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Phospholamban

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.

AlphaFold DB , UniProt , Accession U3I3G3, Species ANAPP (Anas platyrhynchos platyrhynchos, Northern mallard), Gene PLN, Length 52 aa.

						>U3I3G3_ANAPP|U3I3G3|PLN
MEKVQYITRSALRRASTIEVNPQARQRLQELFVNFCLILICLLLICIIVMLL
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	53.6	Low	62.8	Low	213 Å²	213	130.6 Å²	130.6	100%	1.049	64%	0.638	S	S	*	*				0	-30.8	0	-81.1	-171.1	164.6	0	0	113.6	K3 V4	M1-K3 PolarHBondContact O-N 3.26Å; M1-V4 PolarHBondContact O-N 3.29Å
2	E	57.7	Low	62.9	Low	167 Å²	167	129.8 Å²	129.8	78%	0.78	64%	0.637	S	S	*	*	H	α-helix	trans	-59.6	-35	-176.5	-63.6	176.9	153.6	0	0	115.3	V4 Q5 Y6	E2-V4 VanDerWaalsContact C-N 3.32Å; E2-V4 PolarHBondContact O-N 3.08Å; E2-Q5 PolarHBondContact O-N 3.39Å; E2-Y6 PolarHBondContact O-N 3.36Å; E2-Y6 VanDerWaalsContact O-N 3.08Å
3	K	58.8	Low	62.8	Low	178 Å²	178	134.8 Å²	134.8	77%	0.774	65%	0.645	S	S	*	*	H	α-helix	trans	-63	-34.8	179.5	-70.4	-177	-179.1	179.5	0	113.2	M1 Y6 I7	M1-K3 PolarHBondContact O-N 3.26Å; K3-Y6 PolarHBondContact O-N 3.1Å; K3-I7 WeakPolarHBondContact O-CD1 3.38Å; K3-I7 VanDerWaalsContact O-CG1 3.26Å; K3-I7 WeakPolarHBondContact O-CG1 3.26Å; K3-I7 PolarHBondContact O-N 3.49Å; K3-I7 VanDerWaalsContact O-N 3.1Å
4	V	62.2	Low	62.5	Low	98 Å²	98	139.8 Å²	139.8	59%	0.594	65%	0.654	S	S	*	*	H	α-helix	trans	-72.3	-43.9	-179.7	-174.3	0	0	0	0	110.1	M1 E2 Y6 I7 T8	M1-V4 PolarHBondContact O-N 3.29Å; E2-V4 VanDerWaalsContact C-N 3.32Å; E2-V4 PolarHBondContact O-N 3.08Å; V4-Y6 VanDerWaalsContact C-N 3.28Å; V4-Y6 PolarHBondContact O-N 2.89Å; V4-I7 PolarHBondContact O-N 2.86Å; V4-T8 PolarHBondContact O-N 2.95Å; V4-T8 PolarHBondContact O-OG1 3.34Å
5	Q	61	Low	62.2	Low	129 Å²	129	134.4 Å²	134.4	60%	0.603	64%	0.643	S	S	*	*	H	α-helix	trans	-60.6	-36.6	174.8	-91.2	-176.5	-66.4	0	0	112.8	E2 R9	E2-Q5 PolarHBondContact O-N 3.39Å; Q5-R9 WeakPolarHBondContact O-CB 3.35Å; Q5-R9 PolarHBondContact O-N 3.49Å
6	Y	66.7	Low	61.9	Low	172 Å²	172	131.1 Å²	131.1	68%	0.675	64%	0.639	S	S	*	*	H	α-helix	trans	-65.6	-45.5	174.6	-175.9	-95.9	0	0	0	111.7	E2 K3 V4 T8 R9 S10	E2-Y6 PolarHBondContact O-N 3.36Å; E2-Y6 VanDerWaalsContact O-N 3.08Å; K3-Y6 PolarHBondContact O-N 3.1Å; V4-Y6 VanDerWaalsContact C-N 3.28Å; V4-Y6 PolarHBondContact O-N 2.89Å; Y6-T8 PolarHBondContact O-N 2.64Å; Y6-R9 PolarHBondContact O-N 3.5Å; Y6-S10 WeakPolarHBondContact O-CB 3.45Å; Y6-S10 PolarHBondContact O-N 3.37Å; Y6-S10 PolarHBondContact O-OG 3.49Å
7	I	68.3	Low	61.4	Low	111 Å²	111	129.8 Å²	129.8	57%	0.569	64%	0.64	S	S	*	*	H	α-helix	trans	-61.5	-46.3	176.6	-66.4	164.4	0	0	0	110.4	K3 V4 R9 S10 A11	K3-I7 WeakPolarHBondContact O-CD1 3.38Å; K3-I7 VanDerWaalsContact O-CG1 3.26Å; K3-I7 WeakPolarHBondContact O-CG1 3.26Å; K3-I7 PolarHBondContact O-N 3.49Å; K3-I7 VanDerWaalsContact O-N 3.1Å; V4-I7 PolarHBondContact O-N 2.86Å; I7-R9 PolarHBondContact O-N 3.48Å; I7-S10 PolarHBondContact O-N 3.22Å; I7-A11 WeakPolarHBondContact O-CB 3.47Å; I7-A11 PolarHBondContact O-N 3.19Å
