X5D337_HUMAN Loading...

Ribosomal protein S6 kinase 90kDa polypeptide 2 isoform B

AlphaFold DB , UniProt , Accession X5D337, Species HUMAN (Homo sapiens, Human), Gene RPS6KA2, Length 26 aa.

						>X5D337_HUMAN|X5D337|RPS6KA2
MPIAQLLELWKKIEVEPMEIETSWQK
					

Structure Viewer

Loading PAE data...

(Predicted Aligned Error values between residue pairs)

Download Structure PDB PAE Table

Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	66.4	Low	86	Confident	141 Å²	141	113.7 Å²	113.7	70%	0.695	57%	0.567	S	S	*	*				0	147.8	0	-77.6	-174.5	-51.8	0	109.5	Q5 L6 L9	M1-Q5 HydrophobicContact SD-CB 4.11Å; M1-Q5 HydrophobicContact CB-CB 4.26Å; M1-Q5 VanDerWaalsContact SD-OE1 3.4Å; M1-Q5 PolarHBondContact SD-OE1 2.85Å; M1-L6 HydrophobicContact CE-CD2 3.49Å; M1-L6 VanDerWaalsContact CE-CD2 3.49Å; M1-L6 HydrophobicContact CE-CG 4.16Å; M1-L9 HydrophobicContact CE-CD1 3.58Å; M1-L9 HydrophobicContact SD-CD1 4.3Å
2	P	88.3	Confident	85.8	Confident	81 Å²	81	117.8 Å²	117.8	53%	0.526	58%	0.579	S	S	.	*			trans	-56.9	148.4	167.8	-21.3	32.8	0	0	111.8	A4 Q5	P2-A4 PolarHBondContact O-N 2.96Å; P2-A4 VanDerWaalsContact O-N 3.15Å; P2-Q5 PolarHBondContact O-N 3.18Å
3	I	91.7	Very high	85.7	Confident	130 Å²	130	116.8 Å²	116.8	67%	0.667	58%	0.576	S	S	*	*	H	α-helix	trans	-55.4	-35.8	-176.8	-67.1	166.1	0	0	112	Q5 L6 L7	I3-Q5 VanDerWaalsContact C-N 3.29Å; I3-Q5 PolarHBondContact O-N 3Å; I3-L6 PolarHBondContact O-N 2.81Å; I3-L6 VanDerWaalsContact O-N 3.16Å; I3-L7 WeakPolarHBondContact O-CG 3.35Å; I3-L7 VanDerWaalsContact O-N 3.07Å; I3-L7 PolarHBondContact O-N 2.74Å; I3-L7 HydrophobicContact CG2-CG 4.31Å; I3-L7 HydrophobicContact CG2-CD1 4.06Å
4	A	89.2	Confident	84.4	Confident	61 Å²	61	121.9 Å²	121.9	50%	0.504	60%	0.598	S	S	.	*	H	α-helix	trans	-56.7	-40	177.7	0	0	0	0	113.2	P2 L7 E8	P2-A4 PolarHBondContact O-N 2.96Å; P2-A4 VanDerWaalsContact O-N 3.15Å; A4-L7 PolarHBondContact O-N 2.92Å; A4-E8 WeakPolarHBondContact O-CG 3.32Å; A4-E8 PolarHBondContact O-N 2.94Å
5	Q	89.9	Confident	83.5	Confident	87 Å²	87	121.2 Å²	121.2	41%	0.407	60%	0.603	S	S	.	*	H	α-helix	trans	-70.8	-35.5	179.9	-66.2	178	-5.7	0	111.7	M1 P2 I3 L7 E8 L9	M1-Q5 HydrophobicContact SD-CB 4.11Å; M1-Q5 HydrophobicContact CB-CB 4.26Å; M1-Q5 VanDerWaalsContact SD-OE1 3.4Å; M1-Q5 PolarHBondContact SD-OE1 2.85Å; P2-Q5 PolarHBondContact O-N 3.18Å; I3-Q5 VanDerWaalsContact C-N 3.29Å; I3-Q5 PolarHBondContact O-N 3Å; Q5-L7 VanDerWaalsContact C-N 3.34Å; Q5-E8 PolarHBondContact O-N 3.24Å; Q5-L9 VanDerWaalsContact O-CG 3.27Å; Q5-L9 WeakPolarHBondContact O-CG 3.49Å; Q5-L9 PolarHBondContact O-N 2.77Å
