%	0.106	C	C	.	.	H	α-helix	trans	-68.3	-35.1	178.3	-58.7	0	0	0	0	112.8	C92 F386 I387 F388 V393 G394	C92-S390 PolarHBondContact SG-OG 2.83Å; C92-S390 VanDerWaalsContact SG-OG 3.33Å; F386-S390 WeakPolarHBondContact O-CB 3.42Å; F386-S390 PolarHBondContact O-N 3.44Å; F386-S390 PolarHBondContact O-OG 2.92Å; I387-S390 PolarHBondContact O-N 2.93Å; F388-S390 VanDerWaalsContact C-N 3.3Å; F388-S390 PolarHBondContact O-N 2.82Å; S390-V393 WeakPolarHBondContact O-CG1 3.41Å; S390-G394 WeakPolarHBondContact O-CA 3.38Å; S390-G394 PolarHBondContact O-N 3.37Å
391	V	95.1	Very high	87.8	Confident	5 Å²	5	17.2 Å²	17.2	3%	0.03	12%	0.119	C	C	.	.	H	α-helix	trans	-64.7	-45.9	173	171.2	0	0	0	0	110.6	A234 F237 I238 L250 I387 F388 G394 K395	A234-V391 HydrophobicContact CB-CG2 3.93Å; F237-V391 HydrophobicContact CB-CG2 3.83Å; F237-V391 HydrophobicContact CD2-CG2 4.11Å; I238-V391 HydrophobicContact CG1-CG1 4.39Å; I238-V391 HydrophobicContact CG1-CG2 4.4Å; L250-V391 HydrophobicContact CD1-CG1 4.33Å; L250-V391 HydrophobicContact CD2-CB 4.47Å; L250-V391 HydrophobicContact CD2-CG1 4.21Å; I387-V391 HydrophobicContact CG2-CG2 4.29Å; I387-V391 VanDerWaalsContact O-CG2 3.25Å; I387-V391 WeakPolarHBondContact O-CG2 3.24Å; I387-V391 PolarHBondContact O-N 3.5Å; F388-V391 PolarHBondContact O-N 3.14Å; V391-G394 PolarHBondContact O-N 3.46Å; V391-K395 HydrophobicContact CG1-CG 4.17Å; V391-K395 WeakPolarHBondContact O-CB 3.24Å; V391-K395 VanDerWaalsContact O-CG 3.25Å; V391-K395 WeakPolarHBondContact O-CG 3.31Å; V391-K395 PolarHBondContact O-N 2.84Å
392	L	95.3	Very high	87.4	Confident	0 Å²	0	18.1 Å²	18.1	0%	0	13%	0.132	C	C	.	.	H	α-helix	trans	-59.6	-56.2	179.3	-169.6	159.9	0	0	0	111	W247 L250 F388 Y389 G394 K395 A396 C410 I414 I439 L443	W247-L392 HydrophobicContact CZ3-CG 4.19Å; L250-L392 HydrophobicContact CD1-CB 4.02Å; L250-L392 HydrophobicContact CD1-CG 4.3Å; F388-L392 PolarHBondContact O-N 3.41Å; Y389-L392 PolarHBondContact O-N 2.95Å; L392-G394 VanDerWaalsContact C-N 3.29Å; L392-G394 PolarHBondContact O-N 3.42Å; L392-K395 PolarHBondContact O-N 2.94Å; L392-A396 PolarHBondContact O-N 3.46Å; L392-C410 HydrophobicContact CD2-CB 3.78Å; L392-I414 HydrophobicContact CB-CD1 4.37Å; L392-I414 HydrophobicContact CD2-CD1 4.1Å; L392-I439 HydrophobicContact CB-CD1 4.35Å; L392-I439 HydrophobicContact CD1-CD1 3.67Å; L392-I439 HydrophobicContact CD1-CG2 4.27Å; L392-L443 HydrophobicContact CD1-CD2 4.45Å; L392-L443 HydrophobicContact CD1-CG 4.39Å
393	V	95.3	Very high	87.5	Confident	0 Å²	0	18.7 Å²	18.7	0%	0	13%	0.128	C	C	.	.	H	α-helix	trans	-65.4	-34.8	-178.8	72.1	0	0	0	0	111.8	M93 V97 Y389 S390 A396 S397 T407 F411 I414	M93-V393 HydrophobicContact CB-CG1 4.01Å; M93-V393 HydrophobicContact CG-CG1 3.86Å; M93-V393 HydrophobicContact SD-CG1 4.19Å; V97-V393 HydrophobicContact CG2-CB 4.47Å; V97-V393 HydrophobicContact CG2-CG1 3.98Å; V97-V393 HydrophobicContact CG2-CG2 3.77Å; Y389-V393 WeakPolarHBondContact O-CG1 3.12Å; Y389-V393 PolarHBondContact O-N 3.44Å; Y389-V393 VanDerWaalsContact O-N 3.08Å; S390-V393 WeakPolarHBondContact O-CG1 3.41Å; V393-A396 PolarHBondContact O-N 3.3Å; V393-S397 WeakPolarHBondContact O-CB 3.1Å; V393-S397 PolarHBondContact O-N 3.49Å; V393-T407 HydrophobicContact CG2-CG2 3.73Å; V393-F411 HydrophobicContact CG2-CB 4.2Å; V393-I414 HydrophobicContact CB-CD1 4.45Å
394	G	94.2	Very high	87.9	Confident	0 Å²	0	25.1 Å²	25.1	0%	0	15%	0.151	C	C	.	.	H	α-helix	trans	-70.5	-41.2	178.6	0	0	0	0	0	113	I100 S390 V391 L392 S397 A398	I100-G394 WeakPolarHBondContact CD1-O 3.4Å; S390-G394 WeakPolarHBondContact O-CA 3.38Å; S390-G394 PolarHBondContact O-N 3.37Å; V391-G394 PolarHBondContact O-N 3.46Å; L392-G394 VanDerWaalsContact C-N 3.29Å; L392-G394 PolarHBondContact O-N 3.42Å; G394-S397 PolarHBondContact O-N 3Å; G394-A398 WeakPolarHBondContact O-CB 3.31Å; G394-A398 PolarHBondContact O-N 3.38Å
395	K	93	Very high	88.2	Confident	12 Å²	12	27.4 Å²	27.4	5%	0.052	16%	0.156	C	C	.	.	H	α-helix	trans	-64.5	-41.2	172.1	-69.9	-65.6	-69.1	-169.8	0	111.1	I238 L241 A246 W247 V391 L392 S397 A398 T399	I238-K395 HydrophobicContact CB-CD 4.35Å; I238-K395 HydrophobicContact CG1-CD 4.17Å; I238-K395 HydrophobicContact CG1-CG 4.22Å; I238-K395 HydrophobicContact CG2-CD 4.07Å; L241-K395 PolarHBondContact O-NZ 3.44Å; A246-K395 HydrophobicContact CB-CD 4.32Å; A246-K395 HydrophobicContact CB-CG 4.4Å; W247-K395 HydrophobicContact CH2-CB 4.11Å; W247-K395 HydrophobicContact CZ2-CB 4Å; V391-K395 HydrophobicContact CG1-CG 4.17Å; V391-K395 WeakPolarHBondContact O-CB 3.24Å; V391-K395 VanDerWaalsContact O-CG 3.25Å; V391-K395 WeakPolarHBondContact O-CG 3.31Å; V391-K395 PolarHBondContact O-N 2.84Å; L392-K395 PolarHBondContact O-N 2.94Å; K395-S397 VanDerWaalsContact C-N 3.32Å; K395-S397 PolarHBondContact O-N 3.21Å; K395-A398 PolarHBondContact O-N 2.99Å; K395-T399 WeakPolarHBondContact O-CB 3.43Å; K395-T399 PolarHBondContact O-N 2.87Å; K395-T399 PolarHBondContact O-OG1 3.21Å
396	A	93.2	Very high	88.5	Confident	0 Å²	0	26.4 Å²	26.4	0%	0	15%	0.151	C	C	.	.	H	α-helix	trans	-57.4	-46.1	173.1	0	0	0	0	0	111.5	L392 V393 A398 A400 T406 C410 Y446	L392-A396 PolarHBondContact O-N 3.46Å; V393-A396 PolarHBondContact O-N 3.3Å; A396-A398 VanDerWaalsContact C-N 3.32Å; A396-A398 PolarHBondContact O-N 2.95Å; A396-A400 WeakPolarHBondContact O-CB 3.25Å; A396-A400 PolarHBondContact O-N 3.39Å; A396-A400 VanDerWaalsContact O-N 3.13Å; A396-T406 HydrophobicContact CB-CG2 4.48Å; A396-C410 HydrophobicContact CB-CB 4.4Å; A396-Y446 HydrophobicContact CB-CD2 3.65Å; A396-Y446 HydrophobicContact CB-CE2 3.9Å
397	S	93	Very high	88.6	Confident	3 Å²	3	26.5 Å²	26.5	2%	0.021	15%	0.152	C	C	.	.	H	α-helix	trans	-63.9	-32.2	177.1	174	0	0	0	0	114.3	K101 V393 G394 K395 T407	K101-S397 WeakPolarHBondContact CE-OG 3.37Å; K101-S397 PolarHBondContact NZ-O 3.5Å; K101-S397 VanDerWaalsContact NZ-O 3.09Å; V393-S397 WeakPolarHBondContact O-CB 3.1Å; V393-S397 PolarHBondContact O-N 3.49Å; G394-S397 PolarHBondContact O-N 3Å; K395-S397 VanDerWaalsContact C-N 3.32Å; K395-S397 PolarHBondContact O-N 3.21Å; S397-T407 VanDerWaalsContact CA-OG1 3.28Å; S397-T407 WeakPolarHBondContact CA-OG1 3.39Å