8	T	68.4	Low	61.1	Low	85 Å²	85	129 Å²	129	52%	0.521	64%	0.638	S	S	.	*	H	α-helix	trans	-63	-42.7	178.6	-51.4	0	0	0	0	111.8	V4 Y6 S10 A11 L12	V4-T8 PolarHBondContact O-N 2.95Å; V4-T8 PolarHBondContact O-OG1 3.34Å; Y6-T8 PolarHBondContact O-N 2.64Å; T8-S10 VanDerWaalsContact C-N 3.34Å; T8-S10 PolarHBondContact O-N 2.92Å; T8-A11 PolarHBondContact O-N 2.85Å; T8-L12 WeakPolarHBondContact O-CB 3.32Å; T8-L12 PolarHBondContact O-N 2.89Å
9	R	67.8	Low	60.7	Low	187 Å²	187	131.1 Å²	131.1	71%	0.706	65%	0.645	S	S	*	*	H	α-helix	trans	-66.1	-34.9	175.1	-85.4	-176.5	170.4	-176.4	-1.7	112.8	Q5 Y6 I7 R13	Q5-R9 WeakPolarHBondContact O-CB 3.35Å; Q5-R9 PolarHBondContact O-N 3.49Å; Y6-R9 PolarHBondContact O-N 3.5Å; I7-R9 PolarHBondContact O-N 3.48Å; R9-R13 WeakPolarHBondContact O-CB 3.31Å; R9-R13 PolarHBondContact O-N 2.83Å
10	S	63.1	Low	60.5	Low	41 Å²	41	129.9 Å²	129.9	29%	0.287	65%	0.646	S	S	.	*	H	α-helix	trans	-69.5	-43.9	177.6	-54.6	0	0	0	0	111.4	Y6 I7 T8 R13 R14	Y6-S10 WeakPolarHBondContact O-CB 3.45Å; Y6-S10 PolarHBondContact O-N 3.37Å; Y6-S10 PolarHBondContact O-OG 3.49Å; I7-S10 PolarHBondContact O-N 3.22Å; T8-S10 VanDerWaalsContact C-N 3.34Å; T8-S10 PolarHBondContact O-N 2.92Å; S10-R13 PolarHBondContact O-N 3.48Å; S10-R14 WeakPolarHBondContact O-CG 3.41Å; S10-R14 PolarHBondContact O-N 2.98Å
11	A	63.5	Low	60.5	Low	56 Å²	56	127.4 Å²	127.4	46%	0.463	64%	0.635	S	S	.	*	H	α-helix	trans	-65.5	-42	174.5	0	0	0	0	0	111.4	I7 T8 R14 A15	I7-A11 WeakPolarHBondContact O-CB 3.47Å; I7-A11 PolarHBondContact O-N 3.19Å; T8-A11 PolarHBondContact O-N 2.85Å; A11-R14 PolarHBondContact O-N 3.37Å; A11-A15 WeakPolarHBondContact O-CB 3.18Å; A11-A15 PolarHBondContact O-N 2.9Å
12	L	64.3	Low	61	Low	120 Å²	120	121.8 Å²	121.8	63%	0.628	61%	0.614	S	S	*	*	H	α-helix	trans	-65.1	-41.1	176.8	-171.8	66.2	0	0	0	111.9	T8 A15 S16	T8-L12 WeakPolarHBondContact O-CB 3.32Å; T8-L12 PolarHBondContact O-N 2.89Å; L12-A15 PolarHBondContact O-N 3.11Å; L12-S16 WeakPolarHBondContact O-CB 3.48Å; L12-S16 PolarHBondContact O-N 2.94Å; L12-S16 PolarHBondContact O-OG 2.91Å
13	R	61	Low	61.7	Low	195 Å²	195	120.1 Å²	120.1	74%	0.736	61%	0.607	S	S	*	*	H	α-helix	trans	-62.5	-47	172.8	-96.6	-174.5	168	-173.4	-3.7	111.5	R9 S10 A15 S16 T17	R9-R13 WeakPolarHBondContact O-CB 3.31Å; R9-R13 PolarHBondContact O-N 2.83Å; S10-R13 PolarHBondContact O-N 3.48Å; R13-A15 VanDerWaalsContact C-N 3.28Å; R13-A15 PolarHBondContact O-N 2.85Å; R13-S16 WeakPolarHBondContact CA-OG 3.35Å; R13-S16 PolarHBondContact O-N 2.74Å; R13-S16 VanDerWaalsContact O-N 3.11Å; R13-S16 PolarHBondContact O-OG 3.37Å; R13-T17 PolarHBondContact O-N 3.33Å; R13-T17 PolarHBondContact O-OG1 2.89Å
14	R	59.1	Low	62.5	Low	205 Å²	205	113.9 Å²	113.9	77%	0.774	59%	0.588	S	S	*	*	H	α-helix	trans	-60.3	-37.7	175.4	-77.5	-178	175.5	177.1	-0.9	112.2	S10 A11 I18	S10-R14 WeakPolarHBondContact O-CG 3.41Å; S10-R14 PolarHBondContact O-N 2.98Å; A11-R14 PolarHBondContact O-N 3.37Å; R14-I18 VanDerWaalsContact O-CG1 3.31Å; R14-I18 WeakPolarHBondContact O-CG1 3.37Å; R14-I18 PolarHBondContact O-N 3.33Å
15	A	57.9	Low	63.3	Low	59 Å²	59	117.6 Å²	117.6	49%	0.488	59%	0.591	S	S	.	*	H	α-helix	trans	-68.7	-36.7	174.1	0	0	0	0	0	112.5	A11 L12 R13 I18	A11-A15 WeakPolarHBondContact O-CB 3.18Å; A11-A15 PolarHBondContact O-N 2.9Å; L12-A15 PolarHBondContact O-N 3.11Å; R13-A15 VanDerWaalsContact C-N 3.28Å; R13-A15 PolarHBondContact O-N 2.85Å; A15-I18 WeakPolarHBondContact O-CB 3.42Å; A15-I18 PolarHBondContact O-N 3.38Å
