DLP_SCHMA Loading...

Dermaseptin-like peptide

Has antimicrobial activity against the Gram-positive bacterium M.luteus and the yeast C.albicans. Has hemolytic activity on human and duck erythrocytes.

AlphaFold DB , UniProt , Accession P83914, Species SCHMA (Schistosoma mansoni, Blood fluke), Gene n/a, Length 27 aa.

						>DLP_SCHMA|P83914
DLWNSIKDMAAAAGRAALNAVTGMVNQ
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	D	88.8	Confident	95.4	Very high	161 Å²	161	103.6 Å²	103.6	86%	0.861	55%	0.552	S	S	*	*				0	138.3	0	-52.4	-30.5	0	0	0	111.8	W3 N4 S5	D1-W3 PolarHBondContact O-N 3.5Å; D1-W3 VanDerWaalsContact O-N 3.07Å; D1-N4 PolarHBondContact O-N 2.93Å; D1-S5 PolarHBondContact O-N 3.07Å
2	L	94.3	Very high	95.5	Very high	139 Å²	139	100 Å²	100	73%	0.728	55%	0.548	S	S	*	.	H	α-helix	trans	-46.4	-37.6	175.8	176.3	63.2	0	0	0	112.4	N4 S5 I6	L2-N4 VanDerWaalsContact C-N 3.35Å; L2-N4 PolarHBondContact O-N 2.97Å; L2-S5 WeakPolarHBondContact O-CB 3.38Å; L2-S5 PolarHBondContact O-N 3.17Å; L2-I6 HydrophobicContact CD1-CD1 4.36Å; L2-I6 HydrophobicContact CD1-CG1 4.45Å; L2-I6 HydrophobicContact CG-CD1 3.96Å; L2-I6 HydrophobicContact CG-CG1 4.48Å; L2-I6 WeakPolarHBondContact O-CG1 3.46Å; L2-I6 PolarHBondContact O-N 2.95Å
3	W	94.3	Very high	95.5	Very high	160 Å²	160	97 Å²	97	61%	0.606	54%	0.544	S	S	*	.	H	α-helix	trans	-59.3	-39.2	177.5	-176.5	-127.9	0	0	0	114.1	D1 I6 K7	D1-W3 PolarHBondContact O-N 3.5Å; D1-W3 VanDerWaalsContact O-N 3.07Å; W3-I6 HydrophobicContact CZ3-CG2 4.46Å; W3-I6 PolarHBondContact O-N 3.2Å; W3-K7 VanDerWaalsContact CE2-CE 3.41Å; W3-K7 VanDerWaalsContact NE1-NZ 3.18Å; W3-K7 WeakPolarHBondContact O-CG 3.42Å; W3-K7 PolarHBondContact O-N 3.4Å
4	N	96.9	Very high	95.6	Very high	80 Å²	80	92.9 Å²	92.9	43%	0.428	53%	0.534	S	S	.	.	H	α-helix	trans	-67.4	-41.3	176	-68.3	-20.4	0	0	0	110.6	D1 L2 I6 K7 D8	D1-N4 PolarHBondContact O-N 2.93Å; L2-N4 VanDerWaalsContact C-N 3.35Å; L2-N4 PolarHBondContact O-N 2.97Å; N4-I6 VanDerWaalsContact C-N 3.33Å; N4-I6 PolarHBondContact O-N 3.49Å; N4-K7 WeakPolarHBondContact O-CB 3.46Å; N4-K7 PolarHBondContact O-N 3.4Å; N4-D8 VanDerWaalsContact O-CG 3.32Å; N4-D8 PolarHBondContact O-N 3.01Å
5	S	96.4	Very high	95.6	Very high	57 Å²	57	98.9 Å²	98.9	40%	0.399	55%	0.545	S	S	.	.	H	α-helix	trans	-62.7	-38.8	175.8	-169	0	0	0	0	112.5	D1 L2 D8 M9	D1-S5 PolarHBondContact O-N 3.07Å; L2-S5 WeakPolarHBondContact O-CB 3.38Å; L2-S5 PolarHBondContact O-N 3.17Å; S5-D8 PolarHBondContact O-N 3.38Å; S5-M9 WeakPolarHBondContact O-CG 3.44Å; S5-M9 PolarHBondContact O-N 2.95Å