398	A	90.7	Very high	88.7	Confident	32 Å²	32	29.8 Å²	29.8	26%	0.264	17%	0.169	S	C	.	.	H	α-helix	trans	-83.7	-41.6	-178.6	0	0	0	0	0	113.2	I100 T107 G394 K395 A396	I100-A398 HydrophobicContact CG2-CB 3.87Å; T107-A398 HydrophobicContact CG2-CB 4.12Å; G394-A398 WeakPolarHBondContact O-CB 3.31Å; G394-A398 PolarHBondContact O-N 3.38Å; K395-A398 PolarHBondContact O-N 2.99Å; A396-A398 VanDerWaalsContact C-N 3.32Å; A396-A398 PolarHBondContact O-N 2.95Å
399	T	84.6	Confident	88.7	Confident	36 Å²	36	29.2 Å²	29.2	22%	0.221	17%	0.17	C	C	.	.	H	α-helix	trans	-90.3	-34	-171.4	-61.5	0	0	0	0	113.2	K395 S401	K395-T399 WeakPolarHBondContact O-CB 3.43Å; K395-T399 PolarHBondContact O-N 2.87Å; K395-T399 PolarHBondContact O-OG1 3.21Å; T399-S401 PolarHBondContact O-N 3.46Å
400	A	73.2	Confident	88.7	Confident	0 Å²	0	29.2 Å²	29.2	0%	0	17%	0.17	C	C	.	.	S	Bend	trans	-76.3	50.8	-174.9	0	0	0	0	0	112.8	A396 G402 D403 T406	A396-A400 WeakPolarHBondContact O-CB 3.25Å; A396-A400 PolarHBondContact O-N 3.39Å; A396-A400 VanDerWaalsContact O-N 3.13Å; A400-G402 PolarHBondContact O-N 2.83Å; A400-D403 WeakPolarHBondContact O-CB 3.27Å; A400-D403 PolarHBondContact O-N 3.32Å; A400-T406 HydrophobicContact CB-CG2 4Å
401	S	62.9	Low	88.6	Confident	108 Å²	108	31.3 Å²	31.3	76%	0.755	18%	0.179	S	C	*	.	T	Hydrogen-bonded Turn	trans	51.6	13.7	176.8	-59.8	0	0	0	0	116.9	T399	T399-S401 PolarHBondContact O-N 3.46Å
402	G	63	Low	88.6	Confident	35 Å²	35	34 Å²	34	36%	0.361	20%	0.196	S	C	.	.	T	Hydrogen-bonded Turn	trans	94.8	2.3	-173.8	0	0	0	0	0	114.7	K101 A400	K101-G402 VanDerWaalsContact NZ-CA 3.34Å; K101-G402 PolarHBondContact NZ-O 2.98Å; A400-G402 PolarHBondContact O-N 2.83Å
403	D	79.6	Confident	88.7	Confident	43 Å²	43	34.1 Å²	34.1	23%	0.23	20%	0.196	C	C	.	.			trans	-72.6	132.8	-174.3	-75.8	-0.9	0	0	0	113.3	A400 T407 Q454	A400-D403 WeakPolarHBondContact O-CB 3.27Å; A400-D403 PolarHBondContact O-N 3.32Å; D403-T407 PolarHBondContact O-OG1 3.48Å; D403-T407 VanDerWaalsContact O-OG1 3.13Å; D403-Q454 WeakPolarHBondContact OD2-CG 3.41Å; D403-Q454 PolarHBondContact OD2-NE2 3.07Å
404	W	90.2	Very high	88.6	Confident	145 Å²	145	34.1 Å²	34.1	55%	0.549	20%	0.196	S	C	.	.	H	α-helix	trans	-74.7	-29.7	176.8	-73	98.5	0	0	0	112	V97 K101 T406 T407 I408	V97-W404 HydrophobicContact CG1-CH2 4.34Å; V97-W404 HydrophobicContact CG1-CZ3 3.96Å; K101-W404 HydrophobicContact CD-CZ2 4.36Å; K101-W404 HydrophobicContact CG-CH2 4.01Å; K101-W404 HydrophobicContact CG-CZ2 4.05Å; W404-T406 PolarHBondContact O-N 2.87Å; W404-T407 PolarHBondContact O-N 3.37Å; W404-I408 HydrophobicContact CB-CD1 4.19Å; W404-I408 WeakPolarHBondContact O-CB 3.47Å; W404-I408 VanDerWaalsContact O-CG1 3.24Å; W404-I408 WeakPolarHBondContact O-CG1 3.28Å; W404-I408 PolarHBondContact O-N 2.87Å
405	N	92.3	Very high	88.6	Confident	78 Å²	78	35.7 Å²	35.7	42%	0.417	20%	0.204	S	C	.	.	H	α-helix	trans	-58.6	-52.7	-176.9	-66.5	-19	0	0	0	111.8	T407 I408 A409	N405-T407 VanDerWaalsContact C-N 3.33Å; N405-T407 PolarHBondContact O-N 2.89Å; N405-I408 PolarHBondContact O-N 3.48Å; N405-A409 VanDerWaalsContact O-CB 3.28Å; N405-A409 WeakPolarHBondContact O-CB 3.45Å; N405-A409 PolarHBondContact O-N 3.31Å
406	T	92.9	Very high	88.6	Confident	0 Å²	0	39.2 Å²	39.2	0%	0	22%	0.223	C	C	.	.	H	α-helix	trans	-62.8	-40.2	178.9	-51.2	0	0	0	0	111.7	A396 A400 W404 C410 Y446 D450	A396-T406 HydrophobicContact CB-CG2 4.48Å; A400-T406 HydrophobicContact CB-CG2 4Å; W404-T406 PolarHBondContact O-N 2.87Å; T406-C410 WeakPolarHBondContact O-CB 3.47Å; T406-C410 PolarHBondContact O-N 2.95Å; T406-C410 PolarHBondContact O-SG 2.77Å; T406-Y446 HydrophobicContact CG2-CD2 3.5Å; T406-Y446 HydrophobicContact CG2-CE2 3.81Å; T406-D450 HydrophobicContact CG2-CB 4.44Å
407	T	94.1	Very high	88.6	Confident	4 Å²	4	39.2 Å²	39.2	3%	0.025	22%	0.223	C	C	.	.	H	α-helix	trans	-64.5	-47.1	178.2	-53	0	0	0	0	111.6	V97 V393 S397 D403 W404 N405 C410 F411	V97-T407 HydrophobicContact CG1-CG2 4.02Å; V97-T407 HydrophobicContact CG2-CG2 3.96Å; V393-T407 HydrophobicContact CG2-CG2 3.73Å; S397-T407 VanDerWaalsContact CA-OG1 3.28Å; S397-T407 WeakPolarHBondContact CA-OG1 3.39Å; D403-T407 PolarHBondContact O-OG1 3.48Å; D403-T407 VanDerWaalsContact O-OG1 3.13Å; W404-T407 PolarHBondContact O-N 3.37Å; N405-T407 VanDerWaalsContact C-N 3.33Å; N405-T407 PolarHBondContact O-N 2.89Å; T407-C410 PolarHBondContact O-N 3.39Å; T407-F411 WeakPolarHBondContact O-CB 3.44Å; T407-F411 PolarHBondContact O-N 2.66Å
408	I	94.5	Very high	88.5	Confident	91 Å²	91	39.1 Å²	39.1	47%	0.467	22%	0.222	S	C	.	.	H	α-helix	trans	-67.4	-41.3	179.6	-67.2	167.6	0	0	0	110.4	W404 N405 C410 F411 V412	W404-I408 HydrophobicContact CB-CD1 4.19Å; W404-I408 WeakPolarHBondContact O-CB 3.47Å; W404-I408 VanDerWaalsContact O-CG1 3.24Å; W404-I408 WeakPolarHBondContact O-CG1 3.28Å; W404-I408 PolarHBondContact O-N 2.87Å; N405-I408 PolarHBondContact O-N 3.48Å; I408-C410 VanDerWaalsContact C-N 3.35Å; I408-C410 PolarHBondContact O-N 3.37Å; I408-F411 WeakPolarHBondContact O-CB 3.33Å; I408-F411 PolarHBondContact O-N 2.89Å; I408-V412 HydrophobicContact CG2-CG2 4.32Å; I408-V412 WeakPolarHBondContact O-CG2 3.25Å; I408-V412 PolarHBondContact O-N 3.26Å
409	A	94.8	Very high	88.4	Confident	20 Å²	20	40.1 Å²	40.1	17%	0.165	23%	0.227	C	C	.	.	H	α-helix	trans	-59.1	-45.9	175.2	0	0	0	0	0	111.4	N405 V412 A413 F445 T449	N405-A409 VanDerWaalsContact O-CB 3.28Å; N405-A409 WeakPolarHBondContact O-CB 3.45Å; N405-A409 PolarHBondContact O-N 3.31Å; A409-V412 PolarHBondContact O-N 3.46Å; A409-A413 VanDerWaalsContact O-CB 3.27Å; A409-A413 WeakPolarHBondContact O-CB 3.38Å; A409-A413 PolarHBondContact O-N 3.37Å; A409-F445 HydrophobicContact CB-CD1 4.5Å; A409-T449 HydrophobicContact CB-CG2 4.19Å; A409-T449 WeakPolarHBondContact CB-OG1 3.31Å
410	C	94.1	Very high	88.7	Confident	0 Å²	0	41.2 Å²	41.2	0%	0	23%	0.231	C	C	.	.	H	α-helix	trans	-63.2	-42.7	175	-67	0	0	0	0	112.3	L392 A396 T406 T407 I408 A413 I414 Y446	L392-C410 HydrophobicContact CD2-CB 3.78Å; A396-C410 HydrophobicContact CB-CB 4.4Å; T406-C410 WeakPolarHBondContact O-CB 3.47Å; T406-C410 PolarHBondContact O-N 2.95Å; T406-C410 PolarHBondContact O-SG 2.77Å; T407-C410 PolarHBondContact O-N 3.39Å; I408-C410 VanDerWaalsContact C-N 3.35Å; I408-C410 PolarHBondContact O-N 3.37Å; C410-A413 PolarHBondContact O-N 2.96Å; C410-I414 WeakPolarHBondContact O-CG1 3.3Å; C410-I414 PolarHBondContact O-N 3.3Å; C410-Y446 VanDerWaalsContact SG-CB 3.57Å
