X6RB39_HUMAN Loading...

Mitogen-activated protein kinase kinase 3

AlphaFold DB , UniProt , Accession X6RB39, Species HUMAN (Homo sapiens, Human), Gene MAP2K3, Length 46 aa.

						>X6RB39_HUMAN|X6RB39|MAP2K3
MESPASSQPASMPQSKERLVISMVTIYGPQQVPICAVNPVLSTLQT
					

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(Predicted Aligned Error values between residue pairs)

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Site	Residue	pLDDT	pLDDT confidence	pLDDT₁₀	pLDDT10 confidence	SASA	SASA [Å²]	SASA₁₀	SASA10 [Å²]	RSA	RSA unformatted	RSA₁₀	RSA10 unformatted	Surface	Surface10 (not used)	Disorder (not used)	Disorder	Sec. str.	Secondary structure	Isomer	Phi (φ)	Psi (ψ)	Omega (ω)	Chi 1 (χ₁)	Chi 2 (χ₂)	Chi 3 (χ₃)	Chi 4 (χ₄)	Chi 5 (χ₅)	Tau (τ)	Contacts (colored by PAE)	Contact details
1	M	54.9	Low	59.7	Low	246 Å²	246	136.3 Å²	136.3	100%	1.212	84%	0.84	S	S	*	*				0	101	0	-69.7	179	-168.5	0	0	105.8
2	E	53.3	Low	59.6	Low	198 Å²	198	136.6 Å²	136.6	93%	0.925	83%	0.828	S	S	*	*			trans	-135.5	137.1	178.1	-85.1	178.6	83.9	0	0	109.4
3	S	59.8	Low	59.6	Low	115 Å²	115	132.2 Å²	132.2	80%	0.804	80%	0.803	S	S	*	*	P	Polyproline II helix	trans	-66.2	151.3	-161.3	-62.2	0	0	0	0	114.7	A5	S3-A5 PolarHBondContact O-N 3.46Å
4	P	57.9	Low	59.5	Low	127 Å²	127	133.8 Å²	133.8	83%	0.825	80%	0.798	S	S	*	*	P	Polyproline II helix	trans	-69.6	131.2	176.2	29.1	-31.7	0	0	0	110.1	S6	P4-S6 PolarHBondContact O-N 3.05Å
5	A	62.1	Low	59.4	Low	94 Å²	94	131 Å²	131	78%	0.777	79%	0.787	S	S	*	*	P	Polyproline II helix	trans	-55.8	122.7	171.8	0	0	0	0	0	109.6	S3 S7	S3-A5 PolarHBondContact O-N 3.46Å; A5-S7 PolarHBondContact O-N 3.1Å
6	S	59.5	Low	59.2	Low	101 Å²	101	131.4 Å²	131.4	71%	0.706	78%	0.776	S	S	*	*	P	Polyproline II helix	trans	-49.6	120.7	177.8	-179.8	0	0	0	0	111	P4 Q8	P4-S6 PolarHBondContact O-N 3.05Å; S6-Q8 PolarHBondContact O-N 3.18Å
7	S	65.1	Low	59	Low	119 Å²	119	130.8 Å²	130.8	83%	0.832	76%	0.763	S	S	*	*			trans	-73	79.6	170.5	-52	0	0	0	0	109.1	A5 P9	A5-S7 PolarHBondContact O-N 3.1Å; S7-P9 WeakPolarHBondContact O-CD 3.4Å
8	Q	60.4	Low	58.7	Low	169 Å²	169	134.8 Å²	134.8	79%	0.79	76%	0.763	S	S	*	*			trans	-66.1	125.2	169.6	-85.3	-178	-89.4	0	0	109.1	S6 A10	S6-Q8 PolarHBondContact O-N 3.18Å; Q8-A10 PolarHBondContact O-N 3.31Å
9	P	57.8	Low	58.7	Low	120 Å²	120	133.9 Å²	133.9	78%	0.779	76%	0.756	S	S	*	*			trans	-65.7	122.8	170.7	26.2	-30.4	0	0	0	108	S7 S11	S7-P9 WeakPolarHBondContact O-CD 3.4Å; P9-S11 PolarHBondContact O-N 3.11Å
