X5CR08_HUMAN Loading...

RUNX1/RUNX1T1 fusion protein

AlphaFold DB , UniProt , Accession X5CR08, Species HUMAN (Homo sapiens, Human), Gene RUNX1, Length 33 aa.

						>X5CR08_HUMAN|X5CR08|RUNX1
MASDSIFESFPSYPQCFMRECILGMNPSRDVHG
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	48.8	Very low	60.7	Low	226 Å²	226	108.7 Å²	108.7	100%	1.113	62%	0.616	S	S	*	*				0	85.5	0	-73.4	-68.4	-177.4	0	0	107.3
2	A	51.4	Low	61.5	Low	88 Å²	88	109.7 Å²	109.7	73%	0.727	64%	0.635	S	S	*	*			trans	-133.3	10.4	-177.1	0	0	0	0	0	112.1
3	S	55.2	Low	61.9	Low	68 Å²	68	108.8 Å²	108.8	48%	0.476	62%	0.616	S	S	.	*	S	Bend	trans	-93.3	-25.1	-179.6	-75.7	0	0	0	0	113	S5 F7	S3-S5 PolarHBondContact O-N 3.33Å; S3-F7 WeakPolarHBondContact O-CD2 3.43Å
4	D	57.5	Low	62.4	Low	110 Å²	110	106.9 Å²	106.9	59%	0.588	61%	0.61	S	S	*	*	H	α-helix	trans	-65	-22.9	-177.2	-59.1	-79.1	0	0	0	113.3	E8	D4-E8 WeakPolarHBondContact O-CG 3.33Å; D4-E8 PolarHBondContact O-N 3.18Å
5	S	63	Low	62.9	Low	88 Å²	88	105.1 Å²	105.1	62%	0.615	59%	0.594	S	S	*	*	H	α-helix	trans	-80	-25.7	-172.4	-157.9	0	0	0	0	114.9	S3 S9	S3-S5 PolarHBondContact O-N 3.33Å; S5-S9 PolarHBondContact O-OG 2.86Å; S5-S9 VanDerWaalsContact O-OG 3.14Å
6	I	64.8	Low	63.2	Low	92 Å²	92	105.3 Å²	105.3	47%	0.472	60%	0.602	S	S	.	*	H	α-helix	trans	-81	-38.6	-179.6	-59.9	180	0	0	0	110.2	S9 F10 M18	I6-S9 PolarHBondContact O-N 3.07Å; I6-F10 WeakPolarHBondContact O-CD2 3.43Å; I6-M18 VanDerWaalsContact CG2-SD 3.59Å; I6-M18 HydrophobicContact CG2-SD 3.59Å; I6-M18 HydrophobicContact CG2-CE 4.32Å
7	F	61.7	Low	63.4	Low	46 Å²	46	105.8 Å²	105.8	20%	0.202	60%	0.597	C	S	.	*	H	α-helix	trans	-74.4	-33.7	-177.8	-65	-71.8	0	0	0	113.1	S3 S9 F10 M18 I22	S3-F7 WeakPolarHBondContact O-CD2 3.43Å; F7-S9 VanDerWaalsContact C-N 3.26Å; F7-S9 PolarHBondContact O-N 3.3Å; F7-F10 CarbonylContact O-C 3.48Å; F7-F10 PolarHBondContact O-N 3.4Å; F7-M18 VanDerWaalsContact CE1-SD 3.59Å; F7-M18 HydrophobicContact CZ-SD 4.17Å; F7-M18 HydrophobicContact CZ-CB 3.93Å; F7-M18 HydrophobicContact CE1-SD 3.59Å; F7-M18 HydrophobicContact CE1-CG 4.09Å; F7-M18 HydrophobicContact CE1-CB 3.38Å; F7-M18 HydrophobicContact CD1-CB 4.35Å; F7-M18 HydrophobicContact CD1-SD 3.8Å; F7-M18 HydrophobicContact CD1-CE 3.76Å; F7-M18 HydrophobicContact CE1-CE 4.02Å; F7-I22 HydrophobicContact CE2-CD1 3.98Å; F7-I22 HydrophobicContact CZ-CD1 3.66Å
8	E	63.2	Low	63.6	Low	169 Å²	169	101.3 Å²	101.3	79%	0.79	57%	0.57	S	S	*	*	H	α-helix	trans	-62.6	-30.7	172.3	-83.4	-101.8	101.4	0	0	112.9	D4 F10	D4-E8 WeakPolarHBondContact O-CG 3.33Å; D4-E8 PolarHBondContact O-N 3.18Å; E8-F10 VanDerWaalsContact C-N 3.29Å; E8-F10 PolarHBondContact O-N 3.15Å
