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Transmembrane protein 38B

Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Activated by increased cytosolic Ca(2+) levels.

AlphaFold DB , UniProt , Accession X6RGH1, Species HUMAN (Homo sapiens, Human), Gene TMEM38B, Length 35 aa.

>X6RGH1_HUMAN|X6RGH1|TMEM38B
MLHCFGGGILSCLLLAEPPLKFLANHTNILLASSI
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Site Residue pLDDT pLDDT confidence pLDDT10 pLDDT10 confidence SASA SASA [Ų] SASA10 SASA10 [Ų] RSA RSA unformatted RSA10 RSA10 unformatted Surface Surface10 (not used) Disorder (not used) Disorder Sec. str. Secondary structure Isomer Phi (φ) Psi (ψ) Omega (ω) Chi 1 (χ1) Chi 2 (χ2) Chi 3 (χ3) Chi 4 (χ4) Chi 5 (χ5) Tau (τ) Contacts (colored by PAE) Contact details
1M49.8Very low60.7Low214 Ų21496.8 Ų96.8100%1.05457%0.565SS**  0-25.90-61.8178.2-176.900113.4H3 C4M1-H3 VanDerWaalsContact C-N 3.34Å; M1-H3 PolarHBondContact O-N 3.16Å; M1-C4 PolarHBondContact O-N 3.37Å
2L52.4Low60.8Low159 Ų15992.3 Ų92.383%0.83254%0.542SS*.Hα-helixtrans-65-26.7177-70.8161.1000115.3G6L2-G6 PolarHBondContact O-N 3.45Å
3H55.2Low61.1Low184 Ų18494.2 Ų94.285%0.85255%0.547SS*.Hα-helixtrans-74.7-29-179.2-156170.3000112.9M1M1-H3 VanDerWaalsContact C-N 3.34Å; M1-H3 PolarHBondContact O-N 3.16Å
4C58.2Low61.2Low106 Ų10696.7 Ų96.772%0.71656%0.557SS**Hα-helixtrans-72.9-41.8176.4-1730000111.2M1M1-C4 PolarHBondContact O-N 3.37Å
5F62.5Low61.2Low56 Ų5699.5 Ų99.525%0.24657%0.568CS.*Hα-helixtrans-80.1-30.4-179-83.2-147.1000113G7 G8 I9 L30 S34F5-G7 VanDerWaalsContact C-N 3.29Å; F5-G7 PolarHBondContact O-N 3.07Å; F5-G8 PolarHBondContact O-N 3.13Å; F5-I9 WeakPolarHBondContact O-CG1 3.36Å; F5-I9 PolarHBondContact O-N 2.94Å; F5-L30 HydrophobicContact CB-CD2 4.33Å; F5-L30 HydrophobicContact CD1-CB 3.95Å; F5-L30 HydrophobicContact CD1-CD2 3.14Å; F5-L30 HydrophobicContact CD1-CG 3.38Å; F5-L30 HydrophobicContact CD2-CG 4.48Å; F5-L30 HydrophobicContact CE1-CB 3.29Å; F5-L30 HydrophobicContact CE1-CD1 4.46Å; F5-L30 HydrophobicContact CE1-CD2 3.44Å; F5-L30 VanDerWaalsContact CE1-CD2 3.44Å; F5-L30 HydrophobicContact CE1-CG 3.1Å; F5-L30 VanDerWaalsContact CE1-O 3.27Å; F5-L30 WeakPolarHBondContact CE1-O 3.45Å; F5-L30 HydrophobicContact CE2-CG 4.26Å; F5-L30 HydrophobicContact CG-CD2 3.84Å; F5-L30 HydrophobicContact CG-CG 4.07Å; F5-L30 HydrophobicContact CZ-CB 3.88Å; F5-L30 HydrophobicContact CZ-CD2 4.32Å; F5-L30 HydrophobicContact CZ-CG 3.58Å; F5-L30 VanDerWaalsContact CZ-O 3.23Å; F5-L30 WeakPolarHBondContact CZ-O 3.21Å; F5-S34 WeakPolarHBondContact CE1-OG 3.36Å; F5-S34 WeakPolarHBondContact CZ-OG 3.47Å