411	F	95	Very high	89.4	Confident	45 Å²	45	41.3 Å²	41.3	20%	0.197	23%	0.232	C	C	.	.	H	α-helix	trans	-59.7	-49.2	178	177.9	-90.5	0	0	0	111.5	T90 M93 V393 T407 I408 I414 L415	T90-F411 HydrophobicContact CG2-CE2 4.12Å; T90-F411 HydrophobicContact CG2-CZ 3.63Å; M93-F411 HydrophobicContact CB-CD2 4.09Å; M93-F411 HydrophobicContact CB-CE2 3.99Å; M93-F411 HydrophobicContact CE-CD2 3.99Å; M93-F411 HydrophobicContact CE-CE2 3.77Å; M93-F411 HydrophobicContact SD-CD2 3.96Å; M93-F411 HydrophobicContact SD-CE2 4.27Å; V393-F411 HydrophobicContact CG2-CB 4.2Å; T407-F411 WeakPolarHBondContact O-CB 3.44Å; T407-F411 PolarHBondContact O-N 2.66Å; I408-F411 WeakPolarHBondContact O-CB 3.33Å; I408-F411 PolarHBondContact O-N 2.89Å; F411-I414 PolarHBondContact O-N 3.02Å; F411-L415 HydrophobicContact CD1-CD1 3.96Å; F411-L415 HydrophobicContact CE1-CD1 3.33Å; F411-L415 HydrophobicContact CE1-CG 4.26Å; F411-L415 HydrophobicContact CZ-CD1 3.71Å; F411-L415 HydrophobicContact CZ-CG 4.44Å; F411-L415 WeakPolarHBondContact O-CG 3.47Å; F411-L415 PolarHBondContact O-N 3.02Å; F411-L415 VanDerWaalsContact O-N 3.14Å
412	V	95.6	Very high	90.4	Very high	63 Å²	63	37.9 Å²	37.9	38%	0.382	20%	0.204	S	C	.	.	H	α-helix	trans	-64.6	-41	177.1	174	0	0	0	0	111	I408 A409 I414 L415 I416	I408-V412 HydrophobicContact CG2-CG2 4.32Å; I408-V412 WeakPolarHBondContact O-CG2 3.25Å; I408-V412 PolarHBondContact O-N 3.26Å; A409-V412 PolarHBondContact O-N 3.46Å; V412-I414 PolarHBondContact O-N 2.95Å; V412-L415 PolarHBondContact O-N 3.41Å; V412-I416 HydrophobicContact CG1-CD1 3.64Å; V412-I416 HydrophobicContact CG1-CG1 4.18Å; V412-I416 WeakPolarHBondContact O-CB 3.31Å; V412-I416 WeakPolarHBondContact O-CG1 3.49Å; V412-I416 PolarHBondContact O-N 3.43Å
413	A	95.8	Very high	91.5	Very high	2 Å²	2	40.7 Å²	40.7	2%	0.017	21%	0.211	C	C	.	.	H	α-helix	trans	-60.1	-42.4	177.5	0	0	0	0	0	112.7	A409 C410 I416 G417 F441 F445	A409-A413 VanDerWaalsContact O-CB 3.27Å; A409-A413 WeakPolarHBondContact O-CB 3.38Å; A409-A413 PolarHBondContact O-N 3.37Å; C410-A413 PolarHBondContact O-N 2.96Å; A413-I416 PolarHBondContact O-N 3.49Å; A413-G417 PolarHBondContact O-N 3.34Å; A413-F441 HydrophobicContact CB-CB 4.2Å; A413-F445 HydrophobicContact CB-CB 3.96Å; A413-F445 HydrophobicContact CB-CD1 3.69Å; A413-F445 HydrophobicContact CB-CE1 4.34Å; A413-F445 HydrophobicContact CB-CG 3.85Å
414	I	94.9	Very high	91.8	Very high	0 Å²	0	41 Å²	41	0%	0	21%	0.212	C	C	.	.	H	α-helix	trans	-63	-46.9	175.5	-70	164.6	0	0	0	110.5	M93 Y389 L392 V393 C410 F411 V412 I416 G417 L418	M93-I414 HydrophobicContact CE-CG2 4.25Å; M93-I414 HydrophobicContact SD-CD1 4Å; M93-I414 HydrophobicContact SD-CG2 4.18Å; Y389-I414 HydrophobicContact CD1-CG2 3.79Å; Y389-I414 HydrophobicContact CD2-CG2 4.08Å; Y389-I414 HydrophobicContact CE1-CG2 4.32Å; Y389-I414 HydrophobicContact CG-CG2 3.68Å; L392-I414 HydrophobicContact CB-CD1 4.37Å; L392-I414 HydrophobicContact CD2-CD1 4.1Å; V393-I414 HydrophobicContact CB-CD1 4.45Å; C410-I414 WeakPolarHBondContact O-CG1 3.3Å; C410-I414 PolarHBondContact O-N 3.3Å; F411-I414 PolarHBondContact O-N 3.02Å; V412-I414 PolarHBondContact O-N 2.95Å; I414-I416 PolarHBondContact O-N 2.86Å; I414-G417 PolarHBondContact O-N 3.49Å; I414-L418 WeakPolarHBondContact O-CB 3.47Å; I414-L418 PolarHBondContact O-N 3.02Å
415	L	93.7	Very high	91.4	Very high	32 Å²	32	36.6 Å²	36.6	17%	0.168	20%	0.199	C	C	.	.	H	α-helix	trans	-63	-43.2	179.7	-68.3	-179.1	0	0	0	111.8	F86 M93 F411 V412 L418 C419	F86-L415 HydrophobicContact CD1-CD2 3.68Å; F86-L415 HydrophobicContact CE1-CB 4.13Å; F86-L415 HydrophobicContact CE1-CD2 3.74Å; F86-L415 WeakPolarHBondContact CE1-O 3.49Å; F86-L415 HydrophobicContact CG-CD2 4.46Å; F86-L415 HydrophobicContact CZ-CB 4.31Å; F86-L415 VanDerWaalsContact CZ-O 3.31Å; F86-L415 WeakPolarHBondContact CZ-O 3.27Å; M93-L415 HydrophobicContact CE-CD2 4.08Å; F411-L415 HydrophobicContact CD1-CD1 3.96Å; F411-L415 HydrophobicContact CE1-CD1 3.33Å; F411-L415 HydrophobicContact CE1-CG 4.26Å; F411-L415 HydrophobicContact CZ-CD1 3.71Å; F411-L415 HydrophobicContact CZ-CG 4.44Å; F411-L415 WeakPolarHBondContact O-CG 3.47Å; F411-L415 PolarHBondContact O-N 3.02Å; F411-L415 VanDerWaalsContact O-N 3.14Å; V412-L415 PolarHBondContact O-N 3.41Å; L415-L418 PolarHBondContact O-N 3.12Å; L415-C419 WeakPolarHBondContact O-CB 3.21Å; L415-C419 PolarHBondContact O-N 3.39Å
416	I	93.4	Very high	90.8	Very high	86 Å²	86	36.2 Å²	36.2	44%	0.441	21%	0.207	S	C	.	.	H	α-helix	trans	-63.2	-43.9	175.3	-68.5	174.4	0	0	0	110.6	V412 A413 I414 L418 C419 L420	V412-I416 HydrophobicContact CG1-CD1 3.64Å; V412-I416 HydrophobicContact CG1-CG1 4.18Å; V412-I416 WeakPolarHBondContact O-CB 3.31Å; V412-I416 WeakPolarHBondContact O-CG1 3.49Å; V412-I416 PolarHBondContact O-N 3.43Å; A413-I416 PolarHBondContact O-N 3.49Å; I414-I416 PolarHBondContact O-N 2.86Å; I416-L418 VanDerWaalsContact C-N 3.31Å; I416-L418 PolarHBondContact O-N 3.12Å; I416-C419 VanDerWaalsContact O-CB 3.28Å; I416-C419 WeakPolarHBondContact O-CB 3.28Å; I416-C419 PolarHBondContact O-N 3.11Å; I416-L420 HydrophobicContact CG2-CD1 3.96Å; I416-L420 HydrophobicContact CG2-CG 4.42Å; I416-L420 WeakPolarHBondContact O-CG 3.4Å; I416-L420 PolarHBondContact O-N 3.28Å
417	G	92.7	Very high	90.4	Very high	0 Å²	0	41.6 Å²	41.6	0%	0	23%	0.234	C	C	.	.	H	α-helix	trans	-61.7	-38.7	176.1	0	0	0	0	0	112.9	A413 I414 L420 T421	A413-G417 PolarHBondContact O-N 3.34Å; I414-G417 PolarHBondContact O-N 3.49Å; G417-L420 PolarHBondContact O-N 3.16Å; G417-T421 VanDerWaalsContact O-CG2 3.29Å; G417-T421 WeakPolarHBondContact O-CG2 3.29Å; G417-T421 PolarHBondContact O-N 3.28Å; G417-T421 PolarHBondContact O-OG1 2.89Å