9	S	70	Confident	63.8	Low	80 Å²	80	105.2 Å²	105.2	56%	0.559	58%	0.575	S	S	*	*	T	Hydrogen-bonded Turn	trans	-75.9	-17.7	180	-62	0	0	0	0	113.1	S5 I6 F7	S5-S9 PolarHBondContact O-OG 2.86Å; S5-S9 VanDerWaalsContact O-OG 3.14Å; I6-S9 PolarHBondContact O-N 3.07Å; F7-S9 VanDerWaalsContact C-N 3.26Å; F7-S9 PolarHBondContact O-N 3.3Å
10	F	68.9	Low	64	Low	118 Å²	118	107.2 Å²	107.2	52%	0.518	58%	0.58	S	S	.	*			trans	-134.3	69.5	-176.2	-61.6	-79	0	0	0	111.9	I6 F7 E8 S12 Y13 M18	I6-F10 WeakPolarHBondContact O-CD2 3.43Å; F7-F10 CarbonylContact O-C 3.48Å; F7-F10 PolarHBondContact O-N 3.4Å; E8-F10 VanDerWaalsContact C-N 3.29Å; E8-F10 PolarHBondContact O-N 3.15Å; F10-S12 PolarHBondContact O-N 2.93Å; F10-S12 VanDerWaalsContact O-N 3.15Å; F10-Y13 VanDerWaalsContact O-N 3.07Å; F10-Y13 PolarHBondContact O-N 3.35Å; F10-M18 HydrophobicContact CB-CE 4.43Å
11	P	62.8	Low	64.1	Low	111 Å²	111	104.3 Å²	104.3	72%	0.721	57%	0.568	S	S	*	*	T	Hydrogen-bonded Turn	trans	-62.1	-25.9	-175.4	23.4	-33.7	0	0	0	113.7
12	S	70.9	Confident	64.9	Low	120 Å²	120	97.2 Å²	97.2	84%	0.839	53%	0.533	S	S	*	.	T	Hydrogen-bonded Turn	trans	-95.7	-3.2	179.1	-49.9	0	0	0	0	114.1	F10	F10-S12 PolarHBondContact O-N 2.93Å; F10-S12 VanDerWaalsContact O-N 3.15Å
13	Y	66.1	Low	65.6	Low	98 Å²	98	98.3 Å²	98.3	38%	0.384	53%	0.527	S	S	.	.	S	Bend	trans	-78.5	136.1	180	-167.3	-94.4	0	0	0	109.9	F10 Q15 F17 M18	F10-Y13 VanDerWaalsContact O-N 3.07Å; F10-Y13 PolarHBondContact O-N 3.35Å; Y13-Q15 PolarHBondContact O-N 3.24Å; Y13-Q15 PolarHBondContact O-NE2 3.36Å; Y13-F17 HydrophobicContact CE1-CB 4.47Å; Y13-F17 AromaticContact CE1-CD1 3.89Å; Y13-F17 HydrophobicContact CE1-CD1 3.89Å; Y13-F17 AromaticContact CZ-CD1 3.89Å; Y13-F17 WeakPolarHBondContact OH-CD1 3.19Å; Y13-F17 WeakPolarHBondContact OH-CE1 3.49Å; Y13-M18 HydrophobicContact CG-CE 4.02Å; Y13-M18 HydrophobicContact CE1-CG 3.79Å; Y13-M18 HydrophobicContact CE1-CE 3.98Å; Y13-M18 HydrophobicContact CD1-CG 4.1Å; Y13-M18 HydrophobicContact CE1-CB 4.28Å; Y13-M18 HydrophobicContact CD1-CB 4.47Å; Y13-M18 HydrophobicContact CD1-CE 3.37Å
14	P	69.5	Low	65.9	Low	82 Å²	82	98.1 Å²	98.1	53%	0.532	54%	0.535	S	S	.	.			trans	-59.5	105.2	-178.4	-18	28.5	0	0	0	110.4	C16 F17 M18	P14-C16 PolarHBondContact O-N 2.85Å; P14-F17 HydrophobicContact CB-CB 4.22Å; P14-F17 WeakPolarHBondContact O-CB 3.18Å; P14-F17 PolarHBondContact O-N 3.08Å; P14-M18 PolarHBondContact O-N 3.46Å