6G61.9Low60.7Low37 Ų3798.8 Ų98.838%0.38158%0.577SS.*Hα-helixtrans-58.8-38.4179.200000112.9L2 L10L2-G6 PolarHBondContact O-N 3.45Å; G6-L10 WeakPolarHBondContact O-CB 3.19Å; G6-L10 PolarHBondContact O-N 2.95Å
7G66.3Low60.3Low47 Ų47102.7 Ų102.749%0.48559%0.589SS.*Hα-helixtrans-67.1-43.7178.500000113.7F5 S11F5-G7 VanDerWaalsContact C-N 3.29Å; F5-G7 PolarHBondContact O-N 3.07Å; G7-S11 VanDerWaalsContact O-CB 3.29Å; G7-S11 WeakPolarHBondContact O-CB 3.29Å; G7-S11 PolarHBondContact O-N 3.21Å; G7-S11 VanDerWaalsContact O-N 3.07Å
8G65.2Low59.8Low33 Ų33102.8 Ų102.834%0.3459%0.594SS.*Hα-helixtrans-70.2-42.6179.700000112.8F5 S11 C12F5-G8 PolarHBondContact O-N 3.13Å; G8-S11 PolarHBondContact O-N 3.45Å; G8-C12 PolarHBondContact O-N 3.5Å; G8-C12 VanDerWaalsContact O-N 3.13Å; G8-C12 PolarHBondContact O-SG 3.36Å
9I67.4Low59.6Low59 Ų5999.5 Ų99.530%0.30358%0.576SS.*Hα-helixtrans-69.4-41178.8-62.9-46000111.8F5 S11 C12 L13 L30F5-I9 WeakPolarHBondContact O-CG1 3.36Å; F5-I9 PolarHBondContact O-N 2.94Å; I9-S11 VanDerWaalsContact C-N 3.34Å; I9-S11 PolarHBondContact O-N 3.41Å; I9-C12 PolarHBondContact O-N 2.99Å; I9-L13 WeakPolarHBondContact O-CB 3.04Å; I9-L13 PolarHBondContact O-N 3.03Å; I9-L30 HydrophobicContact CD1-CD2 3.56Å; I9-L30 HydrophobicContact CG1-CD2 3.76Å
10L64.1Low59.4Low105 Ų105102.1 Ų102.155%0.5559%0.587SS.*Hα-helixtrans-67.1-36.8178.1-164.472000111.6G6 L13 L14G6-L10 WeakPolarHBondContact O-CB 3.19Å; G6-L10 PolarHBondContact O-N 2.95Å; L10-L13 PolarHBondContact O-N 3.29Å; L10-L14 HydrophobicContact CG-CD1 4.06Å; L10-L14 WeakPolarHBondContact O-CB 3.39Å; L10-L14 WeakPolarHBondContact O-CD1 3.38Å; L10-L14 WeakPolarHBondContact O-CG 2.91Å; L10-L14 PolarHBondContact O-N 2.87Å
11S65.1Low59.2Low65 Ų65106.3 Ų106.346%0.45560%0.599SS.*Hα-helixtrans-65.3-44.2175.9-170.20000112.4G7 G8 I9 L13 L14 L15G7-S11 VanDerWaalsContact O-CB 3.29Å; G7-S11 WeakPolarHBondContact O-CB 3.29Å; G7-S11 PolarHBondContact O-N 3.21Å; G7-S11 VanDerWaalsContact O-N 3.07Å; G8-S11 PolarHBondContact O-N 3.45Å; I9-S11 VanDerWaalsContact C-N 3.34Å; I9-S11 PolarHBondContact O-N 3.41Å; S11-L13 VanDerWaalsContact C-N 3.29Å; S11-L13 PolarHBondContact O-N 3.32Å; S11-L14 PolarHBondContact O-N 3.49Å; S11-L15 PolarHBondContact O-N 3.34Å; S11-L15 VanDerWaalsContact O-N 3.16Å