16	S	57	Low	64.3	Low	82 Å²	82	116.9 Å²	116.9	57%	0.573	59%	0.588	S	S	*	*	H	α-helix	trans	-74.4	-27.8	178.7	67.4	0	0	0	0	114.2	L12 R13 I18	L12-S16 WeakPolarHBondContact O-CB 3.48Å; L12-S16 PolarHBondContact O-N 2.94Å; L12-S16 PolarHBondContact O-OG 2.91Å; R13-S16 WeakPolarHBondContact CA-OG 3.35Å; R13-S16 PolarHBondContact O-N 2.74Å; R13-S16 VanDerWaalsContact O-N 3.11Å; R13-S16 PolarHBondContact O-OG 3.37Å; S16-I18 VanDerWaalsContact C-N 3.29Å
17	T	54.2	Low	65.1	Low	109 Å²	109	117 Å²	117	67%	0.669	59%	0.587	S	S	*	*	T	Hydrogen-bonded Turn	trans	-85.9	-2.9	174.9	-35.8	0	0	0	0	112.1	R13 E19	R13-T17 PolarHBondContact O-N 3.33Å; R13-T17 PolarHBondContact O-OG1 2.89Å; T17-E19 PolarHBondContact O-N 3.32Å
18	I	55.6	Low	66.1	Low	115 Å²	115	117.3 Å²	117.3	59%	0.59	59%	0.589	S	S	*	*			trans	-75.3	68.9	157.5	-58.4	161.9	0	0	0	105.5	R14 A15 S16 V20	R14-I18 VanDerWaalsContact O-CG1 3.31Å; R14-I18 WeakPolarHBondContact O-CG1 3.37Å; R14-I18 PolarHBondContact O-N 3.33Å; A15-I18 WeakPolarHBondContact O-CB 3.42Å; A15-I18 PolarHBondContact O-N 3.38Å; S16-I18 VanDerWaalsContact C-N 3.29Å; I18-V20 PolarHBondContact O-N 3.07Å
19	E	52.4	Low	67	Low	168 Å²	168	119 Å²	119	79%	0.785	59%	0.591	S	S	*	*			trans	-46.8	120.6	150.5	-72.8	-176.4	121.9	0	0	105.1	T17 N21	T17-E19 PolarHBondContact O-N 3.32Å; E19-N21 VanDerWaalsContact C-N 3.25Å; E19-N21 PolarHBondContact O-N 2.64Å
20	V	58.5	Low	68.2	Low	107 Å²	107	114.1 Å²	114.1	65%	0.648	58%	0.577	S	S	*	*			trans	-51.6	90.7	-170.9	-179.9	0	0	0	0	108.4	I18 P22 R25	I18-V20 PolarHBondContact O-N 3.07Å; V20-P22 WeakPolarHBondContact O-CD 3.4Å; V20-R25 HydrophobicContact CG1-CB 4.4Å
21	N	58.6	Low	69.7	Low	79 Å²	79	117.8 Å²	117.8	42%	0.422	59%	0.592	S	S	.	*			trans	-61.7	112.7	-178.4	-179.5	-3.1	0	0	0	104.8	E19 Q23 A24 R25	E19-N21 VanDerWaalsContact C-N 3.25Å; E19-N21 PolarHBondContact O-N 2.64Å; N21-Q23 PolarHBondContact O-N 2.94Å; N21-Q23 PolarHBondContact OD1-N 3.48Å; N21-A24 HydrophobicContact CB-CB 4.09Å; N21-A24 WeakPolarHBondContact O-CA 3.32Å; N21-A24 WeakPolarHBondContact O-CB 3.26Å; N21-A24 PolarHBondContact O-N 3.5Å; N21-R25 PolarHBondContact O-N 3.23Å
22	P	66.1	Low	71.1	Confident	95 Å²	95	121.7 Å²	121.7	62%	0.617	60%	0.599	S	S	*	*	H	α-helix	trans	-57.8	-29.8	-171.2	20.4	-32.1	0	0	0	110.9	V20 R25 Q26	V20-P22 WeakPolarHBondContact O-CD 3.4Å; P22-R25 PolarHBondContact O-N 3.46Å; P22-Q26 WeakPolarHBondContact O-CB 3.14Å; P22-Q26 PolarHBondContact O-N 3.04Å
23	Q	70.8	Confident	72.6	Confident	132 Å²	132	119.4 Å²	119.4	62%	0.617	59%	0.59	S	S	*	*	H	α-helix	trans	-64.5	-42.7	172.7	-64.1	-176.9	-14	0	0	112.6	N21 R25 Q26 R27	N21-Q23 PolarHBondContact O-N 2.94Å; N21-Q23 PolarHBondContact OD1-N 3.48Å; Q23-R25 VanDerWaalsContact C-N 3.33Å; Q23-R25 PolarHBondContact O-N 2.94Å; Q23-Q26 PolarHBondContact O-N 3.39Å; Q23-R27 WeakPolarHBondContact O-CB 3.42Å; Q23-R27 VanDerWaalsContact O-CG 3.24Å; Q23-R27 WeakPolarHBondContact O-CG 3.47Å; Q23-R27 PolarHBondContact O-N 3.44Å