6	L	90.3	Very high	82.7	Confident	92 Å²	92	124.3 Å²	124.3	48%	0.482	62%	0.615	S	S	.	*	H	α-helix	trans	-65.2	-39.6	174.9	-68	169.9	0	0	111.4	M1 I3 L9 W10	M1-L6 HydrophobicContact CE-CD2 3.49Å; M1-L6 VanDerWaalsContact CE-CD2 3.49Å; M1-L6 HydrophobicContact CE-CG 4.16Å; I3-L6 PolarHBondContact O-N 2.81Å; I3-L6 VanDerWaalsContact O-N 3.16Å; L6-L9 PolarHBondContact O-N 3.39Å; L6-W10 WeakPolarHBondContact O-CB 3.48Å; L6-W10 PolarHBondContact O-N 3.26Å
7	L	87.8	Confident	81.6	Confident	101 Å²	101	124.1 Å²	124.1	53%	0.529	62%	0.624	S	S	.	*	H	α-helix	trans	-67.1	-37.9	176.9	-67.1	172.9	0	0	112.3	I3 A4 Q5 W10 K11	I3-L7 WeakPolarHBondContact O-CG 3.35Å; I3-L7 VanDerWaalsContact O-N 3.07Å; I3-L7 PolarHBondContact O-N 2.74Å; I3-L7 HydrophobicContact CG2-CG 4.31Å; I3-L7 HydrophobicContact CG2-CD1 4.06Å; A4-L7 PolarHBondContact O-N 2.92Å; Q5-L7 VanDerWaalsContact C-N 3.34Å; L7-W10 PolarHBondContact O-N 3.35Å; L7-K11 PolarHBondContact O-N 3.37Å; L7-K11 WeakPolarHBondContact O-CG 3.27Å
8	E	88.9	Confident	81	Confident	117 Å²	117	126 Å²	126	55%	0.547	63%	0.633	S	S	.	*	H	α-helix	trans	-65.4	-40.2	173.6	-75.1	179.3	-173.2	0	112.3	A4 Q5 K12	A4-E8 WeakPolarHBondContact O-CG 3.32Å; A4-E8 PolarHBondContact O-N 2.94Å; Q5-E8 PolarHBondContact O-N 3.24Å; E8-K12 WeakPolarHBondContact O-CG 3.43Å; E8-K12 PolarHBondContact O-N 3.17Å
9	L	87.6	Confident	80.4	Confident	81 Å²	81	129.1 Å²	129.1	42%	0.424	65%	0.645	S	S	.	*	H	α-helix	trans	-65.8	-45.2	175	-70.6	169.1	0	0	111.1	M1 Q5 L6 K11 K12 I13	M1-L9 HydrophobicContact CE-CD1 3.58Å; M1-L9 HydrophobicContact SD-CD1 4.3Å; Q5-L9 VanDerWaalsContact O-CG 3.27Å; Q5-L9 WeakPolarHBondContact O-CG 3.49Å; Q5-L9 PolarHBondContact O-N 2.77Å; L6-L9 PolarHBondContact O-N 3.39Å; L9-K11 VanDerWaalsContact C-N 3.31Å; L9-K11 PolarHBondContact O-N 3.17Å; L9-K12 PolarHBondContact O-N 3.25Å; L9-I13 WeakPolarHBondContact O-CG1 3.33Å; L9-I13 PolarHBondContact O-N 3.05Å
10	W	83.2	Confident	79.8	Confident	189 Å²	189	128.8 Å²	128.8	72%	0.716	64%	0.644	S	S	*	*	H	α-helix	trans	-57.7	-42.6	176.6	-176.9	-91.4	0	0	112.3	L6 L7 K12 I13	L6-W10 WeakPolarHBondContact O-CB 3.48Å; L6-W10 PolarHBondContact O-N 3.26Å; L7-W10 PolarHBondContact O-N 3.35Å; W10-K12 VanDerWaalsContact C-N 3.27Å; W10-K12 PolarHBondContact O-N 3.02Å; W10-I13 PolarHBondContact O-N 3.36Å