15	Q	69.9	Low	66	Low	81 Å²	81	99.6 Å²	99.6	38%	0.379	54%	0.54	S	S	.	.	H	α-helix	trans	-58.1	-32.9	-178.9	-57.7	-70.2	-49	0	0	111.2	Y13 F17 M18 R19	Y13-Q15 PolarHBondContact O-N 3.24Å; Y13-Q15 PolarHBondContact O-NE2 3.36Å; Q15-F17 VanDerWaalsContact C-N 3.27Å; Q15-F17 PolarHBondContact O-N 2.95Å; Q15-M18 PolarHBondContact O-N 2.93Å; Q15-R19 VanDerWaalsContact O-N 3.08Å; Q15-R19 PolarHBondContact O-N 3.23Å; Q15-R19 WeakPolarHBondContact O-CB 3.28Å
16	C	67.7	Low	65.7	Low	107 Å²	107	101.7 Å²	101.7	72%	0.723	55%	0.545	S	S	*	.	H	α-helix	trans	-56.6	-38.9	173.9	-55.7	0	0	0	0	112.4	P14 E20	P14-C16 PolarHBondContact O-N 2.85Å; C16-E20 WeakPolarHBondContact O-CG 3.33Å; C16-E20 PolarHBondContact O-N 3.28Å
17	F	66.6	Low	65.3	Low	115 Å²	115	102.1 Å²	102.1	50%	0.504	55%	0.553	S	S	.	*	H	α-helix	trans	-75.8	-45.1	-177.7	-174.5	-95.5	0	0	0	111.8	Y13 P14 Q15 R19 E20 C21	Y13-F17 HydrophobicContact CE1-CB 4.47Å; Y13-F17 AromaticContact CE1-CD1 3.89Å; Y13-F17 HydrophobicContact CE1-CD1 3.89Å; Y13-F17 AromaticContact CZ-CD1 3.89Å; Y13-F17 WeakPolarHBondContact OH-CD1 3.19Å; Y13-F17 WeakPolarHBondContact OH-CE1 3.49Å; P14-F17 HydrophobicContact CB-CB 4.22Å; P14-F17 WeakPolarHBondContact O-CB 3.18Å; P14-F17 PolarHBondContact O-N 3.08Å; Q15-F17 VanDerWaalsContact C-N 3.27Å; Q15-F17 PolarHBondContact O-N 2.95Å; F17-R19 VanDerWaalsContact C-N 3.28Å; F17-R19 PolarHBondContact O-N 3.49Å; F17-E20 WeakPolarHBondContact O-CB 3.39Å; F17-E20 PolarHBondContact O-N 3.45Å; F17-C21 WeakPolarHBondContact CE1-SG 3.48Å; F17-C21 PolarHBondContact O-N 3.39Å; F17-C21 PolarHBondContact O-SG 3.44Å
18	M	67.6	Low	65.2	Low	25 Å²	25	104 Å²	104	12%	0.123	57%	0.572	C	S	.	*	H	α-helix	trans	-64.2	-35.4	178.1	-112.2	-165.2	-86.2	0	0	112.1	I6 F7 F10 Y13 P14 Q15 C21 I22	I6-M18 VanDerWaalsContact CG2-SD 3.59Å; I6-M18 HydrophobicContact CG2-SD 3.59Å; I6-M18 HydrophobicContact CG2-CE 4.32Å; F7-M18 VanDerWaalsContact CE1-SD 3.59Å; F7-M18 HydrophobicContact CZ-SD 4.17Å; F7-M18 HydrophobicContact CZ-CB 3.93Å; F7-M18 HydrophobicContact CE1-SD 3.59Å; F7-M18 HydrophobicContact CE1-CG 4.09Å; F7-M18 HydrophobicContact CE1-CB 3.38Å; F7-M18 HydrophobicContact CD1-CB 4.35Å; F7-M18 HydrophobicContact CD1-SD 3.8Å; F7-M18 HydrophobicContact CD1-CE 3.76Å; F7-M18 HydrophobicContact CE1-CE 4.02Å; F10-M18 HydrophobicContact CB-CE 4.43Å; Y13-M18 HydrophobicContact CG-CE 4.02Å; Y13-M18 HydrophobicContact CE1-CG 3.79Å; Y13-M18 HydrophobicContact CE1-CE 