24	A	75.7	Confident	74.3	Confident	46 Å²	46	114.6 Å²	114.6	38%	0.38	58%	0.579	S	S	.	*	H	α-helix	trans	-64.1	-40.3	177.8	0	0	0	0	0	111.4	N21 Q26 R27 L28	N21-A24 HydrophobicContact CB-CB 4.09Å; N21-A24 WeakPolarHBondContact O-CA 3.32Å; N21-A24 WeakPolarHBondContact O-CB 3.26Å; N21-A24 PolarHBondContact O-N 3.5Å; A24-Q26 VanDerWaalsContact C-N 3.34Å; A24-Q26 PolarHBondContact O-N 2.82Å; A24-R27 PolarHBondContact O-N 2.85Å; A24-L28 WeakPolarHBondContact O-CB 3.24Å; A24-L28 VanDerWaalsContact O-CG 3.26Å; A24-L28 WeakPolarHBondContact O-CG 3.3Å; A24-L28 PolarHBondContact O-N 2.89Å
25	R	79	Confident	76.1	Confident	176 Å²	176	110.6 Å²	110.6	66%	0.664	57%	0.567	S	S	*	*	H	α-helix	trans	-61.4	-43.7	173.5	-176.5	178.3	175.3	-170.7	-1.3	111.5	V20 N21 P22 Q23 L28 Q29	V20-R25 HydrophobicContact CG1-CB 4.4Å; N21-R25 PolarHBondContact O-N 3.23Å; P22-R25 PolarHBondContact O-N 3.46Å; Q23-R25 VanDerWaalsContact C-N 3.33Å; Q23-R25 PolarHBondContact O-N 2.94Å; R25-L28 PolarHBondContact O-N 2.99Å; R25-Q29 WeakPolarHBondContact O-CB 3.48Å; R25-Q29 PolarHBondContact O-N 3.17Å
26	Q	82.1	Confident	78	Confident	115 Å²	115	109.7 Å²	109.7	54%	0.537	56%	0.557	S	S	.	*	H	α-helix	trans	-66.5	-41.8	179.6	-156.4	167.9	6.8	0	0	111.8	P22 Q23 A24 Q29 E30	P22-Q26 WeakPolarHBondContact O-CB 3.14Å; P22-Q26 PolarHBondContact O-N 3.04Å; Q23-Q26 PolarHBondContact O-N 3.39Å; A24-Q26 VanDerWaalsContact C-N 3.34Å; A24-Q26 PolarHBondContact O-N 2.82Å; Q26-Q29 PolarHBondContact O-N 3.14Å; Q26-E30 WeakPolarHBondContact O-CG 3.37Å; Q26-E30 PolarHBondContact O-N 3.35Å
27	R	84.9	Confident	79.9	Confident	173 Å²	173	110.2 Å²	110.2	65%	0.653	55%	0.553	S	S	*	*	H	α-helix	trans	-62.5	-41.9	173.5	-68.4	-58.9	-174.3	-172.2	3.7	112.7	Q23 A24 Q29 E30 L31	Q23-R27 WeakPolarHBondContact O-CB 3.42Å; Q23-R27 VanDerWaalsContact O-CG 3.24Å; Q23-R27 WeakPolarHBondContact O-CG 3.47Å; Q23-R27 PolarHBondContact O-N 3.44Å; A24-R27 PolarHBondContact O-N 2.85Å; R27-Q29 VanDerWaalsContact C-N 3.32Å; R27-E30 IonicContact NH1-OE2 3.14Å; R27-E30 PolarHBondContact NH1-OE2 2.92Å; R27-E30 VanDerWaalsContact NH1-OE2 3.14Å; R27-E30 PolarHBondContact O-N 3.38Å; R27-L31 WeakPolarHBondContact O-CB 3.4Å; R27-L31 PolarHBondContact O-N 3.25Å
28	L	88.7	Confident	82	Confident	118 Å²	118	109.8 Å²	109.8	62%	0.618	55%	0.546	S	S	*	.	H	α-helix	trans	-66.2	-37.4	175.7	-72.9	171.7	0	0	0	111.6	A24 R25 L31 F32	A24-L28 WeakPolarHBondContact O-CB 3.24Å; A24-L28 VanDerWaalsContact O-CG 3.26Å; A24-L28 WeakPolarHBondContact O-CG 3.3Å; A24-L28 PolarHBondContact O-N 2.89Å; R25-L28 PolarHBondContact O-N 2.99Å; L28-L31 PolarHBondContact O-N 3.29Å; L28-F32 VanDerWaalsContact O-CB 3.3Å; L28-F32 WeakPolarHBondContact O-CB 3.39Å; L28-F32 PolarHBondContact O-N 3.43Å
29	Q	87.3	Confident	84	Confident	120 Å²	120	108.3 Å²	108.3	56%	0.561	54%	0.538	S	S	*	.	H	α-helix	trans	-66.5	-45.9	175.8	-170.5	175.1	-0.5	0	0	111.5	R25 Q26 R27 L31 F32 V33	R25-Q29 WeakPolarHBondContact O-CB 3.48Å; R25-Q29 PolarHBondContact O-N 3.17Å; Q26-Q29 PolarHBondContact O-N 3.14Å; R27-Q29 VanDerWaalsContact C-N 3.32Å; Q29-L31 VanDerWaalsContact C-N 3.33Å; Q29-L31 PolarHBondContact O-N 3.48Å; Q29-F32 PolarHBondContact O-N 2.9Å; Q29-V33 VanDerWaalsContact O-CG2 3.29Å; Q29-V33 WeakPolarHBondContact O-CG2 3.27Å; Q29-V33 PolarHBondContact O-N 3.44Å