10	A	63.2	Low	58.6	Low	97 Å²	97	132 Å²	132	80%	0.802	75%	0.747	S	S	*	*			trans	-56.5	111.3	174.5	0	0	0	0	0	108.5	Q8 M12	Q8-A10 PolarHBondContact O-N 3.31Å; A10-M12 PolarHBondContact O-N 3.18Å
11	S	62.3	Low	58.5	Low	113 Å²	113	131.1 Å²	131.1	79%	0.79	74%	0.739	S	S	*	*			trans	-57	111.9	171.6	54.5	0	0	0	0	107.7	P9	P9-S11 PolarHBondContact O-N 3.11Å
12	M	58.9	Low	58.5	Low	140 Å²	140	122.3 Å²	122.3	69%	0.69	70%	0.702	S	S	*	*			trans	-53.6	134.6	177.7	-110.9	-165.1	154.6	0	0	109.3	A10 Q14	A10-M12 PolarHBondContact O-N 3.18Å; M12-Q14 PolarHBondContact O-N 3.05Å
13	P	59.1	Low	58.7	Low	79 Å²	79	117.8 Å²	117.8	51%	0.513	68%	0.682	S	S	.	*			trans	-64.4	114.8	178.5	22.7	-30.3	0	0	0	109.6	S15 K16	P13-S15 PolarHBondContact O-N 3.33Å; P13-K16 PolarHBondContact O-N 3.13Å; P13-K16 VanDerWaalsContact O-N 3.08Å
14	Q	58.7	Low	58.7	Low	155 Å²	155	117 Å²	117	72%	0.724	67%	0.672	S	S	*	*	T	Hydrogen-bonded Turn	trans	-49.5	-15	179.2	-65.2	175.5	-45.1	0	0	114.2	M12 K16	M12-Q14 PolarHBondContact O-N 3.05Å; Q14-K16 VanDerWaalsContact C-N 3.31Å; Q14-K16 PolarHBondContact O-N 2.97Å
15	S	58.3	Low	58.7	Low	92 Å²	92	116.4 Å²	116.4	64%	0.643	67%	0.666	S	S	*	*	H	α-helix	trans	-64.4	-30	176.2	-46.8	0	0	0	0	113.5	P13	P13-S15 PolarHBondContact O-N 3.33Å
16	K	56.2	Low	58.6	Low	138 Å²	138	117.1 Å²	117.1	60%	0.6	66%	0.656	S	S	*	*	H	α-helix	trans	-75.1	-36.2	179	-73.1	-173.8	178	-180	0	112.6	P13 Q14 R18 L19 V20	P13-K16 PolarHBondContact O-N 3.13Å; P13-K16 VanDerWaalsContact O-N 3.08Å; Q14-K16 VanDerWaalsContact C-N 3.31Å; Q14-K16 PolarHBondContact O-N 2.97Å; K16-R18 VanDerWaalsContact C-N 3.35Å; K16-R18 PolarHBondContact O-N 3.01Å; K16-L19 PolarHBondContact O-N 2.82Å; K16-V20 PolarHBondContact O-N 2.88Å
17	E	55.2	Low	58.6	Low	120 Å²	120	121.3 Å²	121.3	56%	0.561	66%	0.657	S	S	*	*	H	α-helix	trans	-65.1	-38.9	179.4	-67.3	174.2	98.4	0	0	111.7	L19 V20 I21	E17-L19 VanDerWaalsContact C-N 3.32Å; E17-L19 PolarHBondContact O-N 2.9Å; E17-V20 PolarHBondContact O-N 2.94Å; E17-I21 WeakPolarHBondContact O-CD1 3.37Å; E17-I21 WeakPolarHBondContact O-CG1 3.3Å; E17-I21 PolarHBondContact O-N 3.23Å
18	R	54.5	Low	58.4	Low	203 Å²	203	116.8 Å²	116.8	77%	0.766	63%	0.63	S	S	*	*	H	α-helix	trans	-62.6	-35.8	175.5	-76.9	-173.8	-179.2	-137.3	0.7	113.5	K16 S22	K16-R18 VanDerWaalsContact C-N 3.35Å; K16-R18 PolarHBondContact O-N 3.01Å; R18-S22 PolarHBondContact O-N 3.32Å
19	L	57.3	Low	58.6	Low	119 Å²	119	114.8 Å²	114.8	62%	0.623	63%	0.632	S	S	*	*	H	α-helix	trans	-68.2	-39.1	-179.6	-161.5	95.7	0	0	0	111.5	K16 E17 S22 M23	K16-L19 PolarHBondContact O-N 2.82Å; E17-L19 VanDerWaalsContact C-N 3.32Å; E17-L19 PolarHBondContact O-N 2.9Å; L19-S22 PolarHBondContact O-N 3.38Å; L19-M23 PolarHBondContact O-N 3.3Å