6	I	96.1	Very high	95.7	Very high	80 Å²	80	96.6 Å²	96.6	41%	0.41	54%	0.542	S	S	.	.	H	α-helix	trans	-64.1	-43.1	175.7	-69.4	167.7	0	0	0	110.4	L2 W3 N4 D8 M9 A10	L2-I6 HydrophobicContact CD1-CD1 4.36Å; L2-I6 HydrophobicContact CD1-CG1 4.45Å; L2-I6 HydrophobicContact CG-CD1 3.96Å; L2-I6 HydrophobicContact CG-CG1 4.48Å; L2-I6 WeakPolarHBondContact O-CG1 3.46Å; L2-I6 PolarHBondContact O-N 2.95Å; W3-I6 HydrophobicContact CZ3-CG2 4.46Å; W3-I6 PolarHBondContact O-N 3.2Å; N4-I6 VanDerWaalsContact C-N 3.33Å; N4-I6 PolarHBondContact O-N 3.49Å; I6-D8 VanDerWaalsContact C-N 3.34Å; I6-D8 PolarHBondContact O-N 3.06Å; I6-M9 PolarHBondContact O-N 3.41Å; I6-A10 VanDerWaalsContact O-CB 3.27Å; I6-A10 WeakPolarHBondContact O-CB 3.27Å; I6-A10 PolarHBondContact O-N 3.4Å
7	K	96.6	Very high	95.7	Very high	103 Å²	103	94.3 Å²	94.3	45%	0.448	54%	0.539	S	S	.	.	H	α-helix	trans	-60.9	-43.6	176.1	-75.3	174.1	173	171.6	0	112	W3 N4 A10 A11	W3-K7 VanDerWaalsContact CE2-CE 3.41Å; W3-K7 VanDerWaalsContact NE1-NZ 3.18Å; W3-K7 WeakPolarHBondContact O-CG 3.42Å; W3-K7 PolarHBondContact O-N 3.4Å; N4-K7 WeakPolarHBondContact O-CB 3.46Å; N4-K7 PolarHBondContact O-N 3.4Å; K7-A10 PolarHBondContact O-N 3.5Å; K7-A11 VanDerWaalsContact O-CB 3.31Å; K7-A11 WeakPolarHBondContact O-CB 3.49Å; K7-A11 PolarHBondContact O-N 2.95Å
8	D	96.9	Very high	95.6	Very high	117 Å²	117	95.1 Å²	95.1	63%	0.626	54%	0.54	S	S	*	.	H	α-helix	trans	-64.4	-42.9	179.4	-66.8	-23.5	0	0	0	111.1	N4 S5 I6 A11 A12	N4-D8 VanDerWaalsContact O-CG 3.32Å; N4-D8 PolarHBondContact O-N 3.01Å; S5-D8 PolarHBondContact O-N 3.38Å; I6-D8 VanDerWaalsContact C-N 3.34Å; I6-D8 PolarHBondContact O-N 3.06Å; D8-A11 PolarHBondContact O-N 2.82Å; D8-A12 WeakPolarHBondContact O-CB 3.43Å; D8-A12 PolarHBondContact O-N 3.41Å
9	M	95.8	Very high	95.6	Very high	131 Å²	131	95.9 Å²	95.9	65%	0.645	54%	0.543	S	S	*	.	H	α-helix	trans	-63.7	-44	173.8	-73.9	-178.2	178.1	0	0	112.3	S5 I6 A11 A12 A13	S5-M9 WeakPolarHBondContact O-CG 3.44Å; S5-M9 PolarHBondContact O-N 2.95Å; I6-M9 PolarHBondContact O-N 3.41Å; M9-A11 VanDerWaalsContact C-N 3.34Å; M9-A11 PolarHBondContact O-N 3.33Å; M9-A12 PolarHBondContact O-N 3.5Å; M9-A13 WeakPolarHBondContact O-CB 3.31Å; M9-A13 PolarHBondContact O-N 2.79Å
10	A	96.3	Very high	95.5	Very high	60 Å²	60	93.9 Å²	93.9	50%	0.496	54%	0.539	S	S	.	.	H	α-helix	trans	-64.7	-38.6	177.7	0	0	0	0	0	111.7	I6 K7 A13 G14	I6-A10 VanDerWaalsContact O-CB 3.27Å; I6-A10 WeakPolarHBondContact O-CB 3.27Å; I6-A10 PolarHBondContact O-N 3.4Å; K7-A10 PolarHBondContact O-N 3.5Å; A10-A13 PolarHBondContact O-N 3.32Å; A10-G14 PolarHBondContact O-N 2.84Å