30	E	93.1	Very high	86.1	Confident	86 Å²	86	105 Å²	105	40%	0.402	53%	0.525	S	S	.	.	H	α-helix	trans	-57	-46.7	173.2	-76.4	172.7	-177.4	0	0	111.3	Q26 R27 F32 V33 N34	Q26-E30 WeakPolarHBondContact O-CG 3.37Å; Q26-E30 PolarHBondContact O-N 3.35Å; R27-E30 IonicContact NH1-OE2 3.14Å; R27-E30 PolarHBondContact NH1-OE2 2.92Å; R27-E30 VanDerWaalsContact NH1-OE2 3.14Å; R27-E30 PolarHBondContact O-N 3.38Å; E30-F32 PolarHBondContact O-N 3Å; E30-V33 PolarHBondContact O-N 3.47Å; E30-N34 WeakPolarHBondContact O-CB 3.36Å; E30-N34 VanDerWaalsContact O-CG 3.31Å; E30-N34 PolarHBondContact O-N 3.02Å; E30-N34 PolarHBondContact O-ND2 3.29Å
31	L	93.4	Very high	88	Confident	118 Å²	118	103.2 Å²	103.2	62%	0.618	52%	0.517	S	S	*	.	H	α-helix	trans	-62.7	-43.4	179.2	-166.9	72	0	0	0	111.6	R27 L28 Q29 N34 F35	R27-L31 WeakPolarHBondContact O-CB 3.4Å; R27-L31 PolarHBondContact O-N 3.25Å; L28-L31 PolarHBondContact O-N 3.29Å; Q29-L31 VanDerWaalsContact C-N 3.33Å; Q29-L31 PolarHBondContact O-N 3.48Å; L31-N34 PolarHBondContact O-N 3.37Å; L31-F35 VanDerWaalsContact O-CB 3.27Å; L31-F35 WeakPolarHBondContact O-CB 3.42Å; L31-F35 PolarHBondContact O-N 3.46Å
32	F	94.5	Very high	89.9	Confident	137 Å²	137	104 Å²	104	60%	0.601	52%	0.521	S	S	*	.	H	α-helix	trans	-66.3	-43.8	179.7	-171.3	-96.8	0	0	0	111.9	L28 Q29 E30 F35 C36	L28-F32 VanDerWaalsContact O-CB 3.3Å; L28-F32 WeakPolarHBondContact O-CB 3.39Å; L28-F32 PolarHBondContact O-N 3.43Å; Q29-F32 PolarHBondContact O-N 2.9Å; E30-F32 PolarHBondContact O-N 3Å; F32-F35 PolarHBondContact O-N 3.45Å; F32-C36 WeakPolarHBondContact O-CB 3.48Å; F32-C36 PolarHBondContact O-N 2.95Å; F32-C36 PolarHBondContact O-SG 3.37Å; F32-C36 VanDerWaalsContact O-SG 3.37Å
33	V	96	Very high	91.4	Very high	72 Å²	72	105 Å²	105	44%	0.436	52%	0.52	S	S	.	.	H	α-helix	trans	-62.2	-47.3	176.8	171.8	0	0	0	0	110.4	Q29 E30 F35 C36 L37	Q29-V33 VanDerWaalsContact O-CG2 3.29Å; Q29-V33 WeakPolarHBondContact O-CG2 3.27Å; Q29-V33 PolarHBondContact O-N 3.44Å; E30-V33 PolarHBondContact O-N 3.47Å; V33-F35 VanDerWaalsContact C-N 3.33Å; V33-F35 PolarHBondContact O-N 3.45Å; V33-C36 PolarHBondContact O-N 2.9Å; V33-L37 HydrophobicContact CG1-CD1 4Å; V33-L37 HydrophobicContact CG1-CG 4.5Å; V33-L37 WeakPolarHBondContact O-CG 3.29Å; V33-L37 PolarHBondContact O-N 3.35Å
34	N	95.6	Very high	92.6	Very high	94 Å²	94	103.2 Å²	103.2	50%	0.503	51%	0.514	S	S	.	.	H	α-helix	trans	-61.6	-42	177.7	-75.2	-16.4	0	0	0	111.9	E30 L31 L37 I38	E30-N34 WeakPolarHBondContact O-CB 3.36Å; E30-N34 VanDerWaalsContact O-CG 3.31Å; E30-N34 PolarHBondContact O-N 3.02Å; E30-N34 PolarHBondContact O-ND2 3.29Å; L31-N34 PolarHBondContact O-N 3.37Å; N34-L37 PolarHBondContact O-N 3.49Å; N34-I38 VanDerWaalsContact O-CG1 3.29Å; N34-I38 WeakPolarHBondContact O-CG1 3.42Å; N34-I38 PolarHBondContact O-N 2.96Å
35	F	96.9	Very high	93.7	Very high	121 Å²	121	105.7 Å²	105.7	53%	0.531	52%	0.52	S	S	.	.	H	α-helix	trans	-62.7	-45.2	176.8	-178.4	-105.9	0	0	0	112.2	L31 F32 V33 L37 I38 L39	L31-F35 VanDerWaalsContact O-CB 3.27Å; L31-F35 WeakPolarHBondContact O-CB 3.42Å; L31-F35 PolarHBondContact O-N 3.46Å; F32-F35 PolarHBondContact O-N 3.45Å; V33-F35 VanDerWaalsContact C-N 3.33Å; V33-F35 PolarHBondContact O-N 3.45Å; F35-L37 PolarHBondContact O-N 3.48Å; F35-I38 PolarHBondContact O-N 3.45Å; F35-L39 HydrophobicContact CD1-CD1 3.85Å; F35-L39 HydrophobicContact CD1-CG 4.5Å; F35-L39 HydrophobicContact CE1-CD1 3.35Å; F35-L39 HydrophobicContact CE1-CG 4.13Å; F35-L39 HydrophobicContact CZ-CD1 3.78Å; F35-L39 HydrophobicContact CZ-CD2 4.43Å; F35-L39 HydrophobicContact CZ-CG 4.17Å; F35-L39 PolarHBondContact O-N 2.87Å