20	V	58	Low	58.8	Low	95 Å²	95	117.6 Å²	117.6	58%	0.576	63%	0.634	S	S	*	*	H	α-helix	trans	-67.9	-40.8	179.8	179	0	0	0	0	111.2	K16 E17 S22 M23 V24	K16-V20 PolarHBondContact O-N 2.88Å; E17-V20 PolarHBondContact O-N 2.94Å; V20-S22 VanDerWaalsContact C-N 3.28Å; V20-S22 PolarHBondContact O-N 3.29Å; V20-M23 PolarHBondContact O-N 3.13Å; V20-V24 PolarHBondContact O-N 3.39Å
21	I	56.3	Low	58.9	Low	113 Å²	113	121.9 Å²	121.9	58%	0.579	64%	0.638	S	S	*	*	H	α-helix	trans	-63.7	-35.6	177.6	-63.7	163.9	0	0	0	111.3	E17 T25	E17-I21 WeakPolarHBondContact O-CD1 3.37Å; E17-I21 WeakPolarHBondContact O-CG1 3.3Å; E17-I21 PolarHBondContact O-N 3.23Å; I21-T25 PolarHBondContact O-N 2.93Å; I21-T25 PolarHBondContact O-OG1 3.39Å
22	S	54.9	Low	59.2	Low	62 Å²	62	122 Å²	122	43%	0.434	63%	0.633	S	S	.	*	H	α-helix	trans	-65.1	-43	177.8	-166.2	0	0	0	0	112.3	R18 L19 V20 T25 I26	R18-S22 PolarHBondContact O-N 3.32Å; L19-S22 PolarHBondContact O-N 3.38Å; V20-S22 VanDerWaalsContact C-N 3.28Å; V20-S22 PolarHBondContact O-N 3.29Å; S22-T25 PolarHBondContact O-N 2.95Å; S22-I26 WeakPolarHBondContact O-CG1 3.42Å; S22-I26 VanDerWaalsContact O-N 3.13Å; S22-I26 PolarHBondContact O-N 3.36Å
23	M	57.8	Low	59.6	Low	102 Å²	102	120.5 Å²	120.5	50%	0.502	63%	0.634	S	S	.	*	H	α-helix	trans	-68.6	-37.3	-178.9	-69.8	-65.8	-178.6	0	0	113.1	L19 V20 T25 I26 Y27	L19-M23 PolarHBondContact O-N 3.3Å; V20-M23 PolarHBondContact O-N 3.13Å; M23-T25 PolarHBondContact O-N 3.24Å; M23-I26 PolarHBondContact O-N 3.47Å; M23-Y27 PolarHBondContact O-N 3.31Å; M23-Y27 HydrophobicContact SD-CD2 4.18Å; M23-Y27 HydrophobicContact SD-CE2 3.92Å
24	V	58.3	Low	60.2	Low	99 Å²	99	124.4 Å²	124.4	60%	0.6	65%	0.649	S	S	*	*	H	α-helix	trans	-65.8	-29.8	175.5	177.1	0	0	0	0	111.5	V20 G28	V20-V24 PolarHBondContact O-N 3.39Å; V24-G28 WeakPolarHBondContact O-CA 3.04Å; V24-G28 PolarHBondContact O-N 3.27Å
25	T	58.3	Low	61	Low	115 Å²	115	122.5 Å²	122.5	71%	0.706	65%	0.652	S	S	*	*	H	α-helix	trans	-75.5	-35.2	176.8	-52.8	0	0	0	0	111.8	I21 S22 M23	I21-T25 PolarHBondContact O-N 2.93Å; I21-T25 PolarHBondContact O-OG1 3.39Å; S22-T25 PolarHBondContact O-N 2.95Å; M23-T25 PolarHBondContact O-N 3.24Å
26	I	60.8	Low	61.6	Low	109 Å²	109	122.8 Å²	122.8	56%	0.559	66%	0.66	S	S	*	*	H	α-helix	trans	-81.5	-36.9	-177.4	-63.2	167.6	0	0	0	111.9	S22 M23	S22-I26 WeakPolarHBondContact O-CG1 3.42Å; S22-I26 VanDerWaalsContact O-N 3.13Å; S22-I26 PolarHBondContact O-N 3.36Å; M23-I26 PolarHBondContact O-N 3.47Å