11	K	82.3	Confident	79	Confident	171 Å²	171	130.4 Å²	130.4	74%	0.743	65%	0.65	S	S	*	*	H	α-helix	trans	-64.4	-27.8	175.9	-75.8	178.4	-180	-175.3	113.8	L7 L9	L7-K11 PolarHBondContact O-N 3.37Å; L7-K11 WeakPolarHBondContact O-CG 3.27Å; L9-K11 VanDerWaalsContact C-N 3.31Å; L9-K11 PolarHBondContact O-N 3.17Å
12	K	83.9	Confident	78.8	Confident	162 Å²	162	129.2 Å²	129.2	70%	0.704	65%	0.651	S	S	*	*	H	α-helix	trans	-81.5	-21.2	178.3	-71.9	174.2	-175.3	178.5	112.7	E8 L9 W10 E14	E8-K12 WeakPolarHBondContact O-CG 3.43Å; E8-K12 PolarHBondContact O-N 3.17Å; L9-K12 PolarHBondContact O-N 3.25Å; W10-K12 VanDerWaalsContact C-N 3.27Å; W10-K12 PolarHBondContact O-N 3.02Å; K12-E14 VanDerWaalsContact C-N 3.25Å; K12-E14 PolarHBondContact O-N 3.02Å; K12-E14 VanDerWaalsContact O-N 3.17Å
13	I	84.6	Confident	77.6	Confident	106 Å²	106	129 Å²	129	54%	0.544	65%	0.652	S	S	.	*			trans	-88.3	73.4	175	-54.1	162.5	0	0	106.1	L9 W10 V15	L9-I13 WeakPolarHBondContact O-CG1 3.33Å; L9-I13 PolarHBondContact O-N 3.05Å; W10-I13 PolarHBondContact O-N 3.36Å; I13-V15 PolarHBondContact O-N 3.07Å; I13-V15 HydrophobicContact CG2-CG2 3.84Å; I13-V15 WeakPolarHBondContact O-CG2 3.4Å; I13-V15 VanDerWaalsContact C-N 3.32Å
14	E	67.7	Low	76.2	Confident	188 Å²	188	134.4 Å²	134.4	88%	0.879	66%	0.664	S	S	*	*			trans	-63.9	102.2	158.9	-88.9	-176.8	161.5	0	106.4	K12 E16	K12-E14 VanDerWaalsContact C-N 3.25Å; K12-E14 PolarHBondContact O-N 3.02Å; K12-E14 VanDerWaalsContact O-N 3.17Å; E14-E16 PolarHBondContact O-N 3.42Å
15	V	70.4	Confident	74.5	Confident	111 Å²	111	139.2 Å²	139.2	67%	0.673	68%	0.676	S	S	*	*			trans	-79.4	104.5	179.8	-158.5	0	0	0	106.4	I13	I13-V15 PolarHBondContact O-N 3.07Å; I13-V15 HydrophobicContact CG2-CG2 3.84Å; I13-V15 WeakPolarHBondContact O-CG2 3.4Å; I13-V15 VanDerWaalsContact C-N 3.32Å
16	E	71.1	Confident	72.5	Confident	171 Å²	171	148.1 Å²	148.1	80%	0.799	71%	0.713	S	S	*	*			trans	-59.4	134.8	162.2	-69.3	-162.9	151.7	0	107.7	E14 M18	E14-E16 PolarHBondContact O-N 3.42Å; E16-M18 PolarHBondContact O-N 3.36Å
17	P	64.8	Low	71.7	Confident	120 Å²	120	150.9 Å²	150.9	78%	0.779	73%	0.725	S	S	*	*			trans	-59.6	108.3	174.9	24.9	-31.1	0	0	107.1	E19	P17-E19 PolarHBondContact O-N 2.88Å