36	C	97.4	Very high	94.5	Very high	41 Å²	41	101 Å²	101	28%	0.277	51%	0.514	S	S	.	.	H	α-helix	trans	-62.4	-41.5	176	-74.7	0	0	0	0	112.2	F32 V33 I38 L39 I40	F32-C36 WeakPolarHBondContact O-CB 3.48Å; F32-C36 PolarHBondContact O-N 2.95Å; F32-C36 PolarHBondContact O-SG 3.37Å; F32-C36 VanDerWaalsContact O-SG 3.37Å; V33-C36 PolarHBondContact O-N 2.9Å; C36-I38 VanDerWaalsContact C-N 3.35Å; C36-I38 PolarHBondContact O-N 2.92Å; C36-L39 PolarHBondContact O-N 2.9Å; C36-I40 VanDerWaalsContact O-CG1 3.29Å; C36-I40 WeakPolarHBondContact O-CG1 3.47Å; C36-I40 PolarHBondContact O-N 2.97Å
37	L	97.3	Very high	95.2	Very high	92 Å²	92	100 Å²	100	48%	0.482	51%	0.51	S	S	.	.	H	α-helix	trans	-60.5	-44.3	175.6	-76.2	169.2	0	0	0	111.6	V33 N34 F35 L39 I40 C41	V33-L37 HydrophobicContact CG1-CD1 4Å; V33-L37 HydrophobicContact CG1-CG 4.5Å; V33-L37 WeakPolarHBondContact O-CG 3.29Å; V33-L37 PolarHBondContact O-N 3.35Å; N34-L37 PolarHBondContact O-N 3.49Å; F35-L37 PolarHBondContact O-N 3.48Å; L37-L39 VanDerWaalsContact C-N 3.35Å; L37-L39 PolarHBondContact O-N 3.22Å; L37-I40 PolarHBondContact O-N 3.31Å; L37-C41 PolarHBondContact O-N 2.92Å; L37-C41 PolarHBondContact O-SG 3.3Å
38	I	97.7	Very high	95.8	Very high	101 Å²	101	96.9 Å²	96.9	52%	0.518	51%	0.506	S	S	.	.	H	α-helix	trans	-60.7	-45.6	176.4	-68.3	164.9	0	0	0	110.7	N34 F35 C36 I40 C41 L42	N34-I38 VanDerWaalsContact O-CG1 3.29Å; N34-I38 WeakPolarHBondContact O-CG1 3.42Å; N34-I38 PolarHBondContact O-N 2.96Å; F35-I38 PolarHBondContact O-N 3.45Å; C36-I38 VanDerWaalsContact C-N 3.35Å; C36-I38 PolarHBondContact O-N 2.92Å; I38-I40 VanDerWaalsContact C-N 3.35Å; I38-I40 PolarHBondContact O-N 2.93Å; I38-C41 WeakPolarHBondContact O-CB 3.44Å; I38-C41 PolarHBondContact O-N 3.3Å; I38-L42 HydrophobicContact CG2-CD1 4.09Å; I38-L42 HydrophobicContact CG2-CG 4.45Å; I38-L42 WeakPolarHBondContact O-CG 3.38Å; I38-L42 PolarHBondContact O-N 3Å
39	L	97.9	Very high	96.2	Very high	83 Å²	83	95.4 Å²	95.4	44%	0.435	50%	0.501	S	S	.	.	H	α-helix	trans	-60.6	-43.3	177.8	-76.6	175.6	0	0	0	112.3	F35 C36 L37 L42 L43	F35-L39 HydrophobicContact CD1-CD1 3.85Å; F35-L39 HydrophobicContact CD1-CG 4.5Å; F35-L39 HydrophobicContact CE1-CD1 3.35Å; F35-L39 HydrophobicContact CE1-CG 4.13Å; F35-L39 HydrophobicContact CZ-CD1 3.78Å; F35-L39 HydrophobicContact CZ-CD2 4.43Å; F35-L39 HydrophobicContact CZ-CG 4.17Å; F35-L39 PolarHBondContact O-N 2.87Å; C36-L39 PolarHBondContact O-N 2.9Å; L37-L39 VanDerWaalsContact C-N 3.35Å; L37-L39 PolarHBondContact O-N 3.22Å; L39-L42 PolarHBondContact O-N 3.48Å; L39-L43 WeakPolarHBondContact O-CB 3.29Å; L39-L43 PolarHBondContact O-N 3.38Å
40	I	97.9	Very high	96.5	Very high	98 Å²	98	97.3 Å²	97.3	50%	0.503	51%	0.512	S	S	.	.	H	α-helix	trans	-62.2	-45.1	176.8	-68.2	165.2	0	0	0	110.3	C36 L37 I38 L42 L43 L44	C36-I40 VanDerWaalsContact O-CG1 3.29Å; C36-I40 WeakPolarHBondContact O-CG1 3.47Å; C36-I40 PolarHBondContact O-N 2.97Å; L37-I40 PolarHBondContact O-N 3.31Å; I38-I40 VanDerWaalsContact C-N 3.35Å; I38-I40 PolarHBondContact O-N 2.93Å; I40-L42 PolarHBondContact O-N 2.93Å; I40-L43 WeakPolarHBondContact O-CB 3.3Å; I40-L43 PolarHBondContact O-N 3.33Å; I40-L44 HydrophobicContact CG2-CD1 4.07Å; I40-L44 HydrophobicContact CG2-CG 4.45Å; I40-L44 WeakPolarHBondContact O-CG 3.29Å; I40-L44 PolarHBondContact O-N 3.34Å