418	L	89.8	Confident	89.8	Confident	1 Å²	1	47.2 Å²	47.2	1%	0.005	26%	0.259	C	S	.	.	H	α-helix	trans	-69.5	-38.8	175.1	-171	135.4	0	0	0	111.3	F86 Y389 I414 L415 I416 L420 T421 L422 S438	F86-L418 HydrophobicContact CD1-CD2 3.45Å; F86-L418 VanDerWaalsContact CD1-CD2 3.45Å; F86-L418 HydrophobicContact CE1-CB 4.09Å; F86-L418 HydrophobicContact CE1-CD2 3.29Å; F86-L418 HydrophobicContact CE1-CG 4.28Å; F86-L418 HydrophobicContact CZ-CD2 4.31Å; Y389-L418 HydrophobicContact CE2-CD1 3.75Å; I414-L418 WeakPolarHBondContact O-CB 3.47Å; I414-L418 PolarHBondContact O-N 3.02Å; L415-L418 PolarHBondContact O-N 3.12Å; I416-L418 VanDerWaalsContact C-N 3.31Å; I416-L418 PolarHBondContact O-N 3.12Å; L418-L420 PolarHBondContact O-N 2.87Å; L418-T421 VanDerWaalsContact CA-OG1 3.32Å; L418-T421 WeakPolarHBondContact CA-OG1 3.46Å; L418-T421 PolarHBondContact O-N 3.39Å; L418-T421 PolarHBondContact O-OG1 3.39Å; L418-L422 HydrophobicContact CD2-CD1 3.64Å; L418-L422 HydrophobicContact CD2-CG 4.43Å; L418-L422 HydrophobicContact CG-CD1 4.43Å; L418-L422 WeakPolarHBondContact O-CB 3.43Å; L418-L422 VanDerWaalsContact O-CG 3.28Å; L418-L422 WeakPolarHBondContact O-CG 3.48Å; L418-L422 PolarHBondContact O-N 2.72Å; L418-S438 PolarHBondContact N-OG 2.84Å; L418-S438 VanDerWaalsContact N-OG 3.14Å
419	C	89.5	Confident	89	Confident	53 Å²	53	52 Å²	52	36%	0.358	28%	0.276	S	S	.	.	H	α-helix	trans	-56.8	-48.1	169.4	-109.1	0	0	0	0	112	F86 L415 I416 L422 L423	F86-C419 VanDerWaalsContact CE2-SG 3.52Å; F86-C419 HydrophobicContact CZ-CB 4.06Å; F86-C419 WeakPolarHBondContact CZ-SG 3.49Å; L415-C419 WeakPolarHBondContact O-CB 3.21Å; L415-C419 PolarHBondContact O-N 3.39Å; I416-C419 VanDerWaalsContact O-CB 3.28Å; I416-C419 WeakPolarHBondContact O-CB 3.28Å; I416-C419 PolarHBondContact O-N 3.11Å; C419-L422 PolarHBondContact O-N 3.03Å; C419-L423 WeakPolarHBondContact O-CB 3.33Å; C419-L423 PolarHBondContact O-N 3.1Å
420	L	90.2	Very high	88	Confident	60 Å²	60	58.5 Å²	58.5	31%	0.314	30%	0.3	S	S	.	.	H	α-helix	trans	-66.3	-42	-179.3	-72.6	170.6	0	0	0	111.6	I416 G417 L418 L422 L423 L424 F441	I416-L420 HydrophobicContact CG2-CD1 3.96Å; I416-L420 HydrophobicContact CG2-CG 4.42Å; I416-L420 WeakPolarHBondContact O-CG 3.4Å; I416-L420 PolarHBondContact O-N 3.28Å; G417-L420 PolarHBondContact O-N 3.16Å; L418-L420 PolarHBondContact O-N 2.87Å; L420-L422 VanDerWaalsContact C-N 3.34Å; L420-L422 PolarHBondContact O-N 3.32Å; L420-L423 HydrophobicContact CD2-CD2 4.45Å; L420-L423 PolarHBondContact O-N 3.2Å; L420-L424 WeakPolarHBondContact O-CB 3.28Å; L420-L424 WeakPolarHBondContact O-CD1 3.35Å; L420-L424 PolarHBondContact O-N 3.35Å; L420-F441 HydrophobicContact CD1-CD2 4.44Å; L420-F441 HydrophobicContact CD1-CE2 3.51Å; L420-F441 HydrophobicContact CD1-CZ 4.18Å
421	T	88.1	Confident	86.9	Confident	2 Å²	2	62.5 Å²	62.5	1%	0.012	33%	0.334	C	S	.	.	H	α-helix	trans	-61.3	-42.6	175.5	53.2	0	0	0	0	111.7	G417 L418 L424 L425 I437	G417-T421 VanDerWaalsContact O-CG2 3.29Å; G417-T421 WeakPolarHBondContact O-CG2 3.29Å; G417-T421 PolarHBondContact O-N 3.28Å; G417-T421 PolarHBondContact O-OG1 2.89Å; L418-T421 VanDerWaalsContact CA-OG1 3.32Å; L418-T421 WeakPolarHBondContact CA-OG1 3.46Å; L418-T421 PolarHBondContact O-N 3.39Å; L418-T421 PolarHBondContact O-OG1 3.39Å; T421-L424 PolarHBondContact O-N 2.85Å; T421-L425 WeakPolarHBondContact O-CB 3.49Å; T421-L425 VanDerWaalsContact O-CG 3.24Å; T421-L425 WeakPolarHBondContact O-CG 3.41Å; T421-L425 PolarHBondContact O-N 3.36Å; T421-I437 HydrophobicContact CG2-CB 3.66Å; T421-I437 HydrophobicContact CG2-CD1 3.74Å; T421-I437 HydrophobicContact CG2-CG1 4.01Å; T421-I437 HydrophobicContact CG2-CG2 4.33Å
422	L	83.8	Confident	86.1	Confident	35 Å²	35	62.7 Å²	62.7	18%	0.183	34%	0.336	C	S	.	.	H	α-helix	trans	-64.3	-40.1	174.5	-68.8	173.1	0	0	0	112.5	V82 L85 L418 C419 L420 L425 A426	V82-L422 HydrophobicContact CB-CD1 4.15Å; V82-L422 HydrophobicContact CG1-CD1 4.11Å; V82-L422 HydrophobicContact CG2-CB 4.24Å; V82-L422 HydrophobicContact CG2-CD1 3.7Å; L85-L422 HydrophobicContact CD1-CD1 4.1Å; L85-L422 HydrophobicContact CD1-CD2 3.9Å; L418-L422 HydrophobicContact CD2-CD1 3.64Å; L418-L422 HydrophobicContact CD2-CG 4.43Å; L418-L422 HydrophobicContact CG-CD1 4.43Å; L418-L422 WeakPolarHBondContact O-CB 3.43Å; L418-L422 VanDerWaalsContact O-CG 3.28Å; L418-L422 WeakPolarHBondContact O-CG 3.48Å; L418-L422 PolarHBondContact O-N 2.72Å; C419-L422 PolarHBondContact O-N 3.03Å; L420-L422 VanDerWaalsContact C-N 3.34Å; L420-L422 PolarHBondContact O-N 3.32Å; L422-L425 HydrophobicContact CD2-CD1 4.08Å; L422-L425 WeakPolarHBondContact O-CB 3.46Å; L422-L425 PolarHBondContact O-N 2.9Å; L422-A426 PolarHBondContact O-N 3.48Å
423	L	86.4	Confident	85.5	Confident	95 Å²	95	60.2 Å²	60.2	50%	0.497	32%	0.322	S	S	.	.	H	α-helix	trans	-62.8	-44.1	174.3	-175.1	70	0	0	0	111.5	C419 L420 L425 A426 I427	C419-L423 WeakPolarHBondContact O-CB 3.33Å; C419-L423 PolarHBondContact O-N 3.1Å; L420-L423 HydrophobicContact CD2-CD2 4.45Å; L420-L423 PolarHBondContact O-N 3.2Å; L423-L425 VanDerWaalsContact C-N 3.34Å; L423-L425 PolarHBondContact O-N 3.43Å; L423-A426 PolarHBondContact O-N 3.49Å; L423-I427 HydrophobicContact CD1-CD1 4.43Å; L423-I427 HydrophobicContact CG-CD1 4.03Å; L423-I427 WeakPolarHBondContact O-CG1 3.5Å; L423-I427 PolarHBondContact O-N 2.93Å
424	L	86.2	Confident	84.9	Confident	49 Å²	49	60.7 Å²	60.7	26%	0.257	33%	0.326	S	S	.	.	H	α-helix	trans	-64.7	-38	176.7	-90.6	72.9	0	0	0	111.8	L420 T421 A426 I427 F428 L432 I437	L420-L424 WeakPolarHBondContact O-CB 3.28Å; L420-L424 WeakPolarHBondContact O-CD1 3.35Å; L420-L424 PolarHBondContact O-N 3.35Å; T421-L424 PolarHBondContact O-N 2.85Å; L424-A426 VanDerWaalsContact C-N 3.35Å; L424-I427 PolarHBondContact O-N 3.4Å; L424-F428 HydrophobicContact CB-CD2 4.23Å; L424-F428 HydrophobicContact CB-CE2 4.41Å; L424-F428 HydrophobicContact CD2-CE2 4.18Å; L424-F428 HydrophobicContact CG-CD2 4.36Å; L424-F428 HydrophobicContact CG-CE2 4.04Å; L424-F428 WeakPolarHBondContact O-CB 3.32Å; L424-F428 WeakPolarHBondContact O-CD2 3.12Å; L424-F428 PolarHBondContact O-N 3.44Å; L424-L432 HydrophobicContact CB-CD1 3.8Å; L424-L432 HydrophobicContact CD2-CD1 4.43Å; L424-I437 HydrophobicContact CD2-CD1 3.99Å
425	L	81.5	Confident	84.4	Confident	52 Å²	52	61 Å²	61	27%	0.272	33%	0.327	S	S	.	.	H	α-helix	trans	-60.8	-43.7	173.1	-76.5	169.1	0	0	0	111.3	T421 L422 L423 K429 K430 L432	T421-L425 WeakPolarHBondContact O-CB 3.49Å; T421-L425 VanDerWaalsContact O-CG 3.24Å; T421-L425 WeakPolarHBondContact O-CG 3.41Å; T421-L425 PolarHBondContact O-N 3.36Å; L422-L425 HydrophobicContact CD2-CD1 4.08Å; L422-L425 WeakPolarHBondContact O-CB 3.46Å; L422-L425 PolarHBondContact O-N 2.9Å; L423-L425 VanDerWaalsContact C-N 3.34Å; L423-L425 PolarHBondContact O-N 3.43Å; L425-K429 WeakPolarHBondContact O-CA 3.44Å; L425-K429 PolarHBondContact O-N 2.95Å; L425-K430 WeakPolarHBondContact CD2-O 3.33Å; L425-L432 HydrophobicContact CD2-CB 3.71Å; L425-L432 HydrophobicContact CD2-CG 4.11Å; L425-L432 HydrophobicContact CG-CB 4.24Å
