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Rho GTPase-activating protein Graf

GTPase-activating protein for Rho family proteins¹. Essential component of the CLIC (clathrin-independent carrier)/GEEC (GPI-anchored protein-enriched early endocytic compartment) endocytic pathway². During hematopoiesis, inhibits Egfr-ras-MAPK signaling by promoting Spi-induced Egfr internalization through CLIC/GEEC endocytosis, thereby preventing plasmatocyte overproliferation³. Essential for normal mushroom body (MB) development and consequently the formation of olfactory long-term memories⁴. During MD development, required to stop the MB beta-lobe from crossing the brain midline, possibly acting via its role in the CLIC/GEEC endocytic pathway to down-regulate the Egfr-ras-MAPK signaling at the tip of the beta-lobes⁵. Required during embryo cellularization for maintaining and regulating the rate of actomyosin ring constriction⁶. During cellularization, inhibits Rho-GTP levels at the furrow canal tip in a spatiotemporal manner, thus delaying the onset of actomyosin contraction and ensuring appropriate closure of the cells at the base of nuclei after membrane extension⁷.

AlphaFold DB , UniProt , Accession X2JDY8, Species DROME (Drosophila melanogaster, Fruit fly), Gene Graf, Length 1,025 aa.