12C61.4Low59.5Low43 Ų43101.1 Ų101.129%0.29157%0.57SS.*Hα-helixtrans-66.8-30.1175.9-64.10000113.1G8 I9 F22G8-C12 PolarHBondContact O-N 3.5Å; G8-C12 VanDerWaalsContact O-N 3.13Å; G8-C12 PolarHBondContact O-SG 3.36Å; I9-C12 PolarHBondContact O-N 2.99Å; C12-F22 HydrophobicContact CB-CD1 4.38Å; C12-F22 HydrophobicContact CB-CE1 4.18Å; C12-F22 WeakPolarHBondContact SG-CE1 3.38Å
13L65.6Low59.9Low117 Ų11797.4 Ų97.461%0.61355%0.551SS**Hα-helixtrans-74.7-37175.9-159.474.8000111.8I9 L10 S11 A16I9-L13 WeakPolarHBondContact O-CB 3.04Å; I9-L13 PolarHBondContact O-N 3.03Å; L10-L13 PolarHBondContact O-N 3.29Å; S11-L13 VanDerWaalsContact C-N 3.29Å; S11-L13 PolarHBondContact O-N 3.32Å; L13-A16 PolarHBondContact O-N 2.79Å
14L61.3Low60.1Low129 Ų12991.6 Ų91.668%0.67554%0.535SS*.Hα-helixtrans-73.2-27.4-179.7-75.7168.1000113.5L10 S11 A16L10-L14 HydrophobicContact CG-CD1 4.06Å; L10-L14 WeakPolarHBondContact O-CB 3.39Å; L10-L14 WeakPolarHBondContact O-CD1 3.38Å; L10-L14 WeakPolarHBondContact O-CG 2.91Å; L10-L14 PolarHBondContact O-N 2.87Å; S11-L14 PolarHBondContact O-N 3.49Å; L14-A16 PolarHBondContact O-N 2.73Å
15L62Low60.1Low139 Ų13992 Ų9273%0.72853%0.53SS*.THydrogen-bonded Turntrans-79.93.7175.6-9778.7000114.5S11 E17S11-L15 PolarHBondContact O-N 3.34Å; S11-L15 VanDerWaalsContact O-N 3.16Å; L15-E17 PolarHBondContact O-N 3.34Å
16A53.7Low60.3Low87 Ų8791.8 Ų91.872%0.71953%0.529SS*.  trans53.624.3160.900000117.3L13 L14L13-A16 PolarHBondContact O-N 2.79Å; L14-A16 PolarHBondContact O-N 2.73Å
17E53.6Low60.4Low166 Ų16693 Ų9378%0.77653%0.53SS*.SBendtrans-93.3120.6165.4-155167.588.400107.9L15 P19L15-E17 PolarHBondContact O-N 3.34Å; E17-P19 WeakPolarHBondContact O-CD 3.43Å
18P51.2Low60.1Low104 Ų10496 Ų9668%0.67554%0.535SS*.  trans-53.9112.8-166.319.6-32.4000110.4L20P18-L20 PolarHBondContact O-N 3.35Å
19P56.1Low59.9Low40 Ų4099.5 Ų99.526%0.2654%0.544SS..THydrogen-bonded Turntrans-82.524.3-160.934.7-38.2000111.6E17 K21 F22 L23E17-P19 WeakPolarHBondContact O-CD 3.43Å; P19-K21 PolarHBondContact O-N 3.37Å; P19-F22 PolarHBondContact O-N 3.33Å; P19-L23 HydrophobicContact CB-CB 4.19Å; P19-L23 WeakPolarHBondContact O-CA 3.11Å; P19-L23 WeakPolarHBondContact O-CB 3.27Å; P19-L23 PolarHBondContact O-N 3.48Å
20L55.7Low59.7Low152 Ų15297.9 Ų97.980%0.79654%0.536SS*.Hα-helixtrans-64.4-32.4-178.2-63.4-179.1000112.1P18P18-L20 PolarHBondContact O-N 3.35Å