18	M	70.2	Confident	70.8	Confident	159 Å²	159	153.5 Å²	153.5	78%	0.783	74%	0.735	S	S	*	*			trans	-61.1	110.5	172	-165	170	86.2	0	105.5	E16 I20	E16-M18 PolarHBondContact O-N 3.36Å; M18-I20 VanDerWaalsContact C-N 3.26Å; M18-I20 PolarHBondContact O-N 3.49Å
19	E	69.2	Low	69.8	Low	185 Å²	185	155.6 Å²	155.6	86%	0.864	75%	0.745	S	S	*	*			trans	-62.1	99.9	170.6	-68.6	-156.9	171.5	0	106	P17 E21	P17-E19 PolarHBondContact O-N 2.88Å; E19-E21 VanDerWaalsContact C-N 3.27Å; E19-E21 PolarHBondContact O-N 3.4Å
20	I	67.8	Low	68.8	Low	122 Å²	122	159.9 Å²	159.9	63%	0.626	76%	0.764	S	S	*	*			trans	-67.8	101	169.6	-55.3	175.2	0	0	103	M18 T22	M18-I20 VanDerWaalsContact C-N 3.26Å; M18-I20 PolarHBondContact O-N 3.49Å; I20-T22 HydrophobicContact CG2-CG2 4.43Å; I20-T22 PolarHBondContact O-N 3.07Å
21	E	63.2	Low	67.9	Low	164 Å²	164	158.1 Å²	158.1	77%	0.766	77%	0.767	S	S	*	*			trans	-53.3	102.1	158.5	-81.8	-173.6	163.6	0	104.9	E19 S23	E19-E21 VanDerWaalsContact C-N 3.27Å; E19-E21 PolarHBondContact O-N 3.4Å; E21-S23 PolarHBondContact O-N 3.03Å
22	T	62.7	Low	66.9	Low	115 Å²	115	157.3 Å²	157.3	71%	0.706	77%	0.769	S	S	*	*			trans	-71.9	57.1	167.7	55.6	0	0	0	107.4	I20 W24	I20-T22 HydrophobicContact CG2-CG2 4.43Å; I20-T22 PolarHBondContact O-N 3.07Å; T22-W24 PolarHBondContact O-N 3.3Å
23	S	63.6	Low	65.7	Low	78 Å²	78	156.9 Å²	156.9	55%	0.545	77%	0.774	S	S	.	*			trans	-81.5	49.8	156.3	69.3	0	0	0	108.4	E21 Q25	E21-S23 PolarHBondContact O-N 3.03Å; S23-Q25 PolarHBondContact O-N 3.15Å
24	W	62.1	Low	64.2	Low	242 Å²	242	160.8 Å²	160.8	92%	0.917	79%	0.791	S	S	*	*			trans	-71.2	64.8	141.2	-65.3	99.2	0	0	105.8	T22 K26	T22-W24 PolarHBondContact O-N 3.3Å; W24-K26 PolarHBondContact O-N 3.16Å
25	Q	52.9	Low	63.9	Low	163 Å²	163	158.6 Å²	158.6	76%	0.762	78%	0.784	S	S	*	*			trans	-76.7	118	178.3	-80.7	-143.3	-30.5	0	108.2	S23	S23-Q25 PolarHBondContact O-N 3.15Å
26	K	49.2	Very low	63.3	Low	273 Å²	273	162.9 Å²	162.9	100%	1.187	79%	0.794	S	S	*	*			trans	68	0	151.7	-82.1	178.8	171.8	174.9	118.9	W24	W24-K26 PolarHBondContact O-N 3.16Å

Retrieved 26 of 26 residues in 11.8 ms (Link to these results)

U.S. Privacy Notice - Disclaimer / Registrations / Copyright Statement - Linking Policy - Notice of Privacy Practices (HIPAA) - Notice of Non‑Discrimination
© Copyright 2026 St. Jude Children's Research Hospital, a not-for-profit, section 501(c)(3).