11	A	96.8	Very high	95.4	Very high	52 Å²	52	93.5 Å²	93.5	43%	0.43	54%	0.538	S	S	.	.	H	α-helix	trans	-65.5	-40.8	174.4	0	0	0	0	0	111.5	K7 D8 M9 R15	K7-A11 VanDerWaalsContact O-CB 3.31Å; K7-A11 WeakPolarHBondContact O-CB 3.49Å; K7-A11 PolarHBondContact O-N 2.95Å; D8-A11 PolarHBondContact O-N 2.82Å; M9-A11 VanDerWaalsContact C-N 3.34Å; M9-A11 PolarHBondContact O-N 3.33Å; A11-R15 WeakPolarHBondContact O-CB 3.46Å; A11-R15 VanDerWaalsContact O-CG 3.27Å; A11-R15 WeakPolarHBondContact O-CG 3.34Å; A11-R15 PolarHBondContact O-N 3.27Å
12	A	96.8	Very high	95.7	Very high	60 Å²	60	88.7 Å²	88.7	50%	0.496	51%	0.514	S	S	.	.	H	α-helix	trans	-64.7	-47.4	175.1	0	0	0	0	0	111.8	D8 M9 G14 R15 A16	D8-A12 WeakPolarHBondContact O-CB 3.43Å; D8-A12 PolarHBondContact O-N 3.41Å; M9-A12 PolarHBondContact O-N 3.5Å; A12-G14 PolarHBondContact O-N 3.28Å; A12-R15 PolarHBondContact O-N 3.49Å; A12-A16 WeakPolarHBondContact O-CB 3.36Å; A12-A16 PolarHBondContact O-N 2.82Å
13	A	95.9	Very high	95.6	Very high	61 Å²	61	83.8 Å²	83.8	50%	0.504	50%	0.497	S	S	.	.	H	α-helix	trans	-62.7	-42.4	176.8	0	0	0	0	0	111.7	M9 A10 R15 A16 A17	M9-A13 WeakPolarHBondContact O-CB 3.31Å; M9-A13 PolarHBondContact O-N 2.79Å; A10-A13 PolarHBondContact O-N 3.32Å; A13-R15 PolarHBondContact O-N 2.88Å; A13-A16 PolarHBondContact O-N 2.99Å; A13-A17 WeakPolarHBondContact O-CB 3.27Å; A13-A17 PolarHBondContact O-N 3.4Å
14	G	96.4	Very high	95.3	Very high	39 Å²	39	82.9 Å²	82.9	40%	0.402	50%	0.501	S	S	.	.	H	α-helix	trans	-61.8	-42.3	176.5	0	0	0	0	0	112.3	A10 A12 L18	A10-G14 PolarHBondContact O-N 2.84Å; A12-G14 PolarHBondContact O-N 3.28Å; G14-L18 VanDerWaalsContact O-CB 3.22Å; G14-L18 WeakPolarHBondContact O-CB 3.47Å; G14-L18 PolarHBondContact O-N 2.94Å
15	R	96.2	Very high	94.9	Very high	184 Å²	184	84.3 Å²	84.3	69%	0.694	51%	0.513	S	S	*	.	H	α-helix	trans	-64.8	-42.4	173.8	-73.9	172.6	-176.4	-116.3	2.4	112.2	A11 A12 A13 L18 N19	A11-R15 WeakPolarHBondContact O-CB 3.46Å; A11-R15 VanDerWaalsContact O-CG 3.27Å; A11-R15 WeakPolarHBondContact O-CG 3.34Å; A11-R15 PolarHBondContact O-N 3.27Å; A12-R15 PolarHBondContact O-N 3.49Å; A13-R15 PolarHBondContact O-N 2.88Å; R15-L18 PolarHBondContact O-N 3.47Å; R15-N19 WeakPolarHBondContact O-CB 3.34Å; R15-N19 PolarHBondContact O-N 3.49Å; R15-N19 PolarHBondContact O-ND2 2.99Å
16	A	95.8	Very high	94.2	Very high	61 Å²	61	87.9 Å²	87.9	50%	0.504	53%	0.527	S	S	.	.	H	α-helix	trans	-64.5	-45.7	178	0	0	0	0	0	111.7	A12 A13 N19 A20	A12-A16 WeakPolarHBondContact O-CB 3.36Å; A12-A16 PolarHBondContact O-N 2.82Å; A13-A16 PolarHBondContact O-N 2.99Å; A16-N19 PolarHBondContact O-N 2.85Å; A16-A20 WeakPolarHBondContact O-CB 3.22Å; A16-A20 PolarHBondContact O-N 2.88Å
