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Nucleoside diphosphate kinase C

Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis^1,2,3. In vitro, can also use other phosphate donors such as UTP and GTP^4,5. Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization^6,7. Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity⁸. Inhibits granulocyte differentiation⁹. May be required for ciliary function during renal development (By similarity).

AlphaFold DB , UniProt , Accession Q13232, Species HUMAN (Homo sapiens, Human), Gene NME3, Length 169 aa.