426	A	79.9	Confident	84.2	Confident	70 Å²	70	60 Å²	60	58%	0.579	32%	0.323	S	S	*	.	H	α-helix	trans	-64.5	-41.6	178.2	0	0	0	0	0	112.2	L422 L423 L424	L422-A426 PolarHBondContact O-N 3.48Å; L423-A426 PolarHBondContact O-N 3.49Å; L424-A426 VanDerWaalsContact C-N 3.35Å
427	I	83.5	Confident	84.1	Confident	113 Å²	113	58.3 Å²	58.3	58%	0.579	31%	0.314	S	S	*	.	H	α-helix	trans	-73	-50.1	-179.6	-65.2	167.1	0	0	0	111.6	L423 L424	L423-I427 HydrophobicContact CD1-CD1 4.43Å; L423-I427 HydrophobicContact CG-CD1 4.03Å; L423-I427 WeakPolarHBondContact O-CG1 3.5Å; L423-I427 PolarHBondContact O-N 2.93Å; L424-I427 PolarHBondContact O-N 3.4Å
428	F	83.2	Confident	84.2	Confident	123 Å²	123	58.3 Å²	58.3	54%	0.539	31%	0.314	S	S	.	.	H	α-helix	trans	-84.4	-13	-172.9	-66.1	-50.1	0	0	0	114.1	L424 K430 L432	L424-F428 HydrophobicContact CB-CD2 4.23Å; L424-F428 HydrophobicContact CB-CE2 4.41Å; L424-F428 HydrophobicContact CD2-CE2 4.18Å; L424-F428 HydrophobicContact CG-CD2 4.36Å; L424-F428 HydrophobicContact CG-CE2 4.04Å; L424-F428 WeakPolarHBondContact O-CB 3.32Å; L424-F428 WeakPolarHBondContact O-CD2 3.12Å; L424-F428 PolarHBondContact O-N 3.44Å; F428-K430 WeakPolarHBondContact O-CG 3.46Å; F428-K430 PolarHBondContact O-N 2.89Å; F428-L432 HydrophobicContact CD2-CD1 4.22Å
429	K	78.1	Confident	84.3	Confident	192 Å²	192	58.2 Å²	58.2	84%	0.835	31%	0.314	S	S	*	.			trans	48.8	30.9	-176.6	-60.2	-175.1	177.1	179	0	113.1	L425	L425-K429 WeakPolarHBondContact O-CA 3.44Å; L425-K429 PolarHBondContact O-N 2.95Å
430	K	73.8	Confident	84.6	Confident	155 Å²	155	58.9 Å²	58.9	67%	0.674	32%	0.316	S	S	*	.	S	Bend	trans	-123.4	141	179.4	-76	176.4	-178.2	176.9	0	108.6	L425 F428 L432	L425-K430 WeakPolarHBondContact CD2-O 3.33Å; F428-K430 WeakPolarHBondContact O-CG 3.46Å; F428-K430 PolarHBondContact O-N 2.89Å; K430-L432 PolarHBondContact O-N 3.22Å
431	A	70.8	Confident	84.8	Confident	84 Å²	84	59.7 Å²	59.7	69%	0.694	32%	0.317	S	S	*	.			trans	-63.1	121.6	173.2	0	0	0	0	0	110.2
432	L	78.3	Confident	85.1	Confident	49 Å²	49	59.6 Å²	59.6	26%	0.257	32%	0.317	S	S	.	.			trans	-120.1	142.7	177.2	-66.3	175.2	0	0	0	109.1	L262 L424 L425 F428 K430 A434	L262-L432 HydrophobicContact CD2-CD2 4.5Å; L424-L432 HydrophobicContact CB-CD1 3.8Å; L424-L432 HydrophobicContact CD2-CD1 4.43Å; L425-L432 HydrophobicContact CD2-CB 3.71Å; L425-L432 HydrophobicContact CD2-CG 4.11Å; L425-L432 HydrophobicContact CG-CB 4.24Å; F428-L432 HydrophobicContact CD2-CD1 4.22Å; K430-L432 PolarHBondContact O-N 3.22Å; L432-A434 PolarHBondContact O-N 3.39Å
433	P	82.5	Confident	85.6	Confident	12 Å²	12	59 Å²	59	8%	0.078	31%	0.313	C	S	.	.			trans	-68	129.2	172.4	21.3	-21.5	0	0	0	110.1	D257 L258 V261 P436	D257-P433 WeakPolarHBondContact OD2-CB 3.41Å; L258-P433 HydrophobicContact CD1-CG 3.85Å; V261-P433 HydrophobicContact CB-CB 4.39Å; V261-P433 HydrophobicContact CB-CG 4.14Å; V261-P433 HydrophobicContact CG1-CG 4.36Å; V261-P433 HydrophobicContact CG2-CB 4.16Å; V261-P433 HydrophobicContact CG2-CG 4.45Å; P433-P436 HydrophobicContact CB-CG 4.13Å; P433-P436 HydrophobicContact CG-CG 3.98Å; P433-P436 WeakPolarHBondContact O-CD 3.32Å
434	A	82.9	Confident	86	Confident	12 Å²	12	58.4 Å²	58.4	10%	0.099	31%	0.314	C	S	.	.	S	Bend	trans	-79.4	-23	-179.3	0	0	0	0	0	112.9	Y389 L432 S438	Y389-A434 VanDerWaalsContact OH-C 3.31Å; Y389-A434 PolarHBondContact OH-O 3.44Å; Y389-A434 VanDerWaalsContact OH-O 3.08Å; L432-A434 PolarHBondContact O-N 3.39Å; A434-S438 PolarHBondContact O-OG 3.46Å
435	L	83.6	Confident	86.4	Confident	5 Å²	5	60.3 Å²	60.3	3%	0.026	32%	0.32	C	S	.	.	H	α-helix	trans	-64.6	-48	-175.4	-161.9	154.7	0	0	0	114.3	I253 S254 D257 F388 I437 I439	I253-L435 HydrophobicContact CG2-CD1 4.27Å; I253-L435 HydrophobicContact CG2-CD2 4.4Å; S254-L435 VanDerWaalsContact CA-CD2 3.43Å; D257-L435 WeakPolarHBondContact OD2-CB 3.13Å; F388-L435 HydrophobicContact CB-CD1 4.26Å; F388-L435 HydrophobicContact CD2-CD1 3.5Å; F388-L435 VanDerWaalsContact CD2-CD1 3.5Å; F388-L435 HydrophobicContact CE2-CD1 4.22Å; F388-L435 HydrophobicContact CG-CD1 4.16Å; L435-I437 PolarHBondContact O-N 2.9Å; L435-I439 HydrophobicContact CD2-CB 4.35Å; L435-I439 HydrophobicContact CD2-CG1 3.64Å; L435-I439 HydrophobicContact CG-CG1 3.98Å; L435-I439 WeakPolarHBondContact O-CB 3.25Å; L435-I439 VanDerWaalsContact O-CG1 3.24Å; L435-I439 WeakPolarHBondContact O-CG1 3.03Å; L435-I439 PolarHBondContact O-N 3.49Å
436	P	89.9	Confident	86.9	Confident	13 Å²	13	58.1 Å²	58.1	8%	0.084	31%	0.308	C	S	.	.	H	α-helix	trans	-64	-47.3	-168.6	19.8	-32.1	0	0	0	115.3	L258 P433 T440	L258-P436 HydrophobicContact CB-CG 4.37Å; L258-P436 HydrophobicContact CD1-CG 4.29Å; P433-P436 HydrophobicContact CB-CG 4.13Å; P433-P436 HydrophobicContact CG-CG 3.98Å; P433-P436 WeakPolarHBondContact O-CD 3.32Å; P436-T440 VanDerWaalsContact O-CB 3.26Å; P436-T440 WeakPolarHBondContact O-CB 3.28Å; P436-T440 PolarHBondContact O-N 2.64Å; P436-T440 PolarHBondContact O-OG1 2.74Å
437	I	91.9	Very high	87.6	Confident	49 Å²	49	58.6 Å²	58.6	25%	0.251	30%	0.298	S	S	.	.	H	α-helix	trans	-65.6	-46.3	-176.8	-62.7	178.6	0	0	0	109.8	T421 L424 L435 T440 F441	T421-I437 HydrophobicContact CG2-CB 3.66Å; T421-I437 HydrophobicContact CG2-CD1 3.74Å; T421-I437 HydrophobicContact CG2-CG1 4.01Å; T421-I437 HydrophobicContact CG2-CG2 4.33Å; L424-I437 HydrophobicContact CD2-CD1 3.99Å; L435-I437 PolarHBondContact O-N 2.9Å; I437-T440 PolarHBondContact O-N 2.82Å; I437-F441 HydrophobicContact CG2-CD2 3.89Å; I437-F441 HydrophobicContact CG2-CE2 3.47Å; I437-F441 VanDerWaalsContact CG2-CE2 3.47Å; I437-F441 HydrophobicContact CG2-CZ 4.17Å; I437-F441 PolarHBondContact O-N 2.66Å
438	S	93.6	Very high	88.1	Confident	0 Å²	0	55 Å²	55	0%	0	29%	0.285	C	S	.	.	H	α-helix	trans	-63.8	-45.2	-179.3	-46	0	0	0	0	112.5	L418 A434 G442	L418-S438 PolarHBondContact N-OG 2.84Å; L418-S438 VanDerWaalsContact N-OG 3.14Å; A434-S438 PolarHBondContact O-OG 3.46Å; S438-G442 PolarHBondContact O-N 3.08Å