21K55.7Low59.6Low190 Ų19098.7 Ų98.783%0.82654%0.54SS*.Hα-helixtrans-86.7-37.6172.7-100.6169.961.8174.70113.2P19P19-K21 PolarHBondContact O-N 3.37Å
22F54.7Low59.4Low105 Ų10598.6 Ų98.646%0.46154%0.544SS..Hα-helixtrans-76.8-41.1-176.9-168.9-92.3000112.2C12 P19 A24 N25 H26C12-F22 HydrophobicContact CB-CD1 4.38Å; C12-F22 HydrophobicContact CB-CE1 4.18Å; C12-F22 WeakPolarHBondContact SG-CE1 3.38Å; P19-F22 PolarHBondContact O-N 3.33Å; F22-A24 PolarHBondContact O-N 2.9Å; F22-N25 PolarHBondContact O-N 3.03Å; F22-H26 HydrophobicContact CD1-CB 4.01Å; F22-H26 HydrophobicContact CE1-CB 3.76Å; F22-H26 AromaticContact CE1-CG 3.73Å; F22-H26 AromaticContact CE1-ND1 3.81Å; F22-H26 HydrophobicContact CZ-CB 4.32Å; F22-H26 WeakPolarHBondContact O-CB 2.98Å; F22-H26 PolarHBondContact O-N 2.57Å
23L60.3Low59.3Low81 Ų81100.5 Ų100.542%0.42456%0.557SS.*Hα-helixtrans-65.5-38177.5-163.367.3000110.9P19 N25 T27P19-L23 HydrophobicContact CB-CB 4.19Å; P19-L23 WeakPolarHBondContact O-CA 3.11Å; P19-L23 WeakPolarHBondContact O-CB 3.27Å; P19-L23 PolarHBondContact O-N 3.48Å; L23-N25 VanDerWaalsContact C-N 3.34Å; L23-N25 PolarHBondContact O-N 2.81Å; L23-T27 WeakPolarHBondContact O-CA 3.15Å; L23-T27 WeakPolarHBondContact O-CB 3.36Å; L23-T27 PolarHBondContact O-N 3.41Å; L23-T27 PolarHBondContact O-OG1 3.47Å
24A59.7Low59.1Low62 Ų6298.6 Ų98.651%0.51255%0.554SS.*Hα-helixtrans-63.2-38.5177.100000113F22 N28F22-A24 PolarHBondContact O-N 2.9Å; A24-N28 PolarHBondContact O-ND2 2.98Å
25N58.6Low58.9Low115 Ų115102 Ų10262%0.61557%0.571SS**Hα-helixtrans-82.8-43.3-180-16758.9000112.4F22 L23 N28 I29F22-N25 PolarHBondContact O-N 3.03Å; L23-N25 VanDerWaalsContact C-N 3.34Å; L23-N25 PolarHBondContact O-N 2.81Å; N25-N28 PolarHBondContact O-N 3.26Å; N25-I29 PolarHBondContact O-N 3.4Å
26H65.9Low58.7Low51 Ų51100.2 Ų100.224%0.23656%0.563CS.*Hα-helixtrans-74.1-32.2-179.7-159.1-128.5000111.5F22 N28 I29 L30F22-H26 HydrophobicContact CD1-CB 4.01Å; F22-H26 HydrophobicContact CE1-CB 3.76Å; F22-H26 AromaticContact CE1-CG 3.73Å; F22-H26 AromaticContact CE1-ND1 3.81Å; F22-H26 HydrophobicContact CZ-CB 4.32Å; F22-H26 WeakPolarHBondContact O-CB 2.98Å; F22-H26 PolarHBondContact O-N 2.57Å; H26-N28 VanDerWaalsContact C-N 3.34Å; H26-N28 PolarHBondContact O-N 2.63Å; H26-I29 PolarHBondContact O-N 3.15Å; H26-L30 WeakPolarHBondContact CE1-CD1 3.39Å; H26-L30 VanDerWaalsContact ND1-CD1 3.27Å; H26-L30 WeakPolarHBondContact ND1-CD1 3.42Å; H26-L30 WeakPolarHBondContact NE2-CD1 3.23Å; H26-L30 VanDerWaalsContact O-CB 3.28Å; H26-L30 WeakPolarHBondContact O-CB 3.28Å; H26-L30 WeakPolarHBondContact O-CD1 3.47Å; H26-L30 PolarHBondContact O-N 2.74Å
