X5C404_HUMAN Loading...

RUNX1/RUNX1T1 fusion protein

AlphaFold DB , UniProt , Accession X5C404, Species HUMAN (Homo sapiens, Human), Gene RUNX1, Length 40 aa.

>X5C404_HUMAN|X5C404|RUNX1
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDQLAPAAA
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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1M49Very low55.1Low238 Ų238122 Ų122100%1.17268%0.682SS**  094.60-102.9-68.7177.600106
2A57.2Low55.6Low90 Ų90118.3 Ų118.374%0.74467%0.67SS**  trans-100.3143.1-172.900000108.9
3S53.8Low56Low85 Ų85114.5 Ų114.559%0.59464%0.64SS**  trans90.644.1145.5-148.10000118.7
4D57.2Low56.6Low126 Ų126108.2 Ų108.267%0.67461%0.606SS**SBendtrans-892.8166.7-72.6-61.7000114.4
5S56.4Low57Low92 Ų92110.6 Ų110.664%0.64361%0.61SS**Hα-helixtrans-103.2-18-167-45.60000115.8S9S5-S9 PolarHBondContact O-OG 3.41Å
6I56.2Low57.4Low114 Ų114108.3 Ų108.359%0.58560%0.603SS**Hα-helixtrans-87.4-34.5-177.4-57.8177.6000110.9
7F51.6Low57.7Low142 Ų142106.1 Ų106.162%0.62359%0.586SS**Hα-helixtrans-79.2-29.1-177.1-97.1-96.6000113.9P14F7-P14 HydrophobicContact CD1-CB 4.4Å; F7-P14 HydrophobicContact CD1-CG 3.71Å; F7-P14 HydrophobicContact CE1-CB 3.7Å; F7-P14 HydrophobicContact CE1-CG 3.43Å; F7-P14 VanDerWaalsContact CE1-CG 3.43Å; F7-P14 HydrophobicContact CZ-CB 4.42Å; F7-P14 HydrophobicContact CZ-CG 4.22Å
8E53.8Low58Low167 Ų167106 Ų10678%0.7858%0.582SS**Hα-helixtrans-76.8-25.6175.3-79.1-160.4120.900113.4
9S58.5Low58.3Low86 Ų86109.8 Ų109.860%0.60159%0.587SS**Hα-helixtrans-78.2-19.8-178-58.80000113.4S5 P11S5-S9 PolarHBondContact O-OG 3.41Å; S9-P11 WeakPolarHBondContact O-CD 3.49Å
10F57.4Low58.6Low108 Ų108107.9 Ų107.947%0.47457%0.574SS.*  trans-127.170.1-179.3-65.1-84.4000110.7S12 Y13 P14F10-S12 PolarHBondContact O-N 2.83Å; F10-Y13 PolarHBondContact O-N 3.43Å; F10-P14 WeakPolarHBondContact O-CD 3.38Å
11P55.4Low58.7Low94 Ų94105.7 Ų105.761%0.6157%0.567SS**THydrogen-bonded Turntrans-59.4-21.7-176.923.1-33000113.1S9S9-P11 WeakPolarHBondContact O-CD 3.49Å
12S60.8Low59.3Low77 Ų77101.1 Ų101.154%0.53855%0.546SS..THydrogen-bonded Turntrans-97-25.7-177.5-35.30000114F10 Q15 C16F10-S12 PolarHBondContact O-N 2.83Å; S12-Q15 PolarHBondContact O-N 2.85Å; S12-C16 WeakPolarHBondContact O-CB 3.41Å; S12-C16 PolarHBondContact O-N 3.29Å; S12-C16 PolarHBondContact O-SG 2.82Å