3.98Å; Y13-M18 HydrophobicContact CD1-CG 4.1Å; Y13-M18 HydrophobicContact CE1-CB 4.28Å; Y13-M18 HydrophobicContact CD1-CB 4.47Å; Y13-M18 HydrophobicContact CD1-CE 3.37Å; P14-M18 PolarHBondContact O-N 3.46Å; Q15-M18 PolarHBondContact O-N 2.93Å; M18-C21 PolarHBondContact O-N 3.4Å; M18-I22 VanDerWaalsContact O-CG1 3.25Å; M18-I22 WeakPolarHBondContact O-CG1 3.17Å; M18-I22 PolarHBondContact O-N 2.77Å; M18-I22 WeakPolarHBondContact O-CB 3.25Å
19	R	66.9	Low	65	Low	175 Å²	175	107.1 Å²	107.1	66%	0.66	58%	0.576	S	S	*	*	H	α-helix	trans	-62.6	-44	175.8	-167.6	178.3	-168.8	-142	3.4	111.4	Q15 F17 I22 L23	Q15-R19 VanDerWaalsContact O-N 3.08Å; Q15-R19 PolarHBondContact O-N 3.23Å; Q15-R19 WeakPolarHBondContact O-CB 3.28Å; F17-R19 VanDerWaalsContact C-N 3.28Å; F17-R19 PolarHBondContact O-N 3.49Å; R19-I22 PolarHBondContact O-N 3.39Å; R19-L23 HydrophobicContact CG-CD1 3.8Å; R19-L23 HydrophobicContact CG-CG 4.42Å; R19-L23 VanDerWaalsContact O-CB 3.28Å; R19-L23 WeakPolarHBondContact O-CB 3.37Å; R19-L23 WeakPolarHBondContact O-CG 3.19Å; R19-L23 PolarHBondContact O-N 2.86Å
20	E	67.2	Low	64.3	Low	145 Å²	145	110.3 Å²	110.3	68%	0.678	59%	0.587	S	S	*	*	H	α-helix	trans	-62.8	-40.2	173.2	-71.2	-92.1	96.9	0	0	111.5	C16 F17 G24	C16-E20 WeakPolarHBondContact O-CG 3.33Å; C16-E20 PolarHBondContact O-N 3.28Å; F17-E20 WeakPolarHBondContact O-CB 3.39Å; F17-E20 PolarHBondContact O-N 3.45Å; E20-G24 PolarHBondContact O-N 3.27Å; E20-G24 WeakPolarHBondContact O-CA 3.47Å
21	C	66.6	Low	63.8	Low	47 Å²	47	110.9 Å²	110.9	32%	0.318	60%	0.6	S	S	.	*	H	α-helix	trans	-64.4	-45.9	175.7	-65.5	0	0	0	0	112.5	F17 M18 G24 M25	F17-C21 WeakPolarHBondContact CE1-SG 3.48Å; F17-C21 PolarHBondContact O-N 3.39Å; F17-C21 PolarHBondContact O-SG 3.44Å; M18-C21 PolarHBondContact O-N 3.4Å; C21-G24 PolarHBondContact O-N 3.14Å; C21-M25 WeakPolarHBondContact O-CB 3.11Å; C21-M25 WeakPolarHBondContact O-CG 3.42Å; C21-M25 PolarHBondContact O-N 3.17Å
22	I	66.5	Low	63.3	Low	77 Å²	77	114.5 Å²	114.5	40%	0.395	61%	0.607	S	S	.	*	H	α-helix	trans	-68	-39.7	-178.8	-66.8	164.3	0	0	0	110.7	F7 M18 R19	F7-I22 HydrophobicContact CE2-CD1 3.98Å; F7-I22 HydrophobicContact CZ-CD1 3.66Å; M18-I22 VanDerWaalsContact O-CG1 3.25Å; M18-I22 WeakPolarHBondContact O-CG1 3.17Å; M18-I22 PolarHBondContact O-N 2.77Å; M18-I22 WeakPolarHBondContact O-CB 3.25Å; R19-I22 PolarHBondContact O-N 3.39Å