17	A	95.8	Very high	92.5	Very high	58 Å²	58	94.9 Å²	94.9	48%	0.479	56%	0.558	S	S	.	*	H	α-helix	trans	-63.2	-44.2	175.9	0	0	0	0	0	111.6	A13 A20 V21	A13-A17 WeakPolarHBondContact O-CB 3.27Å; A13-A17 PolarHBondContact O-N 3.4Å; A17-A20 PolarHBondContact O-N 2.77Å; A17-V21 WeakPolarHBondContact O-CG2 3.27Å; A17-V21 PolarHBondContact O-N 2.89Å
18	L	95.4	Very high	92.3	Very high	108 Å²	108	94.5 Å²	94.5	57%	0.565	56%	0.564	S	S	*	*	H	α-helix	trans	-62.7	-44.6	176.7	-174.3	140.3	0	0	0	111.2	G14 R15 A20 V21 T22	G14-L18 VanDerWaalsContact O-CB 3.22Å; G14-L18 WeakPolarHBondContact O-CB 3.47Å; G14-L18 PolarHBondContact O-N 2.94Å; R15-L18 PolarHBondContact O-N 3.47Å; L18-A20 VanDerWaalsContact C-N 3.31Å; L18-A20 PolarHBondContact O-N 3.28Å; L18-V21 PolarHBondContact O-N 3.41Å; L18-T22 VanDerWaalsContact O-CB 3.31Å; L18-T22 WeakPolarHBondContact O-CB 3.31Å; L18-T22 PolarHBondContact O-N 3.26Å; L18-T22 PolarHBondContact O-OG1 3.4Å
19	N	95.3	Very high	92	Very high	112 Å²	112	93.3 Å²	93.3	60%	0.599	56%	0.561	S	S	*	*	H	α-helix	trans	-61.5	-39.1	175.8	-73.3	-14.3	0	0	0	112.2	R15 A16 G23	R15-N19 WeakPolarHBondContact O-CB 3.34Å; R15-N19 PolarHBondContact O-N 3.49Å; R15-N19 PolarHBondContact O-ND2 2.99Å; A16-N19 PolarHBondContact O-N 2.85Å; N19-G23 PolarHBondContact O-N 2.84Å
20	A	94	Very high	91.8	Very high	55 Å²	55	91.2 Å²	91.2	46%	0.455	56%	0.556	S	S	.	*	H	α-helix	trans	-64.3	-47.1	175.7	0	0	0	0	0	111.3	A16 A17 L18 G23 M24	A16-A20 WeakPolarHBondContact O-CB 3.22Å; A16-A20 PolarHBondContact O-N 2.88Å; A17-A20 PolarHBondContact O-N 2.77Å; L18-A20 VanDerWaalsContact C-N 3.31Å; L18-A20 PolarHBondContact O-N 3.28Å; A20-G23 PolarHBondContact O-N 2.97Å; A20-M24 VanDerWaalsContact O-CG 3.27Å; A20-M24 WeakPolarHBondContact O-CG 3.27Å; A20-M24 PolarHBondContact O-N 2.9Å
21	V	93.2	Very high	91.5	Very high	86 Å²	86	93 Å²	93	52%	0.521	56%	0.559	S	S	.	*	H	α-helix	trans	-64.8	-45.1	177.4	173.5	0	0	0	0	111.3	A17 L18 G23 M24 V25	A17-V21 WeakPolarHBondContact O-CG2 3.27Å; A17-V21 PolarHBondContact O-N 2.89Å; L18-V21 PolarHBondContact O-N 3.41Å; V21-G23 VanDerWaalsContact C-N 3.29Å; V21-G23 PolarHBondContact O-N 3.41Å; V21-M24 CarbonylContact O-C 3.6Å; V21-M24 PolarHBondContact O-N 2.82Å; V21-M24 VanDerWaalsContact O-N 3.13Å; V21-V25 HydrophobicContact CG1-CG2 4.19Å; V21-V25 WeakPolarHBondContact O-CB 3.34Å; V21-V25 VanDerWaalsContact O-CG2 3.32Å; V21-V25 WeakPolarHBondContact O-CG2 3.37Å; V21-V25 PolarHBondContact O-N 3.13Å