13Y60.9Low59.9Low70 Ų70102.1 Ų102.128%0.27554%0.538SS..Hα-helixtrans-69.7-49.3-165.9-175.4-99.1000113.8F10 Q15 F17 L35F10-Y13 PolarHBondContact O-N 3.43Å; Y13-Q15 VanDerWaalsContact C-N 3.25Å; Y13-Q15 PolarHBondContact O-N 3.38Å; Y13-F17 WeakPolarHBondContact O-CB 3.47Å; Y13-F17 PolarHBondContact O-N 3.11Å; Y13-L35 HydrophobicContact CD1-CD2 3.64Å; Y13-L35 HydrophobicContact CD2-CD1 3.64Å; Y13-L35 HydrophobicContact CD2-CD2 3.8Å; Y13-L35 HydrophobicContact CD2-CG 4.2Å; Y13-L35 HydrophobicContact CE1-CD2 3.16Å; Y13-L35 HydrophobicContact CE1-CG 4.35Å; Y13-L35 HydrophobicContact CE2-CB 3.8Å; Y13-L35 HydrophobicContact CE2-CD1 3.52Å; Y13-L35 HydrophobicContact CE2-CD2 3.34Å; Y13-L35 HydrophobicContact CE2-CG 3.66Å; Y13-L35 HydrophobicContact CG-CD1 4.34Å; Y13-L35 HydrophobicContact CG-CD2 3.94Å; Y13-L35 VanDerWaalsContact OH-CD2 3.31Å; Y13-L35 WeakPolarHBondContact OH-CD2 3.3Å
14P64.7Low60.2Low26 Ų26101 Ų10117%0.16954%0.54CS..Hα-helixtrans-66.7-32179.4-1528.5000111.8F7 F10 M18F7-P14 HydrophobicContact CD1-CB 4.4Å; F7-P14 HydrophobicContact CD1-CG 3.71Å; F7-P14 HydrophobicContact CE1-CB 3.7Å; F7-P14 HydrophobicContact CE1-CG 3.43Å; F7-P14 VanDerWaalsContact CE1-CG 3.43Å; F7-P14 HydrophobicContact CZ-CB 4.42Å; F7-P14 HydrophobicContact CZ-CG 4.22Å; F10-P14 WeakPolarHBondContact O-CD 3.38Å; P14-M18 HydrophobicContact CB-CE 3.97Å; P14-M18 VanDerWaalsContact O-CB 3.28Å; P14-M18 WeakPolarHBondContact O-CB 3.12Å; P14-M18 VanDerWaalsContact O-CE 3.3Å; P14-M18 WeakPolarHBondContact O-CE 3.28Å; P14-M18 WeakPolarHBondContact O-CG 3.36Å; P14-M18 PolarHBondContact O-N 3.49Å
15Q62.1Low60.4Low144 Ų144100.3 Ų100.367%0.67353%0.534SS*.Hα-helixtrans-78.8-40.5-175-60.9-151300112.7S12 Y13 R19S12-Q15 PolarHBondContact O-N 2.85Å; Y13-Q15 VanDerWaalsContact C-N 3.25Å; Y13-Q15 PolarHBondContact O-N 3.38Å; Q15-R19 WeakPolarHBondContact O-CB 3.31Å; Q15-R19 PolarHBondContact O-N 3.14Å
16C63.3Low60.6Low74 Ų74103.4 Ų103.450%0.554%0.543SS..Hα-helixtrans-62.4-47.6174.5-71.60000110.9S12 R19 E20S12-C16 WeakPolarHBondContact O-CB 3.41Å; S12-C16 PolarHBondContact O-N 3.29Å; S12-C16 PolarHBondContact O-SG 2.82Å; C16-R19 PolarHBondContact O-N 3.36Å; C16-E20 PolarHBondContact O-N 3.42Å
17F63Low60.8Low71 Ų7199.5 Ų99.531%0.31153%0.525SS..Hα-helixtrans-65.3-48.5-179.6-176.8-97.2000112.5Y13 R19 E20 C21 P27Y13-F17 WeakPolarHBondContact O-CB 3.47Å; Y13-F17 PolarHBondContact O-N 3.11Å; F17-R19 VanDerWaalsContact C-N 3.28Å; F17-R19 PolarHBondContact O-N 3.29Å; F17-E20 PolarHBondContact O-N 2.92Å; F17-C21 VanDerWaalsContact CE1-SG 3.59Å; F17-C21 PolarHBondContact O-N 2.97Å; F17-C21 PolarHBondContact O-SG 3.12Å; F17-P27 HydrophobicContact CD2-CB 4.4Å; F17-P27 HydrophobicContact CD2-CG 3.85Å; F17-P27 HydrophobicContact CE2-CB 4.34Å; F17-P27 HydrophobicContact CE2-CG 3.42Å; F17-P27 VanDerWaalsContact CE2-CG 3.42Å; F17-P27 HydrophobicContact CZ-CG 4.29Å