23	L	64.9	Low	62.1	Low	111 Å²	111	115.6 Å²	115.6	58%	0.581	64%	0.637	S	S	*	*	H	α-helix	trans	-75.4	-34.7	178.3	-66.1	173.7	0	0	0	112.3	R19	R19-L23 HydrophobicContact CG-CD1 3.8Å; R19-L23 HydrophobicContact CG-CG 4.42Å; R19-L23 VanDerWaalsContact O-CB 3.28Å; R19-L23 WeakPolarHBondContact O-CB 3.37Å; R19-L23 WeakPolarHBondContact O-CG 3.19Å; R19-L23 PolarHBondContact O-N 2.86Å
24	G	62.4	Low	61.9	Low	64 Å²	64	116.5 Å²	116.5	66%	0.66	65%	0.65	S	S	*	*	H	α-helix	trans	-77.2	-20.1	175.6	0	0	0	0	0	113.9	E20 C21 N26	E20-G24 PolarHBondContact O-N 3.27Å; E20-G24 WeakPolarHBondContact O-CA 3.47Å; C21-G24 PolarHBondContact O-N 3.14Å; G24-N26 PolarHBondContact O-N 2.87Å; G24-N26 VanDerWaalsContact O-N 3.14Å
25	M	58.7	Low	61.5	Low	140 Å²	140	118.3 Å²	118.3	69%	0.69	66%	0.656	S	S	*	*			trans	-83.3	45.3	169.3	-73.9	170.4	65.4	0	0	111.7	C21 P27	C21-M25 WeakPolarHBondContact O-CB 3.11Å; C21-M25 WeakPolarHBondContact O-CG 3.42Å; C21-M25 PolarHBondContact O-N 3.17Å; M25-P27 WeakPolarHBondContact O-CD 2.9Å
26	N	57.8	Low	61.1	Low	133 Å²	133	120.3 Å²	120.3	71%	0.711	67%	0.672	S	S	*	*			trans	-85.3	90.5	150.2	-113.4	-81.9	0	0	0	106.5	G24 S28	G24-N26 PolarHBondContact O-N 2.87Å; G24-N26 VanDerWaalsContact O-N 3.14Å; N26-S28 PolarHBondContact O-N 2.79Å
27	P	56.2	Low	60.7	Low	101 Å²	101	121.1 Å²	121.1	66%	0.656	67%	0.668	S	S	*	*			trans	-62.6	104.2	158.9	28.4	-30.2	0	0	0	104.5	M25 R29	M25-P27 WeakPolarHBondContact O-CD 2.9Å; P27-R29 VanDerWaalsContact C-N 3.34Å; P27-R29 PolarHBondContact O-N 3.14Å
28	S	58.9	Low	60.3	Low	84 Å²	84	121.5 Å²	121.5	59%	0.587	68%	0.679	S	S	*	*			trans	-46.2	105.4	169.4	-178.8	0	0	0	0	107.1	N26 D30	N26-S28 PolarHBondContact O-N 2.79Å; S28-D30 PolarHBondContact O-N 3.02Å
29	R	58.3	Low	59.8	Low	235 Å²	235	127.9 Å²	127.9	89%	0.887	72%	0.716	S	S	*	*	T	Hydrogen-bonded Turn	trans	-74.7	22.2	175.5	-86.4	-178.9	60.9	-150	-4.1	111.3	P27	P27-R29 VanDerWaalsContact C-N 3.34Å; P27-R29 PolarHBondContact O-N 3.14Å
30	D	56.5	Low	59.3	Low	148 Å²	148	124.6 Å²	124.6	79%	0.791	72%	0.72	S	S	*	*	T	Hydrogen-bonded Turn	trans	-107.7	21.4	180	-101.3	-83.6	0	0	0	112.9	S28	S28-D30 PolarHBondContact O-N 3.02Å
31	V	58.6	Low	58.7	Low	130 Å²	130	123 Å²	123	79%	0.788	72%	0.723	S	S	*	*			trans	-114.5	56.7	160.7	-171.3	0	0	0	0	109
32	H	50.8	Low	58.1	Low	186 Å²	186	129.3 Å²	129.3	86%	0.861	76%	0.757	S	S	*	*			trans	-112.9	87.6	147	-108.6	90.9	0	0	0	105.7
33	G	47.2	Very low	57.3	Low	143 Å²	143	134.1 Å²	134.1	100%	1.474	79%	0.79	S	S	*	*			trans	-72	0	150	0	0	0	0	0	110.3

Retrieved 33 of 33 residues in 8.1 ms (Link to these results)

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