439	I	93.6	Very high	88.5	Confident	0 Å²	0	49.8 Å²	49.8	0%	0	26%	0.263	C	S	.	.	H	α-helix	trans	-67.8	-40	176.6	-66	-63.8	0	0	0	111.1	L250 F388 Y389 L392 L435 F441 G442 L443	L250-I439 HydrophobicContact CB-CG2 4.35Å; F388-I439 HydrophobicContact CB-CD1 4.41Å; Y389-I439 HydrophobicContact CD1-CD1 3.93Å; Y389-I439 HydrophobicContact CD1-CG1 4.49Å; Y389-I439 HydrophobicContact CE1-CD1 4.29Å; Y389-I439 HydrophobicContact CE1-CG1 4.35Å; L392-I439 HydrophobicContact CB-CD1 4.35Å; L392-I439 HydrophobicContact CD1-CD1 3.67Å; L392-I439 HydrophobicContact CD1-CG2 4.27Å; L435-I439 HydrophobicContact CD2-CB 4.35Å; L435-I439 HydrophobicContact CD2-CG1 3.64Å; L435-I439 HydrophobicContact CG-CG1 3.98Å; L435-I439 WeakPolarHBondContact O-CB 3.25Å; L435-I439 VanDerWaalsContact O-CG1 3.24Å; L435-I439 WeakPolarHBondContact O-CG1 3.03Å; L435-I439 PolarHBondContact O-N 3.49Å; I439-F441 PolarHBondContact O-N 2.68Å; I439-G442 PolarHBondContact O-N 2.91Å; I439-L443 HydrophobicContact CG2-CD1 3.88Å; I439-L443 HydrophobicContact CG2-CG 4.12Å; I439-L443 WeakPolarHBondContact O-CB 3.28Å; I439-L443 VanDerWaalsContact O-CG 3.29Å; I439-L443 WeakPolarHBondContact O-CG 3.26Å; I439-L443 PolarHBondContact O-N 3.31Å
440	T	94.2	Very high	89.2	Confident	67 Å²	67	42.1 Å²	42.1	41%	0.411	23%	0.231	S	C	.	.	H	α-helix	trans	-60.3	-49.3	177.9	-57.9	0	0	0	0	111	P436 I437 G442 L443 V444	P436-T440 VanDerWaalsContact O-CB 3.26Å; P436-T440 WeakPolarHBondContact O-CB 3.28Å; P436-T440 PolarHBondContact O-N 2.64Å; P436-T440 PolarHBondContact O-OG1 2.74Å; I437-T440 PolarHBondContact O-N 2.82Å; T440-G442 PolarHBondContact O-N 3.37Å; T440-L443 PolarHBondContact O-N 2.99Å; T440-V444 VanDerWaalsContact O-CG2 3.31Å; T440-V444 WeakPolarHBondContact O-CG2 3.49Å; T440-V444 PolarHBondContact O-N 2.96Å
441	F	94.8	Very high	90	Very high	76 Å²	76	42.1 Å²	42.1	33%	0.333	23%	0.228	S	C	.	.	H	α-helix	trans	-63.6	-41.3	175.5	-68	-31.4	0	0	0	112.3	A413 L420 I437 I439 L443 V444 F445	A413-F441 HydrophobicContact CB-CB 4.2Å; L420-F441 HydrophobicContact CD1-CD2 4.44Å; L420-F441 HydrophobicContact CD1-CE2 3.51Å; L420-F441 HydrophobicContact CD1-CZ 4.18Å; I437-F441 HydrophobicContact CG2-CD2 3.89Å; I437-F441 HydrophobicContact CG2-CE2 3.47Å; I437-F441 VanDerWaalsContact CG2-CE2 3.47Å; I437-F441 HydrophobicContact CG2-CZ 4.17Å; I437-F441 PolarHBondContact O-N 2.66Å; I439-F441 PolarHBondContact O-N 2.68Å; F441-L443 PolarHBondContact O-N 3.02Å; F441-V444 PolarHBondContact O-N 2.94Å; F441-F445 WeakPolarHBondContact O-CB 3.46Å; F441-F445 PolarHBondContact O-N 3.45Å
442	G	94.1	Very high	91.1	Very high	0 Å²	0	44.2 Å²	44.2	0%	0	23%	0.227	C	C	.	.	H	α-helix	trans	-57.3	-45.2	175	0	0	0	0	0	112.9	S438 I439 T440 Y446	S438-G442 PolarHBondContact O-N 3.08Å; I439-G442 PolarHBondContact O-N 2.91Å; T440-G442 PolarHBondContact O-N 3.37Å; G442-Y446 VanDerWaalsContact O-CB 3.24Å; G442-Y446 WeakPolarHBondContact O-CB 3.36Å; G442-Y446 PolarHBondContact O-N 2.93Å
443	L	94	Very high	91.7	Very high	22 Å²	22	44.7 Å²	44.7	12%	0.115	23%	0.231	C	C	.	.	H	α-helix	trans	-66.9	-44.9	177.8	-70.1	175.6	0	0	0	112.1	W247 A251 L392 I439 T440 F441 Y446 F447	W247-L443 HydrophobicContact CD2-CD2 4.44Å; W247-L443 HydrophobicContact CE3-CD2 3.31Å; W247-L443 HydrophobicContact CZ3-CD2 3.6Å; A251-L443 HydrophobicContact CB-CD1 4.14Å; L392-L443 HydrophobicContact CD1-CD2 4.45Å; L392-L443 HydrophobicContact CD1-CG 4.39Å; I439-L443 HydrophobicContact CG2-CD1 3.88Å; I439-L443 HydrophobicContact CG2-CG 4.12Å; I439-L443 WeakPolarHBondContact O-CB 3.28Å; I439-L443 VanDerWaalsContact O-CG 3.29Å; I439-L443 WeakPolarHBondContact O-CG 3.26Å; I439-L443 PolarHBondContact O-N 3.31Å; T440-L443 PolarHBondContact O-N 2.99Å; F441-L443 PolarHBondContact O-N 3.02Å; L443-Y446 WeakPolarHBondContact O-CB 3.32Å; L443-Y446 PolarHBondContact O-N 2.71Å; L443-F447 WeakPolarHBondContact O-CD2 3.49Å; L443-F447 PolarHBondContact O-N 3.47Å
444	V	95.2	Very high	92.1	Very high	83 Å²	83	45.2 Å²	45.2	50%	0.503	23%	0.233	S	C	.	.	H	α-helix	trans	-61.4	-46.6	177.9	171.5	0	0	0	0	110.3	T440 F441 A448	T440-V444 VanDerWaalsContact O-CG2 3.31Å; T440-V444 WeakPolarHBondContact O-CG2 3.49Å; T440-V444 PolarHBondContact O-N 2.96Å; F441-V444 PolarHBondContact O-N 2.94Å; V444-A448 WeakPolarHBondContact O-CB 3.41Å; V444-A448 PolarHBondContact O-N 3.2Å
445	F	94.4	Very high	92.4	Very high	90 Å²	90	47.8 Å²	47.8	40%	0.395	25%	0.249	S	C	.	.	H	α-helix	trans	-69.2	-35.1	179.5	-85.3	-143.4	0	0	0	111.7	A409 A413 F441 T449	A409-F445 HydrophobicContact CB-CD1 4.5Å; A413-F445 HydrophobicContact CB-CB 3.96Å; A413-F445 HydrophobicContact CB-CD1 3.69Å; A413-F445 HydrophobicContact CB-CE1 4.34Å; A413-F445 HydrophobicContact CB-CG 3.85Å; F441-F445 WeakPolarHBondContact O-CB 3.46Å; F441-F445 PolarHBondContact O-N 3.45Å; F445-T449 WeakPolarHBondContact O-CB 3.16Å; F445-T449 PolarHBondContact O-N 3.42Å; F445-T449 PolarHBondContact O-OG1 3.34Å
446	Y	93.8	Very high	92.8	Very high	5 Å²	5	52.9 Å²	52.9	2%	0.02	27%	0.271	C	S	.	.	H	α-helix	trans	-56.2	-60.7	172.4	174.6	-106.3	0	0	0	110.8	W247 A396 T406 C410 G442 L443 A448 T449 D450	W247-Y446 HydrophobicContact CD2-CE1 4.33Å; W247-Y446 AromaticContact CE2-CE1 3.53Å; W247-Y446 AromaticContact CE2-CZ 3.92Å; W247-Y446 AromaticContact CH2-CD1 3.59Å; W247-Y446 HydrophobicContact CH2-CD1 3.59Å; W247-Y446 AromaticContact CH2-CD2 3.76Å; W247-Y446 HydrophobicContact CH2-CD2 3.76Å; W247-Y446 AromaticContact CH2-CE1 3.67Å; W247-Y446 HydrophobicContact CH2-CE1 3.67Å; W247-Y446 AromaticContact CH2-CE2 3.88Å; W247-Y446 HydrophobicContact CH2-CE2 3.88Å; W247-Y446 AromaticContact CH2-CG 3.64Å; W247-Y446 HydrophobicContact CH2-CG 3.64Å; W247-Y446 AromaticContact CH2-CZ 3.83Å; W247-Y446 AromaticContact CZ2-CD1 3.65Å; W247-Y446 HydrophobicContact CZ2-CD1 3.65Å; W247-Y446 HydrophobicContact CZ2-CD2 4.05Å; W247-Y446 AromaticContact CZ2-CE1 3.19Å; W247-Y446 HydrophobicContact CZ2-CE1 3.19Å; W247-Y446 AromaticContact CZ2-CE2 3.68Å; W247-Y446 HydrophobicContact CZ2-CE2 3.68Å; W247-Y446 HydrophobicContact CZ2-CG 4.05Å; W247-Y446 AromaticContact CZ2-CZ 3.23Å; W247-Y446 HydrophobicContact CZ3-CD1 4.05Å; W247-Y446 HydrophobicContact CZ3-CE1 4.4Å; W247-Y446 HydrophobicContact CZ3-CG 4.22Å; W247-Y446 AromaticContact NE1-CE1 3.94Å; A396-Y446 HydrophobicContact CB-CD2 3.65Å; A396-Y446 HydrophobicContact CB-CE2 3.9Å; T406-Y446 HydrophobicContact CG2-CD2 3.5Å; T406-Y446 HydrophobicContact CG2-CE2 3.81Å; C410-Y446 VanDerWaalsContact SG-CB 3.57Å; G442-Y446 VanDerWaalsContact O-CB 3.24Å; G442-Y446 WeakPolarHBondContact O-CB 3.36Å; G442-Y446 PolarHBondContact O-N 2.93Å; L443-Y446 WeakPolarHBondContact O-CB 3.32Å; L443-Y446 PolarHBondContact O-N 2.71Å; Y446-A448 PolarHBondContact O-N 2.96Å; Y446-T449 PolarHBondContact O-N 3.19Å; Y446-D450 VanDerWaalsContact O-CB 3.25Å; Y446-D450 WeakPolarHBondContact O-CB 3.35Å; Y446-D450 PolarHBondContact O-N 3.5Å