18M63.3Low61.4Low104 Ų10496 Ų9651%0.51252%0.519SS..Hα-helixtrans-61-38.7176.8-81.8-170.8-83.700112.1P14 C21 I22P14-M18 HydrophobicContact CB-CE 3.97Å; P14-M18 VanDerWaalsContact O-CB 3.28Å; P14-M18 WeakPolarHBondContact O-CB 3.12Å; P14-M18 VanDerWaalsContact O-CE 3.3Å; P14-M18 WeakPolarHBondContact O-CE 3.28Å; P14-M18 WeakPolarHBondContact O-CG 3.36Å; P14-M18 PolarHBondContact O-N 3.49Å; M18-C21 PolarHBondContact O-N 3.4Å; M18-I22 WeakPolarHBondContact O-CB 3.07Å; M18-I22 WeakPolarHBondContact O-CD1 3.19Å; M18-I22 WeakPolarHBondContact O-CG1 3.43Å; M18-I22 PolarHBondContact O-N 3.38Å
19R63.6Low61.6Low179 Ų17997.8 Ų97.868%0.67552%0.518SS*.Hα-helixtrans-63.5-42.4177.3-174.9178.2-177.1-1640.2111.7Q15 C16 F17 I22 L23Q15-R19 WeakPolarHBondContact O-CB 3.31Å; Q15-R19 PolarHBondContact O-N 3.14Å; C16-R19 PolarHBondContact O-N 3.36Å; F17-R19 VanDerWaalsContact C-N 3.28Å; F17-R19 PolarHBondContact O-N 3.29Å; R19-I22 PolarHBondContact O-N 2.88Å; R19-L23 HydrophobicContact CG-CD1 3.97Å; R19-L23 WeakPolarHBondContact O-CB 3.16Å; R19-L23 WeakPolarHBondContact O-CD1 3.46Å; R19-L23 WeakPolarHBondContact O-CG 3.47Å; R19-L23 PolarHBondContact O-N 2.96Å; R19-L23 VanDerWaalsContact O-N 3.11Å
20E63.3Low61.5Low70 Ų7098.6 Ų98.633%0.32752%0.516SS..Hα-helixtrans-65.1-41.8175.5-75.7179.1136.300111.9C16 F17 L23 G24 M25C16-E20 PolarHBondContact O-N 3.42Å; F17-E20 PolarHBondContact O-N 2.92Å; E20-L23 PolarHBondContact O-N 3.3Å; E20-G24 PolarHBondContact O-N 3.09Å; E20-M25 CarbonylContact C-O 3.49Å; E20-M25 PolarHBondContact O-N 3.29Å; E20-M25 VanDerWaalsContact O-N 3.09Å; E20-M25 VanDerWaalsContact O-O 3.1Å
21C61.8Low61.7Low63 Ų6396.8 Ų96.843%0.42651%0.514SS..Hα-helixtrans-61.9-43.9175.3-65.80000112.9F17 M18 L23 G24F17-C21 VanDerWaalsContact CE1-SG 3.59Å; F17-C21 PolarHBondContact O-N 2.97Å; F17-C21 PolarHBondContact O-SG 3.12Å; M18-C21 PolarHBondContact O-N 3.4Å; C21-L23 VanDerWaalsContact C-N 3.27Å; C21-L23 PolarHBondContact O-N 3.39Å; C21-G24 PolarHBondContact O-N 2.9Å; C21-G24 VanDerWaalsContact O-N 3.14Å
22I61.4Low61.8Low142 Ų14297.7 Ų97.773%0.72851%0.509SS*.Hα-helixtrans-66-32.8179.4-68.5164.1000111M18 R19 G24M18-I22 WeakPolarHBondContact O-CB 3.07Å; M18-I22 WeakPolarHBondContact O-CD1 3.19Å; M18-I22 WeakPolarHBondContact O-CG1 3.43Å; M18-I22 PolarHBondContact O-N 3.38Å; R19-I22 PolarHBondContact O-N 2.88Å; I22-G24 PolarHBondContact O-N 3.08Å
23L68.6Low61.6Low110 Ų11099.8 Ų99.858%0.57652%0.515SS*.THydrogen-bonded Turntrans-81.93.9177.2-66172.2000113.4R19 E20 C21 M25R19-L23 HydrophobicContact CG-CD1 3.97Å; R19-L23 WeakPolarHBondContact O-CB 3.16Å; R19-L23 WeakPolarHBondContact O-CD1 3.46Å; R19-L23 WeakPolarHBondContact O-CG 3.47Å; R19-L23 PolarHBondContact O-N 2.96Å; R19-L23 VanDerWaalsContact O-N 3.11Å; E20-L23 PolarHBondContact O-N 3.3Å; C21-L23 VanDerWaalsContact C-N 3.27Å; C21-L23 PolarHBondContact O-N 3.39Å; L23-M25 PolarHBondContact O-N 2.71Å