22	T	93.6	Very high	91.2	Very high	59 Å²	59	95.6 Å²	95.6	36%	0.362	57%	0.568	S	S	.	*	H	α-helix	trans	-60.8	-40.7	175	-62.2	0	0	0	0	111.2	L18 M24 V25 N26	L18-T22 VanDerWaalsContact O-CB 3.31Å; L18-T22 WeakPolarHBondContact O-CB 3.31Å; L18-T22 PolarHBondContact O-N 3.26Å; L18-T22 PolarHBondContact O-OG1 3.4Å; T22-M24 VanDerWaalsContact C-N 3.34Å; T22-V25 PolarHBondContact O-N 3.42Å; T22-N26 WeakPolarHBondContact CG2-ND2 3.5Å; T22-N26 VanDerWaalsContact O-CB 3.27Å; T22-N26 WeakPolarHBondContact O-CB 3.34Å; T22-N26 VanDerWaalsContact O-CG 3.28Å; T22-N26 PolarHBondContact O-N 3.29Å; T22-N26 PolarHBondContact O-ND2 3.34Å
23	G	92.5	Very high	90.8	Very high	36 Å²	36	97.9 Å²	97.9	37%	0.371	57%	0.572	S	S	.	*	H	α-helix	trans	-60.7	-41.7	172.8	0	0	0	0	0	112.4	N19 A20 V21 Q27	N19-G23 PolarHBondContact O-N 2.84Å; A20-G23 PolarHBondContact O-N 2.97Å; V21-G23 VanDerWaalsContact C-N 3.29Å; V21-G23 PolarHBondContact O-N 3.41Å; G23-Q27 WeakPolarHBondContact O-CG 3.32Å; G23-Q27 PolarHBondContact O-N 3.4Å
24	M	89.5	Confident	90.5	Very high	141 Å²	141	100.6 Å²	100.6	70%	0.695	58%	0.577	S	S	*	*	H	α-helix	trans	-70.7	-35.5	177	-69.8	173	70.4	0	0	113.6	A20 V21 T22	A20-M24 VanDerWaalsContact O-CG 3.27Å; A20-M24 WeakPolarHBondContact O-CG 3.27Å; A20-M24 PolarHBondContact O-N 2.9Å; V21-M24 CarbonylContact O-C 3.6Å; V21-M24 PolarHBondContact O-N 2.82Å; V21-M24 VanDerWaalsContact O-N 3.13Å; T22-M24 VanDerWaalsContact C-N 3.34Å
25	V	86.8	Confident	90	Very high	110 Å²	110	105.3 Å²	105.3	67%	0.667	59%	0.591	S	S	*	*	H	α-helix	trans	-76.5	-31.2	179.6	171.1	0	0	0	0	111.5	V21 T22 Q27	V21-V25 HydrophobicContact CG1-CG2 4.19Å; V21-V25 WeakPolarHBondContact O-CB 3.34Å; V21-V25 VanDerWaalsContact O-CG2 3.32Å; V21-V25 WeakPolarHBondContact O-CG2 3.37Å; V21-V25 PolarHBondContact O-N 3.13Å; T22-V25 PolarHBondContact O-N 3.42Å; V25-Q27 VanDerWaalsContact C-N 3.3Å
26	N	81.8	Confident	89.5	Confident	132 Å²	132	98.8 Å²	98.8	71%	0.706	58%	0.582	S	S	*	*	T	Hydrogen-bonded Turn	trans	-86.4	3.6	178.2	-69.1	-22.1	0	0	0	113.6	T22	T22-N26 WeakPolarHBondContact CG2-ND2 3.5Å; T22-N26 VanDerWaalsContact O-CB 3.27Å; T22-N26 WeakPolarHBondContact O-CB 3.34Å; T22-N26 VanDerWaalsContact O-CG 3.28Å; T22-N26 PolarHBondContact O-N 3.29Å; T22-N26 PolarHBondContact O-ND2 3.34Å
27	Q	60.4	Low	88.9	Confident	227 Å²	227	102.2 Å²	102.2	100%	1.061	59%	0.589	S	S	*	*			trans	-106.5	0	172.4	-77.6	-161.9	-36.4	0	0	110.9	G23 V25	G23-Q27 WeakPolarHBondContact O-CG 3.32Å; G23-Q27 PolarHBondContact O-N 3.4Å; V25-Q27 VanDerWaalsContact C-N 3.3Å

Retrieved 27 of 27 residues in 27.6 ms (Link to these results)

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