27T65.3Low59Low63 Ų63100.9 Ų100.939%0.38756%0.555SS.*Hα-helixtrans-65-37.5172.6-55.40000110.9L23 I29 L31L23-T27 WeakPolarHBondContact O-CA 3.15Å; L23-T27 WeakPolarHBondContact O-CB 3.36Å; L23-T27 PolarHBondContact O-N 3.41Å; L23-T27 PolarHBondContact O-OG1 3.47Å; T27-I29 PolarHBondContact O-N 3.48Å; T27-L31 WeakPolarHBondContact O-CA 3.27Å; T27-L31 WeakPolarHBondContact O-CB 3.42Å; T27-L31 PolarHBondContact O-N 3.15Å
28N60.3Low59.3Low111 Ų11197.3 Ų97.359%0.59454%0.543SS*.Hα-helixtrans-61.9-43.3172.7-105.2-80.2000112.1A24 N25 H26 A32A24-N28 PolarHBondContact O-ND2 2.98Å; N25-N28 PolarHBondContact O-N 3.26Å; H26-N28 VanDerWaalsContact C-N 3.34Å; H26-N28 PolarHBondContact O-N 2.63Å; N28-A32 WeakPolarHBondContact O-CB 3.46Å; N28-A32 PolarHBondContact O-N 3.5Å
29I61.2Low59.8Low105 Ų10596.9 Ų96.954%0.53854%0.535SS..Hα-helixtrans-70.3-42.2178.6-67.5-65000112.2N25 H26 T27 A32 S33N25-I29 PolarHBondContact O-N 3.4Å; H26-I29 PolarHBondContact O-N 3.15Å; T27-I29 PolarHBondContact O-N 3.48Å; I29-A32 PolarHBondContact O-N 2.77Å; I29-S33 WeakPolarHBondContact O-CB 3.46Å; I29-S33 PolarHBondContact O-N 2.84Å
30L61.9Low60Low26 Ų26100.4 Ų100.414%0.13655%0.552CS.*Hα-helixtrans-62.9-46173.6-103.373.4000110.7F5 I9 H26 A32 S33 S34F5-L30 HydrophobicContact CB-CD2 4.33Å; F5-L30 HydrophobicContact CD1-CB 3.95Å; F5-L30 HydrophobicContact CD1-CD2 3.14Å; F5-L30 HydrophobicContact CD1-CG 3.38Å; F5-L30 HydrophobicContact CD2-CG 4.48Å; F5-L30 HydrophobicContact CE1-CB 3.29Å; F5-L30 HydrophobicContact CE1-CD1 4.46Å; F5-L30 HydrophobicContact CE1-CD2 3.44Å; F5-L30 VanDerWaalsContact CE1-CD2 3.44Å; F5-L30 HydrophobicContact CE1-CG 3.1Å; F5-L30 VanDerWaalsContact CE1-O 3.27Å; F5-L30 WeakPolarHBondContact CE1-O 3.45Å; F5-L30 HydrophobicContact CE2-CG 4.26Å; F5-L30 HydrophobicContact CG-CD2 3.84Å; F5-L30 HydrophobicContact CG-CG 4.07Å; F5-L30 HydrophobicContact CZ-CB 3.88Å; F5-L30 HydrophobicContact CZ-CD2 4.32Å; F5-L30 HydrophobicContact CZ-CG 3.58Å; F5-L30 VanDerWaalsContact CZ-O 3.23Å; F5-L30 WeakPolarHBondContact CZ-O 3.21Å; I9-L30 HydrophobicContact CD1-CD2 3.56Å; I9-L30 HydrophobicContact CG1-CD2 3.76Å; H26-L30 WeakPolarHBondContact CE1-CD1 3.39Å; H26-L30 VanDerWaalsContact ND1-CD1 