24G61.1Low61.4Low61 Ų61104.5 Ų104.563%0.62954%0.539SS*.THydrogen-bonded Turntrans69.310.6178.500000114.1E20 C21 I22 N26E20-G24 PolarHBondContact O-N 3.09Å; C21-G24 PolarHBondContact O-N 2.9Å; C21-G24 VanDerWaalsContact O-N 3.14Å; I22-G24 PolarHBondContact O-N 3.08Å; G24-N26 PolarHBondContact O-N 3.21Å
25M62Low60.8Low112 Ų112106.5 Ų106.555%0.55255%0.548SS*.  trans-83.7108.2172.8-73.1169.161.800106.8E20 L23 P27E20-M25 CarbonylContact C-O 3.49Å; E20-M25 PolarHBondContact O-N 3.29Å; E20-M25 VanDerWaalsContact O-N 3.09Å; E20-M25 VanDerWaalsContact O-O 3.1Å; L23-M25 PolarHBondContact O-N 2.71Å; M25-P27 WeakPolarHBondContact O-CD 3.49Å; M25-P27 VanDerWaalsContact O-N 3.09Å
26N60.3Low60.2Low157 Ų157102.1 Ų102.184%0.8454%0.537SS*.  trans-61.7112.6169.9-90.2-90.5000107.4G24 S28G24-N26 PolarHBondContact O-N 3.21Å; N26-S28 PolarHBondContact O-N 3.05Å
27P60.4Low59.4Low32 Ų32104 Ų10421%0.20855%0.548CS..  trans-60.913717624.1-30000108.1F17 M25 R29F17-P27 HydrophobicContact CD2-CB 4.4Å; F17-P27 HydrophobicContact CD2-CG 3.85Å; F17-P27 HydrophobicContact CE2-CB 4.34Å; F17-P27 HydrophobicContact CE2-CG 3.42Å; F17-P27 VanDerWaalsContact CE2-CG 3.42Å; F17-P27 HydrophobicContact CZ-CG 4.29Å; M25-P27 WeakPolarHBondContact O-CD 3.49Å; M25-P27 VanDerWaalsContact O-N 3.09Å; P27-R29 PolarHBondContact O-N 3.03Å
28S63.7Low58.8Low70 Ų70105 Ų10549%0.4957%0.569SS.*  trans-54.9133.9-178.7-156.90000109N26 D30 V31N26-S28 PolarHBondContact O-N 3.05Å; S28-D30 PolarHBondContact O-N 3.23Å; S28-D30 PolarHBondContact OG-OD2 3.27Å; S28-V31 WeakPolarHBondContact O-CB 3.42Å; S28-V31 PolarHBondContact O-N 3.02Å
29R58.4Low58.1Low204 Ų204105.5 Ų105.577%0.7759%0.59SS**Hα-helixtrans-51.1-27.9179.4-94.3171.861.8-159.4-1.1112.3P27 V31 H32 D33P27-R29 PolarHBondContact O-N 3.03Å; R29-V31 VanDerWaalsContact C-N 3.3Å; R29-V31 PolarHBondContact O-N 3.36Å; R29-H32 WeakPolarHBondContact O-CB 3.13Å; R29-H32 PolarHBondContact O-N 3.04Å; R29-H32 VanDerWaalsContact O-N 3.12Å; R29-D33 PolarHBondContact O-N 3.33Å
30D56.6Low56.9Low102 Ų102104.7 Ų104.755%0.54562%0.621SS.*Hα-helixtrans-61.2-33176.3-47.1-83.5000113.8S28 Q34S28-D30 PolarHBondContact O-N 3.23Å; S28-D30 PolarHBondContact OG-OD2 3.27Å; D30-Q34 WeakPolarHBondContact O-CG 3.21Å; D30-Q34 PolarHBondContact O-N 3.35Å; D30-Q34 VanDerWaalsContact O-N 3.08Å
31V60.1Low56.6Low71 Ų71106.5 Ų106.543%0.4364%0.636SS.*Hα-helixtrans-72.5-34.3175.9-179.60000110.5S28 R29S28-V31 WeakPolarHBondContact O-CB 3.42Å; S28-V31 PolarHBondContact O-N 3.02Å; R29-V31 VanDerWaalsContact C-N 3.3Å; R29-V31 PolarHBondContact O-N 3.36Å