447	F	92.9	Very high	92.9	Very high	81 Å²	81	54.8 Å²	54.8	36%	0.355	28%	0.279	S	S	.	.	H	α-helix	trans	-67	-37.5	-176.5	-68.9	-61.2	0	0	0	112.8	W247 L443 Y451	W247-F447 HydrophobicContact CD2-CZ 4.5Å; W247-F447 HydrophobicContact CG-CZ 4.37Å; L443-F447 WeakPolarHBondContact O-CD2 3.49Å; L443-F447 PolarHBondContact O-N 3.47Å; F447-Y451 HydrophobicContact CB-CD2 4.34Å; F447-Y451 HydrophobicContact CD1-CD2 4.35Å; F447-Y451 AromaticContact CD1-CE2 3.8Å; F447-Y451 HydrophobicContact CD1-CE2 3.8Å; F447-Y451 WeakPolarHBondContact O-CB 3.48Å; F447-Y451 VanDerWaalsContact O-CD2 3.27Å; F447-Y451 WeakPolarHBondContact O-CD2 3.47Å; F447-Y451 PolarHBondContact O-N 3.06Å
448	A	94.2	Very high	92.9	Very high	37 Å²	37	56.4 Å²	56.4	31%	0.306	29%	0.288	S	S	.	.	H	α-helix	trans	-66.2	-41.3	176.1	0	0	0	0	0	111.7	V444 Y446 L452 V453	V444-A448 WeakPolarHBondContact O-CB 3.41Å; V444-A448 PolarHBondContact O-N 3.2Å; Y446-A448 PolarHBondContact O-N 2.96Å; A448-L452 WeakPolarHBondContact O-CA 3.46Å; A448-L452 VanDerWaalsContact O-CB 3.23Å; A448-L452 WeakPolarHBondContact O-CB 3.44Å; A448-L452 PolarHBondContact O-N 3.49Å; A448-V453 PolarHBondContact O-N 3.17Å
449	T	93	Very high	92.9	Very high	13 Å²	13	61.9 Å²	61.9	8%	0.08	31%	0.314	C	S	.	.	I	π-helix	trans	-71.1	-43.8	-179.1	-51.7	0	0	0	0	111.1	A409 F445 Y446 V453 Q454	A409-T449 HydrophobicContact CB-CG2 4.19Å; A409-T449 WeakPolarHBondContact CB-OG1 3.31Å; F445-T449 WeakPolarHBondContact O-CB 3.16Å; F445-T449 PolarHBondContact O-N 3.42Å; F445-T449 PolarHBondContact O-OG1 3.34Å; Y446-T449 PolarHBondContact O-N 3.19Å; T449-V453 HydrophobicContact CG2-CB 3.98Å; T449-V453 HydrophobicContact CG2-CG1 4.31Å; T449-V453 PolarHBondContact O-N 3.42Å; T449-Q454 WeakPolarHBondContact O-CB 3.36Å; T449-Q454 PolarHBondContact O-N 3.08Å
450	D	91	Very high	92.9	Very high	32 Å²	32	62.9 Å²	62.9	17%	0.171	32%	0.319	C	S	.	.	I	π-helix	trans	-65.3	-43.9	-179.2	-159.3	53.7	0	0	0	112	T406 Y446 Q454	T406-D450 HydrophobicContact CG2-CB 4.44Å; Y446-D450 VanDerWaalsContact O-CB 3.25Å; Y446-D450 WeakPolarHBondContact O-CB 3.35Å; Y446-D450 PolarHBondContact O-N 3.5Å; D450-Q454 PolarHBondContact OD1-OE1 3.09Å
451	Y	91.2	Very high	92.8	Very high	154 Å²	154	63 Å²	63	60%	0.604	33%	0.327	S	S	*	.	I	π-helix	trans	-91.9	-30.7	-176.4	-68.4	-61.2	0	0	0	115.5	F447	F447-Y451 HydrophobicContact CB-CD2 4.34Å; F447-Y451 HydrophobicContact CD1-CD2 4.35Å; F447-Y451 AromaticContact CD1-CE2 3.8Å; F447-Y451 HydrophobicContact CD1-CE2 3.8Å; F447-Y451 WeakPolarHBondContact O-CB 3.48Å; F447-Y451 VanDerWaalsContact O-CD2 3.27Å; F447-Y451 WeakPolarHBondContact O-CD2 3.47Å; F447-Y451 PolarHBondContact O-N 3.06Å
452	L	93.4	Very high	92.8	Very high	128 Å²	128	67.4 Å²	67.4	67%	0.67	35%	0.346	S	S	*	.	I	π-helix	trans	-108.6	-51.4	-174.1	-55.4	174.3	0	0	0	112.3	A448	A448-L452 WeakPolarHBondContact O-CA 3.46Å; A448-L452 VanDerWaalsContact O-CB 3.23Å; A448-L452 WeakPolarHBondContact O-CB 3.44Å; A448-L452 PolarHBondContact O-N 3.49Å
453	V	92.3	Very high	92.8	Very high	59 Å²	59	72 Å²	72	36%	0.358	37%	0.367	S	S	.	.	I	π-helix	trans	-76.7	-42.5	-170.7	-177.4	0	0	0	0	111.3	A448 T449 F456 M457	A448-V453 PolarHBondContact O-N 3.17Å; T449-V453 HydrophobicContact CG2-CB 3.98Å; T449-V453 HydrophobicContact CG2-CG1 4.31Å; T449-V453 PolarHBondContact O-N 3.42Å; V453-F456 PolarHBondContact O-N 2.99Å; V453-M457 HydrophobicContact CG1-CG 3.7Å; V453-M457 WeakPolarHBondContact O-CB 3.33Å; V453-M457 VanDerWaalsContact O-CG 3.27Å; V453-M457 WeakPolarHBondContact O-CG 3.5Å; V453-M457 PolarHBondContact O-N 2.95Å
454	Q	89.6	Confident	92.8	Very high	23 Å²	23	77.5 Å²	77.5	11%	0.107	39%	0.393	C	S	.	.	H	α-helix	trans	-62	-51.8	-175.4	176.6	-176.4	-1.9	0	0	112.3	D403 T449 D450 F456 M457 D458	D403-Q454 WeakPolarHBondContact OD2-CG 3.41Å; D403-Q454 PolarHBondContact OD2-NE2 3.07Å; T449-Q454 WeakPolarHBondContact O-CB 3.36Å; T449-Q454 PolarHBondContact O-N 3.08Å; D450-Q454 PolarHBondContact OD1-OE1 3.09Å; Q454-F456 PolarHBondContact O-N 2.94Å; Q454-M457 PolarHBondContact O-N 3.41Å; Q454-D458 WeakPolarHBondContact O-CB 3.22Å; Q454-D458 VanDerWaalsContact O-CG 3.26Å; Q454-D458 PolarHBondContact O-N 3.48Å
455	P	90.5	Very high	92.8	Very high	67 Å²	67	79.8 Å²	79.8	44%	0.435	40%	0.396	S	S	.	.	H	α-helix	trans	-60.1	-34.2	176.4	-23.2	33.8	0	0	0	113.3	Q459	P455-Q459 VanDerWaalsContact O-CG 3.28Å; P455-Q459 WeakPolarHBondContact O-CG 3.41Å; P455-Q459 PolarHBondContact O-N 2.91Å
456	F	92.4	Very high	92.7	Very high	111 Å²	111	84.6 Å²	84.6	49%	0.487	41%	0.413	S	S	.	.	H	α-helix	trans	-69.5	-46.8	176.7	177.3	-110.9	0	0	0	111.6	V453 Q454 D458 Q459 L460 I467	V453-F456 PolarHBondContact O-N 2.99Å; Q454-F456 PolarHBondContact O-N 2.94Å; F456-D458 VanDerWaalsContact C-N 3.33Å; F456-D458 PolarHBondContact O-N 3.3Å; F456-Q459 PolarHBondContact O-N 2.96Å; F456-L460 HydrophobicContact CD1-CD1 4.22Å; F456-L460 HydrophobicContact CD2-CD1 3.82Å; F456-L460 HydrophobicContact CE1-CD1 3.88Å; F456-L460 HydrophobicContact CE1-CD2 4.16Å; F456-L460 HydrophobicContact CE2-CD1 3.45Å; F456-L460 VanDerWaalsContact CE2-CD1 3.45Å; F456-L460 HydrophobicContact CG-CD1 4.19Å; F456-L460 HydrophobicContact CZ-CD1 3.48Å; F456-L460 VanDerWaalsContact CZ-CD1 3.48Å; F456-L460 HydrophobicContact CZ-CD2 4.21Å; F456-L460 WeakPolarHBondContact O-CD1 3.11Å; F456-L460 PolarHBondContact O-N 3.47Å; F456-I467 HydrophobicContact CE1-CD1 3.8Å; F456-I467 HydrophobicContact CZ-CD1 4.28Å