3.27Å; H26-L30 WeakPolarHBondContact ND1-CD1 3.42Å; H26-L30 WeakPolarHBondContact NE2-CD1 3.23Å; H26-L30 VanDerWaalsContact O-CB 3.28Å; H26-L30 WeakPolarHBondContact O-CB 3.28Å; H26-L30 WeakPolarHBondContact O-CD1 3.47Å; H26-L30 PolarHBondContact O-N 2.74Å; L30-A32 VanDerWaalsContact C-N 3.32Å; L30-A32 PolarHBondContact O-N 3.5Å; L30-S33 CarbonylContact O-C 3.49Å; L30-S33 PolarHBondContact O-N 3.26Å; L30-S33 VanDerWaalsContact O-N 3.15Å; L30-S34 WeakPolarHBondContact O-CB 2.96Å; L30-S34 PolarHBondContact O-N 3.5Å; L30-S34 PolarHBondContact O-OG 3.49Å
31L62.3Low60.3Low121 Ų12197 Ų9763%0.63454%0.536SS*.Hα-helixtrans-63.7-40178.4-163.3102.6000110.4T27 S33 S34T27-L31 WeakPolarHBondContact O-CA 3.27Å; T27-L31 WeakPolarHBondContact O-CB 3.42Å; T27-L31 PolarHBondContact O-N 3.15Å; L31-S33 VanDerWaalsContact C-N 3.33Å; L31-S33 PolarHBondContact O-N 3.4Å; L31-S34 WeakPolarHBondContact O-CB 3.13Å; L31-S34 PolarHBondContact O-N 2.83Å; L31-S34 VanDerWaalsContact O-N 3.15Å
32A61.2Low60.6Low63 Ų6390.4 Ų90.452%0.52152%0.515SS..Hα-helixtrans-69.3-25.8173.400000113.8N28 I29 L30 S34 I35N28-A32 WeakPolarHBondContact O-CB 3.46Å; N28-A32 PolarHBondContact O-N 3.5Å; I29-A32 PolarHBondContact O-N 2.77Å; L30-A32 VanDerWaalsContact C-N 3.32Å; L30-A32 PolarHBondContact O-N 3.5Å; A32-S34 VanDerWaalsContact C-N 3.32Å; A32-I35 WeakPolarHBondContact O-CG2 3.32Å
33S59.5Low61.1Low83 Ų8389.2 Ų89.258%0.5852%0.519SS*.THydrogen-bonded Turntrans-85.6-6.4171.6-179.30000112.8I29 L30 L31I29-S33 WeakPolarHBondContact O-CB 3.46Å; I29-S33 PolarHBondContact O-N 2.84Å; L30-S33 CarbonylContact O-C 3.49Å; L30-S33 PolarHBondContact O-N 3.26Å; L30-S33 VanDerWaalsContact O-N 3.15Å; L31-S33 VanDerWaalsContact C-N 3.33Å; L31-S33 PolarHBondContact O-N 3.4Å
34S60.4Low61.1Low77 Ų7789.9 Ų89.954%0.53853%0.527SS..  trans-98.31.2179.6-55.10000113.2F5 L30 L31 A32F5-S34 WeakPolarHBondContact CE1-OG 3.36Å; F5-S34 WeakPolarHBondContact CZ-OG 3.47Å; L30-S34 WeakPolarHBondContact O-CB 2.96Å; L30-S34 PolarHBondContact O-N 3.5Å; L30-S34 PolarHBondContact O-OG 3.49Å; L31-S34 WeakPolarHBondContact O-CB 3.13Å; L31-S34 PolarHBondContact O-N 2.83Å; L31-S34 VanDerWaalsContact O-N 3.15Å; A32-S34 VanDerWaalsContact C-N 3.32Å
35I57.3Low61.3Low202 Ų20292.5 Ų92.5100%1.03653%0.529SS*.  trans-108.10171.8-163.5154.9000110.1A32A32-I35 WeakPolarHBondContact O-CG2 3.32Å

Retrieved 35 of 35 residues in 22.8 ms (Link to these results)