32H58.5Low56.3Low112 Ų112108.7 Ų108.752%0.51965%0.647SS.*Hα-helixtrans-72.7-38.2175.6-165.672.1000111.8R29 L35 A36R29-H32 WeakPolarHBondContact O-CB 3.13Å; R29-H32 PolarHBondContact O-N 3.04Å; R29-H32 VanDerWaalsContact O-N 3.12Å; H32-L35 PolarHBondContact O-N 3.21Å; H32-A36 WeakPolarHBondContact O-CB 3.33Å; H32-A36 PolarHBondContact O-N 2.96Å
33D56.4Low56Low122 Ų122106.9 Ų106.965%0.65264%0.643SS**Hα-helixtrans-72.2-33.7179.3-122.7-90.3000112.5R29 L35R29-D33 PolarHBondContact O-N 3.33Å; D33-L35 VanDerWaalsContact C-N 3.28Å; D33-L35 PolarHBondContact O-N 3.46Å
34Q56.6Low55.3Low169 Ų169106.7 Ų106.779%0.7965%0.647SS**Hα-helixtrans-70.7-21.5174-76.7178.52800113.6D30D30-Q34 WeakPolarHBondContact O-CG 3.21Å; D30-Q34 PolarHBondContact O-N 3.35Å; D30-Q34 VanDerWaalsContact O-N 3.08Å
35L52.4Low54.9Low67 Ų67109.6 Ų109.635%0.35165%0.648SS.*Hα-helixtrans-118.5-0.5-176.7-152.2122.7000115.4Y13 H32 D33 P37Y13-L35 HydrophobicContact CD1-CD2 3.64Å; Y13-L35 HydrophobicContact CD2-CD1 3.64Å; Y13-L35 HydrophobicContact CD2-CD2 3.8Å; Y13-L35 HydrophobicContact CD2-CG 4.2Å; Y13-L35 HydrophobicContact CE1-CD2 3.16Å; Y13-L35 HydrophobicContact CE1-CG 4.35Å; Y13-L35 HydrophobicContact CE2-CB 3.8Å; Y13-L35 HydrophobicContact CE2-CD1 3.52Å; Y13-L35 HydrophobicContact CE2-CD2 3.34Å; Y13-L35 HydrophobicContact CE2-CG 3.66Å; Y13-L35 HydrophobicContact CG-CD1 4.34Å; Y13-L35 HydrophobicContact CG-CD2 3.94Å; Y13-L35 VanDerWaalsContact OH-CD2 3.31Å; Y13-L35 WeakPolarHBondContact OH-CD2 3.3Å; H32-L35 PolarHBondContact O-N 3.21Å; D33-L35 VanDerWaalsContact C-N 3.28Å; D33-L35 PolarHBondContact O-N 3.46Å; L35-P37 WeakPolarHBondContact O-CD 3.48Å
36A49.4Very low54.4Low53 Ų53109.4 Ų109.444%0.43865%0.654SS.*SBendtrans-68.5106.5153.800000105.9H32 A38H32-A36 WeakPolarHBondContact O-CB 3.33Å; H32-A36 PolarHBondContact O-N 2.96Å; A36-A38 PolarHBondContact O-N 3.18Å
37P45.9Very low54Low114 Ų114106 Ų10674%0.7464%0.641SS**  trans-55.7126.3166.927.1-31.8000105L35 A39L35-P37 WeakPolarHBondContact O-CD 3.48Å; P37-A39 PolarHBondContact O-N 3.01Å
38A50.8Low53.5Low91 Ų91111.7 Ų111.775%0.75267%0.674SS**  trans-39108.5172.900000108.1A36 A40A36-A38 PolarHBondContact O-N 3.18Å; A38-A40 PolarHBondContact O-N 3Å
39A49.3Very low52.7Low115 Ų115115.2 Ų115.295%0.9569%0.69SS**  trans-71.880.7170.100000106.1P37P37-A39 PolarHBondContact O-N 3.01Å
40A37.6Very low52.2Low162 Ų162107.1 Ų107.1100%1.33968%0.682SS**  trans-146.20170.900000108.8A38A38-A40 PolarHBondContact O-N 3Å

Retrieved 40 of 40 residues in 38.3 ms (Link to these results)