ZY11B_HUMAN Loading...

Protein zyg-11 homolog B

Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements^1,2,3. Prefers Nt-Gly but also has the capacity to recognize Nt-Ser, -Ala and -Cys⁴. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation⁵. In addition, plays a role in the amplification of cGAS to enhance innate immune response. Mechanistically, strengthens the processes of cGAS binding with dsDNA and assembling oligomers and also accelerates and stabilizes cGAS-DNA condensation, thereby enhancing production of antiviral IFNs and inflammatory cytokines⁶.

AlphaFold DB , UniProt , Accession Q9C0D3, Species HUMAN (Homo sapiens, Human), Gene ZYG11B, Length 744 aa.