27	Y	58.5	Low	62.3	Low	188 Å²	188	122.7 Å²	122.7	74%	0.737	67%	0.67	S	S	*	*	H	α-helix	trans	-114.6	8.4	-177	-62.6	-79.3	0	0	0	113.9	M23	M23-Y27 PolarHBondContact O-N 3.31Å; M23-Y27 HydrophobicContact SD-CD2 4.18Å; M23-Y27 HydrophobicContact SD-CE2 3.92Å
28	G	62.6	Low	62.9	Low	25 Å²	25	121.5 Å²	121.5	26%	0.258	67%	0.668	S	S	.	*	S	Bend	trans	-62	164.8	175.3	0	0	0	0	0	111.9	V24 Q30	V24-G28 WeakPolarHBondContact O-CA 3.04Å; V24-G28 PolarHBondContact O-N 3.27Å; G28-Q30 PolarHBondContact O-N 3.31Å
29	P	63.5	Low	63.5	Low	127 Å²	127	116.4 Å²	116.4	83%	0.825	66%	0.661	S	S	*	*			trans	-56.6	110.9	178.3	23.7	-32.3	0	0	0	109	Q31	P29-Q31 PolarHBondContact O-N 3.39Å
30	Q	61.4	Low	64	Low	179 Å²	179	115.3 Å²	115.3	84%	0.836	66%	0.659	S	S	*	*			trans	-61	106.6	172.1	-170.9	171.5	81.4	0	0	105.8	G28 V32	G28-Q30 PolarHBondContact O-N 3.31Å; Q30-V32 VanDerWaalsContact C-N 3.35Å; Q30-V32 PolarHBondContact O-N 3.37Å
31	Q	65.3	Low	64	Low	186 Å²	186	116.7 Å²	116.7	87%	0.869	66%	0.663	S	S	*	*			trans	-60.1	102.2	180	-70	-174.9	14.6	0	0	107.4	P29	P29-Q31 PolarHBondContact O-N 3.39Å
32	V	68.6	Low	64.1	Low	115 Å²	115	115.9 Å²	115.9	70%	0.697	67%	0.667	S	S	*	*			trans	-67.8	127.3	174.6	-177.6	0	0	0	0	106.1	Q30 I34	Q30-V32 VanDerWaalsContact C-N 3.35Å; Q30-V32 PolarHBondContact O-N 3.37Å; V32-I34 PolarHBondContact O-N 3.25Å
33	P	67.2	Low	64.4	Low	110 Å²	110	118 Å²	118	71%	0.714	68%	0.677	S	S	*	*			trans	-59.3	116.6	175.4	22.9	-30.8	0	0	0	108.3	C35	P33-C35 PolarHBondContact O-N 3.06Å; P33-C35 VanDerWaalsContact O-N 3.13Å
34	I	73.5	Confident	64.4	Low	161 Å²	161	119.7 Å²	119.7	83%	0.826	69%	0.688	S	S	*	*			trans	-67.8	112.1	172.3	-62.9	169.8	0	0	0	106	V32 A36	V32-I34 PolarHBondContact O-N 3.25Å; I34-A36 PolarHBondContact O-N 3Å
35	C	75.3	Confident	64.5	Low	115 Å²	115	123.3 Å²	123.3	78%	0.777	70%	0.698	S	S	*	*			trans	-62.1	106.5	169.7	-66.8	0	0	0	0	108	P33 V37	P33-C35 PolarHBondContact O-N 3.06Å; P33-C35 VanDerWaalsContact O-N 3.13Å; C35-V37 PolarHBondContact O-N 3.08Å
36	A	71.1	Confident	64	Low	98 Å²	98	127.5 Å²	127.5	81%	0.81	72%	0.724	S	S	*	*			trans	-65	108	173.2	0	0	0	0	0	108.4	I34 N38	I34-A36 PolarHBondContact O-N 3Å; A36-N38 PolarHBondContact O-N 3.45Å
37	V	69.8	Low	64.2	Low	136 Å²	136	128.5 Å²	128.5	82%	0.824	73%	0.732	S	S	*	*			trans	-66.9	123.1	173.7	-143.7	0	0	0	0	107.3	C35 P39	C35-V37 PolarHBondContact O-N 3.08Å; V37-P39 VanDerWaalsContact O-CD 3.3Å; V37-P39 WeakPolarHBondContact O-CD 3.47Å