41	C	97.7	Very high	96.2	Very high	71 Å²	71	100.6 Å²	100.6	48%	0.48	53%	0.532	S	S	.	.	H	α-helix	trans	-59	-45.3	176.4	-71.8	0	0	0	0	112	L37 I38 L43 L44 I45	L37-C41 PolarHBondContact O-N 2.92Å; L37-C41 PolarHBondContact O-SG 3.3Å; I38-C41 WeakPolarHBondContact O-CB 3.44Å; I38-C41 PolarHBondContact O-N 3.3Å; C41-L43 VanDerWaalsContact C-N 3.33Å; C41-L43 PolarHBondContact O-N 3.49Å; C41-L44 PolarHBondContact O-N 3.28Å; C41-I45 WeakPolarHBondContact O-CG1 3.5Å; C41-I45 PolarHBondContact O-N 3.26Å
42	L	97.6	Very high	95.7	Very high	96 Å²	96	104.6 Å²	104.6	50%	0.503	55%	0.553	S	S	.	*	H	α-helix	trans	-62.6	-41.2	176.4	-70.6	173.4	0	0	0	111.7	I38 L39 I40 L44 I45 C46	I38-L42 HydrophobicContact CG2-CD1 4.09Å; I38-L42 HydrophobicContact CG2-CG 4.45Å; I38-L42 WeakPolarHBondContact O-CG 3.38Å; I38-L42 PolarHBondContact O-N 3Å; L39-L42 PolarHBondContact O-N 3.48Å; I40-L42 PolarHBondContact O-N 2.93Å; L42-L44 VanDerWaalsContact C-N 3.34Å; L42-L44 PolarHBondContact O-N 3.45Å; L42-I45 PolarHBondContact O-N 3.45Å; L42-C46 PolarHBondContact O-N 3.31Å; L42-C46 PolarHBondContact O-SG 2.93Å; L42-C46 VanDerWaalsContact O-SG 3.35Å
43	L	97.4	Very high	95.8	Very high	116 Å²	116	103 Å²	103	61%	0.607	55%	0.55	S	S	*	*	H	α-helix	trans	-62.3	-43.5	177.7	-150	103.7	0	0	0	111.3	L39 I40 C41 C46 I47	L39-L43 WeakPolarHBondContact O-CB 3.29Å; L39-L43 PolarHBondContact O-N 3.38Å; I40-L43 WeakPolarHBondContact O-CB 3.3Å; I40-L43 PolarHBondContact O-N 3.33Å; C41-L43 VanDerWaalsContact C-N 3.33Å; C41-L43 PolarHBondContact O-N 3.49Å; L43-C46 WeakPolarHBondContact O-CB 3.21Å; L43-C46 PolarHBondContact O-N 3.47Å; L43-I47 HydrophobicContact CD2-CD1 4.18Å; L43-I47 VanDerWaalsContact O-CG1 3.32Å; L43-I47 WeakPolarHBondContact O-CG1 3.32Å; L43-I47 PolarHBondContact O-N 2.94Å
44	L	97.3	Very high	95.8	Very high	94 Å²	94	104.6 Å²	104.6	49%	0.492	56%	0.556	S	S	.	*	H	α-helix	trans	-62.6	-42.6	176.3	-73.8	170.9	0	0	0	111.8	I40 C41 L42 C46 I47 I48	I40-L44 HydrophobicContact CG2-CD1 4.07Å; I40-L44 HydrophobicContact CG2-CG 4.45Å; I40-L44 WeakPolarHBondContact O-CG 3.29Å; I40-L44 PolarHBondContact O-N 3.34Å; C41-L44 PolarHBondContact O-N 3.28Å; L42-L44 VanDerWaalsContact C-N 3.34Å; L42-L44 PolarHBondContact O-N 3.45Å; L44-C46 VanDerWaalsContact C-N 3.34Å; L44-C46 PolarHBondContact O-N 3.2Å; L44-I47 PolarHBondContact O-N 3.23Å; L44-I48 VanDerWaalsContact O-CG1 3.3Å; L44-I48 WeakPolarHBondContact O-CG1 3.32Å; L44-I48 PolarHBondContact O-N 3.48Å
45	I	97.6	Very high	95.8	Very high	97 Å²	97	105.2 Å²	105.2	50%	0.497	56%	0.559	S	S	.	*	H	α-helix	trans	-60.1	-46.6	174.8	-67.5	165	0	0	0	110.2	C41 L42 I47 I48 V49	C41-I45 WeakPolarHBondContact O-CG1 3.5Å; C41-I45 PolarHBondContact O-N 3.26Å; L42-I45 PolarHBondContact O-N 3.45Å; I45-I47 VanDerWaalsContact C-N 3.3Å; I45-I47 PolarHBondContact O-N 3.31Å; I45-I48 PolarHBondContact O-N 3.48Å; I45-V49 HydrophobicContact CG2-CG2 4.32Å; I45-V49 VanDerWaalsContact O-CG2 3.3Å; I45-V49 WeakPolarHBondContact O-CG2 3.32Å; I45-V49 PolarHBondContact O-N 2.96Å