457	M	91.8	Very high	92.6	Very high	54 Å²	54	93.1 Å²	93.1	27%	0.266	46%	0.457	S	S	.	.	H	α-helix	trans	-62.9	-38.3	176.3	-72.3	-65.6	106.2	0	0	112	V453 Q454 Q459 L460 A461 I467	V453-M457 HydrophobicContact CG1-CG 3.7Å; V453-M457 WeakPolarHBondContact O-CB 3.33Å; V453-M457 VanDerWaalsContact O-CG 3.27Å; V453-M457 WeakPolarHBondContact O-CG 3.5Å; V453-M457 PolarHBondContact O-N 2.95Å; Q454-M457 PolarHBondContact O-N 3.41Å; M457-Q459 VanDerWaalsContact C-N 3.35Å; M457-Q459 PolarHBondContact O-N 2.77Å; M457-L460 HydrophobicContact CE-CD2 3.97Å; M457-L460 PolarHBondContact O-N 3.21Å; M457-A461 VanDerWaalsContact O-CB 3.3Å; M457-A461 WeakPolarHBondContact O-CB 3.22Å; M457-A461 PolarHBondContact O-N 3.37Å; M457-I467 HydrophobicContact CE-CD1 3.95Å
458	D	91.2	Very high	92.6	Very high	82 Å²	82	93.7 Å²	93.7	44%	0.439	46%	0.462	S	S	.	.	H	α-helix	trans	-63.8	-40.3	176.4	-71.8	-17.5	0	0	0	111.5	Q454 F456 A461 F462	Q454-D458 WeakPolarHBondContact O-CB 3.22Å; Q454-D458 VanDerWaalsContact O-CG 3.26Å; Q454-D458 PolarHBondContact O-N 3.48Å; F456-D458 VanDerWaalsContact C-N 3.33Å; F456-D458 PolarHBondContact O-N 3.3Å; D458-A461 PolarHBondContact O-N 2.92Å; D458-F462 VanDerWaalsContact O-CB 3.24Å; D458-F462 WeakPolarHBondContact O-CB 3.33Å; D458-F462 PolarHBondContact O-N 3.5Å
459	Q	92.5	Very high	92.5	Very high	115 Å²	115	96.7 Å²	96.7	54%	0.537	47%	0.47	S	S	.	.	H	α-helix	trans	-65.7	-40	174.8	-71.9	-68.1	-18.6	0	0	112.3	P455 F456 M457 H463	P455-Q459 VanDerWaalsContact O-CG 3.28Å; P455-Q459 WeakPolarHBondContact O-CG 3.41Å; P455-Q459 PolarHBondContact O-N 2.91Å; F456-Q459 PolarHBondContact O-N 2.96Å; M457-Q459 VanDerWaalsContact C-N 3.35Å; M457-Q459 PolarHBondContact O-N 2.77Å; Q459-H463 PolarHBondContact O-N 3.23Å; Q459-H463 PolarHBondContact O-ND1 3.19Å
460	L	94	Very high	92.4	Very high	22 Å²	22	101.3 Å²	101.3	12%	0.115	49%	0.492	C	S	.	.	H	α-helix	trans	-64.4	-47.6	174.6	-94.5	73.1	0	0	0	111.1	F456 M457 F462 H463 Q464 F465 I467	F456-L460 HydrophobicContact CD1-CD1 4.22Å; F456-L460 HydrophobicContact CD2-CD1 3.82Å; F456-L460 HydrophobicContact CE1-CD1 3.88Å; F456-L460 HydrophobicContact CE1-CD2 4.16Å; F456-L460 HydrophobicContact CE2-CD1 3.45Å; F456-L460 VanDerWaalsContact CE2-CD1 3.45Å; F456-L460 HydrophobicContact CG-CD1 4.19Å; F456-L460 HydrophobicContact CZ-CD1 3.48Å; F456-L460 VanDerWaalsContact CZ-CD1 3.48Å; F456-L460 HydrophobicContact CZ-CD2 4.21Å; F456-L460 WeakPolarHBondContact O-CD1 3.11Å; F456-L460 PolarHBondContact O-N 3.47Å; M457-L460 HydrophobicContact CE-CD2 3.97Å; M457-L460 PolarHBondContact O-N 3.21Å; L460-F462 VanDerWaalsContact C-N 3.34Å; L460-F462 PolarHBondContact O-N 2.73Å; L460-H463 CarbonylContact O-C 3.52Å; L460-H463 PolarHBondContact O-N 3.35Å; L460-Q464 WeakPolarHBondContact O-CA 3.48Å; L460-Q464 PolarHBondContact O-N 3.25Å; L460-F465 HydrophobicContact CG-CB 4.42Å; L460-F465 PolarHBondContact O-N 3.26Å; L460-I467 HydrophobicContact CD2-CB 4.3Å; L460-I467 HydrophobicContact CD2-CD1 3.81Å; L460-I467 HydrophobicContact CD2-CG1 3.66Å; L460-I467 HydrophobicContact CD2-CG2 3.78Å
461	A	92.6	Very high	92.5	Very high	69 Å²	69	105.4 Å²	105.4	57%	0.57	51%	0.511	S	S	*	.	H	α-helix	trans	-63.3	-39.6	179.1	0	0	0	0	0	111.9	M457 D458 H463 Q464	M457-A461 VanDerWaalsContact O-CB 3.3Å; M457-A461 WeakPolarHBondContact O-CB 3.22Å; M457-A461 PolarHBondContact O-N 3.37Å; D458-A461 PolarHBondContact O-N 2.92Å; A461-H463 VanDerWaalsContact C-N 3.35Å; A461-H463 PolarHBondContact O-N 3.35Å; A461-Q464 PolarHBondContact O-N 2.93Å; A461-Q464 VanDerWaalsContact O-N 3.13Å
462	F	94.2	Very high	92.6	Very high	168 Å²	168	102.4 Å²	102.4	74%	0.737	51%	0.505	S	S	*	.	H	α-helix	trans	-61.5	-40.7	176.2	-179	-96.8	0	0	0	112.5	D458 L460 Q464	D458-F462 VanDerWaalsContact O-CB 3.24Å; D458-F462 WeakPolarHBondContact O-CB 3.33Å; D458-F462 PolarHBondContact O-N 3.5Å; L460-F462 VanDerWaalsContact C-N 3.34Å; L460-F462 PolarHBondContact O-N 2.73Å; F462-Q464 VanDerWaalsContact C-N 3.32Å
463	H	95.5	Very high	92.6	Very high	96 Å²	96	100.7 Å²	100.7	44%	0.444	49%	0.494	S	S	.	.	H	α-helix	trans	-87.1	-2.2	176	-66.5	88.3	0	0	0	113.5	Q459 L460 A461 F465	Q459-H463 PolarHBondContact O-N 3.23Å; Q459-H463 PolarHBondContact O-ND1 3.19Å; L460-H463 CarbonylContact O-C 3.52Å; L460-H463 PolarHBondContact O-N 3.35Å; A461-H463 VanDerWaalsContact C-N 3.35Å; A461-H463 PolarHBondContact O-N 3.35Å; H463-F465 HydrophobicContact CB-CD1 4.32Å; H463-F465 HydrophobicContact CB-CD2 3.55Å; H463-F465 HydrophobicContact CB-CE1 4.32Å; H463-F465 HydrophobicContact CB-CE2 3.55Å; H463-F465 HydrophobicContact CB-CG 3.96Å; H463-F465 HydrophobicContact CB-CZ 3.96Å; H463-F465 PolarHBondContact O-N 2.63Å
464	Q	93.6	Very high	92.6	Very high	138 Å²	138	103.6 Å²	103.6	65%	0.645	50%	0.504	S	S	*	.	T	Hydrogen-bonded Turn	trans	55	35.2	-173.4	-156.9	-178.4	-26.8	0	0	113.1	L460 A461 F462 Y466	L460-Q464 WeakPolarHBondContact O-CA 3.48Å; L460-Q464 PolarHBondContact O-N 3.25Å; A461-Q464 PolarHBondContact O-N 2.93Å; A461-Q464 VanDerWaalsContact O-N 3.13Å; F462-Q464 VanDerWaalsContact C-N 3.32Å; Q464-Y466 HydrophobicContact CG-CE1 4.46Å
465	F	94.4	Very high	92.8	Very high	131 Å²	131	109.8 Å²	109.8	58%	0.575	53%	0.534	S	S	*	.			trans	-89.1	131.6	172.4	-62.5	-28.4	0	0	0	110.1	L460 H463	L460-F465 HydrophobicContact CG-CB 4.42Å; L460-F465 PolarHBondContact O-N 3.26Å; H463-F465 HydrophobicContact CB-CD1 4.32Å; H463-F465 HydrophobicContact CB-CD2 3.55Å; H463-F465 HydrophobicContact CB-CE1 4.32Å; H463-F465 HydrophobicContact CB-CE2 3.55Å; H463-F465 HydrophobicContact CB-CG 3.96Å; H463-F465 HydrophobicContact CB-CZ 3.96Å; H463-F465 PolarHBondContact O-N 2.63Å
466	Y	92.3	Very high	93	Very high	191 Å²	191	113.4 Å²	113.4	75%	0.749	54%	0.542	S	S	*	.			trans	-112.1	140.9	178	-54.8	-43.1	0	0	0	110.1	Q464	Q464-Y466 HydrophobicContact CG-CE1 4.46Å
467	I	91.6	Very high	93	Very high	184 Å²	184	113.6 Å²	113.6	94%	0.944	55%	0.547	S	S	*	.			trans	-126.1	0	179.2	59.5	166.3	0	0	0	112	F456 M457 L460	F456-I467 HydrophobicContact CE1-CD1 3.8Å; F456-I467 HydrophobicContact CZ-CD1 4.28Å; M457-I467 HydrophobicContact CE-CD1 3.95Å; L460-I467 HydrophobicContact CD2-CB 4.3Å; L460-I467 HydrophobicContact CD2-CD1 3.81Å; L460-I467 HydrophobicContact CD2-CG1 3.66Å; L460-I467 HydrophobicContact CD2-CG2 3.78Å

Retrieved 467 of 467 residues in 1016.8 ms (Link to these results)

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