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Importin-9

Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin^1,2,3. Serves as receptor for nuclear localization signals (NLS) in cargo substrates⁴. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism⁵. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran⁶. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus⁷. Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex^8,9. Mediates the nuclear import of histones H2A, H2B, H4 and H4^10,11. In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions¹². Mediates the nuclear import of actin (By similarity).

AlphaFold DB , UniProt , Accession Q96P70, Species HUMAN (Homo sapiens, Human), Gene IPO9, Length 1,041 aa.