38	N	68.8	Low	64.5	Low	94 Å²	94	125.3 Å²	125.3	50%	0.503	73%	0.732	S	S	.	*			trans	-66.4	115.8	179.1	-172.8	-20.6	0	0	0	109.1	A36 V40 L41	A36-N38 PolarHBondContact O-N 3.45Å; N38-V40 PolarHBondContact O-N 2.92Å; N38-V40 VanDerWaalsContact O-N 3.1Å; N38-V40 WeakPolarHBondContact OD1-CB 3.33Å; N38-V40 WeakPolarHBondContact OD1-CG2 3.34Å; N38-V40 PolarHBondContact OD1-N 3.23Å; N38-L41 PolarHBondContact O-N 2.83Å
39	P	65.6	Low	64.6	Low	97 Å²	97	130.9 Å²	130.9	63%	0.63	76%	0.758	S	S	*	*	H	α-helix	trans	-64.2	-18.7	-174.5	25.7	-34.5	0	0	0	113.2	V37 L41 S42	V37-P39 VanDerWaalsContact O-CD 3.3Å; V37-P39 WeakPolarHBondContact O-CD 3.47Å; P39-L41 PolarHBondContact O-N 3.25Å; P39-S42 WeakPolarHBondContact O-CB 3.47Å; P39-S42 PolarHBondContact O-N 2.98Å
40	V	68.4	Low	64.6	Low	96 Å²	96	131.1 Å²	131.1	58%	0.582	75%	0.754	S	S	*	*	H	α-helix	trans	-64.2	-27.2	177.8	-180	0	0	0	0	112.3	N38 T43	N38-V40 PolarHBondContact O-N 2.92Å; N38-V40 VanDerWaalsContact O-N 3.1Å; N38-V40 WeakPolarHBondContact OD1-CB 3.33Å; N38-V40 WeakPolarHBondContact OD1-CG2 3.34Å; N38-V40 PolarHBondContact OD1-N 3.23Å; V40-T43 PolarHBondContact O-OG1 3.21Å; V40-T43 VanDerWaalsContact O-OG1 3.11Å
41	L	58.6	Low	64.8	Low	124 Å²	124	128.1 Å²	128.1	65%	0.649	75%	0.749	S	S	*	*	H	α-helix	trans	-80	-21.2	175	-69.6	169	0	0	0	112.6	N38 P39 T43	N38-L41 PolarHBondContact O-N 2.83Å; P39-L41 PolarHBondContact O-N 3.25Å; L41-T43 VanDerWaalsContact C-N 3.3Å; L41-T43 PolarHBondContact O-N 3.44Å
42	S	58.4	Low	64.8	Low	95 Å²	95	124.3 Å²	124.3	66%	0.664	74%	0.741	S	S	*	*	H	α-helix	trans	-74.9	-20	-179.6	-167.3	0	0	0	0	112.9	P39	P39-S42 WeakPolarHBondContact O-CB 3.47Å; P39-S42 PolarHBondContact O-N 2.98Å
43	T	61.3	Low	64.5	Low	106 Å²	106	124.9 Å²	124.9	65%	0.65	74%	0.744	S	S	*	*	T	Hydrogen-bonded Turn	trans	-89.2	-0.2	-178	54.4	0	0	0	0	113.7	V40 L41	V40-T43 PolarHBondContact O-OG1 3.21Å; V40-T43 VanDerWaalsContact O-OG1 3.11Å; L41-T43 VanDerWaalsContact C-N 3.3Å; L41-T43 PolarHBondContact O-N 3.44Å
44	L	58.2	Low	64.3	Low	139 Å²	139	126.1 Å²	126.1	73%	0.728	75%	0.747	S	S	*	*	T	Hydrogen-bonded Turn	trans	-96.9	10.5	-177.3	-101.3	147.9	0	0	0	113.9
45	Q	60.4	Low	63.6	Low	174 Å²	174	123.2 Å²	123.2	81%	0.813	74%	0.74	S	S	*	*			trans	-116.4	29.9	-177.9	-65.5	-165.7	-70.8	0	0	115.4
46	T	47	Very low	62.5	Low	204 Å²	204	123.9 Å²	123.9	100%	1.252	74%	0.737	S	S	*	*			trans	-136	0	168.1	23.9	0	0	0	0	111.9

Retrieved 46 of 46 residues in 10.3 ms (Link to these results)

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