46	C	96.9	Very high	95.7	Very high	79 Å²	79	104.2 Å²	104.2	53%	0.534	56%	0.561	S	S	.	*	H	α-helix	trans	-58.9	-41.5	176.3	-70.3	0	0	0	0	112.2	L42 L43 L44 V49 M50	L42-C46 PolarHBondContact O-N 3.31Å; L42-C46 PolarHBondContact O-SG 2.93Å; L42-C46 VanDerWaalsContact O-SG 3.35Å; L43-C46 WeakPolarHBondContact O-CB 3.21Å; L43-C46 PolarHBondContact O-N 3.47Å; L44-C46 VanDerWaalsContact C-N 3.34Å; L44-C46 PolarHBondContact O-N 3.2Å; C46-V49 PolarHBondContact O-N 2.89Å; C46-M50 WeakPolarHBondContact O-CB 3.3Å; C46-M50 WeakPolarHBondContact O-CG 3.38Å; C46-M50 PolarHBondContact O-N 3.21Å
47	I	97.1	Very high	95.6	Very high	92 Å²	92	108.2 Å²	108.2	47%	0.472	58%	0.579	S	S	.	*	H	α-helix	trans	-63.3	-46.3	176.3	-69	165.6	0	0	0	110.7	L43 L44 I45 V49 M50 L51	L43-I47 HydrophobicContact CD2-CD1 4.18Å; L43-I47 VanDerWaalsContact O-CG1 3.32Å; L43-I47 WeakPolarHBondContact O-CG1 3.32Å; L43-I47 PolarHBondContact O-N 2.94Å; L44-I47 PolarHBondContact O-N 3.23Å; I45-I47 VanDerWaalsContact C-N 3.3Å; I45-I47 PolarHBondContact O-N 3.31Å; I47-V49 VanDerWaalsContact C-N 3.31Å; I47-V49 PolarHBondContact O-N 2.91Å; I47-M50 PolarHBondContact O-N 3.42Å; I47-L51 VanDerWaalsContact O-CB 3.32Å; I47-L51 WeakPolarHBondContact O-CB 3.43Å; I47-L51 PolarHBondContact O-N 2.94Å
48	I	96.8	Very high	95.5	Very high	108 Å²	108	109.3 Å²	109.3	55%	0.554	59%	0.585	S	S	*	*	H	α-helix	trans	-59.2	-44.9	177.8	-69.3	167.6	0	0	0	110.3	L44 I45 M50 L51 L52	L44-I48 VanDerWaalsContact O-CG1 3.3Å; L44-I48 WeakPolarHBondContact O-CG1 3.32Å; L44-I48 PolarHBondContact O-N 3.48Å; I45-I48 PolarHBondContact O-N 3.48Å; I48-M50 VanDerWaalsContact C-N 3.33Å; I48-M50 PolarHBondContact O-N 3.41Å; I48-L51 PolarHBondContact O-N 3Å; I48-L52 WeakPolarHBondContact O-CB 3.36Å; I48-L52 PolarHBondContact O-N 3.28Å
49	V	96.7	Very high	95.4	Very high	87 Å²	87	109.9 Å²	109.9	53%	0.527	59%	0.59	S	S	.	*	H	α-helix	trans	-65.7	-34.2	178.3	171.2	0	0	0	0	112.3	I45 C46 I47	I45-V49 HydrophobicContact CG2-CG2 4.32Å; I45-V49 VanDerWaalsContact O-CG2 3.3Å; I45-V49 WeakPolarHBondContact O-CG2 3.32Å; I45-V49 PolarHBondContact O-N 2.96Å; C46-V49 PolarHBondContact O-N 2.89Å; I47-V49 VanDerWaalsContact C-N 3.31Å; I47-V49 PolarHBondContact O-N 2.91Å
50	M	93.5	Very high	95.2	Very high	160 Å²	160	111.9 Å²	111.9	79%	0.788	60%	0.602	S	S	*	*	H	α-helix	trans	-77.1	-24.5	176.8	-71.7	-74.1	125.7	0	0	113	C46 I47 I48	C46-M50 WeakPolarHBondContact O-CB 3.3Å; C46-M50 WeakPolarHBondContact O-CG 3.38Å; C46-M50 PolarHBondContact O-N 3.21Å; I47-M50 PolarHBondContact O-N 3.42Å; I48-M50 VanDerWaalsContact C-N 3.33Å; I48-M50 PolarHBondContact O-N 3.41Å
51	L	88.1	Confident	95	Very high	155 Å²	155	113.1 Å²	113.1	81%	0.812	61%	0.61	S	S	*	*	H	α-helix	trans	-87.2	-29.8	-179	-163.4	80.7	0	0	0	112.5	I47 I48	I47-L51 VanDerWaalsContact O-CB 3.32Å; I47-L51 WeakPolarHBondContact O-CB 3.43Å; I47-L51 PolarHBondContact O-N 2.94Å; I48-L51 PolarHBondContact O-N 3Å
52	L	82.8	Confident	94.7	Very high	202 Å²	202	116.9 Å²	116.9	100%	1.058	62%	0.622	S	S	*	*			trans	-80.6	0	176	-165.6	85.1	0	0	0	111	I48	I48-L52 WeakPolarHBondContact O-CB 3.36Å; I48-L52 PolarHBondContact O-N 3.28Å

Retrieved 52 of 52 residues in 11.2 ms (Link to these results)

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